MX2017005158A - Derivado heterociclico que tiene actividad de activacion de proteina cinasa activada por adenosina monofostato (ampk). - Google Patents

Derivado heterociclico que tiene actividad de activacion de proteina cinasa activada por adenosina monofostato (ampk).

Info

Publication number
MX2017005158A
MX2017005158A MX2017005158A MX2017005158A MX2017005158A MX 2017005158 A MX2017005158 A MX 2017005158A MX 2017005158 A MX2017005158 A MX 2017005158A MX 2017005158 A MX2017005158 A MX 2017005158A MX 2017005158 A MX2017005158 A MX 2017005158A
Authority
MX
Mexico
Prior art keywords
substituted
unsubstituted
alkenyl
hydrogen atom
alkynyl
Prior art date
Application number
MX2017005158A
Other languages
English (en)
Inventor
Kojima Eiichi
Hinata Yu
Wada Toshihiro
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of MX2017005158A publication Critical patent/MX2017005158A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine

Abstract

La presente invención se refiere a un compuesto representado por la fórmula: (ver Fórmula) o su sal farmacéuticamente aceptable, en donde L es NR2R3, SR7, SO2R8, alquilo sustituido o no sustituido, o alquenilo sustituido o no sustituido; R2 es hidrógeno, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido, o similares; R3 es hidrógeno, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido, o similares; R7 es hidrógeno, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido, o similares; R8 es hidrógeno, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido, o similares, siempre que R8 is not unsubstituted metil o trifluorometilo; Y es alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido, arilo sustituido o no sustituido, o similares, siempre que Y no sea metilo no sustituido o etilo no sustituido; Z es -CR6=, o -N=; R1 es hidrógeno, o alquilo sustituido o no sustituido; R4, R5 y R6 son cada uno independientemente hidrógeno, halógeno, hidroxi, ciano, nitro, carboxi, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido, o similares.
MX2017005158A 2014-10-28 2015-10-27 Derivado heterociclico que tiene actividad de activacion de proteina cinasa activada por adenosina monofostato (ampk). MX2017005158A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014218860 2014-10-28
JP2015085522 2015-04-20
PCT/JP2015/080162 WO2016068099A1 (ja) 2014-10-28 2015-10-27 Ａｍｐｋ活性化作用を有する複素環誘導体

Publications (1)

Publication Number Publication Date
MX2017005158A true MX2017005158A (es) 2017-07-27

Family

ID=55857436

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017005158A MX2017005158A (es) 2014-10-28 2015-10-27 Derivado heterociclico que tiene actividad de activacion de proteina cinasa activada por adenosina monofostato (ampk).

Country Status (10)

Country Link
US (1) US10123994B2 (es)
EP (1) EP3214076A4 (es)
JP (1) JPWO2016068099A1 (es)
KR (1) KR20170077131A (es)
CN (1) CN107108521A (es)
AU (1) AU2015338042A1 (es)
CA (1) CA2965781A1 (es)
MX (1) MX2017005158A (es)
RU (1) RU2700703C2 (es)
WO (1) WO2016068099A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10478425B2 (en) 2016-02-26 2019-11-19 Shionogi & Co., Ltd. 5-phenylazaindole derivative having AMPK-activating activity
JPWO2017188288A1 (ja) * 2016-04-26 2019-02-28 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有する５−置換アザベンズイミダゾール誘導体
US10406140B2 (en) 2016-05-20 2019-09-10 Shionogi & Co., Ltd. 5-substituted benzimidazole and 5-substituted azabenzimidazole derivative both having AMPK activation effect
CN106083707B (zh) * 2016-06-01 2018-10-26 温州大学 一种非对称杂芳基硫醚的合成方法
EP3781572A1 (en) * 2018-04-20 2021-02-24 Virginia Tech Intellectual Properties, Inc. Oxadiazolopyrazines and oxadiazolopyridines useful as mitochondrial uncouplers
WO2021226261A1 (en) 2020-05-06 2021-11-11 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
MX2022014505A (es) 2020-05-19 2022-12-13 Kallyope Inc Activadores de la ampk.
CA3183575A1 (en) 2020-06-26 2021-12-30 Iyassu Sebhat Ampk activators

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8417194D0 (en) * 1984-07-05 1984-08-08 Boots Co Plc Therapeutic agents
JPH05339224A (ja) 1992-06-10 1993-12-21 Tokuyama Soda Co Ltd シアノケトン誘導体の製造方法
JP5042626B2 (ja) * 2003-09-22 2012-10-03 エス＊バイオ プライベート リミティッド ベンズイミダゾール誘導体：製造及び医薬適用
JPWO2005082905A1 (ja) 2004-02-26 2007-08-02 協和醗酵工業株式会社 二環性複素環化合物
EP1789381A4 (en) 2004-07-12 2009-11-11 Merck & Co Inc Histone deacetylase INHIBITORS
US7429608B2 (en) * 2005-01-20 2008-09-30 Amgen Inc. Benzo[d]imidazol analogs as vanilloid receptor ligands and their use in treatments
CN101479249B (zh) * 2006-06-29 2012-10-10 霍夫曼-拉罗奇有限公司 苯并咪唑衍生物、其制备方法、它们作为fxr激动剂的用途及含有它们的药物制剂
JP4866901B2 (ja) 2007-02-07 2012-02-01 協和発酵キリン株式会社 ３環系化合物
EA019309B1 (ru) 2008-02-04 2014-02-28 Меркьюри Терапьютикс, Инк. Модуляторы ampk (амф-активируемой протеинкиназы)
MX2011003239A (es) 2008-09-26 2011-04-28 Merck Sharp & Dohme Nuevos derivados de bencimidazol ciclicos utiles como agentes anti-diabeticos.
WO2010047982A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
EP2352374B1 (en) 2008-10-29 2014-09-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CA2741672A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
PT2389375E (pt) * 2009-01-23 2015-09-17 Euro Celtique Sa Derivados de ácido hidroxâmico
US8492374B2 (en) 2009-04-29 2013-07-23 Industrial Technology Research Institute Azaazulene compounds
US8545681B2 (en) * 2009-12-23 2013-10-01 General Electric Company Waste heat driven desalination process
WO2011106273A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
RU2635662C2 (ru) * 2010-09-10 2017-11-15 Сионоги Энд Ко., Лтд. Конденсированное с гетерокольцом имидазольное производное, обладающее активирующим амрк действием
WO2012040499A2 (en) * 2010-09-22 2012-03-29 Surface Logix, Inc. Metabolic inhibitors
JP2012167027A (ja) 2011-02-10 2012-09-06 Shionogi & Co Ltd Ｎｐｙｙ５受容体拮抗作用を有する縮合ヘテロ環誘導体
EA025380B1 (ru) 2011-02-25 2016-12-30 Мерк Шарп Энд Домэ Корп. Новые циклические производные азабензимидазола, используемые в качестве антидиабетических агентов
WO2012147765A1 (ja) 2011-04-27 2012-11-01 塩野義製薬株式会社 Ｎｐｙ ｙ５受容体拮抗作用を有するベンズイミダゾール誘導体
EP3495366A1 (en) * 2011-07-15 2019-06-12 Shionogi & Co., Ltd Azabenzimidazole derivative having ampk-activating activity
US9382243B2 (en) 2012-08-22 2016-07-05 Merck Sharp & Dohme Corp. Azabenzimidazole tetrahydropyran derivatives
US9868733B2 (en) 2012-08-22 2018-01-16 Merck Sharp & Dohme Corp. Azabenzimidazole tetrahydrofuran derivatives
CN104718004A (zh) 2012-08-22 2015-06-17 默沙东公司 新的氮杂苯并咪唑六氢呋喃并[3,2-b]呋喃衍生物
WO2014031441A1 (en) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel benzimidazole tetrahydrofuran derivatives
ES2755087T3 (es) 2012-08-22 2020-04-21 Merck Sharp & Dohme Derivados de benzimidazol hexahidrofuro[3,2-b]furano útiles como activadores de proteína cinasa activada por AMP
US9527839B2 (en) 2012-08-22 2016-12-27 Merck Sharp & Dohme Corp. Benzimidazole tetrahydropyran derivatives
WO2014069426A1 (ja) 2012-10-31 2014-05-08 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有するベンズイミダゾールおよびアザベンズイミダゾール誘導体
US9890119B2 (en) 2013-02-27 2018-02-13 Shionogi & Co., Ltd. Indole and azaindole derivative having AMPK-activating activity
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
JP6372891B2 (ja) 2013-04-24 2018-08-15 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有する５−オキシベンズイミダゾールおよび５−オキシアザベンズイミダゾール誘導体
KR20160018686A (ko) 2013-06-10 2016-02-17 아스테라스 세이야쿠 가부시키가이샤 이환식 함질소 방향족 헤테로고리 아미드 화합물
DK3022210T3 (en) 2013-07-17 2018-06-06 Boehringer Ingelheim Int NEW AZABENZIMIDAZOLD DERIVATIVES.
EP3063148B1 (en) 2013-10-31 2020-04-29 Boehringer Ingelheim International GmbH Azabenzimidazole derivatives
EP3180338B1 (en) 2014-08-11 2018-05-09 Boehringer Ingelheim International GmbH Azabenzimidazole derivatives as amp protein kinase agonistes
RU2017107543A (ru) 2014-08-27 2018-10-02 Шионоги Энд Ко., Лтд. Производное азаиндола с аmpk-активирующим действием
EP3245212B1 (en) 2015-01-16 2019-03-13 Boehringer Ingelheim International GmbH New azabenzimidazole derivatives
JP6612880B2 (ja) 2015-01-16 2019-11-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ａｍｐ活性化タンパク質キナーゼのアゴニストとしての新規アザベンゾイミダゾール誘導体

