MX2018007203A - Sistema de transposon, kit que comprende el mismo, y sus usos. - Google Patents
Sistema de transposon, kit que comprende el mismo, y sus usos.Info
- Publication number
- MX2018007203A MX2018007203A MX2018007203A MX2018007203A MX2018007203A MX 2018007203 A MX2018007203 A MX 2018007203A MX 2018007203 A MX2018007203 A MX 2018007203A MX 2018007203 A MX2018007203 A MX 2018007203A MX 2018007203 A MX2018007203 A MX 2018007203A
- Authority
- MX
- Mexico
- Prior art keywords
- transposon system
- exogenous dna
- kit
- cell
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Un método in vitro para integrar una secuencia de ADN exógeno en el genoma de una célula usando un sistema de transposón. El sistema de transposón incluye un primer vector que lleva secuencias de repetición invertida y un ADN exógeno, y un segundo vector que expresa una transposasa. También se proporciona un kit que incluye el sistema de transposón para integrar un ADN exógeno en el genoma de una célula. Se describe un método para tratar un sujeto que incluye diseñar una célula inmune para transportar una secuencia de ADN exógeno usando el método y/o el kit descrito anteriormente y administrar una cantidad efectiva de la célula inmune modificada al sujeto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562267270P | 2015-12-14 | 2015-12-14 | |
PCT/CN2016/109510 WO2017101749A1 (en) | 2015-12-14 | 2016-12-12 | Transposon system, kit comprising the same, and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018007203A true MX2018007203A (es) | 2018-11-12 |
Family
ID=59055731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018007203A MX2018007203A (es) | 2015-12-14 | 2016-12-12 | Sistema de transposon, kit que comprende el mismo, y sus usos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US11345926B2 (es) |
JP (1) | JP6956416B2 (es) |
KR (1) | KR102249982B1 (es) |
CN (1) | CN108474005B (es) |
AU (1) | AU2016373365B2 (es) |
CA (1) | CA3004665C (es) |
MX (1) | MX2018007203A (es) |
MY (1) | MY184126A (es) |
NZ (1) | NZ742068A (es) |
TW (1) | TWI609960B (es) |
WO (1) | WO2017101749A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
US20190119636A1 (en) | 2017-10-23 | 2019-04-25 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
JP7275043B2 (ja) * | 2016-12-16 | 2023-05-17 | ビー-モーゲン・バイオテクノロジーズ,インコーポレーテッド | 増大したhATファミリートランスポゾン媒介遺伝子導入ならびに関連する組成物、システムおよび方法 |
US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
JP2021527427A (ja) | 2018-06-21 | 2021-10-14 | ビー−モーゲン・バイオテクノロジーズ,インコーポレーテッド | 強化されたhATファミリーのトランスポゾンが介在する遺伝子導入ならびに関連する組成物、システム、及び方法 |
WO2023282730A1 (ko) * | 2021-07-09 | 2023-01-12 | 주식회사 네오젠티씨 | 트랜스포존 시스템 및 이의 용도 |
WO2023060589A1 (zh) * | 2021-10-15 | 2023-04-20 | 深圳市深研生物科技有限公司 | 多转座子*** |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6962810B2 (en) * | 2000-10-31 | 2005-11-08 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac |
MX2007014139A (es) * | 2005-05-14 | 2008-10-09 | Univ Fudan | Piggybac como una herramienta para manipulacion genetica y analisis en vertebrados. |
US20090042297A1 (en) * | 2007-06-01 | 2009-02-12 | George Jr Alfred L | Piggybac transposon-based vectors and methods of nucleic acid integration |
KR20080041146A (ko) * | 2007-12-13 | 2008-05-09 | 푸단 유니버시티 | 척추동물에서의 유전자 조작 및 분석을 위한 도구로서의피기백 |
CN102421902A (zh) * | 2009-02-25 | 2012-04-18 | 约翰·霍普金斯大学 | Piggybac转座子变异及其使用方法 |
DE102011118018B4 (de) | 2011-10-25 | 2017-10-26 | Plasmidfactory Gmbh & Co. Kg | Minicircles mit Transpositionskassetten und ihre Verwendung zur Transformation von Zellen |
US10398787B2 (en) * | 2012-10-26 | 2019-09-03 | Vrije Universiteit Brussel | Vectors for liver-directed gene therapy of hemophilia and methods and use thereof |
CN102943092B (zh) * | 2012-11-20 | 2014-12-10 | 西北农林科技大学 | 一种通用型PiggyBac转座子转基因载体及其制备方法 |
CN104884626A (zh) * | 2012-11-20 | 2015-09-02 | 杰.尔.辛普洛公司 | Tal介导的转移dna*** |
CN104342453A (zh) * | 2013-08-06 | 2015-02-11 | 深圳先进技术研究院 | 含基因工程抗体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用 |
