MX2018014911A - Metodos para el tratamiento de afecciones malignas de celulas t usando terapia de celulas adoptivas. - Google Patents
Metodos para el tratamiento de afecciones malignas de celulas t usando terapia de celulas adoptivas.Info
- Publication number
- MX2018014911A MX2018014911A MX2018014911A MX2018014911A MX2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- therapy
- cell
- treating
- treatment
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 238000011467 adoptive cell therapy Methods 0.000 title abstract 2
- 230000036210 malignancy Effects 0.000 title abstract 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000004083 survival effect Effects 0.000 abstract 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 abstract 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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Abstract
Se proporcionan métodos de terapia de célula adoptiva que implica la administración de dosis de células para tratar afecciones malignas de células B. Las células que expresan en general receptores recombinantes tal como receptores de antígeno quiméricos (CARs). En algunas modalidades, los métodos son para tratar sujetos con leucemia linfocítica crónica (CLL). En algunas modalidades, los métodos son para tratar sujetos con linfoma no de Hodgkin (NHL). En algunas modalidades, los métodos implican la administración previa de una terapia reductora de linfocitos, tal como administración previa de fludarabina y/u otro agente quimioterapéutico reductor de linfocitos, por ejemplo ciclofosfamida. En algunas modalidades, las características de los métodos incluyen un incremento en la remisión completa, supervivencia total y/o supervivencia sin progresión de sujetos tratados de acuerdo con los métodos proporcionados.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662346547P | 2016-06-06 | 2016-06-06 | |
US201662417292P | 2016-11-03 | 2016-11-03 | |
US201662429737P | 2016-12-03 | 2016-12-03 | |
PCT/US2017/036231 WO2017214207A2 (en) | 2016-06-06 | 2017-06-06 | Methods for the treatment of b cell malignancies using adoptive cell therapy |
Publications (1)
Publication Number | Publication Date |
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MX2018014911A true MX2018014911A (es) | 2019-08-12 |
Family
ID=59227902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MX2018014911A MX2018014911A (es) | 2016-06-06 | 2017-06-06 | Metodos para el tratamiento de afecciones malignas de celulas t usando terapia de celulas adoptivas. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20200016199A1 (es) |
EP (1) | EP3463437A2 (es) |
JP (3) | JP7139318B2 (es) |
KR (3) | KR20240036704A (es) |
CN (1) | CN109562151A (es) |
AU (1) | AU2017277396A1 (es) |
BR (1) | BR112018074406A2 (es) |
CA (1) | CA3024725A1 (es) |
MA (1) | MA45341A (es) |
MX (1) | MX2018014911A (es) |
WO (1) | WO2017214207A2 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016064929A1 (en) | 2014-10-20 | 2016-04-28 | Juno Therapeutics, Inc. | Methods and compositions for dosing in adoptive cell therapy |
ES2818103T3 (es) | 2015-01-16 | 2021-04-09 | Juno Therapeutics Inc | Anticuerpos y receptores de antígenos quiméricos específicos para ROR1 |
MX2018009011A (es) | 2016-02-02 | 2018-11-19 | Hutchinson Fred Cancer Res | Anticuerpos anti receptor 1 transmembrana de tirosina-proteina cinasa (ror1) y usos de los mismos. |
EP3534938A2 (en) * | 2016-11-03 | 2019-09-11 | Juno Therapeutics, Inc. | Combination therapy of a t cell therapy and a btk inhibitor |
MA46995A (fr) | 2016-12-03 | 2019-10-09 | Acerta Pharma Bv | Méthodes et compositions pour l'utilisation de lymphocytes t thérapeutiques en association avec des inhibiteurs de kinase |
AU2018234640B2 (en) | 2017-03-14 | 2024-03-14 | Juno Therapeutics, Inc. | Methods for cryogenic storage |
CN111225675B (zh) | 2017-06-02 | 2024-05-03 | 朱诺治疗学股份有限公司 | 使用过继细胞疗法治疗的制品和方法 |
WO2019079486A1 (en) | 2017-10-18 | 2019-04-25 | Intrexon Corporation | POLYPEPTIDE COMPOSITIONS COMPRISING SPACERS |
US11851679B2 (en) | 2017-11-01 | 2023-12-26 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
WO2019200347A1 (en) * | 2018-04-13 | 2019-10-17 | Fred Hutchinson Cancer Research Center | Methods for adoptive cell therapy targeting ror1 |
SG11202010642TA (en) * | 2018-05-03 | 2020-11-27 | Juno Therapeutics Inc | Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor |
EP3873539A4 (en) * | 2018-10-31 | 2023-01-18 | The Children's Hospital of Philadelphia | T LYMPHOCYTES FROM LYMPHATIC FLUID FOR DIAGNOSTIC AND THERAPEUTIC USE |
SG11202105502RA (en) * | 2018-11-30 | 2021-06-29 | Juno Therapeutics Inc | Methods for treatment using adoptive cell therapy |
WO2020113188A2 (en) * | 2018-11-30 | 2020-06-04 | Juno Therapeutics, Inc. | Methods for dosing and treatment of b cell malignancies in adoptive cell therapy |
CN113766956B (zh) | 2019-03-05 | 2024-05-07 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
JP2022538836A (ja) * | 2019-06-27 | 2022-09-06 | クリスパー セラピューティクス アクチェンゲゼルシャフト | がんを治療するためのキメラ抗原受容体t細胞及びnk細胞阻害剤の使用 |
