MX2020001404A - Dihidrooxadiazinonas. - Google Patents

Dihidrooxadiazinonas.

Info

Publication number
MX2020001404A
MX2020001404A MX2020001404A MX2020001404A MX2020001404A MX 2020001404 A MX2020001404 A MX 2020001404A MX 2020001404 A MX2020001404 A MX 2020001404A MX 2020001404 A MX2020001404 A MX 2020001404A MX 2020001404 A MX2020001404 A MX 2020001404A
Authority
MX
Mexico
Prior art keywords
sup
compounds
preparing
pharmaceutical compositions
diseases
Prior art date
Application number
MX2020001404A
Other languages
English (en)
Inventor
Sülzle Detlev
Lienau Philip
Tersteegen Adrian
Ellermann Manuel
Lange Martin
Nikolaus Gradl Stefan
Christine Kopitz Charlotte
Hegele-Hartung Christa
A Lewis Timothy
Greulich Heidi
Wu Xiaoyun
Burgin Alex
Meyerson Matthew
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2020001404A publication Critical patent/MX2020001404A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catalysts (AREA)

Abstract

La invención proporciona compuestos de dihidrooxidiazinona de la fórmula general (I): (ver Fórmula) en donde R1, R2, R3, y R4 son como se definen en el presente, procedimientos para la preparación de dichos compuestos, compuestos intermedios útiles para la preparación de dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la elaboración de composiciones farmacéuticas para el tratamiento o la profilaxis de enfermedades, en especial de enfermedades hiperproliferativas, como un único agente o en combinación con otros ingredientes activos.
MX2020001404A 2017-08-04 2018-08-02 Dihidrooxadiazinonas. MX2020001404A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762541627P 2017-08-04 2017-08-04
PCT/EP2018/071039 WO2019025562A1 (en) 2017-08-04 2018-08-02 DIHYDROOXADIAZINONES

Publications (1)

Publication Number Publication Date
MX2020001404A true MX2020001404A (es) 2020-03-12

Family

ID=63207725

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020001404A MX2020001404A (es) 2017-08-04 2018-08-02 Dihidrooxadiazinonas.

Country Status (25)

Country Link
US (3) US11427553B2 (es)
EP (1) EP3661517B1 (es)
JP (2) JP2020529439A (es)
KR (1) KR20200036914A (es)
CN (1) CN111212647B (es)
AR (1) AR112402A1 (es)
AU (1) AU2018309356B2 (es)
BR (1) BR112020002351A2 (es)
CA (1) CA3071800A1 (es)
CL (1) CL2020000303A1 (es)
CO (1) CO2020001242A2 (es)
CR (1) CR20200057A (es)
CU (1) CU24608B1 (es)
EA (1) EA202090448A1 (es)
EC (1) ECSP20008441A (es)
IL (1) IL272098B2 (es)
JO (1) JOP20200024A1 (es)
MA (1) MA49750A (es)
MX (1) MX2020001404A (es)
PH (1) PH12020500134A1 (es)
SG (1) SG11201913775UA (es)
TW (1) TWI791581B (es)
UA (1) UA125731C2 (es)
UY (1) UY37832A (es)
WO (1) WO2019025562A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11897867B2 (en) 2017-08-04 2024-02-13 Bayer Aktiengesellschaft 6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives as PDE3A and PDE3B inhibitors for treating cancer
JOP20200024A1 (ar) 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون
WO2020157188A1 (en) * 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Dihydrooxadiazinones for the treatment of hyperproliferative diseases
CN117279644A (zh) 2021-03-03 2023-12-22 拜耳股份有限公司 用于治疗肉瘤的取代的3,6-二氢-2h-1,3,4-噁二嗪-2-酮
EP4289829A1 (en) 2022-06-10 2023-12-13 Bayer Aktiengesellschaft Crystalline forms of (6s)-5-[4'-fluoro-2-(trifluoromethyl)biphenyl-4-yl]-6-methyl-3,6-dihydro- 2h-1,3,4-oxadiazin-2-one
EP4289828A1 (en) 2022-06-10 2023-12-13 Bayer Aktiengesellschaft Method for the preparation of a 3,6-dihydro-2h-1,3,4-oxadiazin-2-one

