MX2019002093A - Métodos para la detección de cambios de copia genómica en muestras de adn. - Google Patents
Métodos para la detección de cambios de copia genómica en muestras de adn.Info
- Publication number
- MX2019002093A MX2019002093A MX2019002093A MX2019002093A MX2019002093A MX 2019002093 A MX2019002093 A MX 2019002093A MX 2019002093 A MX2019002093 A MX 2019002093A MX 2019002093 A MX2019002093 A MX 2019002093A MX 2019002093 A MX2019002093 A MX 2019002093A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- detection
- dna samples
- genomic copy
- copy changes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 230000007614 genetic variation Effects 0.000 abstract 1
- 230000000869 mutational effect Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 230000005945 translocation Effects 0.000 abstract 1
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q2537/16—Assays for determining copy number or wherein the copy number is of special importance
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Abstract
La presente invención se refiere a composiciones y métodos útiles para la detección de un cambio mutacional, SNP, translocación, inversión, deleción, cambio del número de copias u otra variación genética dentro de una muestra de ADN genómico celular o ADN libre de células (cfADN). En algunas modalidades, las composiciones y métodos de la presente invención proporcionan un nivel de resolución extremadamente alto que es particularmente útil en la detecciónde variaciones del número de copias en una pequeña fracción del cfADN total de una muestra biológica (por ejemplo, sangre).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662379593P | 2016-08-25 | 2016-08-25 | |
US201762481538P | 2017-04-04 | 2017-04-04 | |
PCT/US2017/048434 WO2018039463A1 (en) | 2016-08-25 | 2017-08-24 | Methods for the detection of genomic copy changes in dna samples |
Publications (1)
Publication Number | Publication Date |
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MX2019002093A true MX2019002093A (es) | 2019-06-20 |
Family
ID=61245331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019002093A MX2019002093A (es) | 2016-08-25 | 2017-08-24 | Métodos para la detección de cambios de copia genómica en muestras de adn. |
Country Status (12)
Country | Link |
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US (2) | US11319594B2 (es) |
EP (1) | EP3504347A4 (es) |
JP (3) | JP7217224B2 (es) |
KR (2) | KR102505122B1 (es) |
CN (2) | CN109804080B (es) |
AU (1) | AU2017315769B2 (es) |
BR (1) | BR112019003704A2 (es) |
CA (1) | CA3034649A1 (es) |
MX (1) | MX2019002093A (es) |
RU (1) | RU2019108294A (es) |
SG (1) | SG11201901371XA (es) |
WO (1) | WO2018039463A1 (es) |
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WO2017083562A1 (en) | 2015-11-11 | 2017-05-18 | Resolution Bioscience, Inc. | High efficiency construction of dna libraries |
KR102505122B1 (ko) * | 2016-08-25 | 2023-03-08 | 레졸루션 바이오사이언스, 인크. | Dna 샘플 중 게놈 카피 변화의 검출을 위한 방법 |
EP3762513A1 (en) * | 2018-03-08 | 2021-01-13 | St. Johns University | Circulating serum cell-free dna biomarkers and methods |
EP3856903A4 (en) | 2018-09-27 | 2022-07-27 | Grail, LLC | METHYLATION MARKER AND TARGETED METHYLATION PROBE PANEL |
CN111118610A (zh) * | 2018-10-31 | 2020-05-08 | 深圳华大基因股份有限公司 | 用于基因突变高深度测序的基因芯片及其制备方法和应用 |
US20210355546A1 (en) * | 2018-11-02 | 2021-11-18 | The Regents Of The University Of California | Methods to Diagnose and Treat Cancer Using Non-Human Nucleic Acids |
KR102452413B1 (ko) * | 2019-08-19 | 2022-10-11 | 주식회사 지씨지놈 | 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법 |
EP4020484A4 (en) * | 2019-08-19 | 2023-08-30 | Green Cross Genome Corporation | METHOD FOR DETECTING A CHROMOSOME ABNORMALITY USING INFORMATION CONCERNING THE DISTANCE BETWEEN NUCLEIC ACID FRAGMENTS |
KR102184277B1 (ko) * | 2020-01-16 | 2020-11-30 | 성균관대학교산학협력단 | 초음파 진단 및 dna 검사 일체형 ai 자가 건강 관리 장치 및 이를 이용한 원격 의료 진단 방법 |
US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
CN113496760B (zh) * | 2020-04-01 | 2024-01-12 | 深圳华大基因科技服务有限公司 | 基于第三代测序的多倍体基因组组装方法和装置 |
CN113113085B (zh) * | 2021-03-15 | 2022-08-19 | 杭州杰毅生物技术有限公司 | 基于智能宏基因组测序数据肿瘤检测的分析***及方法 |
GB202108237D0 (en) * | 2021-06-09 | 2021-07-21 | Univ London | Cancer methods |
CN114649094B (zh) * | 2022-03-30 | 2022-11-15 | 广东省人民医院 | 一种基于核磁共振的乳腺癌多参数临床决策辅助装置 |
EP4372888A1 (en) | 2022-08-04 | 2024-05-22 | Lg Energy Solution, Ltd. | Battery pack |
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CN109804080B (zh) | 2023-07-21 |
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CA3034649A1 (en) | 2018-03-01 |
JP2019526257A (ja) | 2019-09-19 |
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JP2023078336A (ja) | 2023-06-06 |
RU2019108294A (ru) | 2020-09-25 |
US11319594B2 (en) | 2022-05-03 |
CN117286217A (zh) | 2023-12-26 |
KR20190041510A (ko) | 2019-04-22 |
KR20230035431A (ko) | 2023-03-13 |
CN109804080A (zh) | 2019-05-24 |
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