MX2020002788A - Biomarcadores de preeclampsia y sistemas y metodos relacionados. - Google Patents

Biomarcadores de preeclampsia y sistemas y metodos relacionados.

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Publication number
MX2020002788A
MX2020002788A MX2020002788A MX2020002788A MX2020002788A MX 2020002788 A MX2020002788 A MX 2020002788A MX 2020002788 A MX2020002788 A MX 2020002788A MX 2020002788 A MX2020002788 A MX 2020002788A MX 2020002788 A MX2020002788 A MX 2020002788A
Authority
MX
Mexico
Prior art keywords
methods
related systems
biomarkers
preeclampsia
kits
Prior art date
Application number
MX2020002788A
Other languages
English (en)
Inventor
Sharat Singh
Matthew Cooper
Karen A F Copeland
Lyndal Hesterberg
Amin R Mazloom
Mohammad Abbasi
Mastro Richard Giulio Del
Original Assignee
Progenity Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progenity Inc filed Critical Progenity Inc
Publication of MX2020002788A publication Critical patent/MX2020002788A/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
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    • G01N2333/4701—Details
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    • G—PHYSICS
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    • G01N2333/914—Hydrolases (3)
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Abstract

La presente invención se refiere a métodos, kits, pruebas y sistemas para detectar, predecir, monitorear o descartar la preeclampsia en mujeres embarazadas. También se proporcionan nuevos marcadores de diagnóstico, métodos de análisis de datos, formatos de ensayo y kits que emplean tales marcadores para mejorar una o más características de una prueba para identificar o descartar la preeclampsia con base en biomarcadores de muestras de pacientes.
MX2020002788A 2017-09-13 2018-09-13 Biomarcadores de preeclampsia y sistemas y metodos relacionados. MX2020002788A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762558184P 2017-09-13 2017-09-13
PCT/US2018/050893 WO2019055661A1 (en) 2017-09-13 2018-09-13 PRE-ÉCLAMPSIE BIOMARKERS AND ASSOCIATED SYSTEMS AND METHODS

Publications (1)

Publication Number Publication Date
MX2020002788A true MX2020002788A (es) 2020-09-14

Family

ID=65723874

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020002788A MX2020002788A (es) 2017-09-13 2018-09-13 Biomarcadores de preeclampsia y sistemas y metodos relacionados.

Country Status (10)

Country Link
US (3) US20200264188A1 (es)
EP (1) EP3682250A4 (es)
JP (1) JP2020533595A (es)
KR (1) KR20200109293A (es)
CN (1) CN111094988A (es)
AU (1) AU2018331400A1 (es)
CA (1) CA3075688A1 (es)
MX (1) MX2020002788A (es)
SG (1) SG11202002065VA (es)
WO (1) WO2019055661A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111094988A (zh) 2017-09-13 2020-05-01 普罗根尼蒂公司 先兆子痫生物标志物及相关***和方法
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS
GB202012830D0 (en) * 2020-08-17 2020-09-30 Univ Tartu Method of prognosing preeclampsia
CN113724873B (zh) * 2021-08-31 2024-01-12 陕西佰美基因股份有限公司 一种基于mlp多平台校准的子痫前期风险预测方法

Family Cites Families (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4777964A (en) 1986-01-02 1988-10-18 David Briggs System for obtaining blood samples and submitting for testing of aids
US5096830A (en) 1987-11-17 1992-03-17 Adeza Biomedical Corporation Preterm labor and membrane rupture test
US5223440A (en) 1987-11-17 1993-06-29 Adeza Biomedical Corporation Ex vivo product of conception test to determine abortion
US5281522A (en) 1988-09-15 1994-01-25 Adeza Biomedical Corporation Reagents and kits for determination of fetal fibronectin in a vaginal sample
US4919889A (en) 1988-09-15 1990-04-24 Aspen Diagnostics Corporation Sample collection and transport fluid composition
WO1993009432A1 (en) 1991-11-04 1993-05-13 Adeza Biomedical Corporation Screening method for identifying women at increased risk for imminent delivery
EP0642667B1 (en) 1991-11-04 2001-01-10 Adeza Biomedical Corporation Screening method for identifying women at increased risk for preterm delivery
US5516702A (en) 1991-11-06 1996-05-14 Adeza Biomedical Corporation Screening method for identifying women at increased risk for imminent delivery
AU6267794A (en) 1993-02-24 1994-09-14 Dade International Inc. Immobilization of specific binding assay reagents
US5898005A (en) 1993-02-24 1999-04-27 Dade Behring Inc. Rapid detection of analytes with receptors immobilized on soluble submicron particles
US5783396A (en) 1993-03-23 1998-07-21 Voroteliak; Victor Method of detecting rupture of the amniotic membranes in pregnant mammals
US5431171A (en) 1993-06-25 1995-07-11 The Regents Of The University Of California Monitoring fetal characteristics by radiotelemetric transmission
ES2135597T3 (es) 1993-09-03 1999-11-01 Dade Behring Marburg Gmbh Inmunoensayos fluorescentes de canalizacion del oxigeno.
