MX2012007429A - Compuestos y metodos para la modulacion de quinasa e indicaciones de la misma. - Google Patents
Compuestos y metodos para la modulacion de quinasa e indicaciones de la misma.Info
- Publication number
- MX2012007429A MX2012007429A MX2012007429A MX2012007429A MX2012007429A MX 2012007429 A MX2012007429 A MX 2012007429A MX 2012007429 A MX2012007429 A MX 2012007429A MX 2012007429 A MX2012007429 A MX 2012007429A MX 2012007429 A MX2012007429 A MX 2012007429A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- compounds
- raf
- leukemia
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen compuestos y sales, , fórmulas, conjugados, derivados, formas y usos de los mismos. En ciertos aspectos y formas de realización, los compuestos descritos, sales, formulaciones, conjugados, derivados o formas de los mismos están activos en cada proteína quinasa B-Raf, B-Raf V600E y c-Raf-1. En ciertos aspectos y formas de realización, los compuestos descritos están activos en la proliferación inhibitoria de una línea de células mutantes Ras. También se describen los métodos de uso de los mismos para tratar enfermedades o condiciones, incluyendo melanoma, glioma, glioblastoma, astrocitoma pilocítico, cáncer de hígado, cáncer del tracto biliar, colangiocarcinoma, cáncer colorectal, cáncer de pulmón, cáncer de vejiga, cáncer de la vesícula biliar, cáncer de seno, cáncer pancreático, cáncer de tiroides, cáncer de riñón, cáncer de ovario, cáncer adrenocortical, cáncer de próstata, tumores estromales gastrointestinales, cáncer medular tiroideo, angiogenesis tumoral, leucemia mieloide aguda, leucemia mielomonocítica crónica, leucemia linfoblástica en niños, leucemia celular plasmática, y mieloma múltiple.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28993009P | 2009-12-23 | 2009-12-23 | |
US38331810P | 2010-09-15 | 2010-09-15 | |
PCT/US2010/061601 WO2011079133A2 (en) | 2009-12-23 | 2010-12-21 | Compounds and methods for kinase modulation, and indications therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012007429A true MX2012007429A (es) | 2012-07-23 |
Family
ID=44196390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012007429A MX2012007429A (es) | 2009-12-23 | 2010-12-21 | Compuestos y metodos para la modulacion de quinasa e indicaciones de la misma. |
Country Status (14)
Country | Link |
---|---|
US (2) | US20110183988A1 (es) |
EP (1) | EP2516438A4 (es) |
JP (1) | JP5815558B2 (es) |
KR (1) | KR20120112623A (es) |
CN (1) | CN102753549A (es) |
AR (1) | AR079690A1 (es) |
AU (1) | AU2010336524B2 (es) |
BR (1) | BR112012015745A2 (es) |
CA (1) | CA2784393A1 (es) |
MX (1) | MX2012007429A (es) |
RU (1) | RU2012131373A (es) |
TW (1) | TW201132639A (es) |
UY (1) | UY33159A (es) |
WO (1) | WO2011079133A2 (es) |
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MX2012007429A (es) | 2009-12-23 | 2012-07-23 | Plexxikon Inc | Compuestos y metodos para la modulacion de quinasa e indicaciones de la misma. |
TWI619713B (zh) | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | 用於激酶調節的化合物和方法及其適應症 |
US8642606B2 (en) | 2010-09-29 | 2014-02-04 | Plexxikon Inc. | ZAP-70 active compounds |
MY162950A (en) | 2011-02-07 | 2017-07-31 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
BR112013029163A2 (pt) | 2011-05-17 | 2017-01-31 | Plexxikon Inc | modulação quinase e indicações dos mesmos |
US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
WO2014039714A2 (en) | 2012-09-06 | 2014-03-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
NZ711896A (en) | 2012-12-21 | 2018-04-27 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
DK2970265T3 (en) | 2013-03-15 | 2018-10-01 | Plexxikon Inc | HETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF |
RU2015149937A (ru) | 2013-05-30 | 2017-07-06 | Плексксикон Инк. | Соединения для модулирования киназы и показания к их применению |
-
2010
- 2010-12-21 MX MX2012007429A patent/MX2012007429A/es not_active Application Discontinuation
- 2010-12-21 WO PCT/US2010/061601 patent/WO2011079133A2/en active Application Filing
- 2010-12-21 CA CA2784393A patent/CA2784393A1/en not_active Abandoned
- 2010-12-21 CN CN2010800638309A patent/CN102753549A/zh active Pending
- 2010-12-21 US US12/975,239 patent/US20110183988A1/en not_active Abandoned
- 2010-12-21 JP JP2012546158A patent/JP5815558B2/ja not_active Expired - Fee Related
- 2010-12-21 RU RU2012131373/04A patent/RU2012131373A/ru not_active Application Discontinuation
- 2010-12-21 BR BR112012015745A patent/BR112012015745A2/pt not_active IP Right Cessation
- 2010-12-21 KR KR1020127019219A patent/KR20120112623A/ko not_active Application Discontinuation
- 2010-12-21 AU AU2010336524A patent/AU2010336524B2/en not_active Expired - Fee Related
- 2010-12-21 EP EP10840075.5A patent/EP2516438A4/en not_active Withdrawn
- 2010-12-22 AR ARP100104871A patent/AR079690A1/es unknown
- 2010-12-22 TW TW099145373A patent/TW201132639A/zh unknown
- 2010-12-23 UY UY33159A patent/UY33159A/es not_active Application Discontinuation
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2014
- 2014-10-14 US US14/514,232 patent/US9440969B2/en active Active
Also Published As
Publication number | Publication date |
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US20110183988A1 (en) | 2011-07-28 |
CN102753549A (zh) | 2012-10-24 |
JP5815558B2 (ja) | 2015-11-17 |
EP2516438A2 (en) | 2012-10-31 |
JP2013515736A (ja) | 2013-05-09 |
AU2010336524B2 (en) | 2015-10-08 |
WO2011079133A3 (en) | 2011-11-17 |
CA2784393A1 (en) | 2011-06-30 |
US9440969B2 (en) | 2016-09-13 |
EP2516438A4 (en) | 2013-06-12 |
UY33159A (es) | 2011-07-29 |
RU2012131373A (ru) | 2014-01-27 |
KR20120112623A (ko) | 2012-10-11 |
US20150080372A1 (en) | 2015-03-19 |
BR112012015745A2 (pt) | 2016-05-17 |
AU2010336524A1 (en) | 2012-07-05 |
AR079690A1 (es) | 2012-02-15 |
TW201132639A (en) | 2011-10-01 |
WO2011079133A2 (en) | 2011-06-30 |
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