MX2012006490A - Inhibidores azociclicos de hidrolasa de amidas de acidos grasos. - Google Patents

Inhibidores azociclicos de hidrolasa de amidas de acidos grasos.

Info

Publication number
MX2012006490A
MX2012006490A MX2012006490A MX2012006490A MX2012006490A MX 2012006490 A MX2012006490 A MX 2012006490A MX 2012006490 A MX2012006490 A MX 2012006490A MX 2012006490 A MX2012006490 A MX 2012006490A MX 2012006490 A MX2012006490 A MX 2012006490A
Authority
MX
Mexico
Prior art keywords
fatty acid
acid amide
azocyclic
inhibitors
amide hydrolase
Prior art date
Application number
MX2012006490A
Other languages
English (en)
Inventor
Robert James Pasteris
Mei H Dung
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of MX2012006490A publication Critical patent/MX2012006490A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describe compuestos de la Fórmula 1 que incluyen todos los estereoisómeros, N-óxidos y sales de estos, (Ver Formula) en donde: A, W, X, G, R1, R2, R3, R4, m y n son como se definen en la descripción. Además, se describe composiciones farmacéuticas que contienen los compuestos de la Fórmula 1 y métodos para tratar una enfermedad o afección mediada por la actividad de la hidrolasa de amidas de ácidos grasos; los métodos comprenden aplicar una cantidad con eficacia terapéutica de un compuesto o una composición de la invención.
MX2012006490A 2009-12-11 2010-12-10 Inhibidores azociclicos de hidrolasa de amidas de acidos grasos. MX2012006490A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28560009P 2009-12-11 2009-12-11
PCT/US2010/059850 WO2011072207A1 (en) 2009-12-11 2010-12-10 Azocyclic inhibitors of fatty acid amide hydrolase

Publications (1)

Publication Number Publication Date
MX2012006490A true MX2012006490A (es) 2012-07-03

Family

ID=43478289

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012006490A MX2012006490A (es) 2009-12-11 2010-12-10 Inhibidores azociclicos de hidrolasa de amidas de acidos grasos.

Country Status (12)

Country Link
US (1) US20130045948A1 (es)
EP (1) EP2509978A1 (es)
JP (1) JP2013513615A (es)
KR (1) KR20120093425A (es)
CN (1) CN102652135A (es)
AU (1) AU2010328049A1 (es)
BR (1) BR112012013801A2 (es)
CA (1) CA2780905A1 (es)
IL (1) IL219659A0 (es)
MX (1) MX2012006490A (es)
WO (1) WO2011072207A1 (es)
ZA (1) ZA201203371B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8759527B2 (en) * 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
BR112013019667B1 (pt) * 2011-02-01 2019-07-02 Bayer Intellectual Property Gmbh Compostos derivados de heteroaril-piperidina e -piperazina, seus usos, composição, processos de produção de compostos e de composições, método para o controle de fungos fitopatogênicos prejudiciais
CN107266382B (zh) 2011-12-27 2020-10-27 拜耳知识产权有限责任公司 作为杀菌剂的杂芳基哌啶和杂芳基哌嗪衍生物
ES2672736T3 (es) * 2013-06-24 2018-06-15 Bayer Cropscience Aktiengesellschaft Derivados de ácido piperidincarboxílico como fungicidas
EP3122746B1 (en) 2014-03-24 2018-04-25 Bayer CropScience Aktiengesellschaft Phenylpiperidinecarboxamide derivatives as fungicides
MX2016015624A (es) * 2014-05-28 2017-02-27 Bayer Cropscience Ag Proceso para la preparacion de derivados de tiazol.
KR102430612B1 (ko) 2014-06-11 2022-08-08 바이엘 크롭사이언스 악티엔게젤샤프트 피페리딘-4-카보티오아미드의 제조
MX2017011388A (es) 2015-03-05 2018-03-16 Bayer Cropscience Ag Proceso para la preparacion de derivados de fenilisoxazolina sustituida.
JP6700292B2 (ja) 2015-03-05 2020-05-27 バイエル・クロップサイエンス・アクチェンゲゼルシャフト ピペリジン−４−カルボチオアミド塩酸塩を調製する方法
AU2016261325A1 (en) * 2015-05-08 2017-11-16 Vertellus Holdings Llc Processes for converting carboxamides to thiocarboxamides
CN108409727A (zh) * 2017-10-25 2018-08-17 巨德峰 一种脂肪酰胺水解酶抑制剂及其制备方法
CN110804048A (zh) * 2019-11-08 2020-02-18 暨南大学 恶唑酮类化合物及其应用、faah的正电子药物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3557089A (en) 1968-12-27 1971-01-19 Du Pont Preparation of l-(carbamoyl)-n-(carbamoyloxy) thioformimidates from acetoacetamides
GB9416364D0 (en) 1994-08-12 1994-10-05 Fine Organics Ltd Preparation of thioamides
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
US7541359B2 (en) * 2005-06-30 2009-06-02 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
TW200738701A (en) * 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
CA2665804A1 (en) * 2006-08-23 2008-02-28 Astellas Pharma Inc. Urea compound or salt thereof
EP2260032A2 (en) * 2008-01-25 2010-12-15 E. I. du Pont de Nemours and Company Fungicidal hetercyclic compounds

Also Published As

Publication number Publication date
CA2780905A1 (en) 2011-06-16
BR112012013801A2 (pt) 2019-09-24
WO2011072207A1 (en) 2011-06-16
JP2013513615A (ja) 2013-04-22
IL219659A0 (en) 2012-07-31
AU2010328049A1 (en) 2012-05-31
KR20120093425A (ko) 2012-08-22
ZA201203371B (en) 2013-08-28
US20130045948A1 (en) 2013-02-21
EP2509978A1 (en) 2012-10-17
CN102652135A (zh) 2012-08-29

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