US5650394A (en) 1993-11-04 1997-07-22 Adeza Biomedical Use of urinastatin-like compounds to prevent premature delivery
US5597700A (en) 1994-04-28 1997-01-28 California Research, Llc Method for detecting free insulin-like growth-factor-binding protein 1 and a test device for detecting the ruptures of fetal membranes using the above method
US5641636A (en) 1994-05-20 1997-06-24 University Of Pennsylvania Method of predicting fetal membrane rupture based on matrix metalloproteinase-9 activity
US6140099A (en) 1994-05-20 2000-10-31 The Trustees Of The University Of Pennsylvania Method of delaying fetal membrane rupture by inhibiting matrix metalloproteinase-9 activity
EP0812353A2 (en) 1995-01-26 1997-12-17 Merck Frosst Canada Inc. Prostaglandin receptor dp
EP0913405B1 (en) 1995-10-31 2006-01-04 Maruha Corporation Monoclonal antibody specific for prostaglandin d synthetase
US6678669B2 (en) 1996-02-09 2004-01-13 Adeza Biomedical Corporation Method for selecting medical and biochemical diagnostic tests using neural network-related applications
US6120460A (en) 1996-09-04 2000-09-19 Abreu; Marcio Marc Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions
US6544193B2 (en) 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
FI963989A (fi) 1996-10-04 1998-04-05 Wallac Oy Homogeenisiä määritysmenetelmiä, jotka perustuvat luminesenssienergiasiirtoon
AU6287198A (en) 1997-03-07 1998-09-29 Hospital For Sick Children Methods to diagnose a required regulation of trophoblast invasion
US6875567B1 (en) 1997-11-10 2005-04-05 Genentech, Inc. Method of detecting cardiac hypertrophy through probe hybridization and gene expression analysis
US6610480B1 (en) 1997-11-10 2003-08-26 Genentech, Inc. Treatment and diagnosis of cardiac hypertrophy
US20020031513A1 (en) 1997-11-24 2002-03-14 Shamir Leibovitz Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals
US6267722B1 (en) 1998-02-03 2001-07-31 Adeza Biomedical Corporation Point of care diagnostic systems
US6394952B1 (en) 1998-02-03 2002-05-28 Adeza Biomedical Corporation Point of care diagnostic systems
US6506789B2 (en) 1998-06-03 2003-01-14 Shionogi & Co., Ltd. Methods for the treatment of itching comprising administering PGD2 receptor antagonist
US20010025140A1 (en) 1998-07-22 2001-09-27 Torok Brian A. System for identifying premature rupture of membrane during pregnancy
US6149590A (en) 1998-07-22 2000-11-21 Smith; Ramada S. System for identifying premature rupture of membrane during pregnancy
US6126597A (en) 1998-07-22 2000-10-03 Smith; Ramada S. System for identifying premature rupture of membrane during pregnancy
US7109044B1 (en) 1998-09-04 2006-09-19 Maruha Corporation Method of detection and disease state management for renal diseases
BR9915820A (pt) 1998-10-29 2001-10-30 Univ Texas Uso clìnico de tiazolidinadionas sozinhas ou emconjunto com outros agentes para bloquear asações mediadas pela oxitocina, tal comocontrações uterinas em parto prematuro oulactação
JP2000249709A (ja) 1999-02-26 2000-09-14 Maruha Corp 冠血管インターベンション施行後の再狭窄の予測方法
US6126616A (en) 1999-06-21 2000-10-03 Sanyal; Mrinal K. Collection of biological products from human accessory reproductive organs by absorbent systems
CA2383135C (en) 1999-08-23 2010-11-30 Hiroyuki Hirai Method of identifying properties of substance with respect to human prostaglandin d2 receptors
FR2809182B1 (fr) 2000-05-18 2003-08-15 Univ Rene Descartes Detection de l'il-6 pour la prevision des risques d'accouchement premature
US20010053876A1 (en) 2000-06-15 2001-12-20 Torok Brian A. System for identifying premature rupture of membrane during pregnancy
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
US7314727B2 (en) 2000-07-21 2008-01-01 Maruha Corporation Methods to facilitate diagnosis of normal pressure hydrocephalus
US6410583B1 (en) 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
WO2002017770A2 (en) 2000-08-28 2002-03-07 Morand Patrick G Use of blood and plasma donor samples and data in the drug discovery process
US7217725B2 (en) 2000-09-14 2007-05-15 Allergan, Inc. Prostaglandin D2 antagonist
WO2002032958A2 (en) 2000-10-16 2002-04-25 Bayer Aktiengesellschaft Polynucleotide and polypeptide sequences of human dendritic cell immunoreceptors
US7635571B2 (en) 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
WO2002094830A2 (en) 2001-05-23 2002-11-28 Merck Frosst Canada & Co. DIHYDROPYRROLO[1,2-A]INDOLE AND TETRAHYDROPYRIDO[1,2-a]-INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
WO2003008978A2 (en) 2001-07-18 2003-01-30 Merck Frosst Canada & Co. Eosinophil prostaglandin d2 receptor assays
US20040197834A1 (en) 2001-07-20 2004-10-07 Francois Gervais Method to increase expression of pgd2 receptors and assays for identifying modulators of prostaglandin d2 receptors
US20050101841A9 (en) 2001-12-04 2005-05-12 Kimberly-Clark Worldwide, Inc. Healthcare networks with biosensors
EP1540341A4 (en) 2002-07-01 2007-01-10 Univ Rochester Medical Ct METHOD OF DETERMINING THE PROBABILITY OF RISK OF PREMATURE DELIVERY IN PREGNANT WOMEN
US7435419B2 (en) 2002-07-19 2008-10-14 Beth Israel Deaconess Medical Center Methods of diagnosing and treating pre-eclampsia or eclampsia
OA12890A (en) 2002-07-19 2006-10-13 Beth Israel Hospital Methods of diagnosing and treating pre-eclampsia or eclampsia.
EP2204654B1 (en) 2002-08-13 2012-12-12 N-Dia, Inc. Use of devices and methods for detecting amniotic fluid in vaginal secretions
WO2004021012A2 (en) 2002-08-29 2004-03-11 Diagnostic Technologies Ltd. Method of diagnosis of pregnancy-related complications
WO2004030674A1 (ja) 2002-09-30 2004-04-15 Shionogi & Co., Ltd. プロスタグランジンｄ２、プロスタグランジンｄ２アゴニストおよびプロスタグランジンｄ２アンタゴニストの新規用途
AU2003284166A1 (en) 2002-10-23 2004-05-13 University Of Hawaii Methods for diagnosing and treating pre-term labor
US20040100376A1 (en) 2002-11-26 2004-05-27 Kimberly-Clark Worldwide, Inc. Healthcare monitoring system
EP1590664A4 (en) 2003-02-05 2007-05-23 Ciphergen Biosystems Inc NON-INVASIVE ASSESSMENT OF THE INTRA-NAMINE ENVIRONMENT
EP1590668A2 (en) 2003-02-06 2005-11-02 Adeza Biomedical Corporation Screeninig and treatment methods for prevention of preterm delivery
US7191068B2 (en) 2003-03-25 2007-03-13 Proteogenix, Inc. Proteomic analysis of biological fluids
US8068990B2 (en) 2003-03-25 2011-11-29 Hologic, Inc. Diagnosis of intra-uterine infection by proteomic analysis of cervical-vaginal fluids
US8003765B2 (en) 2003-04-09 2011-08-23 Stony Brook Anaesthesiology, University Faculty Practice Corporation Methods, antibodies and kits for detecting cerebrospinal fluid in a sample
US20070003992A1 (en) 2003-04-09 2007-01-04 Pentyala Srinivas N Methods and kits for detecting cerebrospinal fluid in a sample
US20040203079A1 (en) 2003-04-09 2004-10-14 Research Foundation Of The State University Of New York Methods and kits for detecting cerebrospinal fluid in a sample
US8060195B2 (en) 2003-05-02 2011-11-15 The Johns Hopkins University Devices, systems and methods for bioimpedance measurement of cervical tissue and methods for diagnosis and treatment of human cervix
