MX2020010433A - Compuestos de pirazol sustituidos con heteroarilo y uso farmaceutico de los mismos. - Google Patents

Compuestos de pirazol sustituidos con heteroarilo y uso farmaceutico de los mismos.

Info

Publication number
MX2020010433A
MX2020010433A MX2020010433A MX2020010433A MX2020010433A MX 2020010433 A MX2020010433 A MX 2020010433A MX 2020010433 A MX2020010433 A MX 2020010433A MX 2020010433 A MX2020010433 A MX 2020010433A MX 2020010433 A MX2020010433 A MX 2020010433A
Authority
MX
Mexico
Prior art keywords
medicinal
sup
sub
heteroaryl
compound
Prior art date
Application number
MX2020010433A
Other languages
English (en)
Inventor
Tomoyuki Manabe
Tomoya Miura
Shintaro Hirashima
Tetsuya Iida
Kentaro Sakurai
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of MX2020010433A publication Critical patent/MX2020010433A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen compuestos de pirazol sustituidos con heteroarilo o sus sales farmacéuticamente aceptables que tienen una actividad inhibidora de SGLT1 y son útiles para un fármaco, composiciones farmacéuticas que lo comprenden, y su uso farmacéutico; específicamente, un compuesto de fórmula [X]: (ver Fórmula) en donde R1 es hidrógeno o halógeno, R2 es alquilo de C1-6 o haloalquilo de C1-6, el anillo Het es piridilo sustituido o pirazinilo, pirimidinilo o piridazinilo opcionalmente sustituido, o una sal farmacéuticamente aceptable del mismo, una composición farmacéutica que lo comprende, y su uso farmacéutico se proporciona.
MX2020010433A 2018-04-04 2019-04-03 Compuestos de pirazol sustituidos con heteroarilo y uso farmaceutico de los mismos. MX2020010433A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018072557 2018-04-04
PCT/JP2019/014721 WO2019194207A1 (ja) 2018-04-04 2019-04-03 ヘテロアリールで置換されたピラゾール化合物及びその医薬用途

Publications (1)

Publication Number Publication Date
MX2020010433A true MX2020010433A (es) 2020-10-28

Family

ID=68100257

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020010433A MX2020010433A (es) 2018-04-04 2019-04-03 Compuestos de pirazol sustituidos con heteroarilo y uso farmaceutico de los mismos.

Country Status (19)

