MX2018010971A - Compuestos y métodos para modular la tirosina cinasa de bruton. - Google Patents

Compuestos y métodos para modular la tirosina cinasa de bruton.

Info

Publication number
MX2018010971A
MX2018010971A MX2018010971A MX2018010971A MX2018010971A MX 2018010971 A MX2018010971 A MX 2018010971A MX 2018010971 A MX2018010971 A MX 2018010971A MX 2018010971 A MX2018010971 A MX 2018010971A MX 2018010971 A MX2018010971 A MX 2018010971A
Authority
MX
Mexico
Prior art keywords
bruton
modulating
compounds
methods
tyrosine kinase
Prior art date
Application number
MX2018010971A
Other languages
English (en)
Inventor
A Miller Richard
Verner Erik
Hudson Ryan
- Marie Beausoleil Anne
Original Assignee
Corvus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corvus Pharmaceuticals Inc filed Critical Corvus Pharmaceuticals Inc
Publication of MX2018010971A publication Critical patent/MX2018010971A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

En la presente se proporcionan, entre otros, compuestos y métodos para modular la tirosina cinasa de Bruton.
MX2018010971A 2016-03-11 2017-03-10 Compuestos y métodos para modular la tirosina cinasa de bruton. MX2018010971A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662307399P 2016-03-11 2016-03-11
US201662342004P 2016-05-26 2016-05-26
PCT/US2017/021966 WO2017156495A1 (en) 2016-03-11 2017-03-10 Compounds and methods for modulating bruton's tyrosine kinase

Publications (1)

Publication Number Publication Date
MX2018010971A true MX2018010971A (es) 2019-03-28

Family

ID=59789888

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018010971A MX2018010971A (es) 2016-03-11 2017-03-10 Compuestos y métodos para modular la tirosina cinasa de bruton.

Country Status (13)

Country Link
US (2) US10870652B2 (es)
EP (1) EP3426637B1 (es)
JP (1) JP6972002B2 (es)
KR (1) KR102416971B1 (es)
CN (2) CN109071455B (es)
AU (1) AU2017230098B2 (es)
CA (1) CA3017567A1 (es)
ES (1) ES2912465T3 (es)
IL (1) IL261583A (es)
MX (1) MX2018010971A (es)
PL (1) PL3426637T3 (es)
WO (1) WO2017156495A1 (es)
ZA (1) ZA201805951B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11554118B2 (en) 2017-03-22 2023-01-17 Xibin Liao Bruton's tyrosine kinase inhibitors

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JOP20190113A1 (ar) * 2016-11-18 2019-05-15 Biocad Joint Stock Co مثبطات بروتون تيروزين كيناز
KR102384924B1 (ko) * 2017-07-12 2022-04-08 주식회사 대웅제약 신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
CN108191871B (zh) * 2018-01-02 2020-02-18 成都倍特药业有限公司 新型布鲁顿酪氨酸激酶抑制剂及其制备方法和应用
TWI767148B (zh) * 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN111662232B (zh) * 2019-03-06 2022-08-02 中国科学院上海药物研究所 具有2h-吲唑结构的小分子化合物及其合成和应用
CA3133004A1 (en) 2019-05-31 2020-12-03 Sichuan Haisco Pharmaceutical Co., Ltd. Btk inhibitor ring derivative, preparation method therefor and pharmaceutical application thereof
WO2020252397A1 (en) * 2019-06-12 2020-12-17 Baylor College Of Medicine Small molecule proteolysis-targeting chimeras and methods of use thereof
WO2021057893A1 (zh) * 2019-09-26 2021-04-01 南京明德新药研发有限公司 作为选择性btk激酶抑制剂的吡唑并吡啶类化合物
WO2022253250A1 (zh) * 2021-06-01 2022-12-08 正大天晴药业集团股份有限公司 含有并环或螺环的布鲁顿酪氨酸激酶降解剂
WO2023009785A1 (en) * 2021-07-29 2023-02-02 Cedilla Therapeutics, Inc. Tead inhibitors and uses thereof

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KR102416971B1 (ko) * 2016-03-11 2022-07-04 엔젤 파마슈티칼 컴퍼니, 리미티드 브루톤형 티로신 키나제를 조절하기 위한 화합물 및 방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11554118B2 (en) 2017-03-22 2023-01-17 Xibin Liao Bruton's tyrosine kinase inhibitors

Also Published As

Publication number Publication date
EP3426637A4 (en) 2019-09-18
US20190106423A1 (en) 2019-04-11
JP2019507793A (ja) 2019-03-22
JP6972002B2 (ja) 2021-11-24
US11306099B1 (en) 2022-04-19
US10870652B2 (en) 2020-12-22
CN109071455B (zh) 2022-08-02
PL3426637T3 (pl) 2022-05-30
WO2017156495A1 (en) 2017-09-14
ZA201805951B (en) 2020-12-23
CN115746000A (zh) 2023-03-07
KR20180133415A (ko) 2018-12-14
AU2017230098A1 (en) 2018-09-20
EP3426637B1 (en) 2022-02-09
EP3426637A1 (en) 2019-01-16
IL261583A (en) 2018-10-31
WO2017156495A8 (en) 2018-09-27
ES2912465T3 (es) 2022-05-26
KR102416971B1 (ko) 2022-07-04
CN109071455A (zh) 2018-12-21
CA3017567A1 (en) 2017-09-14
AU2017230098B2 (en) 2021-03-25

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