MX2015006195A - Procedimiento para preparar profarmacos de nucleosidos. - Google Patents
Procedimiento para preparar profarmacos de nucleosidos.Info
- Publication number
- MX2015006195A MX2015006195A MX2015006195A MX2015006195A MX2015006195A MX 2015006195 A MX2015006195 A MX 2015006195A MX 2015006195 A MX2015006195 A MX 2015006195A MX 2015006195 A MX2015006195 A MX 2015006195A MX 2015006195 A MX2015006195 A MX 2015006195A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleoside prodrugs
- preparing nucleoside
- preparing
- prodrugs
- phosphorochloridate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/06—Halogens; Compounds thereof
- B01J27/128—Halogens; Compounds thereof with iron group metals or platinum group metals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S5/00—Semiconductor lasers
- H01S5/30—Structure or shape of the active region; Materials used for the active region
- H01S5/34—Structure or shape of the active region; Materials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers
- H01S5/343—Structure or shape of the active region; Materials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers in AIIIBV compounds, e.g. AlGaAs-laser, InP-based laser
- H01S5/34326—Structure or shape of the active region; Materials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers in AIIIBV compounds, e.g. AlGaAs-laser, InP-based laser with a well layer based on InGa(Al)P, e.g. red laser
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nanotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Materials Engineering (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un proceso para preparar fosforamidatos de nucleósidos, en dónde un anantiomero deseado, que tiene en cuenta el centro quiral asimétrico del atomo de fosforo P, se provee una cantidad enriquecida; el procedimiento comprende una sal de metal seleccionada del grupo que consiste de sales de Cu, Fe, La y Yb.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1220666.0A GB201220666D0 (en) | 2012-11-16 | 2012-11-16 | Process for preparing chemical compounds |
GB201307314A GB201307314D0 (en) | 2013-04-23 | 2013-04-23 | Process for preparing chemical compounds |
PCT/GB2013/053018 WO2014076490A1 (en) | 2012-11-16 | 2013-11-15 | Process for preparing nucleoside prodrugs |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015006195A true MX2015006195A (es) | 2015-12-08 |
Family
ID=49622844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015006195A MX2015006195A (es) | 2012-11-16 | 2013-11-15 | Procedimiento para preparar profarmacos de nucleosidos. |
Country Status (28)
Country | Link |
---|---|
US (3) | US10005810B2 (es) |
EP (3) | EP3235824B1 (es) |
JP (5) | JP2016506371A (es) |
KR (1) | KR20150103669A (es) |
CN (2) | CN104903339A (es) |
AU (1) | AU2013346515B2 (es) |
CA (1) | CA2891266C (es) |
CL (1) | CL2015001307A1 (es) |
CY (2) | CY1119161T1 (es) |
DK (2) | DK3235824T3 (es) |
EA (1) | EA028871B1 (es) |
ES (3) | ES2725491T3 (es) |
