MX2018010427A - Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion. - Google Patents
Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion.Info
- Publication number
- MX2018010427A MX2018010427A MX2018010427A MX2018010427A MX2018010427A MX 2018010427 A MX2018010427 A MX 2018010427A MX 2018010427 A MX2018010427 A MX 2018010427A MX 2018010427 A MX2018010427 A MX 2018010427A MX 2018010427 A MX2018010427 A MX 2018010427A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- solid forms
- production
- acc inhibitor
- thienopyrimidinedione
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Physics & Mathematics (AREA)
Abstract
La presente invención proporciona formas sólidas de compuestos útiles como inhibidores de la acetil CoA carboxilasa (ACC), sus composiciones, sus métodos de producción y métodos de uso de los mismos en el tratamiento de enfermedades mediadas por la ACC.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662302755P | 2016-03-02 | 2016-03-02 | |
US201662303237P | 2016-03-03 | 2016-03-03 | |
PCT/US2017/020271 WO2017151816A1 (en) | 2016-03-02 | 2017-03-01 | Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018010427A true MX2018010427A (es) | 2019-03-06 |
Family
ID=58347936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018010427A MX2018010427A (es) | 2016-03-02 | 2017-03-01 | Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion. |
Country Status (13)
Country | Link |
---|---|
US (4) | US10183951B2 (es) |
EP (2) | EP3423456B1 (es) |
JP (3) | JP6944462B2 (es) |
KR (2) | KR20230035692A (es) |
CN (2) | CN112920200A (es) |
AU (3) | AU2017226267B2 (es) |
BR (1) | BR112018067408A2 (es) |
CA (4) | CA3172549A1 (es) |
IL (1) | IL261255A (es) |
MX (1) | MX2018010427A (es) |
SG (1) | SG11201807077RA (es) |
TW (3) | TWI788281B (es) |
WO (1) | WO2017151816A1 (es) |
Families Citing this family (37)
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TWI491606B (zh) | 2009-07-13 | 2015-07-11 | Gilead Sciences Inc | 調節細胞凋亡信號之激酶的抑制劑 |
SI3329919T1 (sl) | 2011-11-11 | 2020-02-28 | Gilead Apollo, Llc | Inhibitorji ACC in njihove uporabe |
SI3191470T1 (sl) | 2015-07-06 | 2019-04-30 | Gilead Sciences, Inc. | Modulatorji COT in postopki njihove uporabe |
AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
EA201890910A1 (ru) | 2015-11-25 | 2018-11-30 | Джилид Аполло, Ллс | ФУНГИЦИДНЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ПРОИЗВОДНЫЕ 2,4-ДИОКСО-1,4-ДИГИДРОТИЕНО[2,3-d]ПИРИМИДИНА |
CN108349995B (zh) | 2015-11-25 | 2021-08-03 | 吉利德阿波罗公司 | 吡唑acc抑制剂及其用途 |
MX2018006288A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc tipo ester y usos de los mismos. |
TWI788281B (zh) | 2016-03-02 | 2023-01-01 | 美商基利阿波羅有限責任公司 | 噻吩并嘧啶二酮acc抑制劑之固體型式及其製造方法 |
CA3053956C (en) * | 2017-03-03 | 2024-04-23 | Gilead Sciences, Inc. | Processes for preparing acc inhibitors and solid forms thereof |
CN110461328A (zh) | 2017-03-28 | 2019-11-15 | 吉利德科学公司 | 治疗肝疾病的治疗组合 |
JP7067725B2 (ja) * | 2017-07-17 | 2022-05-16 | ナンジン ルイジエ ファーマテック カンパニー, リミテッド | Acc阻害剤としての新規な化合物およびそれらの使用 |
KR20190036705A (ko) * | 2017-09-28 | 2019-04-05 | 한미약품 주식회사 | (2r)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체 |
TWI814744B (zh) | 2017-10-06 | 2023-09-11 | 美商基利科學股份有限公司 | 包含acc抑制劑之組合療法 |
CN109810085B (zh) * | 2019-04-19 | 2019-07-19 | 上海皓元生物医药科技有限公司 | Acc抑制剂及其中间体的制备方法 |
TW202235416A (zh) | 2019-06-14 | 2022-09-16 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
JP2022548617A (ja) | 2019-09-19 | 2022-11-21 | ノバルティス アーゲー | Fxrアゴニストを含む処置 |
CN112574253B (zh) * | 2019-09-29 | 2021-08-27 | 上海喀露蓝科技有限公司 | 磷酸或磷酸酯类衍生物、其制备方法及其在医药上的用途 |
CN110746439B (zh) * | 2019-10-18 | 2020-10-30 | 南京瑞捷医药科技有限公司 | 一种噻吩并嘧啶二酮化合物的制备方法 |
