MX2021005024A - Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b. - Google Patents

Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b.

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Publication number
MX2021005024A
MX2021005024A MX2021005024A MX2021005024A MX2021005024A MX 2021005024 A MX2021005024 A MX 2021005024A MX 2021005024 A MX2021005024 A MX 2021005024A MX 2021005024 A MX2021005024 A MX 2021005024A MX 2021005024 A MX2021005024 A MX 2021005024A
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MX
Mexico
Prior art keywords
methods
antigen
treatment
cell maturation
receptors specific
Prior art date
Application number
MX2021005024A
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English (en)
Inventor
Eric L Smith
Blythe D Sather
Aye Chen
Erik Hess
Imus Cyr De
Audrey Olshefsky
Stefan Ponko
Semih Tareen
Mariana Cota Stirner
Original Assignee
Juno Therapeutics Inc
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Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2021005024A publication Critical patent/MX2021005024A/es

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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Abstract

En la presente se proporcionan métodos de terapia celular adoptiva que implican la administración de dosis de células para tratar enfermedades y condiciones, incluidas ciertas malignidades de células plasmáticas. Las células expresan en general receptores recombinantes tal como receptores de antígenos quiméricos (CAR) específicos para el antígeno de maduración de células B (BCMA). En algunas modalidades, los métodos son para tratar sujetos con mieloma múltiple (MM). También se proporcionan células modificadas genéticamente que contienen estos receptores de unión a BCMA para usos en la terapia celular adoptiva.
MX2021005024A 2018-11-01 2019-10-31 Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b. MX2021005024A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862754577P 2018-11-01 2018-11-01
US201862774167P 2018-11-30 2018-11-30
US201862774856P 2018-12-03 2018-12-03
US201862777066P 2018-12-07 2018-12-07
US201962845817P 2019-05-09 2019-05-09
PCT/US2019/059271 WO2020092848A2 (en) 2018-11-01 2019-10-31 Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen

Publications (1)

Publication Number Publication Date
MX2021005024A true MX2021005024A (es) 2021-07-21

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MX2021005024A MX2021005024A (es) 2018-11-01 2019-10-31 Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b.

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Country Link
US (1) US20210393690A1 (es)
EP (1) EP3873943A2 (es)
JP (1) JP2022512917A (es)
KR (1) KR20210113169A (es)
CN (1) CN113646335A (es)
AU (1) AU2019372331A1 (es)
BR (1) BR112021008289A2 (es)
CA (1) CA3117419A1 (es)
IL (1) IL282667A (es)
MA (1) MA54078A (es)
MX (1) MX2021005024A (es)
SG (1) SG11202104188VA (es)
WO (1) WO2020092848A2 (es)

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CN113388036A (zh) 2014-12-05 2021-09-14 纪念斯隆-凯特琳癌症中心 靶向b-细胞成熟抗原的抗体及其用途
CN117357638A (zh) 2017-02-17 2024-01-09 弗雷德哈钦森癌症中心 用于治疗bcma相关癌症和自身免疫性失调的联合疗法
JP7447006B2 (ja) 2017-11-01 2024-03-11 ジュノー セラピューティクス インコーポレイテッド Ｂ細胞成熟抗原（ｂｃｍａ）に特異的なキメラ抗原受容体
CN114364801B (zh) * 2019-05-30 2024-04-19 莱蒂恩技术公司 用于用抗bcma免疫治疗来治疗癌症的组合物和方法
KR20230015921A (ko) * 2020-04-28 2023-01-31 주노 쎄러퓨티크스 인코퍼레이티드 Ｂｃｍａ-지시된 ｔ 세포 요법 및 면역 조절 화합물의 조합
EP4146703A2 (en) * 2020-05-08 2023-03-15 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Chimeric antigen receptors (cars) targeting natural killer cells
US20230178239A1 (en) 2020-05-13 2023-06-08 Juno Therapeutics, Inc. Methods of identifying features associated with clinical response and uses thereof
WO2023278310A1 (en) * 2021-06-28 2023-01-05 Meridian Therapeutics, Inc. Compositions and methods of treating plasma cell disorders including multiple myeloma with a vaccine composition and myeloma-specific car-t cells
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