HK (1) | HK1210784A1 (es) |
HR (2) | HRP20170791T1 (es) |
HU (2) | HUE033335T2 (es) |
IL (1) | IL238792A (es) |
IN (1) | IN2015DN04090A (es) |
LT (2) | LT3150616T (es) |
MX (1) | MX2015006195A (es) |
MY (1) | MY176133A (es) |
NZ (1) | NZ708177A (es) |
PH (1) | PH12015501090B1 (es) |
PL (2) | PL3150616T3 (es) |
PT (2) | PT3235824T (es) |
RS (2) | RS58849B1 (es) |
SG (3) | SG11201503750YA (es) |
SI (2) | SI3235824T1 (es) |
WO (1) | WO2014076490A1 (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
RS58849B1 (sr) * | 2012-11-16 | 2019-07-31 | Univ College Cardiff Consultants Ltd | Smeša rp/sp gemcitabin-[fenil-(benziloksi-l-alaninil)]-fosfata |
US10034893B2 (en) | 2013-02-01 | 2018-07-31 | Enanta Pharmaceuticals, Inc. | 5, 6-D2 uridine nucleoside/tide derivatives |
JP2017504572A (ja) * | 2013-11-27 | 2017-02-09 | アイデニクス・ファーマシューティカルズ・エルエルシー | 肝臓癌治療のためのヌクレオチド類 |
CN105153257B (zh) * | 2014-06-12 | 2019-03-05 | 正大天晴药业集团股份有限公司 | 索非布韦的制备方法 |
WO2015198058A1 (en) * | 2014-06-25 | 2015-12-30 | Nucana Biomed Limited | Gemcitabine prodrugs |
CN106470672B (zh) | 2014-06-25 | 2019-11-05 | 努卡那生物医药有限责任公司 | 包括吉西他滨前药的制剂 |
CN105254694B (zh) * | 2014-07-14 | 2018-11-27 | 正大天晴药业集团股份有限公司 | 氘代核苷衍生物 |
JP6646663B2 (ja) | 2014-07-22 | 2020-02-14 | ニューカナ バイオメッド リミテッドNucana Biomed Limited | ゲムシタビン−[フェニル(ベンゾキシ−l−アラニニル)]ホスフェートの製造方法リン酸誘導体を製造する方法 |
BR112017001847A2 (pt) * | 2014-07-31 | 2018-02-27 | Sandoz Ag | processo para a preparação de um composto de fórmula (i), mistura, composição e composto de fórmula (ii) |
WO2016033164A1 (en) | 2014-08-26 | 2016-03-03 | Enanta Pharmaceuticals, Inc. | Nucleoside and nucleotide derivatives |
CN105461774B (zh) * | 2014-09-30 | 2020-11-24 | 江苏豪森药业集团有限公司 | 索非布韦的制备方法 |
CN105461773B (zh) * | 2014-09-30 | 2020-12-01 | 江苏豪森药业集团有限公司 | 索非布韦的制备方法及其中间体 |
GB201417644D0 (en) * | 2014-10-06 | 2014-11-19 | Nucana Biomed Ltd | Method of separating phosphate diastereoisomers |
WO2016073756A1 (en) | 2014-11-06 | 2016-05-12 | Enanta Pharmaceuticals, Inc. | Deuterated nucleoside/tide derivatives |
US9732110B2 (en) | 2014-12-05 | 2017-08-15 | Enanta Pharmaceuticals, Inc. | Nucleoside and nucleotide derivatives |
AU2016229966B2 (en) | 2015-03-06 | 2018-09-27 | Atea Pharmaceuticals, Inc. | Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
US10407456B2 (en) | 2015-03-26 | 2019-09-10 | Quimica Sintetica, S.A. | Nucleoside phosphoramidates useful for the treatment of viral infections and preparation thereof |
CN106397515B (zh) * | 2015-07-28 | 2021-05-11 | 广东东阳光药业有限公司 | 一种改良的索菲布韦制备方法 |
CN106543220A (zh) | 2015-09-16 | 2017-03-29 | 博瑞生物医药(苏州)股份有限公司 | 氨基磷酸酯化合物及其制备方法和晶体 |
CN106539810B (zh) * | 2015-09-16 | 2021-03-09 | 济南高合医疗科技有限公司 | 一种富集了nuc-1031单一异构体的组合物及其制备方法和用途 |
CN106543252A (zh) * | 2015-09-16 | 2017-03-29 | 博瑞生物医药(苏州)股份有限公司 | 核苷氨基磷酸酯类前药的制备方法及其中间体 |
MX2018004137A (es) * | 2015-10-05 | 2018-06-13 | NuCana plc | Terapia de combinacion. |
WO2017090264A1 (ja) * | 2015-11-27 | 2017-06-01 | 大原薬品工業株式会社 | 5-アザシチジン又は其の2'-デオキシ体の5'位ジベンジル燐酸エステル |
