MX2019004322A - Polvos secos antifungicos. - Google Patents
Polvos secos antifungicos.Info
- Publication number
- MX2019004322A MX2019004322A MX2019004322A MX2019004322A MX2019004322A MX 2019004322 A MX2019004322 A MX 2019004322A MX 2019004322 A MX2019004322 A MX 2019004322A MX 2019004322 A MX2019004322 A MX 2019004322A MX 2019004322 A MX2019004322 A MX 2019004322A
- Authority
- MX
- Mexico
- Prior art keywords
- dry powders
- antifungal
- antifungal dry
- excipients
- stabilizer
- Prior art date
Links
- 229940121375 antifungal agent Drugs 0.000 title abstract 2
- 239000000843 powder Substances 0.000 title abstract 2
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
La invención se refiere a formulaciones en polvo seco que comprenden partículas secas respirables que contienen 1) un agente antifúngico en forma de partículas cristalinas, 2) un estabilizante y 3) uno o más excipientes. La invención también se refiere a los polvos secos descritos en este documento para su uso en el tratamiento de la aspergilosis. La invención también se refiere a los polvos secos descritos en este documento para su uso en tratamiento de la aspergilosis broncopulmonar alérgica (ABPA) . La invención también se relaciona con polvos secos descritos en este documento para su uso en el tratamiento de una exacerbación aguda de una enfermedad respiratoria en un individuo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662408376P | 2016-10-14 | 2016-10-14 | |
PCT/US2017/056497 WO2018071757A1 (en) | 2016-10-14 | 2017-10-13 | Antifungal dry powders |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019004322A true MX2019004322A (es) | 2019-12-11 |
Family
ID=60186406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019004322A MX2019004322A (es) | 2016-10-14 | 2017-10-13 | Polvos secos antifungicos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US11116722B2 (es) |
EP (1) | EP3525759A1 (es) |
JP (1) | JP7085538B2 (es) |
KR (1) | KR102408798B1 (es) |
CN (1) | CN109996536B (es) |
AU (1) | AU2017341815B2 (es) |
BR (1) | BR112019007459A2 (es) |
CA (1) | CA3039485A1 (es) |
IL (1) | IL265913B2 (es) |
MX (1) | MX2019004322A (es) |
NZ (1) | NZ752353A (es) |
RU (1) | RU2766086C2 (es) |
WO (1) | WO2018071757A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL286573B (en) * | 2010-09-29 | 2022-08-01 | Pulmatrix Operating Co Inc | Monovalent metallic cation dry powders for inhalation |
CA3097419A1 (en) * | 2018-04-18 | 2019-10-24 | Cipla Technologies LLC | Methods of treating fungal infections |
WO2019204583A1 (en) * | 2018-04-18 | 2019-10-24 | Pulmatrix Operating Company, Inc. | Antifungal formulations for pulmonary administration comprising itraconazole |
WO2021092349A1 (en) * | 2019-11-08 | 2021-05-14 | Scynexis, Inc. | Lipid-based formulations of scy-078 salts |
IT202000030443A1 (it) | 2020-12-10 | 2022-06-10 | Zambon Spa | Polvere inalabile comprendente voriconazolo in forma cristallina |
IT202000030437A1 (it) | 2020-12-10 | 2022-06-10 | Zambon Spa | Metodo per la realizzazione di una polvere inalabile comprendente voriconazolo |
WO2023086013A2 (en) * | 2021-11-09 | 2023-05-19 | Agency For Science, Technology And Research | A salt-based antifungal powder platform formulation for aerosolization |
WO2023122522A1 (en) * | 2021-12-20 | 2023-06-29 | Pulmatrix Operating Company, Inc. | Dry powder formulations of narrow spectrum kinase inhibitors |
WO2023247952A1 (en) | 2022-06-21 | 2023-12-28 | Hovione Scientia Limited | Crystalline pharmaceutical composition for inhalation comprising sugar and lipid composite particles and process for manufacture |
WO2024040175A1 (en) | 2022-08-18 | 2024-02-22 | Pulmatrix Operating Company, Inc. | Methods for treating cancer using inhaled angiogenesis inhibitor |
WO2024049982A2 (en) | 2022-08-31 | 2024-03-07 | Pulmatrix Operating Company, Inc. | Methods of using itraconazole dry powders |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
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US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
US4097620A (en) | 1977-05-02 | 1978-06-27 | Xerox Corporation | Magnetic toner particle coating process |
US4916134A (en) | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
US6448401B1 (en) * | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
KR100743404B1 (ko) * | 2000-12-21 | 2007-07-30 | 넥타르 테라퓨틱스 | 폴리엔 항균제의 폐 전달 |
ITMI20010357U1 (it) | 2001-06-28 | 2002-12-30 | Plastiape Spa | Dispositivo inalatore |
JP2006513235A (ja) | 2002-12-31 | 2006-04-20 | ネクター セラピューティクス | 真菌感染症療法のためのエアゾール化可能な医薬製剤 |
WO2005000267A2 (en) | 2003-05-28 | 2005-01-06 | Nektar Therapeutics | Spray drying of an alcoholic aqueous solution for the manufacture of a water-insoluble active agentmicroparticle with a partial or complete amino acid and/or phospholipid coat |
US20050048127A1 (en) | 2003-07-22 | 2005-03-03 | Larry Brown | Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof |
GB0327723D0 (en) | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
US8513204B2 (en) | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
US9061027B2 (en) | 2004-08-27 | 2015-06-23 | Board Of Regents, The University Of Texas System | Enhanced delivery of drug compositions to treat life threatening infections |
GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
ITMI20051999A1 (it) | 2005-10-21 | 2007-04-22 | Eratech S R L | Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita' |
US20120128728A1 (en) | 2005-12-28 | 2012-05-24 | Novartis Pharma Ag | Compositions Comprising Amphotericin B |
EP2040675A1 (en) * | 2006-05-30 | 2009-04-01 | Elan Pharma International Limited | Nanoparticulate posaconazole formulations |
AU2007323007A1 (en) | 2006-08-11 | 2008-05-29 | Panacea Biotec Limited | Particles for delivery of active ingredients, process of making and compositions thereof |
WO2009073843A1 (en) | 2007-12-06 | 2009-06-11 | Cytotech Labs, Llc | Inhalable compositions having enhanced bioavailability |
CA2723314C (en) | 2008-02-13 | 2017-01-10 | The Board Of Regents, The University Of Texas System | Templated open flocs of anisotropic particles for enhanced pulmonary delivery |
EP2095816A1 (en) | 2008-02-29 | 2009-09-02 | Schlichthaar, Rainer, Dr. | Nanosuspension with antifungal medication to be administered via inhalation with improved impurity profile and safety |
EP2172193A1 (en) | 2008-10-02 | 2010-04-07 | Capsulution Nanoscience AG | Improved nanoparticulate compositions of poorly soluble compounds |
US9061352B2 (en) * | 2010-08-30 | 2015-06-23 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
AU2012272804B2 (en) | 2011-06-22 | 2017-07-06 | Vyome Therapeutics Limited | Conjugate-based antifungal and antibacterial prodrugs |
EP2601973A1 (en) * | 2011-12-09 | 2013-06-12 | Laboratoires SMB SA | Dry powder formulation of azole derivative for inhalation |
EP2822539B1 (en) | 2012-03-07 | 2018-11-21 | National Institute Of Pharmaceutical Education And Research (NIPER) | Nanocrystalline solid dispersion compositions |
WO2014106727A1 (en) | 2013-01-03 | 2014-07-10 | Vectura Limited | Inhaler and formulation |
WO2014130922A1 (en) | 2013-02-25 | 2014-08-28 | Trustees Of Boston University | Compositions and methods for treating fungal infections |
EP2981247B1 (en) * | 2013-04-01 | 2023-06-07 | Pulmatrix Operating Company, Inc. | Tiotropium dry powders |
CN104398497B (zh) * | 2014-10-29 | 2017-11-24 | 中山大学 | 伊曲康唑吸入粉雾剂及其制备方法 |
JP2018501903A (ja) * | 2015-01-14 | 2018-01-25 | レスピラ セラピューティクス インコーポレイテッドRespira Therapeutics,Inc. | パウダー分散方法および装置 |
PT3612259T (pt) | 2017-04-17 | 2023-01-26 | Respira Therapeutics Inc | Inalador de pó seco de dosagem unitária |
-
2017
- 2017-10-13 CA CA3039485A patent/CA3039485A1/en active Pending
- 2017-10-13 US US16/341,152 patent/US11116722B2/en active Active
- 2017-10-13 AU AU2017341815A patent/AU2017341815B2/en active Active
- 2017-10-13 IL IL265913A patent/IL265913B2/en unknown
- 2017-10-13 JP JP2019520036A patent/JP7085538B2/ja active Active
- 2017-10-13 MX MX2019004322A patent/MX2019004322A/es unknown
- 2017-10-13 WO PCT/US2017/056497 patent/WO2018071757A1/en unknown
- 2017-10-13 BR BR112019007459A patent/BR112019007459A2/pt active Search and Examination
- 2017-10-13 NZ NZ752353A patent/NZ752353A/en unknown
- 2017-10-13 CN CN201780063648.5A patent/CN109996536B/zh active Active
- 2017-10-13 RU RU2019114112A patent/RU2766086C2/ru active
- 2017-10-13 EP EP17791259.9A patent/EP3525759A1/en active Pending
- 2017-10-13 KR KR1020197013649A patent/KR102408798B1/ko active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
WO2018071757A1 (en) | 2018-04-19 |
KR102408798B1 (ko) | 2022-06-13 |
KR20190068591A (ko) | 2019-06-18 |
JP7085538B2 (ja) | 2022-06-16 |
BR112019007459A2 (pt) | 2019-07-16 |
IL265913B1 (en) | 2024-03-01 |
EP3525759A1 (en) | 2019-08-21 |
RU2019114112A (ru) | 2020-11-16 |
CA3039485A1 (en) | 2018-04-19 |
IL265913B2 (en) | 2024-07-01 |
NZ752353A (en) | 2023-06-30 |
US20200129428A1 (en) | 2020-04-30 |
RU2019114112A3 (es) | 2021-02-12 |
AU2017341815B2 (en) | 2023-06-15 |
JP2019534270A (ja) | 2019-11-28 |
RU2766086C2 (ru) | 2022-02-07 |
AU2017341815A1 (en) | 2019-05-02 |
CN109996536B (zh) | 2023-03-07 |
IL265913A (en) | 2019-06-30 |
US11116722B2 (en) | 2021-09-14 |
CN109996536A (zh) | 2019-07-09 |
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