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097671A (en) * 1975-08-28 1978-06-27 General Electric Company Dihydrooxadiazinones and method for making
US4052395A (en) 1975-09-11 1977-10-04 Sankyo Company Limited Agricultural fungicidal compositions containing 6-(substituted phenyl)-pyridazinones and said pyridazinones
US4258094A (en) * 1979-04-26 1981-03-24 Brunswick Corporation Melt bonded fabrics and a method for their production
US4334030A (en) 1979-11-23 1982-06-08 General Electric Company Thermoplastic foamable blends
DE3172252D1 (en) 1980-11-14 1985-10-17 Ici Plc Heterocyclic compounds
FI72718C (fi) 1981-03-04 1987-07-10 Ciba Geigy Ag Foerfarande foer framstaellning av terapeutiskt verkande, substituerade 6-(4-morfolino-fenyl)-4,5-dihydro- 3(2h)-pyridazinoner och deras syraadditionssalter.
US4495185A (en) 1981-11-12 1985-01-22 Imperial Chemical Industries, Plc 1,2,4-Triazin-3(2H) ones
ZA827641B (en) 1981-11-12 1983-09-28 Ici Plc Thiadiazine, oxadiazine and triazine derivatives which possess cardiotonic and/or antihypertensive activity
US4581356A (en) 1983-03-22 1986-04-08 Fujisawa Pharmaceutical Co., Ltd. Triazine derivatives, and pharmaceutical compositions comprising the same
GB8310435D0 (en) 1983-04-18 1983-05-25 Fujisawa Pharmaceutical Co Triazine derivatives
JPS59196874A (ja) 1983-04-22 1984-11-08 Fujisawa Pharmaceut Co Ltd トリアジン誘導体
JPS6153270A (ja) 1984-08-17 1986-03-17 チバ・ガイギー・アクチエンゲゼルシヤフト 置換ピリダジノン、その製造方法及び該化合物を含む医薬製剤
US4816454A (en) 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
GB8426804D0 (en) 1984-10-23 1984-11-28 Ciba Geigy Ag Pyridazinones preparations
PT83530B (pt) 1985-10-17 1989-05-31 Smith Kline French Lab Processo de preparacao de derivados da piridona, em especial derivados fenilicos
EP0303418A3 (en) 1987-08-11 1990-11-07 Smithkline Beecham Laboratoires Pharmaceutiques Substituted indolones, useful in the treatment of heart or asthmatic diseases
EP0478195B1 (en) 1990-09-21 1999-05-26 Rohm And Haas Company Dihydropyridazinones and pyridazinones as fungicides
JPH0676325B2 (ja) * 1992-05-08 1994-09-28 三井東圧化学株式会社 オキサジアジン誘導体を有効成分として含有する抗血栓剤
AU668206B2 (en) 1992-07-01 1996-04-26 Ortho Pharmaceutical Corporation 1-arylsulphonyl, arylcarbonyl and 1-arylphosphonyl-3-phenyl-1,4,5,6-tetrahydropyridazines
JPH07291968A (ja) 1994-04-26 1995-11-07 Mitsubishi Chem Corp トリアジノン誘導体またはその塩類
DE19929787A1 (de) * 1999-06-29 2001-01-04 Bayer Ag Neue 4-(2-Oxodihydrooxadiazinylphenyl)amide und ihre Verwendung
US20050070529A1 (en) * 2001-02-12 2005-03-31 Merk Pantent Gmbh Use of type 4 phosphodiesterase inhibitors in myocardial diseases
WO2008108602A1 (en) 2007-03-07 2008-09-12 Dong-A Pharm. Co., Ltd. Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators, method of the same, and pharmaceutical composition comprising the same
CN101537006B (zh) 2008-03-18 2012-06-06 中国科学院上海药物研究所 哒嗪酮类化合物在制备抗肿瘤药物中的用途
US9212146B2 (en) 2008-03-18 2015-12-15 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Substituted pyridazinones for the treatment of tumors
EP2419400A1 (en) 2009-04-15 2012-02-22 Research Triangle Institute Monoamine reuptake inhibitors
FR2948940B1 (fr) * 2009-08-04 2011-07-22 Servier Lab Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2566864B1 (en) 2010-05-07 2014-09-03 Boehringer Ingelheim International GmbH Pyridazinones as gpr119 agonists
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
TWI532742B (zh) 2011-02-28 2016-05-11 艾伯維有限公司 激酶之三環抑制劑
EP2970145B1 (en) * 2013-03-11 2020-05-06 The Broad Institute, Inc. Compounds and compositions for the treatment of cancer
TWI656121B (zh) 2014-08-04 2019-04-11 德商拜耳製藥公司 ２－（嗎啉－４－基）－１，７－萘啶
WO2017027854A1 (en) * 2015-08-13 2017-02-16 The Broad Institute, Inc. Compositions and methods for cancer expressing pde3a or slfn12
EP3402795B1 (en) 2016-01-14 2019-10-30 Bayer Pharma Aktiengesellschaft 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines
AR107529A1 (es) 2016-02-05 2018-05-09 Bayer Pharma AG Compuestos, composiciones y métodos para la estratificación de pacientes de cáncer y su tratamiento
KR101831772B1 (ko) * 2016-03-24 2018-03-06 아이디에스(주) 복합 광원 모듈을 가지는 카메라 접사용 기구 및 이를 이용한 지문 시편 촬영 방법
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US11897867B2 (en) 2017-08-04 2024-02-13 Bayer Aktiengesellschaft 6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives as PDE3A and PDE3B inhibitors for treating cancer
JOP20200024A1 (ar) 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون
TW202031677A (zh) 2018-11-01 2020-09-01 美商博得學院股份有限公司 Ｐｄｅ３調節劑反應性癌症之鑑定
TWI750573B (zh) 2019-02-01 2021-12-21 德商拜耳廠股份有限公司 1,2,4-三-3(2h)-酮化合物