CN1791577A (zh) 2003-05-20 2006-06-21 麦克弗罗斯特加拿大有限公司 氟－甲基磺酰取代的环烷并吲哚和它们作为***素d2拮抗剂的用途
WO2005007223A2 (en) 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
JP3897117B2 (ja) 2003-09-24 2007-03-22 マルハ株式会社 妊娠中毒症の重症度判定と予知方法、および妊娠中毒症における胎児・胎盤機能の評価方法
US20080233597A1 (en) 2003-09-26 2008-09-25 Yasuhiko Shiina Method of Detecting or Differentiating Rheumatoid Arthritis and Method of Determining Stage of Disease or Degree of Dysfunction with Regard to Rheumatoid Arthritis
US20050131287A1 (en) 2003-12-16 2005-06-16 Kimberly-Clark Worldwide, Inc. Detection of premature rupture of the amniotic membrane
US7943294B2 (en) 2004-07-30 2011-05-17 Hologic, Inc. Methods for detecting oncofetal fibronectin
US20080090759A1 (en) 2004-08-30 2008-04-17 Robert Kokenyesi Methods and kits for predicting risk for preterm labor
US20080254479A1 (en) 2004-08-30 2008-10-16 Cervimark, Llc Methods and Kits For Predicting Risk For Preterm Labor
DK1804836T3 (da) 2004-09-24 2011-01-24 Beth Israel Hospital Fremgangsmåder til diagnosticering og behandling af graviditetskomplikationer
GB0422057D0 (en) 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
GT200500284A (es) 2004-10-15 2006-03-27 Aventis Pharma Inc Pirimidinas como antagonistas del receptor de prostaglandina d2
JP5009811B2 (ja) 2004-12-21 2012-08-22 イェール ユニバーシティ 子癇前症の検出
US20060166242A1 (en) 2005-01-06 2006-07-27 Mount Sinai Hospital Markers of pre-term labor
DOP2006000016A (es) 2005-01-26 2006-07-31 Aventis Pharma Inc 2-fenil-indoles como antagonistas del receptor de la prostaglandina d2.
GB0505048D0 (en) 2005-03-11 2005-04-20 Oxagen Ltd Compounds with PGD antagonist activity
WO2006102498A2 (en) * 2005-03-24 2006-09-28 Beth Israel Deaconess Medical Center Methods of diagnosing fetal trisomy 13 or a risk of fetal trisomy 13 during pregnancy
CA2615081A1 (en) 2005-07-13 2007-01-18 Eci Biotech Inc. Substrates, sensors, and methods for assessing conditions in females
EP1911759A4 (en) 2005-07-22 2010-07-21 Shionogi & Co AZAINDOL DERIVATIVE ANTAGONISTIC EFFECT ON PGD2 RECEPTOR
US7863007B2 (en) 2005-09-15 2011-01-04 Swiss Asian Property Limited Marker for prolonged rupture of membranes
GT200600457A (es) 2005-10-13 2007-04-27 Aventis Pharma Inc Sal de fosfato dihidrogeno como antagonistas del receptor de prostaglandina d2
WO2007047372A2 (en) 2005-10-14 2007-04-26 The Board Of Trustees Of The University Of Illinois Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists
US20070111326A1 (en) 2005-11-14 2007-05-17 Abbott Laboratories Diagnostic method for proteinaceous binding pairs, cardiovascular conditions and preeclampsia
US20080009552A1 (en) 2006-03-23 2008-01-10 Craig Pennell Markers of pre-term labor
AR060403A1 (es) 2006-04-12 2008-06-11 Sanofi Aventis Compuestos de amino- pirimidina 2,6- sustituidos -4- monosustituidos como antagonistas del receptor de prostaglandina d2
SI2037967T1 (sl) 2006-06-16 2017-04-26 The Trustees Of The University Of Pennsylvania Antagonisti receptorja za prostaglandin d2 za zdravljenje androgene alopecije
EP2066628B1 (en) 2006-07-25 2010-10-20 Sanofi-Aventis 2-phenyl-indoles as prostaglandin d2 receptor antagonists
US8133859B2 (en) 2006-09-27 2012-03-13 The United States Of America As Represented By The Department Of Health And Human Services SCGB3A2 as a growth factor and anti-apoptotic agent
