MX2017005987A - Anticuerpos anti-interleucina(il)-1beta y metodos de uso. - Google Patents

Anticuerpos anti-interleucina(il)-1beta y metodos de uso.

Info

Publication number
MX2017005987A
MX2017005987A MX2017005987A MX2017005987A MX2017005987A MX 2017005987 A MX2017005987 A MX 2017005987A MX 2017005987 A MX2017005987 A MX 2017005987A MX 2017005987 A MX2017005987 A MX 2017005987A MX 2017005987 A MX2017005987 A MX 2017005987A
Authority
MX
Mexico
Prior art keywords
methods
1beta
hvr
seq
amino acid
Prior art date
Application number
MX2017005987A
Other languages
English (en)
Inventor
Georges Guy
Mundigl Olaf
Michael Huelsmann Peter
Hartmann Guido
Schumacher Ralf
Dengl Stefan
Gassner Christian
Breuer Sebastian
Gruener Sabine
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2017005987A publication Critical patent/MX2017005987A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

En el presente documento se reportan anticuerpos anti-IL-1beta humanizados que son variantes humanizadas del anticuerpo murino H34 anti-IL-1beta. Un anticuerpo humanizado específico comprende (a) una HVR-H1 que comprende la secuencia de aminoácidos de SEC ID NO: 25, (b) una HVR-H2 que comprende la secuencia de aminoácidos de SEC ID NO: 27, y (c) una HVR-H3 que comprende la secuencia de aminoácidos de SEC ID NO: 28.
MX2017005987A 2014-11-10 2015-11-06 Anticuerpos anti-interleucina(il)-1beta y metodos de uso. MX2017005987A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14192523 2014-11-10
PCT/EP2015/075875 WO2016075034A1 (en) 2014-11-10 2015-11-06 ANTI-IL-1beta ANTIBODIES AND METHODS OF USE

Publications (1)

Publication Number Publication Date
MX2017005987A true MX2017005987A (es) 2017-06-29

Family

ID=51868114

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017005987A MX2017005987A (es) 2014-11-10 2015-11-06 Anticuerpos anti-interleucina(il)-1beta y metodos de uso.

Country Status (15)

Country Link
US (1) US10344085B2 (es)
EP (1) EP3218402A1 (es)
JP (1) JP6787888B2 (es)
KR (1) KR20170081253A (es)
CN (1) CN107074942A (es)
AR (1) AR102594A1 (es)
AU (1) AU2015345320A1 (es)
BR (1) BR112017009817A2 (es)
CA (1) CA2963719A1 (es)
IL (1) IL251165A0 (es)
MX (1) MX2017005987A (es)
RU (1) RU2017120358A (es)
SG (1) SG11201702550WA (es)
TW (1) TW201632552A (es)
WO (1) WO2016075034A1 (es)

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Also Published As

Publication number Publication date
RU2017120358A3 (es) 2019-05-29
IL251165A0 (en) 2017-04-30
AU2015345320A1 (en) 2017-04-06
CA2963719A1 (en) 2016-05-19
AR102594A1 (es) 2017-03-08
WO2016075034A1 (en) 2016-05-19
TW201632552A (zh) 2016-09-16
RU2017120358A (ru) 2018-12-13
BR112017009817A2 (pt) 2018-02-14
US20170247447A1 (en) 2017-08-31
CN107074942A (zh) 2017-08-18
EP3218402A1 (en) 2017-09-20
SG11201702550WA (en) 2017-04-27
US10344085B2 (en) 2019-07-09
JP6787888B2 (ja) 2020-11-18
KR20170081253A (ko) 2017-07-11
JP2017534646A (ja) 2017-11-24

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