EP4011896A1 (en) * | 2015-12-11 | 2022-06-15 | NuCana plc | Diastereoselective synthesis of (sp)-gemcitabine-[phenyl(benzoxy-l-alaninyl)]phosphate nuc-1031 |
GB201522771D0 (en) * | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Crystalline form of a phosphate derivative |
GB201609602D0 (en) * | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Chemical compounds |
US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
LU100724B1 (en) | 2016-07-14 | 2018-07-31 | Atea Pharmaceuticals Inc | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
US10239910B2 (en) * | 2016-07-20 | 2019-03-26 | Optimus Drugs (P) Limited | Process for the preparation of sofosbuvir |
CN107652342A (zh) * | 2016-07-23 | 2018-02-02 | 江苏万高药业股份有限公司 | 核苷氨基磷酸酯类前药的多晶型及其制备方法 |
DK3512863T3 (da) | 2016-09-07 | 2022-03-07 | Atea Pharmaceuticals Inc | 2¿-substituerede-N6-substituerede purinnukleotider til behandling af RNA-virus |
US10266558B2 (en) * | 2016-10-07 | 2019-04-23 | Alexandre Vasilievich Ivachtchenko | Macroheterocyclic nucleoside derivatives and their analogues, production and use thereof |
WO2018113652A1 (zh) * | 2016-12-23 | 2018-06-28 | 四川科伦博泰生物医药股份有限公司 | 核苷磷酸类化合物及其制备方法和用途 |
KR102592899B1 (ko) | 2017-02-01 | 2023-10-24 | 아테아 파마슈티컬즈, 인크. | C형 간염 바이러스를 치료하기 위한 뉴클레오티드 헤미-술페이트 염 |
GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
JP2021521118A (ja) | 2018-04-10 | 2021-08-26 | アテア ファーマシューティカルズ, インコーポレイテッド | 肝硬変を伴うhcv感染患者の治療 |
WO2019237957A1 (zh) | 2018-06-12 | 2019-12-19 | 四川科伦博泰生物医药股份有限公司 | 膦酰胺酯化合物及其盐和相关晶体形式、制备方法和用途 |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
RU2740058C1 (ru) * | 2020-06-26 | 2020-12-31 | Общество С Ограниченной Ответственностью "Технология Лекарств" | Способ получения софосбувира и фосфорамидаты |
CN112409431B (zh) * | 2020-12-07 | 2023-04-21 | 武汉伯瑞恒医药科技有限公司 | 阿糖胞苷结构类似物及其制备方法和用途 |
CN113549076B (zh) * | 2021-07-23 | 2022-12-06 | 中国药科大学 | 一种多取代嘌呤类化合物及其制备方法和应用 |
WO2024107859A1 (en) * | 2022-11-15 | 2024-05-23 | Rome Therapeutics, Inc. | Cyclopentene-oxymethylene phosphonamidates and related compounds and their use in treating medical conditions |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5728575A (en) | 1990-02-01 | 1998-03-17 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
US6703396B1 (en) | 1990-02-01 | 2004-03-09 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
CA2317505C (en) | 1998-01-23 | 2011-01-04 | Newbiotics, Inc. | Enzyme catalyzed therapeutic agents |
US7462605B2 (en) * | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
BR0307712A (pt) | 2002-02-14 | 2005-05-24 | Pharmasset Ltd | Composto, composição e uso dos mesmos no tratamento de infecções por flaviviridae e proliferação celular anormal |
EP1567169A4 (en) | 2002-11-04 | 2009-10-21 | Xenoport Inc | GEMCITABINE PROMOTERS, THEIR PHARMACEUTICAL COMPOSITIONS AND USES THEREOF |
GB0317009D0 (en) * | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
GB0505781D0 (en) * | 2005-03-21 | 2005-04-27 | Univ Cardiff | Chemical compounds |