DK2083863T3 (da) 2006-10-03 2015-06-22 Genzyme Corp Antistoffer mod tgf-beta til anvendelse til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi
WO2008073491A1 (en) 2006-12-11 2008-06-19 University Of Florida Research Foundation, Inc. System and method for analyzing progress of labor and preterm labor
CA2672373C (en) 2006-12-19 2011-08-30 Pfizer Products Inc. Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases
EP2118652B1 (en) 2006-12-26 2012-05-23 Brigham Young University Serum proteomics system and associated methods
JP2010519328A (ja) 2007-02-26 2010-06-03 ファイザー・プロダクツ・インク Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体およびプロスタグランジンｄ２が媒介する疾患の治療のためのそれらの使用
US20090058072A1 (en) 2007-08-30 2009-03-05 Shirlee Ann Weber Record sheets with integrated themes
US20100251394A1 (en) 2007-09-20 2010-09-30 The Johns Hopkins University Treatment and prevention of ischemic brain injury
US20110002866A1 (en) 2007-10-31 2011-01-06 Lubit Beverly W Methods to prevent a hair-related side effect of treatment with a chemotherapeutic agent
WO2009059259A2 (en) 2007-10-31 2009-05-07 Children's Hospital Medical Center Detection of worsening renal disease in subjects with systemic lupus erythematosus
US20100298368A1 (en) 2007-11-06 2010-11-25 Amira Pharmaceuticals, Inc. Antagonists of pgd2 receptors
US20110065139A1 (en) 2007-11-27 2011-03-17 Jacob Mullerad diagnostic device for identifying rupture of membrane during pregnancy
US20130177485A1 (en) 2007-11-27 2013-07-11 Momtec Life Ltd. Of Yazmot Haemek Diagnostic device for identifying rupture of membrane during pregnancy
DK2229358T3 (da) 2007-12-14 2011-07-04 Pulmagen Therapeutics Asthma Ltd Indoler og deres terapeutiske anvendelse
EP2235529B1 (en) 2008-01-07 2016-12-14 Ortho-Clinical Diagnostics, Inc. Determination of sflt-1:angiogenic factor complex
EP2245010A1 (en) 2008-01-18 2010-11-03 Pulmagen Therapeutics (Asthma) Limited Indoles active on crth2 receptor
CA2713229C (en) 2008-01-25 2017-07-11 Perkinelmer Health Sciences, Inc. Methods for determining the risk of prenatal complications
WO2009097584A1 (en) 2008-01-30 2009-08-06 Proteogenix, Inc. Maternal serum biomarkers for detection of pre-eclampsia
WO2009097579A1 (en) 2008-01-30 2009-08-06 Proteogenix, Inc. Gestational age dependent proteomic changes of human maternal serum for monitoring maternal and fetal health
US20110098352A1 (en) 2008-02-01 2011-04-28 Amira Pharmaceuticals, Inc. N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors
CN101952244B (zh) 2008-02-01 2014-11-05 潘米拉制药公司 ***素d2受体的n，n-二取代氨基烷基联苯拮抗剂
US8242145B2 (en) 2008-02-14 2012-08-14 Panmira Pharmaceuticals, Llc Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors
US8497381B2 (en) 2008-02-25 2013-07-30 Panmira Pharmaceuticals, Llc Antagonists of prostaglandin D2 receptors
EP2268611A2 (en) 2008-04-02 2011-01-05 Amira Pharmaceuticals, Inc. Aminoalkylphenyl antagonists of prostaglandin d2 receptors
CA2724542A1 (en) 2008-05-16 2009-11-19 Corthera, Inc. Method of administering relaxin to reduce cervical dilation
US20110112134A1 (en) 2008-05-16 2011-05-12 Amira Pharmaceuticals, Inc. Tricyclic Antagonists of Prostaglandin D2 Receptors
WO2010008864A2 (en) 2008-06-24 2010-01-21 Amira Pharmaceuticals, Inc. Cycloalkane[b]indole angtagonists of prostaglandin d2 receptors
US8071807B2 (en) 2008-07-03 2011-12-06 Panmira Pharmaceuticals, Llc Antagonists of prostaglandin D2 receptors
FR2934681B1 (fr) 2008-07-29 2011-09-30 Bastien Karkouche Dispositif pour la capture de particules biologiques et utilisation.
