SG11202010642TA - Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor - Google Patents
Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitorInfo
- Publication number
- SG11202010642TA SG11202010642TA SG11202010642TA SG11202010642TA SG11202010642TA SG 11202010642T A SG11202010642T A SG 11202010642TA SG 11202010642T A SG11202010642T A SG 11202010642TA SG 11202010642T A SG11202010642T A SG 11202010642TA SG 11202010642T A SG11202010642T A SG 11202010642TA
- Authority
- SG
- Singapore
- Prior art keywords
- car
- kinase inhibitor
- antigen receptor
- chimeric antigen
- therapy
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title 1
- 238000002659 cell therapy Methods 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464403—Receptors for growth factors
- A61K39/464404—Epidermal growth factor receptors [EGFR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/804—Blood cells [leukemia, lymphoma]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862666653P | 2018-05-03 | 2018-05-03 | |
PCT/US2019/030084 WO2019213184A1 (en) | 2018-05-03 | 2019-04-30 | Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202010642TA true SG11202010642TA (en) | 2020-11-27 |
Family
ID=66676887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202010642TA SG11202010642TA (en) | 2018-05-03 | 2019-04-30 | Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor |
Country Status (11)
Country | Link |
---|---|
US (1) | US20210121466A1 (en) |
EP (1) | EP3787751A1 (en) |
JP (2) | JP7410877B2 (en) |
KR (1) | KR20210044736A (en) |
CN (1) | CN112584902A (en) |
AU (1) | AU2019261986A1 (en) |
BR (1) | BR112020022185A2 (en) |
CA (1) | CA3098497A1 (en) |
MX (1) | MX2020011527A (en) |
SG (1) | SG11202010642TA (en) |
WO (1) | WO2019213184A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3548046A2 (en) | 2016-12-03 | 2019-10-09 | Juno Therapeutics, Inc. | Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors |
MX2019014268A (en) | 2017-06-02 | 2020-08-03 | Juno Therapeutics Inc | Articles of manufacture and methods for treatment using adoptive cell therapy. |
US11364478B2 (en) * | 2019-05-22 | 2022-06-21 | Mezzimatic, LLC | Method of manufacturing throwable paintballs and paintballs made therefrom |
CN115087868A (en) | 2019-11-05 | 2022-09-20 | 朱诺治疗学股份有限公司 | Methods of determining attributes of therapeutic T cell compositions |
BR112022014501A2 (en) * | 2020-01-24 | 2022-09-20 | Juno Therapeutics Inc | METHODS FOR DOSING AND TREATMENT OF FOLLICULAR LYMPHOMA AND MARGINAL ZONE LYMPHOMA IN ADOPTIVE CELL THERAPY |
KR20230022411A (en) * | 2020-05-12 | 2023-02-15 | 라이엘 이뮤노파마, 인크. | Chimeric Antigen Receptor Spacer |
KR20230024283A (en) | 2020-05-13 | 2023-02-20 | 주노 쎄러퓨티크스 인코퍼레이티드 | Methods for identifying features associated with clinical response and uses thereof |
GB2598894A (en) * | 2020-09-10 | 2022-03-23 | Oxford Nanoimaging Ltd | Cell classification algorithm |
EP4071248A1 (en) | 2021-04-07 | 2022-10-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Means and methods for enhancing receptor-targeted gene transfer |
WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
Family Cites Families (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
DE68919715T2 (en) | 1988-12-28 | 1995-04-06 | Stefan Miltenyi | METHOD AND MATERIALS FOR HIGHLY GRADUATED MAGNETIC SPLITTING OF BIOLOGICAL MATERIALS. |
US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
DE4228458A1 (en) | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronic expression units and their use |
