MX2019006983A - Conjugados de anticuerpo-farmaco de multiples farmacos. - Google Patents
Conjugados de anticuerpo-farmaco de multiples farmacos.Info
- Publication number
- MX2019006983A MX2019006983A MX2019006983A MX2019006983A MX2019006983A MX 2019006983 A MX2019006983 A MX 2019006983A MX 2019006983 A MX2019006983 A MX 2019006983A MX 2019006983 A MX2019006983 A MX 2019006983A MX 2019006983 A MX2019006983 A MX 2019006983A
- Authority
- MX
- Mexico
- Prior art keywords
- drug
- units
- conjugates
- adcs
- deprotection
- Prior art date
Links
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 2
- 238000010511 deprotection reaction Methods 0.000 abstract 2
- 238000010276 construction Methods 0.000 abstract 1
Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente descripción proporciona, inter alia, Conjugados de Anticuerpo-fármaco de múltiples fármacos (MDADC) y Unidades de Montaje de Ligación (LA) que se construyen en una materia específica de sitio a través de desprotección "ortogonal" y carga de fármaco. También se proporcionan, Unidades de Montaje de Ligación protegidas, que permiten la desprotección "ortogonal" y construcción de MD-ADC y Unidades LA de la presente descripción.
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US201662434333P | 2016-12-14 | 2016-12-14 | |
JP2017115832A JP7244987B2 (ja) | 2016-12-14 | 2017-06-13 | 多剤抗体薬物コンジュゲート |
PCT/US2017/066504 WO2018112253A1 (en) | 2016-12-14 | 2017-12-14 | Multi-drug antibody drug conjugates |
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MX2019006983A true MX2019006983A (es) | 2019-08-16 |
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MX2019006983A MX2019006983A (es) | 2016-12-14 | 2017-12-14 | Conjugados de anticuerpo-farmaco de multiples farmacos. |
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US (2) | US11541128B2 (es) |
EP (1) | EP3554266A4 (es) |
JP (2) | JP7244987B2 (es) |
KR (1) | KR20190095374A (es) |
CN (2) | CN116271080A (es) |
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CA (1) | CA3043931A1 (es) |
IL (2) | IL267003B1 (es) |
MA (1) | MA50755A (es) |
MX (1) | MX2019006983A (es) |
TW (1) | TWI828614B (es) |
WO (1) | WO2018112253A1 (es) |
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TW202015740A (zh) * | 2018-06-07 | 2020-05-01 | 美商西雅圖遺傳學公司 | 喜樹鹼結合物 |
CN111378006A (zh) * | 2018-12-28 | 2020-07-07 | 联宁(苏州)生物制药有限公司 | 一种用于抗体偶联药物的新型双臂中间体lnd1026-035及其合成方法 |
EP3924378A4 (en) * | 2019-02-15 | 2023-04-05 | WuXi Biologics Ireland Limited | METHODS FOR THE PRODUCTION OF ANTIBODY-DRUG CONJUGATES WITH IMPROVED HOMOGENEITY |
CN112569368A (zh) * | 2019-08-07 | 2021-03-30 | 烟台迈百瑞国际生物医药股份有限公司 | 一种抗体药物偶联物及其应用 |
MX2022009052A (es) * | 2020-01-22 | 2022-08-15 | Medimmune Ltd | Compuestos y conjugados de estos. |
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CN111560078A (zh) * | 2020-06-19 | 2020-08-21 | 联宁(苏州)生物制药有限公司 | 具有马来酰亚胺接头的双臂中间体及其合成方法 |
CN113941007B (zh) * | 2020-07-16 | 2024-06-07 | 成都科岭源医药技术有限公司 | 一种串联的双药物链接组装单元及其应用 |
WO2022022649A1 (zh) * | 2020-07-30 | 2022-02-03 | 成都科岭源医药技术有限公司 | 一种双药链接组装单元及双药靶向接头-药物偶联物 |
CN111892575A (zh) * | 2020-08-20 | 2020-11-06 | 南京大学 | 一类紫草宁硫辛硫醚孪药分子及其合成方法和应用 |
CN115105607A (zh) * | 2021-03-22 | 2022-09-27 | 成都科岭源医药技术有限公司 | 一种用于adc的双药-接头的制备方法及其用途 |
AU2022259314A1 (en) * | 2021-04-14 | 2023-11-30 | Genequantum Healthcare (Suzhou) Co., Ltd. | Linkers, conjugates and applications thereof |
WO2022268050A1 (zh) * | 2021-06-22 | 2022-12-29 | 荣昌生物制药(烟台)股份有限公司 | 一种药物组合及其用途 |
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TW202408588A (zh) * | 2022-05-20 | 2024-03-01 | 瑞士商諾華公司 | 抗體-藥物結合物抗腫瘤化合物及其使用方法 |
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IL267003A (en) | 2019-07-31 |
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CA3043931A1 (en) | 2018-06-21 |
IL308672A (en) | 2024-01-01 |
IL267003B1 (en) | 2024-05-01 |
US11541128B2 (en) | 2023-01-03 |
JP7244987B2 (ja) | 2023-03-23 |
US20240033372A1 (en) | 2024-02-01 |
TW201827085A (zh) | 2018-08-01 |
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