Country Link
US (3) US10988462B2 (es)
EP (1) EP3778593A4 (es)
JP (3) JP7130588B2 (es)
KR (1) KR20200139696A (es)
CN (1) CN111902408B (es)
AR (1) AR114465A1 (es)
AU (1) AU2019249560B2 (es)
BR (1) BR112020019939A2 (es)
CA (1) CA3089092A1 (es)
CL (1) CL2020002550A1 (es)
CO (1) CO2020012353A2 (es)
IL (1) IL277686A (es)
MX (1) MX2020010433A (es)
PE (1) PE20201068A1 (es)
PH (1) PH12020551624A1 (es)
SG (1) SG11202009179TA (es)
TW (1) TWI805727B (es)
WO (1) WO2019194207A1 (es)
ZA (1) ZA202006053B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI805699B (zh) 2018-03-01 2023-06-21 日商日本煙草產業股份有限公司 甲基內醯胺環化合物及其用途
US20230210831A1 (en) * 2019-09-04 2023-07-06 Japan Tobacco Inc. Chronic kidney disease treatment or prevention method
EP4026564A4 (en) * 2019-09-04 2023-03-15 Japan Tobacco Inc. THERAPEUTIC OR PROPHYLACTIC PROCEDURE FOR DIABETES USING COMBINATION MEDICATION
CN115209919A (zh) 2020-03-19 2022-10-18 日本烟草产业株式会社 慢性心衰的治疗或预防方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665898B1 (fr) 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
JPH04247081A (ja) 1991-02-01 1992-09-03 Takeda Chem Ind Ltd ５員複素環酸アミド類
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
KR20050096956A (ko) 2003-02-07 2005-10-06 다이이찌 세이야꾸 가부시기가이샤 피라졸 유도체
AU2004200420A1 (en) 2003-03-11 2004-09-30 Astellas Pharma Inc. Inhibitor of cyclooxygenase
JP2006182648A (ja) 2003-04-08 2006-07-13 Dai Ichi Seiyaku Co Ltd ７員複素環誘導体
US20050075375A1 (en) 2003-05-14 2005-04-07 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis C virus
JP4708187B2 (ja) 2003-06-20 2011-06-22 キッセイ薬品工業株式会社 ピラゾール誘導体、それを含有する医薬組成物及びその製造中間体
TW200526588A (en) 2003-11-17 2005-08-16 Smithkline Beecham Corp Chemical compounds
TW200526641A (en) 2003-12-26 2005-08-16 Daiichi Seiyaku Co Amidopyrazole derivatives
DE102004028241B4 (de) * 2004-06-11 2007-09-13 Sanofi-Aventis Deutschland Gmbh Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel
WO2006017055A2 (en) 2004-07-07 2006-02-16 Merck & Co., Inc. Pyrazole amide derivatives, compositions containing such compounds and methods of use
KR20070089151A (ko) 2004-11-16 2007-08-30 지더블유 파마 리미티드 카나비노이드의 새로운 용도
EP1819681B1 (en) * 2004-11-23 2009-08-12 Warner-Lambert Company LLC 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
JP2008007405A (ja) 2004-12-07 2008-01-17 Takeda Chem Ind Ltd カルボキサミド誘導体
JP4137956B2 (ja) 2005-06-08 2008-08-20 日本たばこ産業株式会社 複素環化合物
CA2610172A1 (en) 2005-06-08 2006-12-14 Japan Tobacco Inc. Heterocyclic compound
WO2007034279A2 (en) 2005-09-19 2007-03-29 Pfizer Products Inc. C3a antagonists and pharmaceutical compositions thereof
TWI378922B (en) * 2005-10-21 2012-12-11 Mitsubishi Tanabe Pharma Corp A pyrazole compound
CA2637530A1 (en) 2006-01-18 2007-09-07 Siena Biotech S.P.A. Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof
US20080027014A1 (en) 2006-07-28 2008-01-31 Tanabe Seiyaku Co., Ltd. Novel SGLT inhibitors
MX2009003821A (es) 2006-10-10 2009-05-25 Amgen Inc Compuestos de n-aril pirazol para usarse contra la diabetes.
WO2008061796A2 (en) 2006-11-24 2008-05-29 Ac Immune Sa Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
CN102838532A (zh) 2006-11-24 2012-12-26 Ac免疫有限公司 用于治疗与淀粉样物质或淀粉样蛋白有关的疾病的吡唑胺和噻唑胺衍生物
CL2008000119A1 (es) 2007-01-16 2008-05-16 Wyeth Corp Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.
JP4994295B2 (ja) 2007-04-20 2012-08-08 田辺三菱製薬株式会社 医薬組成物
WO2009091813A1 (en) 2008-01-14 2009-07-23 Wyeth Compounds useful as alpha7 nicotinic acetylcholine receptor agonists
EP2548618A3 (en) 2008-07-15 2013-02-27 Novartis AG Heteroaryl derivatives as DGAT1 inhibitors
WO2011126903A2 (en) 2010-03-30 2011-10-13 Verseon, Inc. Multisubstituted aromatic compounds as inhibitors of thrombin
WO2011161615A1 (en) 2010-06-24 2011-12-29 Ranbaxy Laboratories Limited 5-lipoxygenase inhibitors
AR087701A1 (es) 2011-08-31 2014-04-09 Japan Tobacco Inc Derivados de pirazol con actividad inhibidora de sglt1
UA113086C2 (xx) * 2012-05-10 2016-12-12 Піразольні сполуки як інгібітори sglt1
WO2016050921A1 (en) * 2014-10-02 2016-04-07 F. Hoffmann-La Roche Ag Pyrazole carboxamide compounds for use in the treament of disorders mediated by bruton's tyrosine kinase (btk)
TWI805699B (zh) 2018-03-01 2023-06-21 日商日本煙草產業股份有限公司 甲基內醯胺環化合物及其用途

