MX2011003502A - Anticuerpo de cadena sencilla biespecifica de psmaxcd3 especifico a traves de especies. - Google Patents

Anticuerpo de cadena sencilla biespecifica de psmaxcd3 especifico a traves de especies.

Info

Publication number
MX2011003502A
MX2011003502A MX2011003502A MX2011003502A MX2011003502A MX 2011003502 A MX2011003502 A MX 2011003502A MX 2011003502 A MX2011003502 A MX 2011003502A MX 2011003502 A MX2011003502 A MX 2011003502A MX 2011003502 A MX2011003502 A MX 2011003502A
Authority
MX
Mexico
Prior art keywords
single chain
chain antibody
bispecific single
antibody molecule
species
Prior art date
Application number
MX2011003502A
Other languages
English (en)
Inventor
Peter Kufer
Ralf Lutterbuese
Evelyne Schaller
Doris Rau
Susanne Mangold
Tobias Raum
Roman Kischel
Patrick Hoffmann
Matthias Klinger
Susanne Hausmann
Petra Fluhr
Carola Steiger
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42073956&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2011003502(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Micromet Ag filed Critical Micromet Ag
Publication of MX2011003502A publication Critical patent/MX2011003502A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a una molécula de anticuerpo de cadena sencilla biespecífica que comprende un primer dominio de enlace capaz de ligar a un epítopo de cadena CD3 épsilon de humano y primate no chimpancé, caracterizado porque el epítopo es parte de una secuencia de aminoácidos comprendida en el grupo que consiste de SEQ ID NOs 2, 4, 6 y 8, y un segundo dominio de enlace capaz de ligar a antígeno de membrana específico de próstata (PSMA). La invención también proporciona ácidos nucleicos que codifican la molécula de anticuerpo de cadena sencilla biespecífica así como vectores y células hospederas y un proceso para su producción. La invención además se refiere a composiciones farmacéuticas que comprenden la molécula de anticuerpo de cadena sencilla biespecífica y usos médicos de la molécula de anticuerpo de cadena sencilla biespecífica.
MX2011003502A 2008-10-01 2009-10-01 Anticuerpo de cadena sencilla biespecifica de psmaxcd3 especifico a traves de especies. MX2011003502A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10185708P 2008-10-01 2008-10-01
PCT/EP2009/062793 WO2010037836A2 (en) 2008-10-01 2009-10-01 Cross-species-specific psmaxcd3 bispecific single chain antibody

Publications (1)

Publication Number Publication Date
MX2011003502A true MX2011003502A (es) 2011-09-01

Family

ID=42073956

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011003502A MX2011003502A (es) 2008-10-01 2009-10-01 Anticuerpo de cadena sencilla biespecifica de psmaxcd3 especifico a traves de especies.

Country Status (27)

Country Link
US (5) US20110293619A1 (es)
EP (3) EP2356153B1 (es)
JP (4) JP6126782B2 (es)
KR (1) KR101820535B1 (es)
CN (1) CN102171248B (es)
AU (1) AU2009299792B2 (es)
BR (1) BRPI0919841A2 (es)
CA (1) CA2738565C (es)
CY (1) CY1118303T1 (es)
DK (1) DK2356153T3 (es)
ES (1) ES2588155T3 (es)
HK (1) HK1158669A1 (es)
HR (1) HRP20160684T1 (es)
HU (1) HUE030090T2 (es)
IL (1) IL212099A (es)
ME (1) ME02485B (es)
MX (1) MX2011003502A (es)
NZ (1) NZ591134A (es)
PL (1) PL2356153T3 (es)
PT (1) PT2356153T (es)
RS (1) RS54900B1 (es)
RU (1) RU2559531C2 (es)
SG (1) SG194398A1 (es)
SI (1) SI2356153T1 (es)
SM (1) SMT201600256B (es)
WO (1) WO2010037836A2 (es)
ZA (1) ZA201101067B (es)

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