US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
DE19608753C1 (en) | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduction system based on rep-negative adeno-associated virus vector |
US6451995B1 (en) | 1996-03-20 | 2002-09-17 | Sloan-Kettering Institute For Cancer Research | Single chain FV polynucleotide or peptide constructs of anti-ganglioside GD2 antibodies, cells expressing same and related methods |
JP2002524081A (en) | 1998-09-04 | 2002-08-06 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | Fusion receptor specific for prostate-specific membrane antigen and uses thereof |
WO2000023573A2 (en) | 1998-10-20 | 2000-04-27 | City Of Hope | Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies |
US20020131960A1 (en) | 2000-06-02 | 2002-09-19 | Michel Sadelain | Artificial antigen presenting cells and methods of use thereof |
ATE338124T1 (en) | 2000-11-07 | 2006-09-15 | Hope City | CD19-SPECIFIC TARGETED IMMUNE CELLS |
PT1347971E (en) | 2000-12-21 | 2006-06-30 | Bristol Myers Squibb Co | TIAHOLYLIC INHIBITORS OF TYROSINE-CINASES OF THE TEC FAMILY |
US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
US7939059B2 (en) | 2001-12-10 | 2011-05-10 | California Institute Of Technology | Method for the generation of antigen-specific lymphocytes |
US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
SE0202461D0 (en) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
SE0202462D0 (en) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel use |
SE0202429D0 (en) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel Compounds |
SE0202463D0 (en) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
RS20060162A (en) | 2003-09-08 | 2008-06-05 | Aventis Pharmaceuticals Inc., | Thienopyrazoles |
US20050176792A1 (en) | 2004-01-14 | 2005-08-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Ketone substituted benzimidazole compounds |
WO2005079791A1 (en) | 2004-02-12 | 2005-09-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders |
MX2007007330A (en) | 2004-12-16 | 2007-10-04 | Vertex Pharma | Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases. |
WO2007016977A1 (en) | 2005-08-05 | 2007-02-15 | Delica Ag | Device for extracting an extraction product contained in a capsule by means of a liquid extraction agent |
EP1919891B1 (en) | 2005-08-29 | 2012-03-07 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
EP1957491A2 (en) | 2005-11-12 | 2008-08-20 | Boehringer Ingelheim International GmbH | Pyrrolo (2,3-b) pyridine derivatives useful as tec kinase inhibitors |
US20080293714A1 (en) | 2005-12-20 | 2008-11-27 | Joerg Martin Bentzien | Tec Kinase Inhibitors |
MX2008014450A (en) | 2006-05-18 | 2009-03-09 | Mannkind Corp | Intracellular kinase inhibitors. |
EP1900727A1 (en) | 2006-08-30 | 2008-03-19 | Cellzome Ag | Aminopyridine derivatives as kinase inhibitors |
EP2057158B8 (en) | 2006-08-30 | 2015-09-30 | Cellzome Limited | Triazole derivatives as kinase inhibitors |
EP1900739A1 (en) | 2006-08-30 | 2008-03-19 | Cellzome Ag | Diazolodiazine derivatives as kinase inhibitors |
ES2585902T3 (en) | 2006-09-22 | 2016-10-10 | Pharmacyclics Llc | Bruton tyrosine kinase inhibitors |
HUE038506T2 (en) | 2007-03-30 | 2018-10-29 | Memorial Sloan Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes |
JP5600063B2 (en) | 2007-10-19 | 2014-10-01 | セルジーン アビロミクス リサーチ, インコーポレイテッド | Heteroaryl compounds and uses thereof |