CA2735525A1 (en) 2008-08-04 2010-02-11 The Board Of Regents Of The University Of Texas System Multiplexed diagnostic test for preterm labor
US8536185B2 (en) 2008-09-22 2013-09-17 Cayman Chemical Company, Incorporated Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases
GB2463788B (en) 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
US8378107B2 (en) 2008-10-01 2013-02-19 Panmira Pharmaceuticals, Llc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010042652A2 (en) 2008-10-08 2010-04-15 Amira Pharmaceuticals, Inc. Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors
GB2465062B (en) 2008-11-06 2011-04-13 Amira Pharmaceuticals Inc Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors
WO2010057118A2 (en) 2008-11-17 2010-05-20 Amira Pharmaceuticals, Inc. Heterocyclic antagonists of prostaglandin d2 receptors
US9180114B2 (en) 2008-11-26 2015-11-10 President And Fellows Of Harvard College Neurodegenerative diseases and methods of modeling
US20120004233A1 (en) 2009-01-26 2012-01-05 Amira Pharmaceuticals, Inc Tricyclic compounds as antagonists of prostaglandin d2 receptors
US20120046261A1 (en) 2009-02-27 2012-02-23 University Of Utah Research Foundation Compositions and methods for diagnosing and preventing spontaneous preterm birth
GB0905964D0 (en) 2009-04-06 2009-05-20 King S College London Marker
CN102596902A (zh) 2009-08-05 2012-07-18 潘米拉制药公司 Dp2拮抗剂及其用途
US20110090048A1 (en) 2009-09-29 2011-04-21 Li Conan K Data Transmission Device with User Identification Capability
US20120270747A1 (en) 2009-10-29 2012-10-25 The Trustees Of The University Of Pennsylvania Method of predicting risk of pre-term birth
RU2556524C2 (ru) 2009-11-12 2015-07-10 Сервиленц Инк. Устройства и способы для измерения шейки матки
WO2011065976A1 (en) 2009-11-25 2011-06-03 Hologic, Inc. Detection of intraamniotic infection
WO2011071893A1 (en) 2009-12-08 2011-06-16 Cedars-Sinai Medical Center Diagnostic biomarker to identify women at risk for preterm delivery
US8874183B2 (en) 2010-02-18 2014-10-28 The Johns Hopkins University Preterm labor monitor
BR112012023039A2 (pt) 2010-03-16 2016-05-17 Aventis Pharma Inc pirimidina substituída como um antagonista de receptor prostaglandina d2
CN103038228A (zh) 2010-03-16 2013-04-10 安万特药物公司 作为***素d2受体拮抗剂的取代的嘧啶类化合物
TWI562987B (en) 2010-03-22 2016-12-21 Actelion Pharmaceuticals Ltd 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
WO2011119757A2 (en) 2010-03-23 2011-09-29 The Reproductive Research Technologies, Lp Noninvasive measurement of uterine emg propagation and power spectrum frequency to predict true preterm labor and delivery
AU2011240039B2 (en) * 2010-04-13 2017-01-19 Mycartis Nv Biomarkers for hypertensive disorders of pregnancy
EP2569253A4 (en) * 2010-05-14 2013-10-02 Beth Israel Hospital EXTRACORPOREAL DEVICES AND METHODS FOR TREATING PREGNANCY COMPLICATIONS
US20110312927A1 (en) 2010-06-18 2011-12-22 Satish Kumar Nachaegari Progesterone Containing Oral Dosage Forms and Related Methods
US20110312928A1 (en) 2010-06-18 2011-12-22 Lipocine Inc. Progesterone Containing Oral Dosage Forms and Related Methods
US20110318308A1 (en) 2010-06-25 2011-12-29 Winthrop-University Hospital Lipocalin-type prostaglandin d2 synthase as a biomarker for lung cancer progression and prognosis
CA2805452C (en) 2010-07-05 2018-07-31 Actelion Pharmaceuticals Ltd 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