Also Published As

Publication number Publication date
TWI805727B (zh) 2023-06-21
AU2019249560A1 (en) 2020-07-23
CN111902408A (zh) 2020-11-06
JP2024050645A (ja) 2024-04-10
CN111902408B (zh) 2023-11-14
WO2019194207A1 (ja) 2019-10-10
RU2020132318A3 (es) 2022-04-29
US10988462B2 (en) 2021-04-27
KR20200139696A (ko) 2020-12-14
JP7130588B2 (ja) 2022-09-05
TW201942114A (zh) 2019-11-01
RU2020132318A (ru) 2022-04-29
SG11202009179TA (en) 2020-10-29
CO2020012353A2 (es) 2021-01-18
PH12020551624A1 (en) 2021-07-12
PE20201068A1 (es) 2020-10-19
IL277686A (en) 2020-11-30
CL2020002550A1 (es) 2021-01-15
US20190330193A1 (en) 2019-10-31
BR112020019939A2 (pt) 2021-01-05
CA3089092A1 (en) 2019-10-10
US20220048896A1 (en) 2022-02-17
AR114465A1 (es) 2020-09-09
EP3778593A4 (en) 2021-12-22
US20240166632A1 (en) 2024-05-23
AU2019249560B2 (en) 2023-10-05
ZA202006053B (en) 2022-03-30
JP2019182852A (ja) 2019-10-24
EP3778593A1 (en) 2021-02-17
JP2022166280A (ja) 2022-11-01

Similar Documents

Publication Publication Date Title
MX2020010433A (es) Compuestos de pirazol sustituidos con heteroarilo y uso farmaceutico de los mismos.
PH12020551305A1 (en) Pharmaceutical Compounds
PH12021550045A1 (en) 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CR20200488A (es) Péptidos macrocíclicos contra actinetobacter baumannii
CR20220062A (es) Inhibidores de shp2 fosfatasa de tipo pirazolo [3,4-b]pirazina
MX2020014116A (es) Agente profilactico o terapeutico para atrofia muscular espinal.
WO2020113213A3 (en) Cyclic pantetheine derivatives and uses thereof
TW200740434A (en) A prophylactic and/or therapeutic agent for for sleep disorders
MX2021006544A (es) Inhibidores de cinasa dependiente de ciclina 9 (cdk9) y polimorfos de los mismos para uso como agentes para el tratamiento de cancer.
GB0112348D0 (en) Compounds
EP4327877A3 (en) Dual atm and dna-pk inhibitors for use in anti-tumor therapy
CR20210216A (es) Derivados de piridinil sulfonamida, composiciones farmacéuticas y usos de estos
WO2021012049A8 (en) Substituted 2-morpholinopyridine derivatives as atr kinase inhibitors
AU2020288567A8 (en) Pyrrolopyrimidine compound and use thereof
MX2021009659A (es) Hidroxipiridoxazepinas como activadores de nrf2.
CR20220014A (es) Derivados de 3,6-diamino-piridazin-3-ilo, composiciones farmacéuticas que los contienen y sus usos como agentes proapoptóticos
MX2021014680A (es) Derivado de benzotriazol.
MX2021003739A (es) Derivados de quinolino-pirrolidin-2-ona como inhibidores del gen mutado de ataxia telangiectasia (atm) y el uso de los mismos en el tratamiento de tumores sólidos.
MY195576A (en) Novel Amino-Imidazopyridine Derivatives as Janus Kinase Inhibitors and Pharmaceutical use Thereof
CR20200619A (es) Compuestos de cianotriazol y usos de los mismos
CR20210284A (es) Pirazoles como modulares de hemoglobina
MX2023000693A (es) Inhibidor de egfr.
JOP20220084A1 (ar) مشتقات 5-أوكسا- 2- آزا سبيرو [3.4] أوكتان كناهضات لـ m4
MX2022005951A (es) Compuestos de pirrolotriazina que actuan como inhibidor de mnk.
JOP20220082A1 (ar) مشتقات 2- آزا سبيرو [3.4] أوكتان كناهضات لـ m4