WO2009010871A3 - Pyrazole derivatives as antagonists of adenosine a3 receptor - Google Patents

Pyrazole derivatives as antagonists of adenosine a3 receptor Download PDF

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Publication number
WO2009010871A3
WO2009010871A3 PCT/IB2008/002243 IB2008002243W WO2009010871A3 WO 2009010871 A3 WO2009010871 A3 WO 2009010871A3 IB 2008002243 W IB2008002243 W IB 2008002243W WO 2009010871 A3 WO2009010871 A3 WO 2009010871A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonists
adenosine
receptor
compounds
pyrazole derivatives
Prior art date
Application number
PCT/IB2008/002243
Other languages
French (fr)
Other versions
WO2009010871A2 (en
Inventor
Christelle Bolea
Sylvain Celanire
Poul Emmanuel Le
Stefania Gagliardi
Anna Rencurosi
Marco Farina
Original Assignee
Addex Pharmaceuticals Sa
Christelle Bolea
Sylvain Celanire
Poul Emmanuel Le
Stefania Gagliardi
Anna Rencurosi
Marco Farina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0713687A external-priority patent/GB0713687D0/en
Priority claimed from GB0723344A external-priority patent/GB0723344D0/en
Priority claimed from GB0803103A external-priority patent/GB0803103D0/en
Application filed by Addex Pharmaceuticals Sa, Christelle Bolea, Sylvain Celanire, Poul Emmanuel Le, Stefania Gagliardi, Anna Rencurosi, Marco Farina filed Critical Addex Pharmaceuticals Sa
Publication of WO2009010871A2 publication Critical patent/WO2009010871A2/en
Publication of WO2009010871A3 publication Critical patent/WO2009010871A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

The present invention relates to novel compounds of Formula (I), wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, M1, M2, M3, Am and Bn are defined as in Formula (I); invention compounds are antagonists of adenosine receptors - subtype 3 (A3) which are useful for the treatment or disorders modulated by A3 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which A3 is involved.
PCT/IB2008/002243 2007-07-13 2008-07-11 Pyrazole derivatives as antagonists of adenosine a3 receptor WO2009010871A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0713687A GB0713687D0 (en) 2007-07-13 2007-07-13 New compounds 1
GB0713687.2 2007-07-13
GB0723344.8 2007-11-28
GB0723344A GB0723344D0 (en) 2007-11-28 2007-11-28 Novel compounds 3
GB0803103A GB0803103D0 (en) 2008-02-20 2008-02-20 Novel compounds 3
GB0803103.1 2008-02-20

Publications (2)

Publication Number Publication Date
WO2009010871A2 WO2009010871A2 (en) 2009-01-22
WO2009010871A3 true WO2009010871A3 (en) 2009-03-12

Family

ID=40089928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/002243 WO2009010871A2 (en) 2007-07-13 2008-07-11 Pyrazole derivatives as antagonists of adenosine a3 receptor

Country Status (1)

Country Link
WO (1) WO2009010871A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9233956B2 (en) 2008-05-06 2016-01-12 Novartis Ag Benzene sulfonamide thiazole and oxazole compounds

