MX2020003508A - Un factor de secrecion de proteinas con alta eficacia secretora y un vector de expresion que lo comprende. - Google Patents

Un factor de secrecion de proteinas con alta eficacia secretora y un vector de expresion que lo comprende.

Info

Publication number
MX2020003508A
MX2020003508A MX2020003508A MX2020003508A MX2020003508A MX 2020003508 A MX2020003508 A MX 2020003508A MX 2020003508 A MX2020003508 A MX 2020003508A MX 2020003508 A MX2020003508 A MX 2020003508A MX 2020003508 A MX2020003508 A MX 2020003508A
Authority
MX
Mexico
Prior art keywords
secretory
same
expression vector
protein
efficiency
Prior art date
Application number
MX2020003508A
Other languages
English (en)
Inventor
Yeon Chul Kim
Seung Hae Kim
Saem Jung
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Publication of MX2020003508A publication Critical patent/MX2020003508A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Abstract

La presente invención se refiere a un nuevo factor de secreción de proteínas, a un vector que incluye una secuencia de ácidos nucleicos que codifica el factor de secreción de proteínas y a una célula transformada en la cual es introducido el vector. La invención también se refiere a un procedimiento para producir una proteína diana usando le célula transformada que incluye el vector.
MX2020003508A 2014-04-30 2016-10-21 Un factor de secrecion de proteinas con alta eficacia secretora y un vector de expresion que lo comprende. MX2020003508A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020140052752A KR102092225B1 (ko) 2014-04-30 2014-04-30 고효율 분비능을 가지는 단백질 분비 인자 및 이를 포함하는 발현 벡터

Publications (1)

Publication Number Publication Date
MX2020003508A true MX2020003508A (es) 2020-07-22

Family

ID=54358915

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016013849A MX2016013849A (es) 2014-04-30 2015-04-30 Un factor de secrecion de proteinas con alta eficacia secretora y un vector de expresion que lo comprende.
MX2020003508A MX2020003508A (es) 2014-04-30 2016-10-21 Un factor de secrecion de proteinas con alta eficacia secretora y un vector de expresion que lo comprende.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016013849A MX2016013849A (es) 2014-04-30 2015-04-30 Un factor de secrecion de proteinas con alta eficacia secretora y un vector de expresion que lo comprende.

Country Status (10)

Country Link
US (3) US10407475B2 (es)
EP (1) EP3137493B1 (es)
JP (2) JP6471175B2 (es)
KR (1) KR102092225B1 (es)
CN (1) CN106255700B (es)
AR (1) AR100255A1 (es)
BR (1) BR112016024895A2 (es)
MX (2) MX2016013849A (es)
TW (1) TWI708780B (es)
WO (1) WO2015167278A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7358347B2 (ja) 2017-10-27 2023-10-10 フェネックス インク． 組み換えＥ．ｃｏｌｉアスパラギナーゼの製造のための方法
WO2019083793A1 (en) 2017-10-27 2019-05-02 Pfenex Inc. PROCESS FOR THE PRODUCTION OF RECOMBINANT ERWINIA ASPARAGINASE
SG11202002989SA (en) * 2017-10-27 2020-05-28 Pfenex Inc Bacterial leader sequences for periplasmic protein expression
KR102263105B1 (ko) 2018-09-05 2021-06-09 주식회사 엘지화학 O-글리코실화 가능한 폴리펩타이드 영역을 포함하는 융합 폴리펩타이드
WO2020123824A1 (en) 2018-12-13 2020-06-18 Huya Bioscience International, Llc Sulcardine administration for treatment of acute atrial fibrillation
JP7253773B2 (ja) * 2019-01-18 2023-04-07 株式会社大一商会 遊技機
JP7253771B2 (ja) * 2019-01-18 2023-04-07 株式会社大一商会 遊技機
EP3978518A4 (en) 2019-04-23 2022-11-02 Lg Chem, Ltd. FUSION POLYPEPTIDE COMPRISING FC REGION OF IMMUNOGLOBULIN AND GDF15
CN114761418A (zh) * 2019-12-02 2022-07-15 株式会社Lg化学 Cho细胞衍生的蛋白分泌因子和包含它的表达载体
CN117042805A (zh) 2021-04-05 2023-11-10 株式会社Lg化学 对抗冠状病毒的疫苗组合物

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US6022847A (en) * 1997-03-19 2000-02-08 Zymogenetics, Inc. Secreted salivary zsig32 polypeptides
WO1999040189A2 (en) * 1998-02-09 1999-08-12 Genset Cdnas encoding secreted proteins
US6365369B1 (en) * 1998-04-01 2002-04-02 Human Genome Sciences, Inc. Prostate specific secreted protein
US20030166132A1 (en) * 1998-08-26 2003-09-04 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1666497A3 (en) * 2000-06-02 2006-06-21 Genentech, Inc. Polypeptide, nucleic acid encoding it, and their use for the diagnosis of cancer
KR20030062854A (ko) * 2002-01-21 2003-07-28 주식회사 엘지생명과학 분비형 벡터를 이용한 효모에서의 재조합 단백질의 제조방법
US7317091B2 (en) * 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
WO2004094589A2 (en) * 2003-04-18 2004-11-04 Incyte Corporation Secreted proteins
KR20070009269A (ko) * 2005-07-15 2007-01-18 한국생명공학연구원 재조합단백질 생산용 단백질융합인자 라이브러리 및이로부터 획득된 단백질융합인자
JP2007209328A (ja) * 2006-01-13 2007-08-23 Galpharma Co Ltd ガレクチン−９利用遺伝子治療剤
KR100954322B1 (ko) * 2006-06-14 2010-04-21 주식회사 엘지생명과학 췌장암과 관련된 신규한 ｌｂｆｌ313 유전자
CN1903876B (zh) * 2006-07-10 2010-09-01 郑鸿 一种多肽、编码它的核酸分子及用途
EP2419447B1 (en) * 2009-04-17 2017-08-23 Immunas Pharma, Inc. Antibodies that specifically bind to a beta oligomers and use thereof
KR101868139B1 (ko) 2010-11-30 2018-06-15 주식회사 엘지화학 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터
AU2013243948A1 (en) * 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
WO2014058389A1 (en) * 2012-10-12 2014-04-17 Agency For Science, Technology And Research Optimised heavy chain and light chain signal peptides for the production of recombinant antibody therapeutics

Also Published As

Publication number Publication date
KR102092225B1 (ko) 2020-03-23
US20170044224A1 (en) 2017-02-16
WO2015167278A1 (en) 2015-11-05
BR112016024895A2 (pt) 2017-10-24
KR20150125402A (ko) 2015-11-09
EP3137493A4 (en) 2017-11-15
JP2019006823A (ja) 2019-01-17
CN106255700B (zh) 2021-06-18
JP6471175B2 (ja) 2019-02-13
US10407475B2 (en) 2019-09-10
CN106255700A (zh) 2016-12-21
EP3137493A1 (en) 2017-03-08
TWI708780B (zh) 2020-11-01
MX2016013849A (es) 2017-02-02
US20230212236A1 (en) 2023-07-06
EP3137493B1 (en) 2019-09-04
US20200255485A1 (en) 2020-08-13
JP2017513511A (ja) 2017-06-01
AR100255A1 (es) 2016-09-21
TW201625665A (zh) 2016-07-16

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