EP1928475B1 (en) * | 2005-08-15 | 2018-05-23 | Riboscience LLC | Antiviral phosphoramidates of 4'-c-azido-substituted pronucleotides |
GB0623493D0 (en) * | 2006-11-24 | 2007-01-03 | Univ Cardiff | Chemical compounds |
US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
PA8852101A1 (es) * | 2008-12-08 | 2010-07-27 | Medivir Ab | Nucleótidos uracil ciclopropílicos |
JP2012514657A (ja) | 2009-01-09 | 2012-06-28 | ユニバーシテイ・カレツジ・オブ・カーデイフ・コンサルタンツ・リミテツド | ウィルス感染を治療するためのグアノシンヌクレオシド化合物のホスホルアミダート誘導体 |
TWI576352B (zh) * | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
UY33312A (es) * | 2010-03-31 | 2011-10-31 | Pharmasset Inc | Fosforamidato de nucleosido de purina |
EP2596004B1 (en) * | 2010-07-19 | 2014-09-10 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
CN105061534A (zh) * | 2010-09-22 | 2015-11-18 | 艾丽奥斯生物制药有限公司 | 取代的核苷酸类似物 |
EP2655392B1 (en) * | 2010-12-22 | 2018-04-18 | Alios Biopharma, Inc. | Cyclic nucleotide analogs |
PL3447061T3 (pl) * | 2011-03-01 | 2022-01-31 | NuCana plc | Farmaceutyczna formulacja zawierająca pochodną fosforoamidynianową 5-fluoro-2'-deoksyurydyny do zastosowania w leczeniu nowotworu |
CN103635196B (zh) * | 2011-03-02 | 2019-05-07 | J·深塔格 | 用于单独治疗肝脂肪变性或治疗伴有丙型肝炎病毒感染的肝脂肪变性的组合物、治疗方法和诊断方法 |
CA2852064A1 (en) * | 2011-10-14 | 2013-04-18 | Stc.Unm | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof |
RS58849B1 (sr) * | 2012-11-16 | 2019-07-31 | Univ College Cardiff Consultants Ltd | Smeša rp/sp gemcitabin-[fenil-(benziloksi-l-alaninil)]-fosfata |
US9815864B2 (en) * | 2013-06-26 | 2017-11-14 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
HRP20220911T1 (hr) | 2013-09-11 | 2022-10-28 | Emory University | Sastav nukleotida i nukleozida i njihova uporaba |
AU2014331863C1 (en) * | 2013-10-11 | 2019-05-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
JP2017504572A (ja) | 2013-11-27 | 2017-02-09 | アイデニクス・ファーマシューティカルズ・エルエルシー | 肝臓癌治療のためのヌクレオチド類 |
US20170001988A1 (en) * | 2013-11-27 | 2017-01-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human | Piperidine and piperazine derivatives and their use in treating viral infections and cancer |
CN106470672B (zh) | 2014-06-25 | 2019-11-05 | 努卡那生物医药有限责任公司 | 包括吉西他滨前药的制剂 |
WO2015198058A1 (en) | 2014-06-25 | 2015-12-30 | Nucana Biomed Limited | Gemcitabine prodrugs |
JP6646663B2 (ja) | 2014-07-22 | 2020-02-14 | ニューカナ バイオメッド リミテッドNucana Biomed Limited | ゲムシタビン−[フェニル(ベンゾキシ−l−アラニニル)]ホスフェートの製造方法リン酸誘導体を製造する方法 |
GB201417644D0 (en) | 2014-10-06 | 2014-11-19 | Nucana Biomed Ltd | Method of separating phosphate diastereoisomers |
EP3197456B2 (en) | 2015-05-14 | 2023-10-11 | NuCana plc | Cancer treatments |
MX2018004137A (es) | 2015-10-05 | 2018-06-13 | NuCana plc | Terapia de combinacion. |
EP4011896A1 (en) | 2015-12-11 | 2022-06-15 | NuCana plc | Diastereoselective synthesis of (sp)-gemcitabine-[phenyl(benzoxy-l-alaninyl)]phosphate nuc-1031 |
WO2017109444A1 (en) | 2015-12-23 | 2017-06-29 | Nucana Biomed Limited | Combination therapy |