US20170216456A1 (en) | 2014-03-21 | 2017-08-03 | The Sydney Children's Hospitals Network (Randwick and Westmead)(Incorporating the Royal Alexandra | Stable Gene Transfer to Proliferating Cells |
WO2015157579A2 (en) | 2014-04-09 | 2015-10-15 | Dna2.0, Inc. | Enhanced nucleic acid constructs for eukaryotic gene expression |
MX2016013144A (es) * | 2014-04-10 | 2017-04-27 | Seattle Children's Hospital (Dba Seattle Children's Res Institute) | Metodo y composiciones para inmunoterapia celular. |
-
2016
- 2016-12-12 JP JP2018524760A patent/JP6956416B2/ja active Active
- 2016-12-12 MX MX2018007203A patent/MX2018007203A/es unknown
- 2016-12-12 WO PCT/CN2016/109510 patent/WO2017101749A1/en active Application Filing
- 2016-12-12 TW TW105141119A patent/TWI609960B/zh active
- 2016-12-12 CA CA3004665A patent/CA3004665C/en active Active
- 2016-12-12 CN CN201680071463.4A patent/CN108474005B/zh active Active
- 2016-12-12 AU AU2016373365A patent/AU2016373365B2/en active Active
- 2016-12-12 NZ NZ742068A patent/NZ742068A/en unknown
- 2016-12-12 US US15/766,707 patent/US11345926B2/en active Active
- 2016-12-12 KR KR1020187017078A patent/KR102249982B1/ko active IP Right Grant
- 2016-12-12 MY MYPI2018701786A patent/MY184126A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN108474005B (zh) | 2022-10-21 |
CA3004665A1 (en) | 2017-06-22 |
KR102249982B1 (ko) | 2021-05-11 |
TW201720926A (zh) | 2017-06-16 |
NZ742068A (en) | 2023-07-28 |
TWI609960B (zh) | 2018-01-01 |
US20180320196A1 (en) | 2018-11-08 |
CN108474005A (zh) | 2018-08-31 |
CA3004665C (en) | 2021-08-24 |
US11345926B2 (en) | 2022-05-31 |
JP6956416B2 (ja) | 2021-11-02 |
AU2016373365A1 (en) | 2018-05-17 |
WO2017101749A1 (en) | 2017-06-22 |
KR20180092989A (ko) | 2018-08-20 |
AU2016373365B2 (en) | 2021-07-08 |
JP2019503653A (ja) | 2019-02-14 |
MY184126A (en) | 2021-03-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY184126A (en) | Transposon system, kit comprising the same, and uses thereof | |
GB2569733A (en) | RNA-guided nucleic acid modifying enzymes and methods of use thereof | |
MX2023007045A (es) | Anticuerpos anti antigeno 4 del linfocito t citotoxico (ctla-4) y metodos de uso de los mismos. | |
MX2023000818A (es) | Anticuerpos anti-antigeno 4 del linfocito t citotoxico (ctla-4) y metodos para uso de los mismos. | |
PH12018500855A1 (en) | Herpes simplex virus vaccine | |
MX2016011690A (es) | Edicion del genoma sin nucleasas. | |
AU2016262093A8 (en) | Enhancing endonuclease based gene editing in primary cells | |
MX2018002315A (es) | Anticuerpos anti muerte programada 1 (pd 1) y metodos de uso de los mismos. | |
MX2018015853A (es) | Anticuerpos multiespecificos frente a los grupos de diferenciacion 40 y 137 (cd40 y cd137). | |
MX2021013665A (es) | Proteinas de union a calicreina en plasma y usos de las mismas para tratar el angioedema hereditario. | |
MX2020005634A (es) | Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva. | |
WO2016100955A3 (en) | Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using crispr/cas system proteins | |
MA51794A (fr) | Procédés d'isolation, de culture et de modification génétique de populations de cellules immunitaires pour thérapie adoptive | |
MX2018010288A (es) | Sistema de transposon y metodos de uso. | |
PH12018500130A1 (en) | Protein-rich biomass of thraustochytrids, culturing method, and uses | |
MY192824A (en) | Compound targeting il-23a and tnf-alpha and uses thereof | |
MX2020003508A (es) | Un factor de secrecion de proteinas con alta eficacia secretora y un vector de expresion que lo comprende. | |
MX2018011162A (es) | Metodos de purificacion de colageno 7. | |
MX2021009554A (es) | Produccion de virus en cultivos celulares. | |
PH12018502061A1 (en) | Differentiation of pluripotent stem cells to intestinal midgut endoderm cells | |
PH12016502554B1 (en) | A dengue virus chimeric polyepitope composed of fragments of non structural proteins and its use in an immunogenic composition against dengue virus infection | |
MY177482A (en) | Microvesicle and method for producing the same | |
PH12017502389A1 (en) | Jasmonic acid pathway activator | |
MX2018005872A (es) | Profarmacos de acido nucleico. | |
IN2013MU02316A (es) |