MX2015011614A - Derivados de pirrolidina, composiciones farmaceuticas que los contienen, y su uso en terapia. - Google Patents
Derivados de pirrolidina, composiciones farmaceuticas que los contienen, y su uso en terapia.Info
- Publication number
- MX2015011614A MX2015011614A MX2015011614A MX2015011614A MX2015011614A MX 2015011614 A MX2015011614 A MX 2015011614A MX 2015011614 A MX2015011614 A MX 2015011614A MX 2015011614 A MX2015011614 A MX 2015011614A MX 2015011614 A MX2015011614 A MX 2015011614A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrrolidine derivatives
- pharmaceutical compositions
- therapy
- compositions containing
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a derivados de pirrolidina de la fórmula (I), (ver Fórmula) o una sal fisiológicamente tolerada de los mismos. La invención se refiere a composiciones farmacéuticas que comprenden tales derivados de pirrolidina, y el uso de tales derivados de pirrolidina para propósitos terapéuticos. Los derivados de pirrolidina son inhibidores GlyT1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361789382P | 2013-03-15 | 2013-03-15 | |
US201361788538P | 2013-03-15 | 2013-03-15 | |
PCT/EP2014/055159 WO2014140310A1 (en) | 2013-03-15 | 2014-03-14 | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015011614A true MX2015011614A (es) | 2016-05-12 |
Family
ID=50280399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015011614A MX2015011614A (es) | 2013-03-15 | 2014-03-14 | Derivados de pirrolidina, composiciones farmaceuticas que los contienen, y su uso en terapia. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2970215B1 (es) |
JP (1) | JP2016514118A (es) |
CN (1) | CN105209457A (es) |
AU (1) | AU2014230122A1 (es) |
BR (1) | BR112015022758A2 (es) |
CA (1) | CA2900888A1 (es) |
MX (1) | MX2015011614A (es) |
WO (1) | WO2014140310A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101771219B1 (ko) | 2015-08-21 | 2017-09-05 | 양지화학 주식회사 | 야누스 키나제 1 선택적 억제제 및 그 의약 용도 |
ES2877763T3 (es) | 2016-09-20 | 2021-11-17 | Glaxosmithkline Ip No 2 Ltd | Antagonistas del trpv4 |
TW201825458A (zh) | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產(第二)有限公司 | Trpv4拮抗劑 |
US10590077B2 (en) | 2016-09-20 | 2020-03-17 | Glaxosmithkline Intellectual Property Development Limited | TRPV4 antagonists |
CN110167930A (zh) * | 2016-11-10 | 2019-08-23 | 百时美施贵宝公司 | RORγ调节剂 |
CA3052479A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
CA3052480A1 (en) * | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
EP4054551A4 (en) * | 2019-11-07 | 2024-03-20 | Univ Illinois | INFLUENZA VIRAL ENTRY INHIBITORS |
CN115181093B (zh) * | 2022-08-01 | 2023-04-25 | 重庆医科大学 | Sunvozertinib中间体的制备方法 |
CN115181047B (zh) * | 2022-08-01 | 2024-01-30 | 重庆医科大学 | 手性3 -(二甲氨基)吡咯烷的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3867391A (en) * | 1973-08-09 | 1975-02-18 | Pfizer | Cyclic n-substituted derivatives of 1,4-benzene disulphonamide |
US7838518B2 (en) * | 2002-02-12 | 2010-11-23 | N.V. Organon | 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders |
MXPA06000701A (es) * | 2003-07-23 | 2006-04-11 | Wyeth Corp | Compuestos de sulfonildihidrobencimidazolona como ligandos de 5-hidroxitriptamina-6. |
DE102005000666B3 (de) * | 2005-01-04 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US8877794B2 (en) * | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
-
2014
- 2014-03-14 CN CN201480015871.9A patent/CN105209457A/zh active Pending
- 2014-03-14 AU AU2014230122A patent/AU2014230122A1/en not_active Abandoned
- 2014-03-14 JP JP2015562214A patent/JP2016514118A/ja active Pending
- 2014-03-14 WO PCT/EP2014/055159 patent/WO2014140310A1/en active Application Filing
- 2014-03-14 MX MX2015011614A patent/MX2015011614A/es unknown
- 2014-03-14 CA CA2900888A patent/CA2900888A1/en not_active Abandoned
- 2014-03-14 BR BR112015022758A patent/BR112015022758A2/pt not_active IP Right Cessation
- 2014-03-14 EP EP14710280.0A patent/EP2970215B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2016514118A (ja) | 2016-05-19 |
WO2014140310A1 (en) | 2014-09-18 |
EP2970215B1 (en) | 2019-04-17 |
EP2970215A1 (en) | 2016-01-20 |
AU2014230122A1 (en) | 2015-08-06 |
BR112015022758A2 (pt) | 2017-07-18 |
CA2900888A1 (en) | 2014-09-18 |
CN105209457A (zh) | 2015-12-30 |
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