GB201522771D0 (en) | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Crystalline form of a phosphate derivative |
WO2017109486A1 (en) | 2015-12-23 | 2017-06-29 | Nucana Biomed Limited | Combination therapy |
GB201713914D0 (en) | 2017-08-30 | 2017-10-11 | Nucana Biomed Ltd | Combination therapy |
-
2013
- 2013-11-15 RS RS20190549A patent/RS58849B1/sr unknown
- 2013-11-15 KR KR1020157015861A patent/KR20150103669A/ko not_active Application Discontinuation
- 2013-11-15 PT PT17169878T patent/PT3235824T/pt unknown
- 2013-11-15 ES ES17169878T patent/ES2725491T3/es active Active
- 2013-11-15 WO PCT/GB2013/053018 patent/WO2014076490A1/en active Application Filing
- 2013-11-15 RS RS20170506A patent/RS56038B1/sr unknown
- 2013-11-15 DK DK17169878.0T patent/DK3235824T3/da active
- 2013-11-15 LT LTEP16195036.5T patent/LT3150616T/lt unknown
- 2013-11-15 EP EP17169878.0A patent/EP3235824B1/en active Active
- 2013-11-15 SG SG11201503750YA patent/SG11201503750YA/en unknown
- 2013-11-15 HU HUE16195036A patent/HUE033335T2/en unknown
- 2013-11-15 AU AU2013346515A patent/AU2013346515B2/en active Active
- 2013-11-15 SG SG10201510322UA patent/SG10201510322UA/en unknown
- 2013-11-15 PL PL16195036T patent/PL3150616T3/pl unknown
- 2013-11-15 CN CN201380069952.2A patent/CN104903339A/zh active Pending
- 2013-11-15 DK DK16195036.5T patent/DK3150616T3/en active
- 2013-11-15 PT PT161950365T patent/PT3150616T/pt unknown
- 2013-11-15 ES ES16195036.5T patent/ES2627195T3/es active Active
- 2013-11-15 US US14/442,987 patent/US10005810B2/en active Active
- 2013-11-15 EP EP16195036.5A patent/EP3150616B1/en active Active
- 2013-11-15 SI SI201331437T patent/SI3235824T1/sl unknown
- 2013-11-15 NZ NZ708177A patent/NZ708177A/en unknown
- 2013-11-15 EP EP13792965.9A patent/EP2920192B1/en not_active Not-in-force
- 2013-11-15 SI SI201330652T patent/SI3150616T1/sl unknown
- 2013-11-15 ES ES13792965.9T patent/ES2618732T3/es active Active
- 2013-11-15 JP JP2015542357A patent/JP2016506371A/ja active Pending
- 2013-11-15 CN CN202010526209.7A patent/CN111592577A/zh active Pending
- 2013-11-15 IN IN4090DEN2015 patent/IN2015DN04090A/en unknown
- 2013-11-15 LT LTEP17169878.0T patent/LT3235824T/lt unknown
- 2013-11-15 PL PL17169878T patent/PL3235824T3/pl unknown
- 2013-11-15 EA EA201590955A patent/EA028871B1/ru unknown
- 2013-11-15 SG SG10201510324YA patent/SG10201510324YA/en unknown
- 2013-11-15 MX MX2015006195A patent/MX2015006195A/es active IP Right Grant
- 2013-11-15 HU HUE17169878 patent/HUE044605T2/hu unknown
- 2013-11-15 CA CA2891266A patent/CA2891266C/en active Active
- 2013-11-15 MY MYPI2015001314A patent/MY176133A/en unknown
-
2015
- 2015-05-13 IL IL238792A patent/IL238792A/en active IP Right Grant
- 2015-05-14 CL CL2015001307A patent/CL2015001307A1/es unknown
- 2015-05-15 PH PH12015501090A patent/PH12015501090B1/en unknown
- 2015-11-19 HK HK15111437.1A patent/HK1210784A1/xx not_active IP Right Cessation
-
2017
- 2017-05-24 CY CY20171100539T patent/CY1119161T1/el unknown
