SG11201505858VA - A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease - Google Patents
A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious diseaseInfo
- Publication number
- SG11201505858VA SG11201505858VA SG11201505858VA SG11201505858VA SG11201505858VA SG 11201505858V A SG11201505858V A SG 11201505858VA SG 11201505858V A SG11201505858V A SG 11201505858VA SG 11201505858V A SG11201505858V A SG 11201505858VA SG 11201505858V A SG11201505858V A SG 11201505858VA
- Authority
- SG
- Singapore
- Prior art keywords
- infectious disease
- cell therapy
- chimeric receptor
- against cancer
- therapy against
- Prior art date
Links
- 208000035473 Communicable disease Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 238000002659 cell therapy Methods 0.000 title 1
- 108700010039 chimeric receptor Proteins 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464429—Molecules with a "CD" designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361757481P | 2013-01-28 | 2013-01-28 | |
| PCT/US2014/013292 WO2014117121A1 (en) | 2013-01-28 | 2014-01-28 | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201505858VA true SG11201505858VA (en) | 2015-09-29 |
Family
ID=51228124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201505858VA SG11201505858VA (en) | 2013-01-28 | 2014-01-28 | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
Country Status (4)
| Country | Link |
|---|---|
| US (7) | US9511092B2 (en) |
| EP (1) | EP2948544A4 (en) |
| SG (1) | SG11201505858VA (en) |
| WO (1) | WO2014117121A1 (en) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10332332B2 (en) | 2007-12-21 | 2019-06-25 | Cfph, Llc | System and method for slot machine game associated with financial market indicators |
| US8758108B2 (en) | 2007-12-21 | 2014-06-24 | Cfph, Llc | System and method for slot machine game associated with market line wagers |
| US11257330B2 (en) | 2008-02-15 | 2022-02-22 | Cfph, Llc | System and method for providing a baccarat game based on financial market indicators |
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| ES2839089T3 (en) | 2014-05-15 | 2021-07-05 | Nat Univ Singapore | Modified natural killer lymphocytes and their uses |
| GB201501175D0 (en) | 2015-01-23 | 2015-03-11 | Univ Oslo Hf | A universal T-cell for personalised medicine |
| EP3270937A4 (en) * | 2015-03-26 | 2018-09-12 | The Trustees Of Dartmouth College | Anti-mica antigen binding fragments, fusion molecules, cells which express and methods of using |
| US11059880B2 (en) | 2015-06-30 | 2021-07-13 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with MHC chimeric receptors and methods of use in immunotherapy |
| US10875919B2 (en) | 2016-04-26 | 2020-12-29 | Alector Llc | Chimeric receptors and methods of use thereof |
| CN110612119A (en) | 2017-02-07 | 2019-12-24 | 西雅图儿童医院（Dba西雅图儿童研究所） | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| US11850262B2 (en) | 2017-02-28 | 2023-12-26 | Purdue Research Foundation | Compositions and methods for CAR T cell therapy |
| WO2018165913A1 (en) * | 2017-03-15 | 2018-09-20 | 南京凯地生物科技有限公司 | Specific chimeric antigen receptor targeting nkg2dl and car-t cell thereof and use thereof |
| CN117363636A (en) * | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | Polynucleotide encoding chimeric receptor |
| AU2018245749A1 (en) | 2017-03-27 | 2019-10-03 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| CA3060443A1 (en) | 2017-04-19 | 2018-10-25 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
| EP3720951A1 (en) * | 2017-12-05 | 2020-10-14 | Celyad S.A. | Compositions and methods for improving persistence of cells for adoptive transfer |
| JP2021505207A (en) | 2017-12-05 | 2021-02-18 | セリアド エス．アー．Ｃｅｌｙａｄ Ｓ．Ａ． | Decrease in fratricide in immune cells expressing NKG2D-based receptors |
| WO2019127215A1 (en) * | 2017-12-28 | 2019-07-04 | Nanjing Legend Biotech Co., Ltd. | Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof |
| JP2021512147A (en) | 2018-01-22 | 2021-05-13 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | How to use CAR T cells |
| WO2019155288A1 (en) * | 2018-02-09 | 2019-08-15 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| EP3749686A4 (en) * | 2018-02-09 | 2022-01-05 | National University of Singapore | Adhesion receptor constructs and uses thereof in natural killer cell immunotherapy |
| CN110343712B (en) * | 2018-04-04 | 2023-12-26 | 达仁生物科技有限公司 | Chimeric antigen receptor and method for treating lung cancer |
| AU2019247371A1 (en) * | 2018-04-06 | 2020-10-01 | H. Lee Moffitt Cancer Center And Research Institute Inc. | NKG2D chimeric antigen receptors |
| US20210269501A1 (en) * | 2018-06-25 | 2021-09-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods of nkg2d chimeric antigen receptor t cells for controlling triple-negative breast cancer |
| US20210338727A1 (en) * | 2018-09-13 | 2021-11-04 | Nkarta, Inc. | Natural killer cell compositions and immunotherapy methods for treating tumors |
| CN113423409A (en) * | 2018-11-06 | 2021-09-21 | 华盛顿大学 | Chimeric antigen receptor memory-like (CARML) NK cells and methods of making and using same |
| WO2020160419A1 (en) * | 2019-02-01 | 2020-08-06 | The Trustees Of Dartmouth College | Signaling platforms for chimeric antigen receptor t cells |
| CN111544585A (en) * | 2019-02-11 | 2020-08-18 | 北京卡替医疗技术有限公司 | Adjuvant capable of boosting immune cells to expand in vivo |
| CA3131533A1 (en) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| US20200308248A1 (en) * | 2019-03-26 | 2020-10-01 | ST Phi Therapeutics | Chimeric Natural Killer Cell Receptors and Method of Using Thereof |
| CN111363046A (en) * | 2020-03-11 | 2020-07-03 | 深圳宾德生物技术有限公司 | Chimeric antigen receptor targeting NKG2D, chimeric antigen receptor T cell, and preparation method and application thereof |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| JP2024500847A (en) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | Chimeric antigen receptor systems with compatible receptor specificities |
| GB202110363D0 (en) | 2021-07-19 | 2021-09-01 | Celyad S A | NKG2D CAR cells expressing IL-18 for adoptive cell therapy |
| WO2023086642A2 (en) * | 2021-11-15 | 2023-05-19 | City Of Hope | Engineering or inducing pdgf and/or pdgfr signaling to enhance nk cell therapy |
Family Cites Families (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19520729A1 (en) | 1995-06-07 | 1996-12-12 | Orpegen Pharma Gmbh | Test system for recording the activity of NK cells |
| WO1999006557A2 (en) * | 1997-08-01 | 1999-02-11 | Schering Corporation | Mammalian cell membrane proteins; related reagents |
| AU741602B2 (en) | 1998-02-02 | 2001-12-06 | Johns Hopkins University School Of Medicine, The | A universal immunomodulatory cytokine-expressing bystander cell line and related compositions and methods of manufacture and use |
| DE19813759C1 (en) | 1998-03-27 | 1999-07-15 | Gsf Forschungszentrum Umwelt | Inducing a natural killer cell immune response ex vivo |
| EP1231262A4 (en) | 1999-10-21 | 2004-09-08 | Keisuke Teshigawara | Method of in vitro culture of lymphocytes and gene therapy compositions |
| JP3619853B2 (en) | 1999-11-26 | 2005-02-16 | 独立行政法人理化学研究所 | Method of growing natural killer cells |
| JP2002045174A (en) | 2000-07-31 | 2002-02-12 | Inst Of Physical & Chemical Res | Method for proliferating natural killer cell |
| EP1578923A4 (en) | 2002-04-22 | 2009-01-21 | Hutchinson Fred Cancer Res | Soluble mic polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimmune diseases or conditions |
| US7740871B2 (en) | 2002-09-19 | 2010-06-22 | Johns Hopkins University School Of Medicine | Cancer immunotherapy with a viral antigen-defined, immunomodulator-secreting cell vaccine |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| US20130266551A1 (en) | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| US20050113564A1 (en) | 2003-11-05 | 2005-05-26 | St. Jude Children's Research Hospital | Chimeric receptors with 4-1BB stimulatory signaling domain |
| WO2006036445A2 (en) * | 2004-09-24 | 2006-04-06 | Trustees Of Dartmouth College | Chimeric nk receptor and methods for treating cancer |
| GB0426903D0 (en) | 2004-12-08 | 2005-01-12 | Alexis Biotech Ltd | Complexes and methods |
| JP2009513608A (en) | 2005-10-28 | 2009-04-02 | ノボ・ノルデイスク・エー／エス | Fusion protein that binds effector lymphocytes to target cells |
| US8389282B2 (en) | 2007-03-30 | 2013-03-05 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes |
| US20110059137A1 (en) | 2008-03-21 | 2011-03-10 | H. Lee Moffitt Cancer Center And Research Institutute, Inc | Chemokine gene-modified cells for cancer immunotherapy |
| WO2016149264A1 (en) | 2015-03-18 | 2016-09-22 | The Johns Hopkins University | Compositions and methods for sensitizing cells to trail-induced apoptosis |
| WO2010110734A1 (en) | 2009-03-26 | 2010-09-30 | Avaris Ab | Expansion of nk cells |
| US20130052158A1 (en) | 2009-10-30 | 2013-02-28 | University Of Arkansas For Medical Science | Use of autologous effector cells for treatment of multiple myeloma |
| WO2011053322A1 (en) | 2009-10-30 | 2011-05-05 | University Of Arkansas For Medical Science | Use of autologous effector cells and antibodies for treatment of multiple myeloma |
| WO2011150976A1 (en) | 2010-06-04 | 2011-12-08 | bioMérieux | Method and kit for the prognosis of colorectal cancer |
| KR101801960B1 (en) | 2010-07-01 | 2017-11-27 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | Driving method of liquid crystal display device |
| JP5996533B2 (en) | 2010-07-13 | 2016-09-21 | アントフロゲネシス コーポレーション | How to generate natural killer cells |
| WO2012136231A1 (en) | 2010-09-08 | 2012-10-11 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| ES2602743T3 (en) | 2010-09-08 | 2017-02-22 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Chimeric antigen receptors with an optimized hinge region |
| WO2012071411A2 (en) | 2010-11-22 | 2012-05-31 | Innate Pharma Sa | Nk cell modulating treatments and methods for treatment of hematological malignancies |
| SG11201400527XA (en) | 2011-09-16 | 2014-04-28 | Univ Pennsylvania | Rna engineered t cells for the treatment of cancer |
| WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
| WO2013126720A2 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for the assessment of target cancer cell resistance to car engineered t cell killing |
| EP2866834B1 (en) | 2012-06-28 | 2019-05-22 | University of Central Florida Research Foundation, Inc. | Methods and compositions for natural killer cells |
| US20160235787A1 (en) | 2012-07-13 | 2016-08-18 | The Trustees Of The University Of Pennsylvania | Epitope Spreading Associated with CAR T-Cells |
| EP2904106A4 (en) | 2012-10-01 | 2016-05-11 | Univ Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
| CN112430580A (en) | 2012-10-02 | 2021-03-02 | 纪念斯隆-凯特琳癌症中心 | Compositions and methods for immunotherapy |
| US10786532B2 (en) | 2012-10-02 | 2020-09-29 | Versiti Blood Research Institute Foundation, Inc. | Method of providing cellular therapy using modified natural killer cells or T lymphocytes |
| WO2014099671A1 (en) | 2012-12-20 | 2014-06-26 | Bluebird Bio, Inc. | Chimeric antigen receptors and immune cells targeting b cell malignancies |
| SG11201505858VA (en) * | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| HUE047487T2 (en) | 2013-02-15 | 2020-04-28 | Univ California | Chimeric antigen receptor and methods of use thereof |
| IL298125A (en) | 2013-02-26 | 2023-01-01 | Memorial Sloan Kettering Cancer Center | Compositions and methods for immunotherapy |
| EP3241897B1 (en) | 2013-03-07 | 2018-10-03 | Baylor College of Medicine | Targeting cd138 in cancer |
| US20160024175A1 (en) | 2013-03-10 | 2016-01-28 | Baylor College Of Medicine | Chemotherapy-resistant immune cells |
| KR20220156663A (en) | 2013-03-15 | 2022-11-25 | 메모리얼 슬로안 케터링 캔서 센터 | Compositions and methods for immunotherapy |
| US9745368B2 (en) | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| JP6578271B2 (en) | 2013-04-17 | 2019-09-18 | ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ | Immunosuppressive TGF-β signal converter |
| US9629877B2 (en) | 2013-05-14 | 2017-04-25 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (CAR) T-cells |
| EA035475B1 (en) | 2013-06-10 | 2020-06-23 | Дана-Фарбер Кэнсер Инститьют, Инк. | Methods and compositions for reducing immunosupression by tumor cells |
| CN109280412B (en) | 2013-07-16 | 2021-02-09 | 阿克佐诺贝尔国际涂料股份有限公司 | Intumescent composition |
| WO2015042661A2 (en) | 2013-09-24 | 2015-04-02 | Vayeron Pty Ltd | An idler, a method for monitoring a plurality of idlers, and a conveyor system |
| SG11201602979RA (en) | 2013-10-17 | 2016-05-30 | Univ Singapore | Chimeric receptor that triggers antibody-dependent cell cytotoxicity against multiple tumors |
| CA2929087A1 (en) | 2013-10-31 | 2015-05-07 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| BR112016011460A2 (en) | 2013-11-21 | 2017-09-26 | Ucl Business Plc | cell |
| KR102483822B1 (en) | 2013-12-20 | 2023-01-03 | 프레드 허친슨 캔서 센터 | Tagged chimeric effector molecules and receptors thereof |
| EP3808410A1 (en) | 2013-12-20 | 2021-04-21 | Cellectis | Method of engineering multi-input signal sensitive t cell for immunotherapy |
| CA2936501A1 (en) | 2014-01-13 | 2015-07-16 | Stephen J. Forman | Chimeric antigen receptors (cars) having mutations in the fc spacer region and methods for their use |
| CN106414723A (en) | 2014-02-10 | 2017-02-15 | 纳维基因股份有限公司 | Cell modulation nanocomposition, and methods of use |
| ES2764471T3 (en) | 2014-02-14 | 2020-06-03 | Univ Texas | Chimeric antigen receptors and manufacturing procedures |
| US20170081411A1 (en) | 2014-03-15 | 2017-03-23 | Novartis Ag | Regulatable chimeric antigen receptor |
| GB201405845D0 (en) | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
| WO2015154012A1 (en) | 2014-04-03 | 2015-10-08 | Memorial Sloan-Kettering Cancer Center | Clonogenic natural killer (nk) cell populations and methods of producing and using such populations |
| CN106536549B (en) | 2014-04-25 | 2020-01-17 | 蓝鸟生物公司 | MND promoter chimeric antigen receptor |
| CN107075483A (en) | 2014-07-15 | 2017-08-18 | 朱诺治疗学股份有限公司 | The engineered cell treated for adoptive cellular |
| CA2958200A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using a gfr alpha-4 chimeric antigen receptor |
| MX2017002605A (en) | 2014-08-28 | 2017-05-19 | Bioatla Llc | Conditionally active chimeric antigen receptors for modified t-cells. |
| GB201415347D0 (en) | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Signalling system |
| BR112017004270B1 (en) | 2014-09-04 | 2023-03-07 | Stemcell Technologies Inc | METHOD OF ACTIVATION OF T CELLS OR NK CELLS |
| KR20170073593A (en) | 2014-09-09 | 2017-06-28 | 유넘 테라퓨틱스 | Chimeric receptors and uses thereof in immune therapy |
| RU2745705C2 (en) | 2014-09-15 | 2021-03-30 | МОЛМЕД СпА | Chimeric antigen receptors |
| EP3193894A1 (en) | 2014-09-16 | 2017-07-26 | Fundación Pública Andaluza Progreso Y Salud | Use of cord blood plasma to treat nk cell-mediated diseases and ifn- mediated diseases |
| MA41538A (en) | 2014-10-17 | 2017-12-26 | Baylor College Medicine | BIPARTITE AND TRIPARTITE IMMUNE CELLS OF SIGNALING |
| WO2016069607A1 (en) | 2014-10-27 | 2016-05-06 | University Of Central Florida Research Foundation, Inc. | Methods and compositions for natural killer cells |
| EP3215534B1 (en) | 2014-11-05 | 2020-04-15 | Board of Regents, The University of Texas System | Chimeric antigen receptors (car) to selectively target protein complexes |
| CA2964785A1 (en) | 2014-11-05 | 2016-05-12 | Board Of Regents, The University Of Texas System | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
| PT3215601T (en) | 2014-11-05 | 2020-08-03 | Juno Therapeutics Inc | Methods for transduction and cell processing |
| IL252295B2 (en) | 2014-12-19 | 2023-10-01 | Dana Farber Cancer Inst Inc | Chimeric antigen receptors and methods of use thereof |
| US20180008637A1 (en) | 2014-12-31 | 2018-01-11 | Anthrogenesis Corporation | Natural killer cells and uses thereof |
| WO2016115482A1 (en) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
| MA41433A (en) | 2015-01-26 | 2017-12-05 | Baylor College Medicine | UNIVERSAL IMMUNE CELLS FOR ANTI-CANCER IMMUNOTHERAPY |
| AU2016211438C1 (en) | 2015-01-29 | 2021-03-04 | Regents Of The University Of Minnesota | Chimeric antigen receptors, compositions, and methods |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| GB201501936D0 (en) | 2015-02-05 | 2015-03-25 | Ucl Business Plc | Signalling system |
| US20190024065A1 (en) | 2015-02-06 | 2019-01-24 | Cellectis | Primary hematopoietic cells genetically engineered by slow release of nucleic acids using nanoparticles |
| AU2016226022B2 (en) | 2015-03-05 | 2020-07-09 | Fred Hutchinson Cancer Center | Immunomodulatory fusion proteins and uses thereof |
| US9777064B2 (en) | 2015-03-17 | 2017-10-03 | Chimera Bioengineering, Inc. | Smart CAR devices, DE CAR polypeptides, side CARs and uses thereof |
| JP2018510160A (en) | 2015-03-20 | 2018-04-12 | ブルーバード バイオ， インコーポレイテッド | Vector preparation |
| GB201504840D0 (en) | 2015-03-23 | 2015-05-06 | Ucl Business Plc | Chimeric antigen receptor |
| WO2016172537A1 (en) | 2015-04-23 | 2016-10-27 | The Trustees Of The University Of Pennsylvania | Compositions to disrupt protein kinase a anchoring and uses thereof |
| WO2016172583A1 (en) | 2015-04-23 | 2016-10-27 | Novartis Ag | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| GB201507115D0 (en) | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
| GB201507119D0 (en) | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
| GB201507111D0 (en) | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic acid construct |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| WO2016174652A1 (en) | 2015-04-30 | 2016-11-03 | Technion Research & Development Foundation Limited | Chimeric antigen receptors and methods of their use |
| US10552969B2 (en) | 2015-05-26 | 2020-02-04 | Memorial Sloan-Kettering Cancer Center | System, method and computer-accessible medium for texture analysis of hepatopancreatobiliary diseases |
| CA2986755A1 (en) | 2015-05-28 | 2016-12-01 | Armo Biosciences, Inc. | Pegylated interleukin-10 for use in treating cancer |
| SG10201913620QA (en) | 2015-05-28 | 2020-03-30 | Kite Pharma Inc | Diagnostic methods for t cell therapy |
| MA43344A (en) | 2015-05-29 | 2018-04-11 | Juno Therapeutics Inc | COMPOSITION AND PROCEDURES FOR REGULATING INHIBITORING INTERACTIONS IN GENETICALLY MODIFIED CELLS |
| US11154572B2 (en) | 2015-06-05 | 2021-10-26 | Board Of Regents, The University Of Texas System | Methods of treatment with natural killer cells matched for killer immunoglobulin receptor type |
| KR20180021137A (en) | 2015-06-25 | 2018-02-28 | 아이셀 진 테라퓨틱스 엘엘씨 | Chimeric antigen receptor (CAR), compositions and methods for their use |
| US20180185434A1 (en) | 2015-06-29 | 2018-07-05 | The Johns Hopkins University | Immune checkpoint chimeric antigen receptors therapy |
| MA42895A (en) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | MODIFIED CELLS FOR ADOPTIVE CELL THERAPY |
| WO2017023859A1 (en) | 2015-07-31 | 2017-02-09 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins targeting cd56 and uses thereof |
| GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| GB201514874D0 (en) | 2015-08-20 | 2015-10-07 | Autolus Ltd | Cell |
| AU2016313082B2 (en) | 2015-08-24 | 2022-03-31 | Cellectis | Chimeric antigen receptors with integrated controllable functions |
| CN106519037B (en) | 2015-09-11 | 2019-07-23 | 科济生物医药（上海）有限公司 | Activable Chimerical receptor |
| EP3350320A1 (en) | 2015-09-17 | 2018-07-25 | Novartis AG | Car t cell therapies with enhanced efficacy |
| WO2017058753A1 (en) | 2015-09-28 | 2017-04-06 | Trustees Of Dartmouth College | Chimeric antigen receptor, regulatory cells and methods of use |
| WO2017058752A1 (en) | 2015-09-28 | 2017-04-06 | Trustees Of Dartmouth College | Chimeric antigen receptor anti-inflammatory cells and methods of use |
| MA44314A (en) | 2015-11-05 | 2018-09-12 | Juno Therapeutics Inc | CHEMERICAL RECEPTORS CONTAINING TRAF-INDUCING DOMAINS, AND ASSOCIATED COMPOSITIONS AND METHODS |
| KR20180096707A (en) | 2016-01-20 | 2018-08-29 | 페이트 세러퓨틱스, 인코포레이티드 | Composition and method for immune cell regulation in adoptive immunotherapy |
-
2014
- 2014-01-28 SG SG11201505858VA patent/SG11201505858VA/en unknown
- 2014-01-28 US US14/764,070 patent/US9511092B2/en active Active
- 2014-01-28 WO PCT/US2014/013292 patent/WO2014117121A1/en active Application Filing
- 2014-01-28 EP EP14743792.5A patent/EP2948544A4/en not_active Withdrawn
-
2016
- 2016-10-28 US US15/337,854 patent/US10538739B2/en active Active
-
2017
- 2017-12-28 US US15/857,268 patent/US10829737B2/en active Active
- 2017-12-28 US US15/857,166 patent/US10774309B2/en active Active
- 2017-12-28 US US15/857,147 patent/US10801012B2/en active Active
- 2017-12-28 US US15/857,315 patent/US10836999B2/en active Active
-
2020
- 2020-10-09 US US17/067,016 patent/US11873512B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10829737B2 (en) | 2020-11-10 |
| US10801012B2 (en) | 2020-10-13 |
| US10836999B2 (en) | 2020-11-17 |
| US20180135016A1 (en) | 2018-05-17 |
| US20160000828A1 (en) | 2016-01-07 |
| WO2014117121A1 (en) | 2014-07-31 |
| EP2948544A4 (en) | 2016-08-03 |
| US9511092B2 (en) | 2016-12-06 |
| US20180135014A1 (en) | 2018-05-17 |
| US20170107491A1 (en) | 2017-04-20 |
| US11873512B2 (en) | 2024-01-16 |
| EP2948544A1 (en) | 2015-12-02 |
| US10538739B2 (en) | 2020-01-21 |
| US10774309B2 (en) | 2020-09-15 |
| US20180135013A1 (en) | 2018-05-17 |
| US20180135015A1 (en) | 2018-05-17 |
| US20210115404A1 (en) | 2021-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201505858VA (en) | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease | |
| ZA201507790B (en) | Enhanced adoptive cell therapy | |
| HK1214661A1 (en) | Facilitating transactions with a user account using a wireless device | |
| IL246083A0 (en) | A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy | |
| EP3043819A4 (en) | Anti-vstm5 antibodies and the use thereof in therapy and diagnosis | |
| PL2831055T3 (en) | Polymerizable alkylidene-1,3-dioxolan-2-ones and use thereof | |
| EP2784843A4 (en) | Slurry with improved dispersibility and use therefor | |
| HK1216980A1 (en) | Improvements in wheeled suitcases | |
| EP3038182A4 (en) | Battery pack having curved surface structure | |
| EP2872973A4 (en) | Improvements in devices for use with computers | |
| HK1211458A1 (en) | Disposable body warmer | |
| IL238453A0 (en) | Trans-clomiphene for use in cancer therapy | |
| EP2836838A4 (en) | Methods for determining a breast cancer-associated disease state and arrays for use in the methods | |
| EP2935215A4 (en) | Radiosensitizer compounds for use in combination with radiation | |
| GB201221227D0 (en) | Carbon materials and their use | |
| EP2808175A4 (en) | Erasing implement and writing implement provided with erasing implement | |
| SG11201502317VA (en) | Telomerase inhibitors for use in therapy | |
| GB201310921D0 (en) | Peptide-resin conjugate and use thereof | |
| GB201305940D0 (en) | Methods and arrays for use in the same | |
| PL2978521T3 (en) | Inclined baseplate in dehydrogenation reactor | |
| EP2954578A4 (en) | Fuel cell catalyst treatment | |
| IL238174A0 (en) | Combination therapy with volasertib | |
| GB201308753D0 (en) | Compounds and their use in therapy | |
| GB201309253D0 (en) | Improvements in or relating to support apparatus for use with a human body | |
| HK1207154A1 (en) | C1q-adiponectin complex and use thereof c1q- |