DK2433713T3 (en) | 2007-12-07 | 2017-09-25 | Miltenyi Biotec Gmbh | CELL PROCESSING SYSTEMS AND PROCEDURES |
US8479118B2 (en) | 2007-12-10 | 2013-07-02 | Microsoft Corporation | Switching search providers within a browser search box |
US20120164718A1 (en) | 2008-05-06 | 2012-06-28 | Innovative Micro Technology | Removable/disposable apparatus for MEMS particle sorting device |
JP5173594B2 (en) | 2008-05-27 | 2013-04-03 | キヤノン株式会社 | Management apparatus, image forming apparatus, and processing method thereof |
DK2361248T3 (en) | 2008-06-27 | 2019-01-14 | Celgene Car Llc | Heteroberl compounds and uses thereof |
US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
WO2011017219A1 (en) | 2009-08-03 | 2011-02-10 | The Regents Of The University Of California | Imidazoquinoxalinones and anti-tumor treatment |
PL2496698T3 (en) | 2009-11-03 | 2019-07-31 | City Of Hope | TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRANSDUCED T CELL SELECTION |
MX2020004501A (en) | 2010-06-03 | 2021-11-09 | Pharmacyclics Llc | The use of inhibitors of bruton's tyrosine kinase (btk). |
BR122021026173B1 (en) | 2010-12-09 | 2023-12-05 | The Trustees Of The University Of Pennsylvania | PHARMACEUTICAL COMPOSITION |
AU2012230780B2 (en) | 2011-03-23 | 2016-10-27 | Fred Hutchinson Cancer Center | Method and compositions for cellular immunotherapy |
US8398282B2 (en) | 2011-05-12 | 2013-03-19 | Delphi Technologies, Inc. | Vehicle front lighting assembly and systems having a variable tint electrowetting element |
KR102134932B1 (en) | 2011-11-11 | 2020-07-17 | 프레드 헛친슨 켄서 리서치 센터 | Cyclin a1 -targeted t-cell immunotherapy for cancer |
WO2013123061A1 (en) | 2012-02-13 | 2013-08-22 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
BR112014027374B1 (en) | 2012-05-03 | 2022-05-31 | Fred Hutchinson Cancer Research Center | Method for generating a t-cell receptor (tcr) with increased affinity |
CA3218491A1 (en) | 2012-06-04 | 2013-12-12 | Pharmacyclics Llc | Crystalline forms of a bruton's tyrosine kinase inhibitor |
US20150140085A1 (en) | 2012-06-29 | 2015-05-21 | Principia Biopharma Inc. | Formulations comprising ibrutinib |
LT2884999T (en) | 2012-08-20 | 2021-04-12 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
NZ746914A (en) | 2012-10-02 | 2020-03-27 | Memorial Sloan Kettering Cancer Center | Compositions and methods for immunotherapy |
WO2014071231A1 (en) | 2012-11-02 | 2014-05-08 | Pharmacyclics, Inc. | Tec family kinase inhibitor adjuvant therapy |
WO2014082085A1 (en) | 2012-11-26 | 2014-05-30 | The University Of North Carolina At Chapel Hill | Use of itk inhibitors for the treatment of cancer |
US9260426B2 (en) | 2012-12-14 | 2016-02-16 | Arrien Pharmaceuticals Llc | Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors |
CN104781789B (en) | 2012-12-20 | 2018-06-05 | 三菱电机株式会社 | Car-mounted device |
US9422267B2 (en) | 2012-12-26 | 2016-08-23 | Medivation Technologies, Inc. | Fused pyrimidine compounds and use thereof |
CA2902613A1 (en) | 2013-03-14 | 2014-10-02 | Pharmacyclics Llc | Combinations of bruton's tyrosine kinase inhibitors and cyp3a4 inhibitors |
CN105377261B (en) | 2013-03-15 | 2017-12-15 | 南特生物科学公司 | The substituted amphyl of indoles 5 and their treatment use |
EP2983670A4 (en) | 2013-04-08 | 2017-03-08 | Pharmacyclics LLC | Ibrutinib combination therapy |
US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
US9206188B2 (en) | 2013-04-18 | 2015-12-08 | Arrien Pharmaceuticals Llc | Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors |
SG11201509609SA (en) | 2013-05-24 | 2015-12-30 | Univ Texas | Chimeric antigen receptor-targeting monoclonal antibodies |
US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
CN103694241A (en) | 2013-11-27 | 2014-04-02 | 苏州晶云药物科技有限公司 | Novel crystal form A of PCI-32765 and preparation method thereof |
SG11201605046YA (en) | 2013-12-20 | 2016-07-28 | Hutchinson Fred Cancer Res | Tagged chimeric effector molecules and receptors thereof |
WO2015127261A1 (en) | 2014-02-21 | 2015-08-27 | Pharmacyclics, Inc. | Biomarkers for predicting response of dlbcl to treatment with ibrutinib |
CA2941087A1 (en) | 2014-03-27 | 2015-10-01 | Perrigo Api Ltd | Ibrutinib solid forms and production process therefor |
WO2015187848A1 (en) | 2014-06-04 | 2015-12-10 | Sampath Deepa | Hdac inhibitor and btk inhibitor combinations |
WO2015192081A1 (en) | 2014-06-13 | 2015-12-17 | Byrd, John C. | Biomarker for predicting response of cll to treatment with a btk inhibitor |
BR112017000556A2 (en) | 2014-07-11 | 2017-11-07 | Celgene Corp | cancer combination therapy |
WO2016014859A1 (en) | 2014-07-25 | 2016-01-28 | Pharmacyclics Llc | Bet inhibitor and bruton's tyrosine kinase inhibitor combinations |
WO2016022942A1 (en) | 2014-08-07 | 2016-02-11 | Pharmacyclics Llc | Novel formulations of a bruton's tyrosine kinase inhibitor |
MX2017001656A (en) | 2014-08-08 | 2017-07-24 | Pharmacyclics Llc | Bruton's tyrosine kinase inhibitor combinations and uses thereof. |
CA2958139A1 (en) | 2014-08-14 | 2016-02-18 | Assia Chemical Industries Ltd. | Solid state forms of ibrutinib |
TWI751102B (en) | 2014-08-28 | 2022-01-01 | 美商奇諾治療有限公司 | Antibodies and chimeric antigen receptors specific for cd19 |
WO2016050422A1 (en) | 2014-10-01 | 2016-04-07 | Ratiopharm Gmbh | Acid addition salt of ibrutinib |
WO2016088074A1 (en) | 2014-12-03 | 2016-06-09 | Dr. Reddy’S Laboratories Limited | Process for the preparation of amorphous ibrutinib |
BR112017013580A2 (en) | 2014-12-23 | 2018-04-10 | Pharmacyclics Llc | btk inhibitor combinations and dosage regimen. |
MA41350A (en) | 2015-01-14 | 2017-11-21 | Janssen Pharmaceutica Nv | SUMMARY OF A BRUTON TYROSINE KINASE INHIBITOR |
CN107530345A (en) | 2015-03-03 | 2018-01-02 | 雷迪博士实验室有限公司 | The polymorph of Buddhist nun is replaced according to Shandong |
AU2016226279B2 (en) | 2015-03-03 | 2021-11-11 | Pharmacyclics Llc | Pharmaceutical formulations of Bruton's tyrosine kinase inhibtor |
WO2016151438A1 (en) | 2015-03-20 | 2016-09-29 | Sun Pharmaceutical Industries Limited | A process for the preparation of ibrutinib |
ES2733460T3 (en) | 2015-04-02 | 2019-11-29 | Ratiopharm Gmbh | Ibrutinib co-crystals |
WO2017040617A1 (en) | 2015-08-31 | 2017-03-09 | Pharmacyclics Llc | Btk inhibitor combinations for treating multiple myeloma |
ITUB20155616A1 (en) | 2015-11-16 | 2017-05-16 | Laboratorio Chimico Int S P A | Process for the preparation of the amorphous form of ibrutinib and new crystalline form. |
US10626117B2 (en) | 2016-02-01 | 2020-04-21 | Natco Pharma Limited | Process for the preparation of Ibrutinib |
WO2017134588A1 (en) | 2016-02-04 | 2017-08-10 | Shilpa Medicare Limited | Process for the preparation of ibrutinib |
GB2558514A (en) | 2016-02-09 | 2018-07-18 | Azad Pharmaceutical Ingredients Ag | Process for the synthesis of stable amorphous ibrutinib |
MA45341A (en) * | 2016-06-06 | 2019-04-10 | Hutchinson Fred Cancer Res | METHODS FOR TREATING B-LYMPHOCYTE MALIGNITIES USING ADOPTIVE CELL THERAPY |