Also Published As

Publication number Publication date
EP3214076A4 (en) 2018-07-25
KR20170077131A (ko) 2017-07-05
EP3214076A1 (en) 2017-09-06
AU2015338042A1 (en) 2017-04-27
US10123994B2 (en) 2018-11-13
WO2016068099A1 (ja) 2016-05-06
US20170333398A1 (en) 2017-11-23
RU2017118335A (ru) 2018-11-29
CA2965781A1 (en) 2016-05-06
CN107108521A (zh) 2017-08-29
RU2017118335A3 (es) 2018-11-29
RU2700703C2 (ru) 2019-09-19
JPWO2016068099A1 (ja) 2017-08-10

Similar Documents

Publication Publication Date Title
MX2017005158A (es) Derivado heterociclico que tiene actividad de activacion de proteina cinasa activada por adenosina monofostato (ampk).
PH12018502136A1 (en) Heterocyclic amides useful as protein modulators
PH12018500341A1 (en) Heterocyclic amides as kinase inhibitors
MX2016011992A (es) Derivados de piperidina-diona.
PH12016501813A1 (en) 1,3-benzodioxole derivative
PH12015502232A1 (en) Naphthyridine derivatives useful as alpha-v-beta-6 integrin antagonists
IN2014MN01897A (es)
PH12015500209A1 (en) Partially saturated nitrogen-containing heterocyclic compound
MX2016006432A (es) Tetrahidro-benzodiazepinonas.
MX2016009794A (es) Derivado de sulfonamida heterociclico y medicina que comprende el mismo.
GEP20186878B (en) 2,6-substituted purine derivatives and their use in the treatment of proliferative disorders
PH12017500095A1 (en) Imidazopyridazine compounds
MY162886A (en) Novel tetrahydropyridopyrimidine compound or salt thereof
MX367554B (es) Derivados heterocíclicos y sus usos.
MX2016012451A (es) Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina.
GEP20186934B (en) Quinolizinone derivatives as pi3k inhibitors
EA201691566A1 (ru) Применение производных пиридазина для предупреждения или лечения атаксического синдрома
MX2015007309A (es) Derivado de hidantoina.
PH12016501645A1 (en) Aminopyrazolone derivative
EA201892424A1 (ru) Гетероциклические амиды, пригодные в качестве модуляторов белков
MX358151B (es) Derivado de sitaxentan.
UA99044U (ru) (4-амино-3-(децилтио)-1,2,4-триазол-5-ил)(фенил)метанола, проявляющей диуретическую активность