MX2015005148A - Formas il-15r alfa, celulas que expresan las formas de il-15 alfa, y usos terapeuticos de il-15r alfa y complejos il-15/il-15r. - Google Patents
Formas il-15r alfa, celulas que expresan las formas de il-15 alfa, y usos terapeuticos de il-15r alfa y complejos il-15/il-15r.Info
- Publication number
- MX2015005148A MX2015005148A MX2015005148A MX2015005148A MX2015005148A MX 2015005148 A MX2015005148 A MX 2015005148A MX 2015005148 A MX2015005148 A MX 2015005148A MX 2015005148 A MX2015005148 A MX 2015005148A MX 2015005148 A MX2015005148 A MX 2015005148A
- Authority
- MX
- Mexico
- Prior art keywords
- alpha
- forms
- complexes
- covalently
- soluble forms
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 102000003812 Interleukin-15 Human genes 0.000 abstract 5
- 108090000172 Interleukin-15 Proteins 0.000 abstract 5
- 230000001404 mediated effect Effects 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 102000004556 Interleukin-15 Receptors Human genes 0.000 abstract 1
- 108010017535 Interleukin-15 Receptors Proteins 0.000 abstract 1
- 206010025327 Lymphopenia Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000036737 immune function Effects 0.000 abstract 1
- 231100001023 lymphopenia Toxicity 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
En un aspecto, en la presente se describen los esquemas cíclicos para la administración de complejos que contienen interleucina-15 ("IL-15") unida en forma covalente o no covalente al receptor de IL-15 alfa ("IL-15Ra") a un paciente con el fin de mejorar la función inmunitaria mediada por IL-15. En un aspecto específico, los esquemas de administración cíclicos son útiles para la prevención, tratamiento y/o manejo de trastornos en los que es benéfica la mejoría de la función mediada por IL-15 como el cáncer, enfermedades infecciosas, deficiencias inmunológicas y linfopenia. También se describen en la presente las formas solubles, purificadas de IL-15Ra, las células que expresan en forma recombinante las formas solubles de IL-15Ra, y las composiciones que contienen complejos de IL-15 unidos en forma covalente o no covalente a las formas solubles de IL-15Ra. Además se describen en la presente las células hospederas que expresan de manera recombinante los derivados de IL-15-Ra que comprenden una mutación o deleción en el sitio de desdoblamiento del dominio extracelular, que incluyen los derivados de IR-15Ra que comprenden el dominio extracelular de IL-15Ra y un domino transmembranal de una molécula heteróloga.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261718169P | 2012-10-24 | 2012-10-24 | |
US201361820035P | 2013-05-06 | 2013-05-06 | |
PCT/US2013/066424 WO2014066527A2 (en) | 2012-10-24 | 2013-10-23 | Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015005148A true MX2015005148A (es) | 2015-09-25 |
MX365527B MX365527B (es) | 2019-06-06 |
Family
ID=50545467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015005148A MX365527B (es) | 2012-10-24 | 2013-10-23 | Formas il-15r alfa, celulas que expresan las formas de il-15 alfa, y usos terapeuticos de il-15r alfa y complejos il-15/il-15r. |
Country Status (11)
Country | Link |
---|---|
US (2) | US20150359853A1 (es) |
EP (1) | EP2911684B1 (es) |
JP (1) | JP6359019B2 (es) |
AU (1) | AU2013334610B2 (es) |
CA (1) | CA2888896A1 (es) |
ES (1) | ES2747997T3 (es) |
HK (1) | HK1211467A1 (es) |
IL (1) | IL238476B (es) |
MX (1) | MX365527B (es) |
NZ (1) | NZ630790A (es) |
WO (1) | WO2014066527A2 (es) |
Families Citing this family (96)
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PL2529747T3 (pl) | 2005-12-02 | 2018-08-31 | Icahn School Of Medicine At Mount Sinai | Chimeryczne wirusy prezentuące nienatywne białka powierzchniowe i zastosowania tych wirusów |
DK2769984T3 (en) | 2007-05-11 | 2017-10-16 | Altor Bioscience Corp | Fusion molecules and IL-15 variants |
US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
PT2918607T (pt) | 2010-09-21 | 2018-01-11 | Altor Bioscience Corp | Moléculas de fusão de il-15 multiméricas solúveis e métodos de produção e utilização das mesmas |
EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
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AU2016333873A1 (en) | 2015-10-06 | 2018-05-17 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for treatment of metastatic and refractory cancers and tumors |
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EP1777294A1 (en) * | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
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EP2724728B1 (en) * | 2007-06-27 | 2018-10-17 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Complexes of il-15 and il-15r alpha and uses thereof |
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AU2013334610A1 (en) | 2015-05-14 |
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AU2013334610B2 (en) | 2018-09-13 |
JP2015536935A (ja) | 2015-12-24 |
IL238476A0 (en) | 2015-06-30 |
EP2911684A2 (en) | 2015-09-02 |
WO2014066527A2 (en) | 2014-05-01 |
NZ630790A (en) | 2016-11-25 |
US20150359853A1 (en) | 2015-12-17 |
IL238476B (en) | 2019-08-29 |
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