MX2021003661A - Moduladores de la monoacilglicerol lipasa. - Google Patents

Moduladores de la monoacilglicerol lipasa.

Info

Publication number
MX2021003661A
MX2021003661A MX2021003661A MX2021003661A MX2021003661A MX 2021003661 A MX2021003661 A MX 2021003661A MX 2021003661 A MX2021003661 A MX 2021003661A MX 2021003661 A MX2021003661 A MX 2021003661A MX 2021003661 A MX2021003661 A MX 2021003661A
Authority
MX
Mexico
Prior art keywords
methods
disorders
formula
monoacylglycerol lipase
modulators
Prior art date
Application number
MX2021003661A
Other languages
English (en)
Inventor
Gang Chen
Wei Zhang
Suchitra Ravula
Michael K Ameriks
Chaofeng Huang
Brian Ngo Laforteza
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2021003661A publication Critical patent/MX2021003661A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Compuestos puenteados de la Fórmula (I) y Fórmula (II), composiciones farmacéuticas que los contienen, métodos para fabricarlos y métodos para usarlos que incluyen métodos para tratar estados de enfermedad, trastornos y afecciones asociados con la modulación de la MGL, tales como aquellos asociados con dolor, trastornos psiquiátricos, trastornos neurológicos (que incluyen, pero no se limitan a, trastorno depresivo mayor, depresión resistente al tratamiento, depresión ansiosa, trastorno bipolar), cánceres y afecciones oculares. (ver formula) y; en donde R2, R3, R4, R5 y R6 se definen en la presente descripción.
MX2021003661A 2018-09-28 2019-09-27 Moduladores de la monoacilglicerol lipasa. MX2021003661A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862738684P 2018-09-28 2018-09-28
PCT/IB2019/058241 WO2020065614A1 (en) 2018-09-28 2019-09-27 Monoacylglycerol lipase modulators

Publications (1)

Publication Number Publication Date
MX2021003661A true MX2021003661A (es) 2021-08-19

Family

ID=68109429

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021003661A MX2021003661A (es) 2018-09-28 2019-09-27 Moduladores de la monoacilglicerol lipasa.

Country Status (12)

Country Link
US (3) US20200102311A1 (es)
EP (1) EP3856179A1 (es)
JP (2) JP7413368B2 (es)
KR (1) KR20210069079A (es)
CN (1) CN113164458A (es)
AU (1) AU2019349962A1 (es)
BR (1) BR112021005936A2 (es)
CA (1) CA3111309A1 (es)
MA (1) MA53722A (es)
MX (1) MX2021003661A (es)
TW (1) TW202035409A (es)
WO (1) WO2020065614A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3856178A1 (en) 2018-09-28 2021-08-04 Janssen Pharmaceutica NV Monoacylglycerol lipase modulators
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Also Published As

Publication number Publication date
MA53722A (fr) 2022-03-30
KR20210069079A (ko) 2021-06-10
US20200102311A1 (en) 2020-04-02
US20230242531A1 (en) 2023-08-03
US11597728B2 (en) 2023-03-07
JP2024038151A (ja) 2024-03-19
WO2020065614A1 (en) 2020-04-02
TW202035409A (zh) 2020-10-01
CN113164458A (zh) 2021-07-23
EP3856179A1 (en) 2021-08-04
JP7413368B2 (ja) 2024-01-15
US20220315583A1 (en) 2022-10-06
CA3111309A1 (en) 2020-04-02
AU2019349962A1 (en) 2021-03-18
BR112021005936A2 (pt) 2021-06-29
JP2022502440A (ja) 2022-01-11

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