MX2021002574A - Metodos para el analisis por espectrometria de masas de composiciones de celulas modificadas. - Google Patents
Metodos para el analisis por espectrometria de masas de composiciones de celulas modificadas.Info
- Publication number
- MX2021002574A MX2021002574A MX2021002574A MX2021002574A MX2021002574A MX 2021002574 A MX2021002574 A MX 2021002574A MX 2021002574 A MX2021002574 A MX 2021002574A MX 2021002574 A MX2021002574 A MX 2021002574A MX 2021002574 A MX2021002574 A MX 2021002574A
- Authority
- MX
- Mexico
- Prior art keywords
- mass spectrometry
- engineered cell
- methods
- cell composition
- profile
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- 238000004949 mass spectrometry Methods 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 6
- 210000004027 cell Anatomy 0.000 abstract 7
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
En la presente se proporcionan métodos para generar un perfil de espectrometría de masas (MS) de una muestra a partir de una composición de células, tal como una composición de células modificadas. En algunas modalidades, el perfil de espectrometría de masas incluye datos basados en uno o más análisis o técnicas de espectrometría de masas. En la presente también se proporcionan métodos para, con base en perfiles de espectrometría de masas de una o más muestras de estas composiciones de células: identificar un perfil de espectrometría de masas (MS) de una composición de células genéticamente modificadas que comprende células inmunitarias que comprenden un receptor recombinante por comparación a un perfil de espectrometría de masas de referencia; caracterizar un proceso para producir composición de células genéticamente modificadas; valorar proteínas de superficie celular de una composición de células modificadas; y valorar un proceso para producir una composición de células genéticamente modificadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862729985P | 2018-09-11 | 2018-09-11 | |
PCT/US2019/050681 WO2020056047A1 (en) | 2018-09-11 | 2019-09-11 | Methods for mass spectrometry analysis of engineered cell compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021002574A true MX2021002574A (es) | 2021-06-08 |
Family
ID=68136527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021002574A MX2021002574A (es) | 2018-09-11 | 2019-09-11 | Metodos para el analisis por espectrometria de masas de composiciones de celulas modificadas. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220050114A1 (es) |
EP (1) | EP3850366A1 (es) |
JP (1) | JP7504891B2 (es) |
KR (1) | KR20210081341A (es) |
CN (1) | CN113167796A (es) |
AU (1) | AU2019339464A1 (es) |
BR (1) | BR112021004261A2 (es) |
CA (1) | CA3111789A1 (es) |
EA (1) | EA202190693A1 (es) |
IL (1) | IL281325A (es) |
MA (1) | MA53612A (es) |
MX (1) | MX2021002574A (es) |
SG (1) | SG11202102108QA (es) |
WO (1) | WO2020056047A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2019012189A (es) | 2017-04-14 | 2020-12-10 | Juno Therapeutics Inc | Metodos para valorar la glucosilacion de la superficie celular. |
EP4277917A4 (en) * | 2021-01-14 | 2024-06-19 | Biocatalyst LLC | COMPOSITIONS AND PROCESSES FOR PRODUCING PEPTIDES |
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ES2688035T3 (es) | 2014-08-29 | 2018-10-30 | Gemoab Monoclonals Gmbh | Receptor de antígeno universal que expresa células inmunes para direccionamiento de antígenos múltiples diversos, procedimiento para fabricación del mismo y utilización del mismo para tratamiento de cáncer, infecciones y enfermedades autoinmunes |
PL3215601T3 (pl) | 2014-11-05 | 2020-11-02 | Juno Therapeutics, Inc. | Sposoby transdukcji i przetwarzania komórek |
EP3344263A4 (en) | 2016-08-04 | 2020-07-01 | Memorial Sloan-Kettering Cancer Center | CANCER ANTIQUES AND USES THEREOF |
CN110582287A (zh) | 2017-02-27 | 2019-12-17 | 朱诺治疗学股份有限公司 | 与在细胞疗法中给药有关的组合物、制品和方法 |
MX2019012189A (es) * | 2017-04-14 | 2020-12-10 | Juno Therapeutics Inc | Metodos para valorar la glucosilacion de la superficie celular. |
-
2019
- 2019-09-11 JP JP2021538180A patent/JP7504891B2/ja active Active
- 2019-09-11 EP EP19782815.5A patent/EP3850366A1/en active Pending
- 2019-09-11 CA CA3111789A patent/CA3111789A1/en active Pending
- 2019-09-11 CN CN201980073541.8A patent/CN113167796A/zh active Pending
- 2019-09-11 AU AU2019339464A patent/AU2019339464A1/en active Pending
- 2019-09-11 WO PCT/US2019/050681 patent/WO2020056047A1/en unknown
- 2019-09-11 MA MA053612A patent/MA53612A/fr unknown
- 2019-09-11 MX MX2021002574A patent/MX2021002574A/es unknown
- 2019-09-11 US US17/274,770 patent/US20220050114A1/en active Pending
- 2019-09-11 KR KR1020217010583A patent/KR20210081341A/ko not_active Application Discontinuation
- 2019-09-11 SG SG11202102108QA patent/SG11202102108QA/en unknown
- 2019-09-11 EA EA202190693A patent/EA202190693A1/ru unknown
- 2019-09-11 BR BR112021004261-0A patent/BR112021004261A2/pt unknown
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2021
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CA3111789A1 (en) | 2020-03-19 |
CN113167796A (zh) | 2021-07-23 |
EP3850366A1 (en) | 2021-07-21 |
US20220050114A1 (en) | 2022-02-17 |
JP2022500674A (ja) | 2022-01-04 |
IL281325A (en) | 2021-04-29 |
AU2019339464A1 (en) | 2021-03-25 |
JP7504891B2 (ja) | 2024-06-24 |
SG11202102108QA (en) | 2021-04-29 |
EA202190693A1 (ru) | 2021-07-27 |
WO2020056047A1 (en) | 2020-03-19 |
BR112021004261A2 (pt) | 2021-05-25 |
KR20210081341A (ko) | 2021-07-01 |
MA53612A (fr) | 2021-09-15 |
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