MX2015015339A - Anticuerpos de receptor anti-glucagon y metodos de uso de los mismos. - Google Patents

Anticuerpos de receptor anti-glucagon y metodos de uso de los mismos.

Info

Publication number
MX2015015339A
MX2015015339A MX2015015339A MX2015015339A MX2015015339A MX 2015015339 A MX2015015339 A MX 2015015339A MX 2015015339 A MX2015015339 A MX 2015015339A MX 2015015339 A MX2015015339 A MX 2015015339A MX 2015015339 A MX2015015339 A MX 2015015339A
Authority
MX
Mexico
Prior art keywords
glucagon receptor
methods
glucose
receptor antibodies
antibodies
Prior art date
Application number
MX2015015339A
Other languages
English (en)
Inventor
Chia-Yang Lin
Javier Fernando Chaparro Riggers
Alison Jane Forgie
Edward Roland Lavallie
Lidia Mosyak
Andrea Rossi
Thomas John Van Blarcom
Original Assignee
Rinat Neuroscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rinat Neuroscience Corp filed Critical Rinat Neuroscience Corp
Publication of MX2015015339A publication Critical patent/MX2015015339A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

La presente invención proporciona anticuerpos antagonizantes que se enlazan al receptor de glucagón y métodos para el uso de los mismos. Los anticuerpos de receptor anti-glucagón pueden ser usados terapéuticamente para reducir los niveles de glucosa en la sangre, y se pueden usar en la prevención y/o tratamiento de padecimientos relacionados con la glucosa, que incluyen diabetes, hiperglucemia, hiperinsulinemia, glucosa en ayunas deteriorada, tolerancia deteriorada a la glucosa, dislipidemia, o síndrome metabólico.
MX2015015339A 2013-05-07 2014-05-02 Anticuerpos de receptor anti-glucagon y metodos de uso de los mismos. MX2015015339A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361820604P 2013-05-07 2013-05-07
US201461981115P 2014-04-17 2014-04-17
PCT/IB2014/061166 WO2014181229A2 (en) 2013-05-07 2014-05-02 Anti-glucagon receptor antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2015015339A true MX2015015339A (es) 2016-07-15

Family

ID=50884431

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015339A MX2015015339A (es) 2013-05-07 2014-05-02 Anticuerpos de receptor anti-glucagon y metodos de uso de los mismos.

Country Status (15)

Country Link
US (2) US9248189B2 (es)
EP (1) EP2994489A2 (es)
JP (1) JP2016520058A (es)
KR (1) KR20160005749A (es)
CN (1) CN105189560A (es)
AU (1) AU2014264295A1 (es)
CA (1) CA2911412A1 (es)
HK (1) HK1218421A1 (es)
MX (1) MX2015015339A (es)
PE (1) PE20151871A1 (es)
PH (1) PH12015502547A1 (es)
RU (1) RU2015147721A (es)
SG (1) SG11201508264UA (es)
TW (2) TW201446803A (es)
WO (1) WO2014181229A2 (es)

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US10610504B2 (en) * 2014-12-23 2020-04-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Alpha-cell re-generation combined with conversion to beta cells
MX2017012694A (es) * 2015-04-02 2018-03-07 Remb Biotherapeutics Inc Metodos para tratar la obesidad y la enfermedad del higado graso no alcoholica o esteatohepatitis no alcoholica utilizando anticuerpos antagonistas del receptor de glucagon.
WO2017055966A1 (en) 2015-10-01 2017-04-06 Pfizer Inc. Low viscosity antibody compositions
US20190062441A1 (en) * 2015-10-07 2019-02-28 Remd Biotherapeutics, Inc. Methods For Treating Rare Genetic Disorders Using Glucagon Receptor Antagonistic Antibodies
US20190002577A1 (en) * 2016-01-04 2019-01-03 Remd Biotherapeutics, Inc. Methods Of Treating Type 2 Diabetes Mellitus Using Glucagon Receptor Antagonistic Antibodies
WO2018005445A1 (en) 2016-06-27 2018-01-04 The Broad Institute, Inc. Compositions and methods for detecting and treating diabetes
JP7038707B2 (ja) * 2016-06-27 2022-03-18 プレジデント アンド フェローズ オブ ハーバード カレッジ 代謝障害の治療に有用な化合物
MA46089A (fr) 2016-08-30 2019-07-10 Regeneron Pharma Procédés de traitement de la résistance à l'insuline grave par interférence avec la signalisation du récepteur du glucagon
EP3529278A1 (en) * 2016-10-20 2019-08-28 Regeneron Pharmaceuticals, Inc. Methods of lowering blood glucose levels
MX2019008722A (es) * 2017-01-27 2019-10-02 Ngm Biopharmaceuticals Inc Proteínas de unión al receptor de glucagón y métodos para usarlas.
CN110357959B (zh) * 2018-04-10 2023-02-28 鸿运华宁（杭州）生物医药有限公司 Gcgr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
WO2020023847A1 (en) 2018-07-27 2020-01-30 Ngm Biopharmaceuticals, Inc. Use of glucagon receptor antagonists with immunotherapeutic agent
MX2021007444A (es) 2018-12-21 2021-08-05 Jiangsu Hengrui Medicine Co Proteina biespecifica.
CN110898225A (zh) * 2019-12-23 2020-03-24 黑龙江中医药大学 mTOR/S6K1及MAPK信号通路抑制在胰岛素抵抗改善中的应用
CN113045657B (zh) * 2019-12-26 2022-06-07 杭州济元基因科技有限公司 一种人源化抗人bcma单克隆抗体及其car-t细胞

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Also Published As

Publication number Publication date
PH12015502547A1 (en) 2016-02-22
SG11201508264UA (en) 2015-11-27
JP2016520058A (ja) 2016-07-11
EP2994489A2 (en) 2016-03-16
CA2911412A1 (en) 2014-11-13
TW201702274A (zh) 2017-01-16
TW201446803A (zh) 2014-12-16
HK1218421A1 (zh) 2017-02-17
RU2015147721A (ru) 2017-06-15
WO2014181229A2 (en) 2014-11-13
WO2014181229A3 (en) 2015-04-16
US20160311912A1 (en) 2016-10-27
KR20160005749A (ko) 2016-01-15
AU2014264295A1 (en) 2015-10-29
US20140335091A1 (en) 2014-11-13
US9248189B2 (en) 2016-02-02
CN105189560A (zh) 2015-12-23
PE20151871A1 (es) 2015-12-24

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