CN112778325A (zh) * | 2019-11-07 | 2021-05-11 | 南京瑞捷医药科技有限公司 | 一种acc抑制剂及其用途 |
KR20220101137A (ko) | 2019-11-15 | 2022-07-19 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제로서의 트라이아졸 카르바메이트 피리딜 설폰아미드 및 이의 용도 |
WO2021110138A1 (zh) * | 2019-12-05 | 2021-06-10 | 漳州片仔癀药业股份有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 |
US11578081B1 (en) | 2019-12-05 | 2023-02-14 | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. | Crystal form as inhibitor of ACC1 and ACC2, and preparation method therefor and use thereof |
AU2021249010A1 (en) | 2020-03-30 | 2022-10-06 | Gilead Sciences, Inc. | Solid forms of (S)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1H-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound |
CN115397824A (zh) | 2020-04-02 | 2022-11-25 | 吉利德科学公司 | 用于制备cot抑制剂化合物的方法 |
US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
JP2023529369A (ja) | 2020-06-03 | 2023-07-10 | ギリアード サイエンシーズ, インコーポレイテッド | Lpa受容体アンタゴニスト及びそれらの使用 |
CA3183097A1 (en) | 2020-06-03 | 2021-12-09 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
WO2022192428A1 (en) | 2021-03-11 | 2022-09-15 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
AU2022252182A1 (en) | 2021-03-29 | 2023-09-28 | Gilead Sciences, Inc. | Khk inhibitors |
TWI818538B (zh) | 2021-05-11 | 2023-10-11 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
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TW202304435A (zh) | 2021-06-04 | 2023-02-01 | 美商基利科學股份有限公司 | 治療nash之方法 |
TW202311256A (zh) | 2021-06-18 | 2023-03-16 | 美商基利科學股份有限公司 | 用於治療fxr誘發之搔癢之il-31調節劑 |
KR102309616B1 (ko) | 2021-07-27 | 2021-10-05 | 최금실 | 호호바오일을 포함하는 피부 재생 및 피부 보습용 화장료 조성물 및 이의 제조방법 |
KR102337422B1 (ko) | 2021-07-27 | 2021-12-08 | (주)최금실 | 호호바오일을 포함하는 피부진정 및 트러블 개선용 화장료 조성물 및 이의 제조방법 |
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MX2018006288A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc tipo ester y usos de los mismos. |
EA201890910A1 (ru) | 2015-11-25 | 2018-11-30 | Джилид Аполло, Ллс | ФУНГИЦИДНЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ПРОИЗВОДНЫЕ 2,4-ДИОКСО-1,4-ДИГИДРОТИЕНО[2,3-d]ПИРИМИДИНА |
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TWI788281B (zh) | 2016-03-02 | 2023-01-01 | 美商基利阿波羅有限責任公司 | 噻吩并嘧啶二酮acc抑制劑之固體型式及其製造方法 |
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KR20190036705A (ko) | 2017-09-28 | 2019-04-05 | 한미약품 주식회사 | (2r)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체 |
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2017
- 2017-03-01 TW TW106106735A patent/TWI788281B/zh active
- 2017-03-01 SG SG11201807077RA patent/SG11201807077RA/en unknown
- 2017-03-01 EP EP17711446.9A patent/EP3423456B1/en active Active
- 2017-03-01 CN CN202110182955.3A patent/CN112920200A/zh active Pending
- 2017-03-01 EP EP23219327.6A patent/EP4364795A2/en active Pending
- 2017-03-01 TW TW111147581A patent/TWI818828B/zh active
- 2017-03-01 MX MX2018010427A patent/MX2018010427A/es unknown
- 2017-03-01 KR KR1020237007117A patent/KR20230035692A/ko not_active Application Discontinuation
- 2017-03-01 BR BR112018067408A patent/BR112018067408A2/pt not_active Application Discontinuation
- 2017-03-01 TW TW112134636A patent/TW202400605A/zh unknown
- 2017-03-01 CA CA3172549A patent/CA3172549A1/en active Pending
- 2017-03-01 WO PCT/US2017/020271 patent/WO2017151816A1/en active Application Filing
- 2017-03-01 CA CA3015526A patent/CA3015526C/en active Active
- 2017-03-01 US US15/446,873 patent/US10183951B2/en active Active
- 2017-03-01 AU AU2017226267A patent/AU2017226267B2/en active Active
- 2017-03-01 KR KR1020187027295A patent/KR102622161B1/ko active IP Right Grant
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