MX2016006303A - Celula. - Google Patents

Celula.

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Publication number
MX2016006303A
MX2016006303A MX2016006303A MX2016006303A MX2016006303A MX 2016006303 A MX2016006303 A MX 2016006303A MX 2016006303 A MX2016006303 A MX 2016006303A MX 2016006303 A MX2016006303 A MX 2016006303A MX 2016006303 A MX2016006303 A MX 2016006303A
Authority
MX
Mexico
Prior art keywords
car
endodomain
cell
activating
inhibitory
Prior art date
Application number
MX2016006303A
Other languages
English (en)
Inventor
PULÉ Martin
Kong Khai
Cordoba Shaun
Original Assignee
Ucl Business Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201320573A external-priority patent/GB201320573D0/en
Priority claimed from GB201410934A external-priority patent/GB201410934D0/en
Application filed by Ucl Business Plc filed Critical Ucl Business Plc
Publication of MX2016006303A publication Critical patent/MX2016006303A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/11—Antigen recognition domain
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Abstract

La presente invención proporciona una célula T que coexpresa un primer receptor antigénico quimérico (CAR) y un segundo CAR en la superficie celular, y cada CAR comprende: (i) un dominio de unión a antígenos; (ii) un espaciador (iii) un dominio transmembranal; y (iv) un endodominio, en donde los dominios de unión a antígenos del primer y segundo CAR se unen a diferentes antígenos, y en donde uno del primer o segundo CAR es un CAR activador que comprende un endodominio activador, y el otro CAR es un CAR inhibitorio que comprende un endodominio inhibitorio de ligación apagada.
MX2016006303A 2013-11-21 2014-11-21 Celula. MX2016006303A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201320573A GB201320573D0 (en) 2013-11-21 2013-11-21 T Cell
GB201410934A GB201410934D0 (en) 2014-06-19 2014-06-19 T cell
PCT/GB2014/053453 WO2015075470A1 (en) 2013-11-21 2014-11-21 Cell

Publications (1)

Publication Number Publication Date
MX2016006303A true MX2016006303A (es) 2016-11-07

Family

ID=52003983

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016006057A MX2016006057A (es) 2013-11-21 2014-11-21 Celula.
MX2016006303A MX2016006303A (es) 2013-11-21 2014-11-21 Celula.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016006057A MX2016006057A (es) 2013-11-21 2014-11-21 Celula.

Country Status (20)

Country Link
US (10) US20160296562A1 (es)
EP (6) EP3626261A1 (es)
JP (4) JP6538684B2 (es)
KR (2) KR101962524B1 (es)
CN (2) CN105848673B (es)
AU (2) AU2014351557B2 (es)
BR (2) BR112016011460A2 (es)
CA (2) CA2930215C (es)
CL (2) CL2016001135A1 (es)
DK (2) DK3071223T3 (es)
ES (2) ES2861501T3 (es)
HK (2) HK1223554A1 (es)
HU (1) HUE051523T2 (es)
IL (2) IL245572B (es)
MX (2) MX2016006057A (es)
PL (2) PL3071222T3 (es)
PT (2) PT3071223T (es)
RU (2) RU2717984C2 (es)
SG (2) SG11201603484PA (es)
WO (3) WO2015075468A1 (es)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
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EP2419143B8 (en) 2009-04-13 2018-06-27 INSERM - Institut National de la Santé et de la Recherche Médicale Hpv particles and uses thereof
SG11201505858VA (en) 2013-01-28 2015-09-29 St Jude Childrens Res Hospital A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
WO2015042325A1 (en) 2013-09-18 2015-03-26 Aura Biosciences, Inc. Virus-like particle conjugates for diagnosis and treatment of tumors
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