AP2013006667A0 (en) 2010-07-12 2013-01-31 Therasyn Sensors Inc A device and methods for in vivo monitoring of an individual
US8765487B2 (en) 2010-09-01 2014-07-01 Clinical Innovations Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes
AU2011308615B2 (en) 2010-10-01 2015-02-05 Hologic, Inc. Immunoassay test strip for use in a diagnostic system
US10669569B2 (en) 2010-10-15 2020-06-02 Navinci Diagnostics Ab Dynamic range methods
WO2012076553A2 (en) 2010-12-06 2012-06-14 Pronota N.V. Biomarkers and parameters for hypertensive disorders of pregnancy
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
JP2014508290A (ja) 2011-01-31 2014-04-03 エソテリックス ジェネティック ラボラトリーズ， エルエルシー 結合分子を用いて微粒子または核酸を富化するための方法
US8951996B2 (en) 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
JP6034394B2 (ja) * 2011-11-09 2016-11-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 切迫妊娠高血圧腎症および／またはＨＥＬＬＰ症候群の指標としてのｓＦｌｔ−１またはエンドグリン／ＰｌＧＦ比の動態
US20130203068A1 (en) 2012-02-06 2013-08-08 Perkinelmer Biosignal, Inc. Dual-acceptor time-resolved-fret
GB2515983A (en) 2012-05-08 2015-01-07 Univ Leland Stanford Junior Methods and compositions for providing a preeclampsia assessment
KR101996123B1 (ko) 2012-06-27 2019-07-03 에프. 호프만-라 로슈 아게 특정 시기 내에 임신중독증의 개시를 배제하기 위한 sFlt-1/PlGF 또는 엔도글린/PlGF 비의 적용 수단 및 방법
US20140141456A1 (en) 2012-08-30 2014-05-22 Ansh Labs, LLC Papp-a2 as a marker for monitoring, predicting and diagnosing preeclampsia
ES2690782T3 (es) 2012-10-24 2018-11-22 Nyu Winthrop Hospital Biomarcador no invasivo para identificar sujetos en riesgo de parto prematuro
US20150330989A1 (en) * 2012-11-15 2015-11-19 The Brigham And Women's Hospital, Inc. Method and system for diagnosing and treating preeclampsia
CA2903929A1 (en) * 2013-03-04 2014-09-12 Iq Products B.V. Prognostic marker to determine the risk for early-onset preeclampsia
EP3077825B1 (en) * 2013-12-03 2020-11-25 Cézanne S.A.S. Method for the selective determination of placental growth factor 2
EP3097422B1 (en) 2014-01-24 2018-07-11 Roche Diagnostics GmbH Prediction of postpartum hellp syndrome, postpartum eclampsia or postpartum preeclampsia
US10281475B2 (en) 2014-03-27 2019-05-07 Wayne State University Systems and methods to identify and treat subjects at risk for obstetrical complications
WO2016019176A1 (en) 2014-07-30 2016-02-04 Matthew Cooper Methods and compositions for diagnosing, prognosing, and confirming preeclampsia
US10357469B2 (en) 2015-02-18 2019-07-23 Aston University Diagnostic assay and treatment for preeclampsia
WO2016134324A1 (en) 2015-02-20 2016-08-25 Neoteryx, Llc Method and apparatus for acquiring blood for testing
US20180114600A1 (en) 2015-03-23 2018-04-26 Adelaide Research & Innovation Pty Ltd Methods and systems for determining risk of a pregnancy complication occurring
WO2017042751A1 (en) 2015-09-11 2017-03-16 Universidad De Los Andes In vitro method for identifying a pregnancy related disease
NL2016967B1 (en) 2016-06-15 2017-12-21 Iq Products B V Markers and their ratio to determine the risk for early-onset preeclampsia.
US20190353667A1 (en) 2017-02-06 2019-11-21 Astute Medical, Inc. Methods and Compositions for Diagnosis and Prognosis of Renal Injury and Renal Failure
US20190079097A1 (en) 2017-09-13 2019-03-14 Progenity, Inc. Preeclampsia biomarkers and related systems and methods
CN111094988A (zh) 2017-09-13 2020-05-01 普罗根尼蒂公司 先兆子痫生物标志物及相关***和方法

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