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0900388D0 (en) 2009-01-12 2009-02-11 Addex Pharmaceuticals Sa New compounds
GB201000655D0 (en) 2010-01-15 2010-03-03 Addex Pharmaceuticals Sa New compounds 2
WO2012068196A1 (en) * 2010-11-18 2012-05-24 Janssen Pharmaceutica Nv Bis heteroaryl inhibitors of pro-matrix metalloproteinase activation
GB201104267D0 (en) 2011-03-14 2011-04-27 Cancer Rec Tech Ltd Pyrrolopyridineamino derivatives
TW201245185A (en) 2011-04-01 2012-11-16 Lundbeck & Co As H New positive allosteric modulators of nicotinic acetylcholine receptor
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
GB201216018D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Pharmacologically active compounds
CN103351339A (en) * 2013-07-12 2013-10-16 雅本化学股份有限公司 3-fluorinated alkyl-1-substituted pyrazole-4-carboxylic acid and preparation method thereof
GB201314452D0 (en) 2013-08-13 2013-09-25 Ostara Biomedical Ltd Embryo implantation
GB201501302D0 (en) 2015-01-27 2015-03-11 Ostara Biomedical Ltd Embryo implantation
WO2017054112A1 (en) * 2015-09-28 2017-04-06 常州市卜弋科研化工有限公司 Method of preparing 3-fluoroalkyl-1-methylpyrazole-4-carboxylic acid
GB201517523D0 (en) 2015-10-05 2015-11-18 Ostara Biomedical Ltd Methods and compositions for managing reproduction
KR20220132042A (en) 2016-04-21 2022-09-29 아스트로사이트 파마슈티컬스, 인코포레이티드 Compounds and methods for treating neurological and cardiovascular conditions
US20190135761A1 (en) * 2016-05-10 2019-05-09 Solvay Sa Composition comprising 3-(haloalkyl or formyl)-1h-pyrazole-4-carboxylic acids or esters, its manufacture and its use for the preparation of carboxamides
ES2676535B1 (en) * 2017-01-20 2019-04-29 Palobiofarma Sl MODULATORS OF A3 ADENOSINE RECEIVERS
WO2018180943A1 (en) * 2017-03-27 2018-10-04 Ａｇｃ株式会社 Method for producing halogen-containing pyrazol carboxylic acid and intermediate thereof
CN108017584B (en) * 2017-06-20 2021-03-23 南开大学 A3Small molecule antagonists of adenosine receptors
US11839615B2 (en) 2018-02-09 2023-12-12 Astrocyte Pharmaceuticals, Inc. Compounds and methods for treating addiction and related disorders
WO2020106773A1 (en) * 2018-11-19 2020-05-28 Saint Louis University Treatment of irritable bowel syndrome

Citations (4)

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Publication number Priority date Publication date Assignee Title
JPH11158073A (en) * 1997-09-26 1999-06-15 Takeda Chem Ind Ltd Adenosine a3 antagonist
WO2001064674A1 (en) * 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
WO2007071348A1 (en) * 2005-12-19 2007-06-28 F. Hoffmann-La Roche Ag Isoquinoline aminopyrazole derivatives, their manufacture and use as pharmaceutical agents for the treatment of cancer
WO2007076473A2 (en) * 2005-12-23 2007-07-05 Kalypsys, Inc. Substituted pyrimidinyloxy ureas useful as inhibitors of protein kinases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11158073A (en) * 1997-09-26 1999-06-15 Takeda Chem Ind Ltd Adenosine a3 antagonist
WO2001064674A1 (en) * 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
WO2007071348A1 (en) * 2005-12-19 2007-06-28 F. Hoffmann-La Roche Ag Isoquinoline aminopyrazole derivatives, their manufacture and use as pharmaceutical agents for the treatment of cancer
WO2007076473A2 (en) * 2005-12-23 2007-07-05 Kalypsys, Inc. Substituted pyrimidinyloxy ureas useful as inhibitors of protein kinases

Non-Patent Citations (7)

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Title
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHELKE, S. N. ET AL: "Synthesis of pyrazolyltriazoles and thiadiazoles by conventional and non-conventional methods", XP002507912, retrieved from STN Database accession no. 2006:1282971 *
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507907, retrieved from STN Database accession no. 255828-23-0 *
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507908, retrieved from STN Database accession no. 255828-22-9 *
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507909, retrieved from STN Database accession no. 255828-21-8 *
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DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507911, retrieved from STN Database accession no. 255828-19-4 *
ORIENTAL JOURNAL OF CHEMISTRY , 22(2), 369-374 CODEN: OJCHEG; ISSN: 0970-020X, 2006 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9233956B2 (en) 2008-05-06 2016-01-12 Novartis Ag Benzene sulfonamide thiazole and oxazole compounds

Also Published As

Publication number Publication date
WO2009010871A2 (en) 2009-01-22

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