MX2012012555A - Derivado novedoso de amida y su uso como medicina. - Google Patents

Derivado novedoso de amida y su uso como medicina.

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Publication number
MX2012012555A
MX2012012555A MX2012012555A MX2012012555A MX2012012555A MX 2012012555 A MX2012012555 A MX 2012012555A MX 2012012555 A MX2012012555 A MX 2012012555A MX 2012012555 A MX2012012555 A MX 2012012555A MX 2012012555 A MX2012012555 A MX 2012012555A
Authority
MX
Mexico
Prior art keywords
amide derivative
medicine
production
novel amide
mmp
Prior art date
Application number
MX2012012555A
Other languages
English (en)
Inventor
Seigo Ishibuchi
Kaoru Tashiro
Akiko Tarao
Jun-Ichi Endoh
Kazuhiro Maeda
Hidemasa Hikawa
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of MX2012012555A publication Critical patent/MX2012012555A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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Abstract

Se proporciona un compuesto novedoso de bajo peso molecular que suprime la producción de MMPs de tipo inducción, en particular MMP-9, más que la producción de MMP-2 tipo hemostática; así como un fármaco profiláctico y/o terapéutico para enfermedades autoinmunes u osteoartritis; un derivado de amida representado por la siguiente fórmula (I) (Ver Formula) en donde cada símbolo es como se define en la especificación, o una sal farmacológicamente aceptable del mismo.
MX2012012555A 2010-04-27 2011-04-27 Derivado novedoso de amida y su uso como medicina. MX2012012555A (es)

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JP2010101953 2010-04-27
PCT/JP2011/060307 WO2011136292A1 (ja) 2010-04-27 2011-04-27 新規アミド誘導体およびその医薬としての用途

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EP3303303A1 (en) * 2015-05-29 2018-04-11 Pfizer Inc Novel heterocyclic compounds as inhibitors of vanin-1 enzyme
AU2016289079B2 (en) * 2015-07-09 2020-10-22 Mitsubishi Tanabe Pharma Corporation Novel imide derivatives and use thereof as medicine
US10544113B2 (en) 2016-03-07 2020-01-28 National Health Research Institute Thiazolidinone compounds and use thereof
AU2017296338A1 (en) 2016-07-14 2019-01-03 Pfizer Inc. Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme
CA3078769A1 (en) 2017-10-27 2019-05-02 Boehringer Ingelheim International Gmbh Pyridine carbonyl derivatives and therapeutic uses thereof as trpc6 inhibitors
AU2019379789B2 (en) * 2018-11-14 2024-03-28 Allinky Biopharma Pyridin-sulfonamide compounds for the treatment of conditions related to interleukin 1 beta

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US6794511B2 (en) * 1997-03-04 2004-09-21 G. D. Searle Sulfonyl aryl or heteroaryl hydroxamic acid compounds
JP4480128B2 (ja) 2002-11-20 2010-06-16 独立行政法人科学技術振興機構 マトリックスメタロプロテアーゼ−９の産生を阻害するための薬剤
WO2004069816A1 (en) 2003-02-07 2004-08-19 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
DE602004009323T2 (de) * 2003-09-09 2008-07-10 F. Hoffmann-La Roche Ag 1-(2-amino-benzoyl)-piperazin-derivate als glycin-aufnahmehemmer zur behandlung von psychosen
WO2005035534A1 (ja) * 2003-10-08 2005-04-21 Ono Pharmaceutical Co., Ltd. 複素ビシクロ環および複素トリシクロ環化合物およびその医薬
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DE102005034912B4 (de) 2005-07-26 2007-10-04 Siemens Ag Partikeltherapieanlage, Verfahren zum Bestimmen von Steuerparametern einer derartigen Therapieanlage, Strahlentherapieplanungsvorrichtung und Bestrahlungsverfahren
WO2007129646A1 (ja) * 2006-05-01 2007-11-15 Taisho Pharmaceutical Co., Ltd. マクロライド誘導体
TW201006816A (en) * 2008-05-15 2010-02-16 Organon Nv Hexafluoroisopropanol derivatives
WO2010050461A1 (ja) * 2008-10-27 2010-05-06 田辺三菱製薬株式会社 新規アミド誘導体およびその医薬としての用途
JP2011246461A (ja) * 2010-04-27 2011-12-08 Mitsubishi Tanabe Pharma Corp 新規アミド誘導体を含有する医薬組成物

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JPWO2011136292A1 (ja) 2013-07-22
WO2011136292A1 (ja) 2011-11-03
DK2565182T3 (en) 2017-12-04
ES2653966T3 (es) 2018-02-09
EP2565182A4 (en) 2014-01-01
TW201206920A (en) 2012-02-16
BR112012027629A2 (pt) 2016-08-09
CN102971291B (zh) 2015-07-22
PT2565182T (pt) 2018-01-08
AU2011246095A1 (en) 2012-12-06
HUE037850T2 (hu) 2018-09-28
KR101800044B1 (ko) 2017-11-21
CN102971291A (zh) 2013-03-13
AU2011246095A8 (en) 2016-10-27
JP5782430B2 (ja) 2015-09-24
US20130040930A1 (en) 2013-02-14
EP2565182A1 (en) 2013-03-06
CA2797230A1 (en) 2011-11-03
AU2011246095B2 (en) 2016-10-20
CA2797230C (en) 2018-07-10
TWI525090B (zh) 2016-03-11
US8816079B2 (en) 2014-08-26
KR20140023201A (ko) 2014-02-26
EP2565182B1 (en) 2017-10-11
PL2565182T3 (pl) 2018-03-30

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