MX2022006715A (es) * | 2019-12-06 | 2022-09-23 | Juno Therapeutics Inc | Metodos relacionados con toxicidad y respuesta asociada con terapia celular para tratar neoplasias malignas de celulas b. |
BR112022014501A2 (pt) * | 2020-01-24 | 2022-09-20 | Juno Therapeutics Inc | Métodos para dosagem e tratamento de linfoma folicular e linfoma de zona marginal em terapia celular adotiva |
MX2022009832A (es) * | 2020-02-12 | 2023-02-14 | Juno Therapeutics Inc | Composiciones de celulas t de receptor de antigeno quimerico dirigido a cd19 y usos de las mismas. |
WO2021236564A2 (en) * | 2020-05-18 | 2021-11-25 | Robert Sackstein | Compositions and methods for treatment of inflammatory disorders |
EP4161563A1 (en) * | 2020-06-05 | 2023-04-12 | Tessa Therapeutics Ltd. | Treatment of cd30-positive cancer |
WO2021260657A1 (en) * | 2020-06-26 | 2021-12-30 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
JP2023546178A (ja) * | 2020-10-20 | 2023-11-01 | クリスパー セラピューティクス アクチェンゲゼルシャフト | Cd19を標的とする遺伝子操作されたt細胞を用いたb細胞悪性腫瘍の同種他家細胞療法 |
RU2758126C1 (ru) * | 2021-04-02 | 2021-10-26 | федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии» Министерства здравоохранения Российской Федерации | Способ прогнозирования развития рецидива диффузной В-крупноклеточной лимфомы |
TW202307210A (zh) * | 2021-06-01 | 2023-02-16 | 瑞士商諾華公司 | Cd19和cd22嵌合抗原受體及其用途 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
IN165717B (es) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
ES2067018T3 (es) | 1988-12-28 | 1995-03-16 | Stefan Miltenyi | Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos. |
US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
DE19608753C1 (de) | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduktionssystem und seine Verwendung |
US6451995B1 (en) | 1996-03-20 | 2002-09-17 | Sloan-Kettering Institute For Cancer Research | Single chain FV polynucleotide or peptide constructs of anti-ganglioside GD2 antibodies, cells expressing same and related methods |
EP1109921A4 (en) | 1998-09-04 | 2002-08-28 | Sloan Kettering Inst Cancer | FOR PROSTATE-SPECIFIC MEMBRANE-ANTI-SPECIFIC FUSION RECEPTORS AND THEIR USE |
US6410319B1 (en) | 1998-10-20 | 2002-06-25 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
CA2410510A1 (en) | 2000-06-02 | 2001-12-13 | Memorial Sloan-Kettering Cancer Center | Artificial antigen presenting cells and methods of use thereof |
US7446179B2 (en) | 2000-11-07 | 2008-11-04 | City Of Hope | CD19-specific chimeric T cell receptor |
US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
ES2663323T3 (es) | 2007-03-30 | 2018-04-12 | Memorial Sloan-Kettering Cancer Center | Expresión constitutiva de ligandos coestimuladores en linfocitos T transferidos de manera adoptiva |
ES2374863T3 (es) | 2007-12-07 | 2012-02-22 | Miltenyi Biotec Gmbh | Centrífuga para separar una muestra en por lo menos dos componentes. |
US8479118B2 (en) | 2007-12-10 | 2013-07-02 | Microsoft Corporation | Switching search providers within a browser search box |
US20120164718A1 (en) | 2008-05-06 | 2012-06-28 | Innovative Micro Technology | Removable/disposable apparatus for MEMS particle sorting device |
JP5173594B2 (ja) | 2008-05-27 | 2013-04-03 | キヤノン株式会社 | 管理装置、画像形成装置及びそれらの処理方法 |
CA2735456C (en) | 2008-08-26 | 2021-11-16 | City Of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
DK2344539T3 (en) * | 2008-11-07 | 2015-05-04 | Amgen Res Munich Gmbh | Treatment of pediatric acute lymphoblastic leukemia |
EP4049674A1 (en) | 2009-11-03 | 2022-08-31 | City of Hope | Truncated epidermal growth factor receptor (egfrt) for transduced t cell selection |
MX347078B (es) | 2010-12-09 | 2017-04-10 | Univ Pennsylvania | Uso de celulas t modificadas por receptor de antigeno quimerico para tratar cancer. |
WO2012129514A1 (en) | 2011-03-23 | 2012-09-27 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
US8398282B2 (en) | 2011-05-12 | 2013-03-19 | Delphi Technologies, Inc. | Vehicle front lighting assembly and systems having a variable tint electrowetting element |
MX359234B (es) | 2011-11-11 | 2018-09-20 | Hutchinson Fred Cancer Res | Inmunoterapia de celulas t objetivadas en ciclina a1 para cancer. |
EP2814846B1 (en) | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
AU2013256159B2 (en) | 2012-05-03 | 2018-08-09 | Fred Hutchinson Cancer Center | Enhanced affinity T cell receptors and methods for making the same |
SI4019041T1 (sl) * | 2012-07-13 | 2023-04-28 | The Trustees Of The University Of Pennsylvania | Obladovanje toksičnosti za protitumorsko delovanje CARS |
SG10201701339RA (en) * | 2012-08-20 | 2017-03-30 | Seattle Children S Hospital Dba Seattle Children S Res Inst | Method and compositions for cellular immunotherapy |
WO2014055668A1 (en) | 2012-10-02 | 2014-04-10 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
JP5372297B1 (ja) | 2012-12-20 | 2013-12-18 | 三菱電機株式会社 | 車載装置及びプログラム |
UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
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WO2017214207A2 (en) | 2017-12-14 |
JP7139318B2 (ja) | 2022-09-20 |
CA3024725A1 (en) | 2017-12-14 |
CN109562151A (zh) | 2019-04-02 |
BR112018074406A2 (pt) | 2019-03-06 |
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