US10688181B2 (en) | 2016-06-27 | 2020-06-23 | The Regents Of The University Of California | Cancer treatment combinations |
-
2019
- 2019-04-30 KR KR1020207034784A patent/KR20210044736A/en unknown
- 2019-04-30 MX MX2020011527A patent/MX2020011527A/en unknown
- 2019-04-30 EP EP19727541.5A patent/EP3787751A1/en active Pending
- 2019-04-30 CA CA3098497A patent/CA3098497A1/en active Pending
- 2019-04-30 US US17/051,714 patent/US20210121466A1/en active Pending
- 2019-04-30 WO PCT/US2019/030084 patent/WO2019213184A1/en unknown
- 2019-04-30 BR BR112020022185-6A patent/BR112020022185A2/en not_active Application Discontinuation
- 2019-04-30 JP JP2020561770A patent/JP7410877B2/en active Active
- 2019-04-30 AU AU2019261986A patent/AU2019261986A1/en active Pending
- 2019-04-30 CN CN201980042845.8A patent/CN112584902A/en active Pending
- 2019-04-30 SG SG11202010642TA patent/SG11202010642TA/en unknown
-
2023
- 2023-12-22 JP JP2023216625A patent/JP2024038044A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112020022185A2 (en) | 2021-02-02 |
MX2020011527A (en) | 2021-02-26 |
CA3098497A1 (en) | 2019-11-07 |
EP3787751A1 (en) | 2021-03-10 |
WO2019213184A1 (en) | 2019-11-07 |
JP2024038044A (en) | 2024-03-19 |
CN112584902A (en) | 2021-03-30 |
US20210121466A1 (en) | 2021-04-29 |
AU2019261986A1 (en) | 2020-11-26 |
KR20210044736A (en) | 2021-04-23 |
JP7410877B2 (en) | 2024-01-10 |
JP2021523122A (en) | 2021-09-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11202010642TA (en) | Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor | |
IL261941A (en) | Chimeric antigen and t cell receptors and methods of use | |
SG11202011383VA (en) | Chimeric antigen receptor t cells (car-t) for the treatment of cancer | |
IL264486A (en) | Combination therapies of chimeric antigen receptors and pd-1 inhibitors | |
IL283734A (en) | Chimeric antigen receptors and car-t cells and methods of use | |
IL276131A (en) | Methods of use for car t cells | |
IL281232A (en) | Chimeric antigen receptor for solid cancer and t cells expressing chimeric antigen receptor | |
IL276397A (en) | Antibodies specific for cd70 and their uses | |
EP3947471A4 (en) | Tn-muc1 chimeric antigen receptor (car) t cell therapy | |
SG11202101169PA (en) | Chimeric antigen receptor that binds hla-dr and car-t cell | |
EP4045539A4 (en) | Enhanced chimeric antigen receptor for immune effector cell engineering and use thereof | |
IL274564A (en) | Anti-pd-l1 antibody and il-7 fusions | |
EP3919515A4 (en) | Chimeric antigen receptor and use thereof | |
IL280329A (en) | Chimeric antigen receptor therapy t cell expansion kinetics and uses thereof | |
ZA201701852B (en) | Combination therapy of inhibitors of c-c chemokine receptor type 9 (ccr9) and anti-alha4beta7 integrin blocking antibodies | |
IL281428A (en) | Chimeric antigen receptor | |
ZA201906663B (en) | Target tiles for an autothermal reformation/secondary reformation unit | |
IL289899A (en) | Anti-hk2 chimeric antigen receptor (car) | |
SG11202001011XA (en) | Chimeric antigen receptor and car-t cells that bind cxcr5 | |
EP4032978A4 (en) | Cd19-targeted chimeric antigen receptor and use thereof | |
GB201807862D0 (en) | Chimeric antigen receptor | |
IL278992A (en) | Chimeric antigen receptor t cell therapy | |
GB2585607B (en) | Chimeric antigen receptor and application thereof | |
EP4106775A4 (en) | Chimeric antigen receptor t cell therapy | |
IL287487A (en) | Rituximab-resistant chimeric antigen receptors and uses thereof |