MX2020001776A - Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3. - Google Patents
Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3.Info
- Publication number
- MX2020001776A MX2020001776A MX2020001776A MX2020001776A MX2020001776A MX 2020001776 A MX2020001776 A MX 2020001776A MX 2020001776 A MX2020001776 A MX 2020001776A MX 2020001776 A MX2020001776 A MX 2020001776A MX 2020001776 A MX2020001776 A MX 2020001776A
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- MX
- Mexico
- Prior art keywords
- sub
- sup
- sulfonylthioureas
- nlrp
- sulfonylureas
- Prior art date
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
La presente invención hace referencia a sulfonilureas y sulfonilureas que comprenden un anillo heteroarilo que contiene nitrógeno de 5 miembros unido al grupo sulfonilo, en donde el anillo heteroarilo se sustituye con un grupo R1 que contiene nitrógeno, en donde R1 contiene de 1 a 7 átomos diferentes de hidrógeno o halógeno. La presente invención también hace referencia a sales, solvatos y profármacos de dichos compuestos, a composiciones farmacéuticas de dichos compuestos y al uso de dichos compuestos en el tratamiento y prevención de trastornos médicos y enfermedades, especialmente mediante la inhibición de NLRP3.
Applications Claiming Priority (6)
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GBGB1713082.4A GB201713082D0 (en) | 2017-08-15 | 2017-08-15 | Novel compounds |
GBGB1718563.8A GB201718563D0 (en) | 2017-11-09 | 2017-11-09 | Novel compounds |
GBGB1721731.6A GB201721731D0 (en) | 2017-12-22 | 2017-12-22 | Novel compounds |
GBGB1721726.6A GB201721726D0 (en) | 2017-12-22 | 2017-12-22 | Novel compounds |
GBGB1810983.5A GB201810983D0 (en) | 2018-07-04 | 2018-07-04 | Novel compounds |
PCT/EP2018/072119 WO2019034690A1 (en) | 2017-08-15 | 2018-08-15 | SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3 |
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MX2020001776A true MX2020001776A (es) | 2020-03-24 |
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MX2020001776A MX2020001776A (es) | 2017-08-15 | 2018-08-15 | Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3. |
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JP2023513935A (ja) | 2020-02-18 | 2023-04-04 | インフレイゾーム リミテッド | 化合物 |
-
2018
- 2018-08-15 MA MA049903A patent/MA49903A/fr unknown
- 2018-08-15 CA CA3071150A patent/CA3071150A1/en active Pending
- 2018-08-15 PE PE2020000111A patent/PE20200758A1/es unknown
- 2018-08-15 MX MX2020001776A patent/MX2020001776A/es unknown
- 2018-08-15 BR BR112020003014-7A patent/BR112020003014A2/pt not_active Application Discontinuation
- 2018-08-15 SG SG11202001166RA patent/SG11202001166RA/en unknown
- 2018-08-15 CN CN201880060178.1A patent/CN111093773A/zh active Pending
- 2018-08-15 TW TW107128475A patent/TW201910316A/zh unknown
- 2018-08-15 AU AU2018317798A patent/AU2018317798A1/en not_active Abandoned
- 2018-08-15 EP EP18759274.6A patent/EP3668599A1/en active Pending
- 2018-08-15 WO PCT/EP2018/072119 patent/WO2019034690A1/en unknown
- 2018-08-15 US US16/638,648 patent/US11613542B2/en active Active
- 2018-08-15 KR KR1020207007257A patent/KR20200041919A/ko not_active Application Discontinuation
- 2018-08-15 UY UY0001037847A patent/UY37847A/es not_active Application Discontinuation
- 2018-08-15 RU RU2020110219A patent/RU2020110219A/ru unknown
- 2018-08-15 JP JP2020508571A patent/JP2020531453A/ja active Pending
-
2019
- 2019-08-12 US US17/267,791 patent/US20210163412A1/en active Pending
- 2019-08-12 CN CN201980064997.8A patent/CN112789264A/zh active Pending
- 2019-08-12 EP EP19761754.1A patent/EP3837242A1/en active Pending
- 2019-08-12 WO PCT/EP2019/071629 patent/WO2020035465A1/en unknown
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2020
- 2020-02-09 IL IL272557A patent/IL272557A/en unknown
- 2020-02-13 CL CL2020000367A patent/CL2020000367A1/es unknown
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JP2020531453A (ja) | 2020-11-05 |
WO2020035465A1 (en) | 2020-02-20 |
CL2020000367A1 (es) | 2020-08-28 |
AU2018317798A1 (en) | 2020-02-13 |
MA49903A (fr) | 2020-06-24 |
TW201910316A (zh) | 2019-03-16 |
US11613542B2 (en) | 2023-03-28 |
US20210163412A1 (en) | 2021-06-03 |
EP3668599A1 (en) | 2020-06-24 |
UY37847A (es) | 2019-03-29 |
US20210130359A1 (en) | 2021-05-06 |
CA3071150A1 (en) | 2019-02-21 |
CN111093773A (zh) | 2020-05-01 |
RU2020110219A (ru) | 2021-09-17 |
KR20200041919A (ko) | 2020-04-22 |
IL272557A (en) | 2020-03-31 |
PE20200758A1 (es) | 2020-07-27 |
RU2020110219A3 (es) | 2022-02-15 |
CN112789264A (zh) | 2021-05-11 |
BR112020003014A2 (pt) | 2020-07-28 |
WO2019034690A1 (en) | 2019-02-21 |
EP3837242A1 (en) | 2021-06-23 |
SG11202001166RA (en) | 2020-03-30 |
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