CR20200619A - Compuestos de cianotriazol y usos de los mismos - Google Patents

Compuestos de cianotriazol y usos de los mismos

Info

Publication number
CR20200619A
CR20200619A CR20200619A CR20200619A CR20200619A CR 20200619 A CR20200619 A CR 20200619A CR 20200619 A CR20200619 A CR 20200619A CR 20200619 A CR20200619 A CR 20200619A CR 20200619 A CR20200619 A CR 20200619A
Authority
CR
Costa Rica
Prior art keywords
sup
compounds
present
cyanotriazole
cyanotriazole compounds
Prior art date
Application number
CR20200619A
Other languages
English (en)
Inventor
Shuyi Pearly Ng
Jan Jiricek
Srinivasa P S Rao
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CR20200619A publication Critical patent/CR20200619A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

<p>Se proporciona un compuesto de Fórmula (I), o una sal farmacéuticamente aceptable del mismo: </p> <p>en donde R1, R2, R3, y R4 han sido definidos en la presente. Además se proporciona usos terapéuticos de estos compuestos, por ejemplo contra la tripanosomiasis africana humana; composiciones farmacéuticas que comprenden estos compuestos y composiciones que comprenden estos compuestos con un coagente terapéutico.</p>
CR20200619A 2018-06-19 2019-06-18 Compuestos de cianotriazol y usos de los mismos CR20200619A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862687045P 2018-06-19 2018-06-19
PCT/IB2019/055123 WO2019244049A1 (en) 2018-06-19 2019-06-18 Cyanotriazole compounds and uses thereof

Publications (1)

Publication Number Publication Date
CR20200619A true CR20200619A (es) 2021-01-21

Family

ID=67841115

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20200619A CR20200619A (es) 2018-06-19 2019-06-18 Compuestos de cianotriazol y usos de los mismos

Country Status (21)

Country Link
US (1) US20220106296A1 (es)
EP (1) EP3810598A1 (es)
JP (1) JP2021528397A (es)
KR (1) KR20210022646A (es)
CN (1) CN112313217A (es)
AU (1) AU2019291490B2 (es)
BR (1) BR112020025538A2 (es)
CA (1) CA3100954A1 (es)
CL (1) CL2020003252A1 (es)
CR (1) CR20200619A (es)
CU (1) CU20200102A7 (es)
EA (1) EA202190064A1 (es)
EC (1) ECSP20080991A (es)
IL (1) IL279483A (es)
JO (1) JOP20200327A1 (es)
MA (1) MA52977A (es)
MX (1) MX2020013729A (es)
PE (1) PE20210780A1 (es)
PH (1) PH12020552186A1 (es)
SG (1) SG11202012628XA (es)
WO (1) WO2019244049A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115181060B (zh) * 2022-08-19 2024-03-19 江苏禾裕泰化学有限公司 一种生产2-氨基-3-氯-5-三氟甲基吡啶的清洁生产工艺
CN116284772B (zh) * 2023-02-09 2024-02-27 四川大学 一种联吡啶***共价有机聚合物及其制备方法和应用
CN116836111A (zh) * 2023-09-01 2023-10-03 峰成医药科技(天津)有限公司 一种氟代吡啶的连续化合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
US8642774B2 (en) * 2011-12-08 2014-02-04 Boehringer Ingelheim International Gmbh Compounds
US9949979B2 (en) * 2011-12-15 2018-04-24 Novartis Ag Use of inhibitors of the activity or function of PI3K
SG11201704584RA (en) * 2014-12-22 2017-07-28 Glaxosmithkline Ip Dev Ltd Thiotriazole compound and its use in parasitic protozoal infections

Also Published As

Publication number Publication date
AU2019291490B2 (en) 2022-02-10
CU20200102A7 (es) 2021-08-06
CL2020003252A1 (es) 2021-07-09
SG11202012628XA (en) 2021-01-28
EA202190064A1 (ru) 2021-03-29
PH12020552186A1 (en) 2021-06-07
CN112313217A (zh) 2021-02-02
JP2021528397A (ja) 2021-10-21
PE20210780A1 (es) 2021-04-21
WO2019244049A1 (en) 2019-12-26
MA52977A (fr) 2021-04-28
MX2020013729A (es) 2021-05-12
BR112020025538A2 (pt) 2021-03-16
US20220106296A1 (en) 2022-04-07
CA3100954A1 (en) 2019-12-26
KR20210022646A (ko) 2021-03-03
JOP20200327A1 (ar) 2020-12-15
IL279483A (en) 2021-01-31
AU2019291490A1 (en) 2021-02-04
ECSP20080991A (es) 2021-02-26
EP3810598A1 (en) 2021-04-28

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