- 2017-05-29 HR HRP20170791TT patent/HRP20170791T1/hr unknown
- 2017-08-10 JP JP2017154931A patent/JP2018009000A/ja not_active Withdrawn
-
2018
- 2018-05-31 US US15/994,378 patent/US11040997B2/en active Active
-
2019
- 2019-05-06 HR HRP20190831TT patent/HRP20190831T1/hr unknown
- 2019-05-09 CY CY20191100503T patent/CY1121663T1/el unknown
- 2019-06-18 JP JP2019112739A patent/JP2019196360A/ja active Pending
-
2020
- 2020-10-12 JP JP2020171815A patent/JP7519259B2/ja active Active
-
2021
- 2021-05-18 US US17/323,367 patent/US20220033433A1/en not_active Abandoned
-
2023
- 2023-01-20 JP JP2023007007A patent/JP2023052536A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12015501090A1 (en) | Process for preparing nucleoside prodrugs | |
HK1256856A1 (zh) | 用於抗病毒治療的2'-取代的卡巴-核苷類似物 | |
CL2011000718A1 (es) | Proceso para la preparacion de compuestos fosforados enantiomericos. | |
IL228680A0 (en) | Analogues of n nucleoside pyrimidine 1' - converted to antiviral therapy | |
EP2796555A4 (en) | METHOD FOR PRODUCING L-LYSINE WITH MICROORGANISMS COMPETITIVE FOR THE PREPARATION OF L-LYSINE | |
SI2681227T1 (sl) | Fosforamidatni derivati 5-fluoro-2'-deoksiuridina za uporabo pri zdravljenju raka | |
EP2674395A4 (en) | PROCESS FOR THE PRODUCTION OF FLUOROSULFONYLIMIDE AMMONIUM SALT | |
IL232843A0 (en) | 4'-azido', 3'-fluoro modified nucleoside derivatives as inhibitors of hepatitis C virus RNA replication | |
EA033455B1 (ru) | Кристаллические формы замещенных 5-фтор-1h-пиразолопиридинов, способы их получения, их применение для получения лекарственного средства, лекарственное средство и способ лечения на их основе | |
MX2012000583A (es) | Procedimiento para la preparacion de derivados de 3-triazolil-sulfoxido quirales. | |
BR112015006874A2 (pt) | ligantes de rig-i inovadores e métodos para produzir os mesmos | |
SG11201401523QA (en) | Process for producing phosphorus modified zeolite catalysts | |
TN2013000369A1 (en) | Preventing or reducing scale in wet-process phosphoric acid production | |
IL235922A0 (en) | Production of ammonium phosphates | |
PL2714589T3 (pl) | Dwuwodzianowo-półwodzianowy sposób wytwarzania kwasu fosforowego | |
EP2834190A4 (en) | PROCESS FOR PREPARING HYPOPHOSPHITE SALTS | |
HK1199004A1 (en) | Process for stabilizing heat exchanger tubes in andrussow process andrussow | |
EP2845859A4 (en) | PROCESS FOR THE PREPARATION OF AMMONIUM SALT OF FOSFOMYCIN | |
RS56101B1 (sr) | 4'-azido-3'-fluoro supstituisani derivati nukleozida kao inhibitori hcv rnk replikacije | |
JO3153B1 (ar) | منع أو اختزال القشور عند إنتاج حمض الفوسفوريك بالمعالجة الرطبة | |
TH134009B (th) | จุลินทรีย์ผลิตโอ-ฟอสโฟเซรีน (o-phosphoserine) และวิธีการผลิตแอล-ซิสเทน (L-cysteine) หรืออนุพันธ์ของ แอล-ซิสเทนจากโอ-ฟอสโฟเซรีน (o-phosphoserine) โดยการใช้จุลินทรีย์เดียวกัน |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
PD | Change of proprietorship |
Owner name: NUCANA PLC |
|
HC | Change of company name or juridical status |
Owner name: NUCANA PLC |