ECSP20008441A - Dihidrooxadiazinonas - Google Patents

Dihidrooxadiazinonas

Info

Publication number
ECSP20008441A
ECSP20008441A ECSENADI20208441A ECDI202008441A ECSP20008441A EC SP20008441 A ECSP20008441 A EC SP20008441A EC SENADI20208441 A ECSENADI20208441 A EC SENADI20208441A EC DI202008441 A ECDI202008441 A EC DI202008441A EC SP20008441 A ECSP20008441 A EC SP20008441A
Authority
EC
Ecuador
Prior art keywords
compounds
preparation
pharmaceutical compositions
diseases
dihydrooxadiazinones
Prior art date
Application number
ECSENADI20208441A
Other languages
English (en)
Inventor
Matthew Meyerson
Philip Lienau
Adrian Tersteegen
Heidi Greulich
Christa Hegele-Hartung
Alex Burgin
Detlev Sülzle
Timothy Lewis
Martin Lange
Stefan Gradl
Charlotte Kopitz
Manuel Ellermann
Xiaoyun Wu
Original Assignee
Bayer Pharma AG
Dana Farber Cancer Inst Inc
Bayer Ag
Broad Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Dana Farber Cancer Inst Inc, Bayer Ag, Broad Inst Inc filed Critical Bayer Pharma AG
Publication of ECSP20008441A publication Critical patent/ECSP20008441A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La invención proporciona compuestos de dihidrooxidiazinona de la fórmula general (I): en donde R1, R2, R3, y R4 son como se definen en el presente, procedimientos para la preparación de dichos compuestos, compuestos intermedios útiles para la preparación de dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la elaboración de composiciones farmacéuticas para el tratamiento o la profilaxis de enfermedades, en especial de enfermedades hiperproliferativas, como un único agente o en combinación con otros ingredientes activos.
ECSENADI20208441A 2017-08-04 2020-02-04 Dihidrooxadiazinonas ECSP20008441A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762541627P 2017-08-04 2017-08-04

Publications (1)

Publication Number Publication Date
ECSP20008441A true ECSP20008441A (es) 2020-05-29

Family

ID=63207725

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI20208441A ECSP20008441A (es) 2017-08-04 2020-02-04 Dihidrooxadiazinonas

Country Status (25)

Country Link
US (3) US11427553B2 (es)
EP (1) EP3661517B1 (es)
JP (2) JP2020529439A (es)
KR (1) KR20200036914A (es)
CN (1) CN111212647B (es)
AR (1) AR112402A1 (es)
AU (1) AU2018309356B2 (es)
BR (1) BR112020002351A2 (es)
CA (1) CA3071800A1 (es)
CL (1) CL2020000303A1 (es)
CO (1) CO2020001242A2 (es)
CR (1) CR20200057A (es)
CU (1) CU24608B1 (es)
EA (1) EA202090448A1 (es)
EC (1) ECSP20008441A (es)
IL (1) IL272098B2 (es)
JO (1) JOP20200024A1 (es)
MA (1) MA49750A (es)
MX (1) MX2020001404A (es)
PH (1) PH12020500134A1 (es)
SG (1) SG11201913775UA (es)
TW (1) TWI791581B (es)
UA (1) UA125731C2 (es)
UY (1) UY37832A (es)
WO (1) WO2019025562A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3661917B1 (en) 2017-08-04 2022-05-11 Bayer Aktiengesellschaft 6-((3-trifluoromethyl)phenyl)-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer
JOP20200024A1 (ar) 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون
WO2020157188A1 (en) * 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Dihydrooxadiazinones for the treatment of hyperproliferative diseases
WO2022184748A1 (en) 2021-03-03 2022-09-09 Bayer Aktiengesellschaft Substituted 3,6-dihydro-2h-1,3,4-oxadiazin-2-ones for the treatment of sarcoma
EP4289828A1 (en) 2022-06-10 2023-12-13 Bayer Aktiengesellschaft Method for the preparation of a 3,6-dihydro-2h-1,3,4-oxadiazin-2-one
EP4289829A1 (en) 2022-06-10 2023-12-13 Bayer Aktiengesellschaft Crystalline forms of (6s)-5-[4'-fluoro-2-(trifluoromethyl)biphenyl-4-yl]-6-methyl-3,6-dihydro- 2h-1,3,4-oxadiazin-2-one

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Also Published As

Publication number Publication date
CL2020000303A1 (es) 2020-11-13
CR20200057A (es) 2020-06-16
CN111212647B (zh) 2024-05-14
JP2023115065A (ja) 2023-08-18
CO2020001242A2 (es) 2020-02-18
UA125731C2 (uk) 2022-05-25
UY37832A (es) 2019-02-28
US20230017200A1 (en) 2023-01-19
MX2020001404A (es) 2020-03-12
PH12020500134A1 (en) 2021-01-25
IL272098B2 (en) 2023-07-01
US11773070B2 (en) 2023-10-03
EA202090448A1 (ru) 2020-05-21
EP3661517A1 (en) 2020-06-10
CN111212647A (zh) 2020-05-29
US20200369633A1 (en) 2020-11-26
IL272098A (en) 2020-03-31
SG11201913775UA (en) 2020-01-30
BR112020002351A2 (pt) 2020-09-08
US11427553B2 (en) 2022-08-30
CU24608B1 (es) 2022-06-06
WO2019025562A1 (en) 2019-02-07
KR20200036914A (ko) 2020-04-07
JOP20200024A1 (ar) 2020-02-02
AR112402A1 (es) 2019-10-23
AU2018309356A1 (en) 2020-01-30
EP3661517B1 (en) 2023-09-13
MA49750A (fr) 2020-06-10
TW201917126A (zh) 2019-05-01
US20220396554A1 (en) 2022-12-15
JP2020529439A (ja) 2020-10-08
TWI791581B (zh) 2023-02-11
CU20200008A7 (es) 2020-11-30
IL272098B1 (en) 2023-03-01
CA3071800A1 (en) 2019-02-07
AU2018309356B2 (en) 2022-12-15

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