MX2019012336A - Compuestos inhibidores del transportador vesicular de monoaminas 2 (vmat2) y composiciones de los mismos. - Google Patents

Compuestos inhibidores del transportador vesicular de monoaminas 2 (vmat2) y composiciones de los mismos.

Info

Publication number
MX2019012336A
MX2019012336A MX2019012336A MX2019012336A MX2019012336A MX 2019012336 A MX2019012336 A MX 2019012336A MX 2019012336 A MX2019012336 A MX 2019012336A MX 2019012336 A MX2019012336 A MX 2019012336A MX 2019012336 A MX2019012336 A MX 2019012336A
Authority
MX
Mexico
Prior art keywords
sup
compounds
compositions
inhibitor compounds
vmat2 inhibitor
Prior art date
Application number
MX2019012336A
Other languages
English (en)
Inventor
Nicole Harriott
Donald Hettinger
Shawn Branum
Jeffrey C Culhane
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62111264&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019012336(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of MX2019012336A publication Critical patent/MX2019012336A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se proporciona un compuesto seleccionado de compuestos de fórmula (I) y sales, solvatos e hidratos farmacéuticamente aceptables de los mismos: (Ver formula) en la que R1, R2, R3 y R4 son tal como se definen en el presente documento. Tales compuestos son inhibidores del transportador vesicular de monoaminas 2 (VMAT2) y tienen utilidad para tratar, por ejemplo, enfermedades y trastornos neurológicos y psiquiátricos. También se dan a conocer composiciones que contienen tales compuestos en combinación con un portador farmacéuticamente aceptable, así como métodos relativos a su uso en sujetos que lo necesitan.
MX2019012336A 2017-04-19 2018-04-17 Compuestos inhibidores del transportador vesicular de monoaminas 2 (vmat2) y composiciones de los mismos. MX2019012336A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762487413P 2017-04-19 2017-04-19
US201862652837P 2018-04-04 2018-04-04
PCT/US2018/028031 WO2018195121A1 (en) 2017-04-19 2018-04-17 Vmat2 inhibitor compounds and compositions thereof

Publications (1)

Publication Number Publication Date
MX2019012336A true MX2019012336A (es) 2020-07-14

Family

ID=62111264

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012336A MX2019012336A (es) 2017-04-19 2018-04-17 Compuestos inhibidores del transportador vesicular de monoaminas 2 (vmat2) y composiciones de los mismos.

Country Status (16)

Country Link
US (1) US11040970B2 (es)
EP (1) EP3612532B1 (es)
JP (1) JP7170662B2 (es)
KR (1) KR20190140968A (es)
CN (1) CN110770236B (es)
AU (1) AU2018254429A1 (es)
BR (1) BR112019021853A2 (es)
CA (1) CA3060251A1 (es)
CL (1) CL2019002919A1 (es)
CO (1) CO2019011604A2 (es)
JO (1) JOP20190239A1 (es)
MA (1) MA50145A (es)
MX (1) MX2019012336A (es)
PE (1) PE20191784A1 (es)
TW (1) TW201841913A (es)
WO (1) WO2018195121A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200066662A (ko) 2017-01-27 2020-06-10 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
MX2020002841A (es) 2017-09-21 2020-07-22 Neurocrine Biosciences Inc Formulacion de valbenazina de alta dosis y composiciones, metodos y kits relacionados con la misma.
EA202090932A1 (ru) 2017-10-10 2021-05-20 Нейрокрин Байосайенсиз, Инк Способы введения некоторых vmat2-ингибиторов
MA52896A (fr) * 2018-06-14 2021-04-21 Neurocrine Biosciences Inc Composés inhibiteurs de vmat2, compositions et méthodes associées
CA3104693A1 (en) 2018-08-15 2020-02-20 Neurocrine Biosciences, Inc. Methods for the administration of certain vmat2 inhibitors
TW202033521A (zh) * 2018-10-24 2020-09-16 美商紐羅克里生物科學有限公司 製備囊泡單胺轉運蛋白2(vmat2)抑制劑之方法
PE20230407A1 (es) 2019-11-11 2023-03-07 Incyte Corp Sales y formas cristalinas de un inhibidor de pd-1/pd-l1
MX2023010566A (es) 2021-03-22 2023-09-21 Neurocrine Biosciences Inc Inhibidores de proteina transportadora vesicular monoaminotransportadora-2 (vmat2) y metodos de uso.
WO2022232380A1 (en) 2021-04-29 2022-11-03 Neurocrine Biosciences, Inc. Processes for preparing a vmat2 inhibitor
IL310907A (en) 2021-08-20 2024-04-01 Neurocrine Biosciences Inc Screening methods for VMAT2 inhibitors

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US5798119A (en) 1995-06-13 1998-08-25 S. C. Johnson & Son, Inc. Osmotic-delivery devices having vapor-permeable coatings
GB0106177D0 (en) 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
AU2004251829B2 (en) 2003-06-20 2009-12-17 F. Hoffmann-La Roche Ag Hexahydropyridoisoqinolines as DPP-IV inhibitors
AU2005272773A1 (en) * 2004-08-13 2006-02-23 Omeros Corporation Novel serotonin receptor ligands and their uses thereof
EA018378B1 (ru) 2006-11-08 2013-07-30 Ньюрокрайн Байосайенсиз, Инк. ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 3-ИЗОБУТИЛ-9,10-ДИМЕТОКСИ-1,3,4,6,7,11b-ГЕКСАГИДРО-2Н-ПИРИДО[2,1-a]ИЗОХИНОЛИН-2-ОЛА И СВЯЗАННЫЕ С НИМИ СПОСОБЫ
FR2912145B1 (fr) 2007-02-02 2009-03-06 Servier Lab Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US9012471B2 (en) * 2008-04-11 2015-04-21 The Trustees Of Columbia University In The City Of New York Glucose metabolism modulating compounds
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CN102285984B (zh) * 2010-11-25 2012-10-10 江苏威凯尔医药科技有限公司 (2R,3R,11bR)-二氢丁苯那嗪及相关化合物的制备方法
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EP3102239A1 (en) 2014-02-07 2016-12-14 Neurocrine Biosciences, Inc. Pharmaceutical compositions comprising an antipsychotic drug and a vmat2 inhibitor and uses thereof
AU2016215033B2 (en) 2015-02-06 2020-06-25 Neurocrine Biosciences, Inc. (9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
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Also Published As

Publication number Publication date
MA50145A (fr) 2020-07-29
US20200131173A1 (en) 2020-04-30
AU2018254429A1 (en) 2019-11-07
US11040970B2 (en) 2021-06-22
EP3612532B1 (en) 2023-12-13
CO2019011604A2 (es) 2019-10-31
JP2020517607A (ja) 2020-06-18
KR20190140968A (ko) 2019-12-20
CN110770236B (zh) 2023-03-24
WO2018195121A1 (en) 2018-10-25
JOP20190239A1 (ar) 2019-10-09
EP3612532C0 (en) 2023-12-13
JP7170662B2 (ja) 2022-11-14
PE20191784A1 (es) 2019-12-24
BR112019021853A2 (pt) 2020-05-26
CA3060251A1 (en) 2018-10-25
TW201841913A (zh) 2018-12-01
CL2019002919A1 (es) 2020-01-17
EP3612532A1 (en) 2020-02-26
CN110770236A (zh) 2020-02-07

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