MX2017004043A - Derivados de acido boronico. - Google Patents
Derivados de acido boronico.Info
- Publication number
- MX2017004043A MX2017004043A MX2017004043A MX2017004043A MX2017004043A MX 2017004043 A MX2017004043 A MX 2017004043A MX 2017004043 A MX2017004043 A MX 2017004043A MX 2017004043 A MX2017004043 A MX 2017004043A MX 2017004043 A MX2017004043 A MX 2017004043A
- Authority
- MX
- Mexico
- Prior art keywords
- acid derivatives
- boronic acid
- lmp7
- inhibitors
- employed
- Prior art date
Links
- 150000001642 boronic acid derivatives Chemical class 0.000 title 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 abstract 1
- 101001136986 Homo sapiens Proteasome subunit beta type-8 Proteins 0.000 abstract 1
- 102100035760 Proteasome subunit beta type-8 Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de la fármula (I) son inhibidores de LMP7 y se pueden emplear, inter alia, para el tratamiento de un trastorno autoinmuitario o malignidades hematolágicas. (ver Fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14003391 | 2014-10-01 | ||
| PCT/EP2015/001931 WO2016050356A1 (en) | 2014-10-01 | 2015-10-01 | Boronic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017004043A true MX2017004043A (es) | 2017-07-04 |
Family
ID=51690788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017004043A MX2017004043A (es) | 2014-10-01 | 2015-10-01 | Derivados de acido boronico. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10253049B2 (es) |
| EP (1) | EP3201208B1 (es) |
| JP (1) | JP6896618B2 (es) |
| KR (1) | KR20170062518A (es) |
| CN (1) | CN107074885B (es) |
| AU (1) | AU2015327412B2 (es) |
| BR (1) | BR112017006349A2 (es) |
| CA (1) | CA2963198A1 (es) |
| ES (1) | ES2876287T3 (es) |
| IL (1) | IL251299A0 (es) |
| MX (1) | MX2017004043A (es) |
| RU (1) | RU2017115191A (es) |
| SG (1) | SG11201702620SA (es) |
| WO (1) | WO2016050356A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201702628XA (en) | 2014-10-01 | 2017-04-27 | Merck Patent Gmbh | Boronic acid derivatives |
| MX370336B (es) | 2014-10-01 | 2019-12-10 | Merck Patent Gmbh | Derivados de acido boronico. |
| WO2016050355A1 (en) | 2014-10-01 | 2016-04-07 | Merck Patent Gmbh | Boronic acid derivatives |
| DK3571208T3 (da) * | 2017-01-18 | 2021-05-10 | Principia Biopharma Inc | Immunproteasominhibitorer |
| CN111183142B (zh) * | 2017-08-24 | 2023-06-16 | 默克专利股份公司 | 硼酸衍生物 |
| WO2019060651A1 (en) | 2017-09-21 | 2019-03-28 | Kezar Life Sciences | POLY THERAPY FOR IMMUNOLOGICAL DISEASES |
| DK3826723T3 (da) | 2018-07-26 | 2024-01-15 | Merck Patent Gmbh | Boronsyrederivater |
| CN113135944A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| CN113135943A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| IL310390A (en) | 2021-07-29 | 2024-03-01 | Merck Patent Gmbh | Crystalline forms of [(R1)-2-benzofuran-3-yl)-1-{[(R4, R2, S1)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid, Their adducts and their use |
| WO2023061445A1 (zh) * | 2021-10-14 | 2023-04-20 | 首药控股(北京)股份有限公司 | 硼酸衍生物 |
| CN117003776A (zh) * | 2022-04-29 | 2023-11-07 | 科辉智药生物科技(深圳)有限公司 | 一种硼酸类蛋白酶体抑制剂及其用途 |
| WO2023232830A1 (en) | 2022-06-02 | 2023-12-07 | Merck Patent Gmbh | Boronic acid adducts |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| EP1196436A2 (en) * | 1999-07-07 | 2002-04-17 | Bristol-Myers Squibb Pharma Company | Peptide boronic acid inhibitors of hepatitis c virus protease |
| EP1863513A2 (en) * | 2005-03-11 | 2007-12-12 | The University of North Carolina at Chapel Hill | Potent and specific immunoproteasome inhibitors |
| US20100286092A1 (en) * | 2007-11-13 | 2010-11-11 | Burns Christopher J | Beta-lactamase inhibitors |
| AR075090A1 (es) * | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| KR20130075723A (ko) * | 2010-03-01 | 2013-07-05 | 오닉스 세라퓨틱스, 인크. | 면역프로테아좀 저해를 위한 화합물 |
| MX352652B (es) | 2011-12-22 | 2017-12-04 | Ares Trading Sa | Inhibidores de inmunoproteasoma selectivos de derivados del acido alfa-amino boronico. |
| CN104822689B (zh) * | 2012-12-03 | 2016-11-02 | 弗·哈夫曼-拉罗切有限公司 | 取代的***硼酸化合物 |
| MX370336B (es) | 2014-10-01 | 2019-12-10 | Merck Patent Gmbh | Derivados de acido boronico. |
| WO2016050355A1 (en) | 2014-10-01 | 2016-04-07 | Merck Patent Gmbh | Boronic acid derivatives |
| SG11201702628XA (en) | 2014-10-01 | 2017-04-27 | Merck Patent Gmbh | Boronic acid derivatives |
-
2015
- 2015-10-01 CA CA2963198A patent/CA2963198A1/en active Pending
- 2015-10-01 ES ES15800714T patent/ES2876287T3/es active Active
- 2015-10-01 WO PCT/EP2015/001931 patent/WO2016050356A1/en active Application Filing
- 2015-10-01 KR KR1020177011646A patent/KR20170062518A/ko unknown
- 2015-10-01 SG SG11201702620SA patent/SG11201702620SA/en unknown
- 2015-10-01 US US15/516,422 patent/US10253049B2/en active Active
- 2015-10-01 JP JP2017518064A patent/JP6896618B2/ja active Active
- 2015-10-01 BR BR112017006349A patent/BR112017006349A2/pt not_active IP Right Cessation
- 2015-10-01 CN CN201580053454.8A patent/CN107074885B/zh active Active
- 2015-10-01 RU RU2017115191A patent/RU2017115191A/ru not_active Application Discontinuation
- 2015-10-01 MX MX2017004043A patent/MX2017004043A/es unknown
- 2015-10-01 AU AU2015327412A patent/AU2015327412B2/en active Active
- 2015-10-01 EP EP15800714.6A patent/EP3201208B1/en active Active
-
2017
- 2017-03-21 IL IL251299A patent/IL251299A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201702620SA (en) | 2017-04-27 |
| BR112017006349A2 (pt) | 2017-12-12 |
| EP3201208B1 (en) | 2021-03-24 |
| RU2017115191A (ru) | 2018-11-06 |
| KR20170062518A (ko) | 2017-06-07 |
| US20180105538A1 (en) | 2018-04-19 |
| CN107074885B (zh) | 2020-11-27 |
| CA2963198A1 (en) | 2016-04-07 |
| AU2015327412A1 (en) | 2017-05-18 |
| EP3201208A1 (en) | 2017-08-09 |
| RU2017115191A3 (es) | 2019-02-12 |
| ES2876287T3 (es) | 2021-11-12 |
| WO2016050356A1 (en) | 2016-04-07 |
| JP2018502048A (ja) | 2018-01-25 |
| CN107074885A (zh) | 2017-08-18 |
| JP6896618B2 (ja) | 2021-06-30 |
| US10253049B2 (en) | 2019-04-09 |
| IL251299A0 (en) | 2017-05-29 |
| AU2015327412B2 (en) | 2020-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12017500293A1 (en) | Boronic acid derivatives | |
| MX2017004043A (es) | Derivados de acido boronico. | |
| MX2017004037A (es) | Derivados de acido boronico. | |
| MX370336B (es) | Derivados de acido boronico. | |
| IL259787A (en) | Mutant isocitrate dehydrogenase 1 (idh1) suppressor for the treatment of malignancies | |
| PH12017500509A1 (en) | Benzyl substituted indazoles as bub1 inhibitors | |
| NZ724691A (en) | Quinoline derivatives as smo inhibitors | |
| MX2016012829A (es) | Inhibidores de biaril cinasa. | |
| TW201613886A (en) | 3-amino-1,5,6,7-tetrahydro-4h-indol-4-ones | |
| IL261717A (en) | Combinations of lsd1 inhibitors for the treatment of hematological malignancies | |
| MX2015008999A (es) | Inhibidores mk2 y usos de los mismos. | |
| PH12017500745A1 (en) | Bromodomain inhibitors | |
| NZ730603A (en) | Mk2 inhibitors and uses thereof | |
| SG10201808940WA (en) | Nox inhibitor and nfкb inhibitor containing methoxyflavone | |
| AU2015299431B2 (en) | Pyrrolidinone derivatives as metAP-2 inhibitors | |
| PH12017501071A1 (en) | Dihydropyrimidin-2-one compounds and medical use thereof | |
| SG10201900564WA (en) | Methods for treating cancer | |
| MX366765B (es) | Agonistas de receptores gamma activados por el proliferador de peroxisoma para el tratamiento de esclerósis múltiple. | |
| MA39824A (fr) | Composés azole amido-substitués | |
| MX2016002924A (es) | Inhibidores de cinasa a base de eter arilico. | |
| MX2016009355A (es) | Inhibidores de aril lactama cinasa. | |
| EA201790687A1 (ru) | Хинолинкарбоксамиды для применения в лечении множественной миеломы | |
| EA201791099A1 (ru) | Хинолин карбоксамиды для применения в лечении лейкоза | |
| PH12016501182A1 (en) | Novel compound for treatment of severe hypoglycemia | |
| TN2016000180A1 (en) | Novel compound for treatment of severe hypoglycemia. |