MX2017000521A - Pirimidinas novedosas 2,5-sustituidas como inhibidores de pde4. - Google Patents

Pirimidinas novedosas 2,5-sustituidas como inhibidores de pde4.

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Publication number
MX2017000521A
MX2017000521A MX2017000521A MX2017000521A MX2017000521A MX 2017000521 A MX2017000521 A MX 2017000521A MX 2017000521 A MX2017000521 A MX 2017000521A MX 2017000521 A MX2017000521 A MX 2017000521A MX 2017000521 A MX2017000521 A MX 2017000521A
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MX
Mexico
Prior art keywords
novel
pde4 inhibitors
substituted pyrimidines
medicaments
indices
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Application number
MX2017000521A
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English (en)
Other versions
MX366839B (es
Inventor
Konetzki Ingo
Hesslinger Christian
Jakob Florian
Craan Tobias
Nardi Antonio
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Gruenenthal Gmbh
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Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2017000521A publication Critical patent/MX2017000521A/es
Publication of MX366839B publication Critical patent/MX366839B/es

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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

La invención se relaciona con compuestos novedosos de pirimidina condensada de la fórmula general (I) en los cuales los agrupamientos químicos, sustituyentes e índices son como se define en la descripción, y con su uso como medicamentos, en particular como medicamentos para el tratamiento de condiciones y enfermedades que se puedan tratar mediante la inhibición de la enzima de PDE4.
MX2017000521A 2014-07-16 2015-07-16 Pirimidinas novedosas 2,5-sustituidas como inhibidores de pde4. MX366839B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14002450 2014-07-16
PCT/EP2015/001473 WO2016008590A1 (en) 2014-07-16 2015-07-16 Novel 2,5-substituted pyrimidines as pde4 inhibitors

Publications (2)

Publication Number Publication Date
MX2017000521A true MX2017000521A (es) 2017-05-01
MX366839B MX366839B (es) 2019-07-26

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MX2017000521A MX366839B (es) 2014-07-16 2015-07-16 Pirimidinas novedosas 2,5-sustituidas como inhibidores de pde4.

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US (2) US9546158B2 (es)
EP (2) EP3169679A1 (es)
JP (1) JP6723217B2 (es)
KR (1) KR20170032421A (es)
CN (1) CN106660996B (es)
AR (1) AR101198A1 (es)
AU (1) AU2015291475B2 (es)
BR (1) BR112017000830A2 (es)
CA (1) CA2955053A1 (es)
CL (1) CL2017000106A1 (es)
CO (1) CO2017001506A2 (es)
EA (1) EA201790206A1 (es)
EC (1) ECSP17010481A (es)
IL (1) IL250026A0 (es)
MX (1) MX366839B (es)
PE (1) PE20170251A1 (es)
TW (1) TW201613896A (es)
WO (1) WO2016008590A1 (es)
ZA (1) ZA201701131B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR101198A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b
AR101196A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos
US11963823B2 (en) 2016-10-03 2024-04-23 Koninklijke Philips N.V. Radiopaque arrangement of electronic components in intra-cardiac echocardiography (ICE) catheter
CN108570052A (zh) * 2017-03-13 2018-09-25 中国科学院上海药物研究所 五元杂环并吡嗪化合物、制备方法、中间体、组合和应用
WO2018234354A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH NOVEL SUBSTITUTED 3-INDOLE AND 3-INDAZOLE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS
WO2018234353A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH NOVEL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE
JP7473544B2 (ja) * 2018-10-25 2024-04-23 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング アデノシン受容体アンタゴニストとしての５－アザインダゾール誘導体
CN110156785B (zh) * 2019-04-15 2020-08-28 浙江大学 吲唑类化合物及其制备方法和应用
EP4255904A2 (en) * 2020-12-03 2023-10-11 Domain Therapeutics Novel par-2 inhibitors
CN115108992A (zh) * 2022-06-29 2022-09-27 浙江手心制药有限公司 6-氯-2-甲基-2h-吲唑-5-胺的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3818830A1 (de) 1988-06-03 1989-12-14 Boehringer Mannheim Gmbh Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel
ES2176252T3 (es) 1993-07-02 2002-12-01 Altana Pharma Ag Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos.
JP2000198734A (ja) 1998-12-30 2000-07-18 Pfizer Inc 胃運動性減弱および関連疾患の治療のための運動性増強薬
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
JP2001233875A (ja) * 1999-10-12 2001-08-28 Takeda Chem Ind Ltd ピリミジン−５−カルボキサミド化合物、その製造法およびその用途
ATE314362T1 (de) * 1999-10-12 2006-01-15 Takeda Pharmaceutical Pyrimidin-5-carboximidverbindungen, verfahren zur herstellung derselben und deren verwendung
US6436965B1 (en) 2000-03-02 2002-08-20 Merck Frosst Canada & Co. PDE IV inhibiting amides, compositions and methods of treatment
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
DE10163991A1 (de) 2001-12-24 2003-07-03 Merck Patent Gmbh Pyrrolo-pyrimidine
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
LT2489659T (lt) 2004-06-24 2018-03-26 Vertex Pharmaceuticals Incorporated Atp rišančios kasetės transporterių moduliatoriai
US20060293343A1 (en) 2005-05-18 2006-12-28 Asahi Kasei Pharma Corporation Pyrimidine derivatives
SG151327A1 (en) 2005-09-30 2009-04-30 Vertex Pharmaceuticals Incopor Deazapurines useful as inhibitors of janus kinases
AU2006335967B2 (en) * 2006-01-19 2012-01-19 Orchid Chemicals & Pharmaceuticals Limited Novel heterocycles
US7863446B2 (en) 2006-01-19 2011-01-04 Orchid Research Laboratories Limited Heterocycles
EP1958947A1 (en) 2007-02-15 2008-08-20 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type 4
TW201512189A (zh) 2013-04-16 2015-04-01 Gruenenthal Chemie 新型被取代之嘧啶縮合化合物
AR101197A1 (es) * 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas
AR101196A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos
AR101198A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b

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US20170065603A1 (en) 2017-03-09
US9546158B2 (en) 2017-01-17
JP2017520598A (ja) 2017-07-27
MX366839B (es) 2019-07-26
AU2015291475B2 (en) 2019-02-07
CN106660996B (zh) 2020-10-16
CL2017000106A1 (es) 2017-08-04
EP3415510A1 (en) 2018-12-19
PE20170251A1 (es) 2017-04-21
AU2015291475A1 (en) 2017-03-09
EP3169679A1 (en) 2017-05-24
IL250026A0 (en) 2017-03-30
KR20170032421A (ko) 2017-03-22
BR112017000830A2 (pt) 2017-12-05
AR101198A1 (es) 2016-11-30
US20160016938A1 (en) 2016-01-21
WO2016008590A1 (en) 2016-01-21
JP6723217B2 (ja) 2020-07-15
ZA201701131B (en) 2019-07-31
CO2017001506A2 (es) 2017-05-10
CA2955053A1 (en) 2016-01-21
CN106660996A (zh) 2017-05-10
TW201613896A (en) 2016-04-16
EA201790206A1 (ru) 2017-07-31
ECSP17010481A (es) 2017-03-31
US10391099B2 (en) 2019-08-27

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