Also Published As

Publication number Publication date
AR112402A1 (es) 2019-10-23
TWI791581B (zh) 2023-02-11
CL2020000303A1 (es) 2020-11-13
SG11201913775UA (en) 2020-01-30
CO2020001242A2 (es) 2020-02-18
US20200369633A1 (en) 2020-11-26
US20220396554A1 (en) 2022-12-15
PH12020500134A1 (en) 2021-01-25
WO2019025562A1 (en) 2019-02-07
CU20200008A7 (es) 2020-11-30
CN111212647B (zh) 2024-05-14
US11427553B2 (en) 2022-08-30
ECSP20008441A (es) 2020-05-29
MA49750A (fr) 2020-06-10
EP3661517B1 (en) 2023-09-13
KR20200036914A (ko) 2020-04-07
JP2020529439A (ja) 2020-10-08
US11773070B2 (en) 2023-10-03
IL272098B1 (en) 2023-03-01
UA125731C2 (uk) 2022-05-25
UY37832A (es) 2019-02-28
IL272098A (en) 2020-03-31
BR112020002351A2 (pt) 2020-09-08
TW201917126A (zh) 2019-05-01
EA202090448A1 (ru) 2020-05-21
AU2018309356A1 (en) 2020-01-30
US20230017200A1 (en) 2023-01-19
AU2018309356B2 (en) 2022-12-15
IL272098B2 (en) 2023-07-01
JP2023115065A (ja) 2023-08-18
EP3661517A1 (en) 2020-06-10
CR20200057A (es) 2020-06-16
JOP20200024A1 (ar) 2020-02-02
CU24608B1 (es) 2022-06-06
CN111212647A (zh) 2020-05-29
CA3071800A1 (en) 2019-02-07

Similar Documents

Publication Publication Date Title
PH12019500932A1 (en) 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of dhodh
WO2018077944A3 (en) 4,5-annulated 1,2,4-triazolones
PH12021550792A1 (en) 2-(morpholin-4-yl)-1,7-naphthyridines
MX2020001403A (es) Nuevos derivados de quinolina.
PH12018550173A1 (en) Pyrazolopyrimidine derivatives
PH12019501846A1 (en) 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer
TN2017000467A1 (en) Amido-substituted cyclohexane derivatives
MX2020001404A (es) Dihidrooxadiazinonas.
CR20210201A (es) Nuevos compuestos antihelmínticos
PH12019502851A1 (en) New azaquinoline derivatives
WO2020126968A3 (en) Urea derivatives for use against proliferative diseases
MX2019012803A (es) Nuevos derivados de pirazol biciclicos.
MX2020011873A (es) Nuevos derivados de quinolina.
WO2017198341A8 (en) MACROCYCLIC INDOLE DERIVATIVES
CR20220236A (es) Aminoquinolonas sustituidas como inhibidores de dgk alfa para la activación inmune
PH12017501133A1 (en) Pyrazolopyridinamines
WO2015150449A3 (en) Amido-substituted azole compounds as inhibitors of tnks1 and/or tnks2
PH12020550494A1 (en) Novel pyrazolo-pyrrolo-pyrimidine-dione derivatives as p2x3 inhibitors
PH12019500808A1 (en) Substituted 6-(1h-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof