MX2015016418A - Dihidroetorfina para proporcionar el alivio del dolor y la anestesia. - Google Patents

Dihidroetorfina para proporcionar el alivio del dolor y la anestesia.

Info

Publication number
MX2015016418A
MX2015016418A MX2015016418A MX2015016418A MX2015016418A MX 2015016418 A MX2015016418 A MX 2015016418A MX 2015016418 A MX2015016418 A MX 2015016418A MX 2015016418 A MX2015016418 A MX 2015016418A MX 2015016418 A MX2015016418 A MX 2015016418A
Authority
MX
Mexico
Prior art keywords
dihydroetorphine
pain relief
anaesthesia
provision
subject
Prior art date
Application number
MX2015016418A
Other languages
English (en)
Inventor
Smith Kevin
Watkins David
Oksche Alexander
Mansikka Heikki
Bailey Paul
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of MX2015016418A publication Critical patent/MX2015016418A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Psychiatry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)

Abstract

La presente invención incluye un método para proporcionar el alivio del dolor en un paciente humano en necesidad del mismo, que comprende administrar (R)-dihidroetorfina a dicho paciente, donde dicha (R)-dihidroetorfina se administra en una dosis de al menos 0.01 mg/kg, preferiblemente de al menos 0.05 mg/kg, y el nivel de depresión respiratoria en dicho paciente es de 65% o menor con relación al nivel de referencia antes de la administración de (R)-dihidroetorfina.
MX2015016418A 2013-05-30 2014-05-30 Dihidroetorfina para proporcionar el alivio del dolor y la anestesia. MX2015016418A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1309654.0A GB201309654D0 (en) 2013-05-30 2013-05-30 Method
PCT/GB2014/000206 WO2014191710A1 (en) 2013-05-30 2014-05-30 Dihydroetorphine for the provision of pain relief and anaesthesia

Publications (1)

Publication Number Publication Date
MX2015016418A true MX2015016418A (es) 2016-11-08

Family

ID=48805475

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015016418A MX2015016418A (es) 2013-05-30 2014-05-30 Dihidroetorfina para proporcionar el alivio del dolor y la anestesia.

Country Status (13)

Country Link
US (2) US10898479B2 (es)
EP (1) EP3003310A1 (es)
JP (3) JP2016520114A (es)
KR (1) KR20160013977A (es)
CN (1) CN105555274A (es)
AU (1) AU2014272924B2 (es)
BR (1) BR112015029709A2 (es)
CA (1) CA2913849A1 (es)
GB (1) GB201309654D0 (es)
HK (1) HK1222585A1 (es)
MX (1) MX2015016418A (es)
PH (1) PH12015502655A1 (es)
WO (1) WO2014191710A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102051800B1 (ko) 2011-03-04 2019-12-04 그뤼넨탈 게엠베하 경구 투여를 위한 타펜타돌의 수성 약제학적 제형
EP3479823B1 (en) 2015-03-27 2020-09-09 Grünenthal GmbH Stable formulation for parenteral administration of tapentadol
GB201513442D0 (en) * 2015-07-30 2015-09-16 Euro Celtique Sa Transdermal patch
EP3515412A1 (en) 2016-09-23 2019-07-31 Grünenthal GmbH Stable formulation for parenteral administration of tapentadol
WO2018153947A1 (en) 2017-02-23 2018-08-30 Grünenthal GmbH Tapentadol as local anesthetic

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Also Published As

Publication number Publication date
CA2913849A1 (en) 2014-12-04
CN105555274A (zh) 2016-05-04
WO2014191710A1 (en) 2014-12-04
JP2020200345A (ja) 2020-12-17
US20160106736A1 (en) 2016-04-21
US20210085673A1 (en) 2021-03-25
EP3003310A1 (en) 2016-04-13
KR20160013977A (ko) 2016-02-05
AU2014272924A1 (en) 2016-01-28
US10898479B2 (en) 2021-01-26
JP2016520114A (ja) 2016-07-11
JP2019123730A (ja) 2019-07-25
BR112015029709A2 (pt) 2017-07-25
HK1222585A1 (zh) 2017-07-07
GB201309654D0 (en) 2013-07-17
AU2014272924B2 (en) 2019-05-02
PH12015502655A1 (en) 2016-03-07

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