MX2015003021A - Derivados de acido glicirretinico y metodos de uso de los mismos. - Google Patents

Derivados de acido glicirretinico y metodos de uso de los mismos.

Info

Publication number
MX2015003021A
MX2015003021A MX2015003021A MX2015003021A MX2015003021A MX 2015003021 A MX2015003021 A MX 2015003021A MX 2015003021 A MX2015003021 A MX 2015003021A MX 2015003021 A MX2015003021 A MX 2015003021A MX 2015003021 A MX2015003021 A MX 2015003021A
Authority
MX
Mexico
Prior art keywords
acid derivatives
inflammatory activity
glycyrrhetinic acid
salts
compounds
Prior art date
Application number
MX2015003021A
Other languages
English (en)
Inventor
Rolf Wagner
Hui-Ju Chen
Jason Shanley
Andrew Bogdan
Jasmina Marjanovic
Xiu Wang
Diana Donnelly-Roberts
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2015003021A publication Critical patent/MX2015003021A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C261/00—Derivatives of cyanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La solicitud actual se refiere a: (a) compuestos de la Fórmula (I) (ver Fórmula) y sales de los mismos, en donde Y, y Z son como se define en la especificación; (b) composiciones que comprenden tales compuestos y sales; y (c) métodos de uso de tales compuestos, sales, y composiciones, particularmente útiles para el tratamiento y prevención de enfermedades tales como aquellas asociadas con tensión oxidante e inflamación.
MX2015003021A 2012-09-10 2013-09-10 Derivados de acido glicirretinico y metodos de uso de los mismos. MX2015003021A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261699123P 2012-09-10 2012-09-10
PCT/US2013/059008 WO2014040052A2 (en) 2012-09-10 2013-09-10 Glycyrrhetinic acid derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2015003021A true MX2015003021A (es) 2015-11-09

Family

ID=49213164

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015003021A MX2015003021A (es) 2012-09-10 2013-09-10 Derivados de acido glicirretinico y metodos de uso de los mismos.

Country Status (7)

Country Link
US (1) US20140073700A1 (es)
EP (1) EP2892910B1 (es)
JP (1) JP2015527407A (es)
CN (1) CN104936972A (es)
CA (1) CA2884400A1 (es)
MX (1) MX2015003021A (es)
WO (1) WO2014040052A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS58486B1 (sr) 2008-01-11 2019-04-30 Reata Pharmaceuticals Inc Sintetički triterpenoidi i metode njihove upotrebe u tretmanu bolesti
BRPI0911105B1 (pt) 2008-04-18 2022-11-08 Reata Pharmaceuticals, Inc Compostos contendo um farmacóforo anti-inflamatório, composição farmacêutica, bem como seus usos
HUE041221T2 (hu) 2008-04-18 2019-05-28 Reata Pharmaceuticals Inc Antioxidáns gyulladás modulátorok: a C-17 atomon amino- és más módosításokkal rendelkezõ oleanolsav-származékok
PE20150160A1 (es) 2012-04-27 2015-02-19 Reata Pharmaceuticals Inc Derivados de 2,2-difluoropropionamida de bardoxolona metilo, formas polimorficas y metodos de uso de los mismos
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
PL2892912T3 (pl) 2012-09-10 2019-10-31 Reata Pharmaceuticals Inc C17-alkanodiylowe i alkenodiylowe pochodne kwasu oleanolowego i sposoby ich zastosowania
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
US9278912B2 (en) 2012-09-10 2016-03-08 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
TWI649330B (zh) 2013-04-24 2019-02-01 艾伯維有限公司 甲基巴多索龍之２，２－二氟丙醯胺衍生物、其多晶形及其使用方法
CA3042123A1 (en) 2016-11-08 2018-05-17 Reata Pharmaceuticals, Inc. Methods of treating alport syndrome using bardoxolone methyl or analogs thereof
EP3856755A4 (en) * 2018-09-28 2022-12-28 Sichuan Haisco Pharmaceutical Co., Ltd. TERPINOID DERIVATIVES AND THEIR USES
WO2021202720A1 (en) * 2020-04-01 2021-10-07 Fronthera U.S. Pharmaceuticals Llc Use of triterpenoid nrf2 inhibitors
CN115677813A (zh) * 2021-03-25 2023-02-03 河北中医学院 化合物在tmem16a激动剂中的应用
CN113698447A (zh) * 2021-09-24 2021-11-26 河北维达康生物科技有限公司 一种18β-甘草次酸甲酯的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025395A (en) * 1994-04-15 2000-02-15 Duke University Method of preventing or delaying the onset and progression of Alzheimer's disease and related disorders
US6326507B1 (en) * 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
JP2006515859A (ja) * 2002-05-13 2006-06-08 トラスティーズ オブ ダートマス カレッジ 阻害剤およびその使用法
CN100417660C (zh) * 2004-12-29 2008-09-10 浙江海正药业股份有限公司 一类含异环共轭烯酮的齐墩果烷三萜衍生物及其医药用途
US8088824B2 (en) * 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
RS58486B1 (sr) * 2008-01-11 2019-04-30 Reata Pharmaceuticals Inc Sintetički triterpenoidi i metode njihove upotrebe u tretmanu bolesti
HUE041221T2 (hu) * 2008-04-18 2019-05-28 Reata Pharmaceuticals Inc Antioxidáns gyulladás modulátorok: a C-17 atomon amino- és más módosításokkal rendelkezõ oleanolsav-származékok
JP5588966B2 (ja) * 2008-04-18 2014-09-10 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーター：ｃ−１７同族体化オレアノール酸誘導体
BRPI0911208B1 (pt) * 2008-04-18 2021-05-25 Reata Pharmaceuticals, Inc Compostos moduladores inflamatórios antioxidantes, seu uso, e composição farmacêutica
EP2558105B1 (en) * 2010-04-12 2019-11-20 Reata Pharmaceuticals, Inc. Bardoxolone methyl for the treatment of obesity
US8828329B2 (en) * 2010-10-01 2014-09-09 Church & Dwight, Co., Inc. Electronic analyte assaying device
SG193404A1 (en) * 2011-03-11 2013-10-30 Reata Pharmaceuticals Inc C4-monomethyl triterpenoid derivatives and methods of use thereof

Also Published As

Publication number Publication date
CA2884400A1 (en) 2014-03-13
WO2014040052A2 (en) 2014-03-13
US20140073700A1 (en) 2014-03-13
EP2892910B1 (en) 2016-09-07
WO2014040052A3 (en) 2014-05-22
CN104936972A (zh) 2015-09-23
JP2015527407A (ja) 2015-09-17
EP2892910A2 (en) 2015-07-15

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