MX2021001771A - Polipéptidos del receptor de antígeno quimérico en combinación con moléculas del metabolismo trans que modulan el ciclo de krebs y usos terapéuticos de los mismos. - Google Patents

Polipéptidos del receptor de antígeno quimérico en combinación con moléculas del metabolismo trans que modulan el ciclo de krebs y usos terapéuticos de los mismos.

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Publication number
MX2021001771A
MX2021001771A MX2021001771A MX2021001771A MX2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A
Authority
MX
Mexico
Prior art keywords
trans
combination
chimeric antigen
krebs cycle
antigen receptor
Prior art date
Application number
MX2021001771A
Other languages
English (en)
Inventor
Seth Ettenberg
Kathleen Mcginness
Gregory Motz
Luke Barron
Michael FRAY
Charles Wilson
Original Assignee
Sotio Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sotio Llc filed Critical Sotio Llc
Publication of MX2021001771A publication Critical patent/MX2021001771A/es

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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
    • C12N2740/14041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Abstract

En el presente documento se describen células hematopoyéticas modificadas genéticamente, que expresan uno o más polipéptidos moduladores del ciclo de Krebs, y opcionalmente un polipéptido del receptor quimérico (p. ej., un polipéptido del receptor de células T acoplado a anticuerpos (ACTR) o un polipéptido del receptor de antígeno quimérico (CAR)) capaces de unirse a un antígeno diana de interés; también se describen en el presente documento los usos de las células hematopoyéticas modificadas para inhibir las células que expresan un antígeno diana en un sujeto que lo necesita.
MX2021001771A 2018-08-14 2019-08-14 Polipéptidos del receptor de antígeno quimérico en combinación con moléculas del metabolismo trans que modulan el ciclo de krebs y usos terapéuticos de los mismos. MX2021001771A (es)

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PCT/US2019/046550 WO2020037066A1 (en) 2018-08-14 2019-08-14 Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof

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