MX2009006921A - Derivados azaespiro. - Google Patents

Derivados azaespiro.

Info

Publication number
MX2009006921A
MX2009006921A MX2009006921A MX2009006921A MX2009006921A MX 2009006921 A MX2009006921 A MX 2009006921A MX 2009006921 A MX2009006921 A MX 2009006921A MX 2009006921 A MX2009006921 A MX 2009006921A MX 2009006921 A MX2009006921 A MX 2009006921A
Authority
MX
Mexico
Prior art keywords
present
concerned
derivatives
azaspiro derivatives
compounds
Prior art date
Application number
MX2009006921A
Other languages
English (en)
Inventor
Mark Rogers-Evans
Raffaello Masciadri
Patrick Schnider
Hasane Ratni
Caterina Bissantz
Christophe Grundschober
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009006921A publication Critical patent/MX2009006921A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a con nuevos derivados de indol-3-il-carbonil-azaespiropiperidina como antagonistas del receptor V1a, con su elaboración, con composiciones farmacéuticas que los contienen y su utilización como medicamentos. Los compuestos activos de la presente invención son útiles en la prevención y/o tratamiento de la ansiedad y trastornos depresivos y otras enfermedades. En particular, la presente invención está relacionada con los compuestos de la fórmula general (I) (ver fórmula (I)) en donde R1 a R6, U, V, W, X, Y y Z son como se ha definido en la especificación.
MX2009006921A 2006-12-29 2007-12-19 Derivados azaespiro. MX2009006921A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06127334 2006-12-29
PCT/EP2007/064183 WO2008080844A1 (en) 2006-12-29 2007-12-19 Azaspiro derivatives

Publications (1)

Publication Number Publication Date
MX2009006921A true MX2009006921A (es) 2009-07-06

Family

ID=39201403

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006921A MX2009006921A (es) 2006-12-29 2007-12-19 Derivados azaespiro.

Country Status (22)

Country Link
US (3) US8039624B2 (es)
EP (1) EP2125827B1 (es)
JP (1) JP2010514727A (es)
KR (1) KR101129861B1 (es)
CN (1) CN101589046B (es)
AR (1) AR064547A1 (es)
AT (1) ATE486877T1 (es)
AU (1) AU2007341379B2 (es)
BR (1) BRPI0720827A2 (es)
CA (1) CA2674154A1 (es)
CL (1) CL2007003832A1 (es)
DE (1) DE602007010359D1 (es)
DK (1) DK2125827T3 (es)
ES (1) ES2351949T3 (es)
MX (1) MX2009006921A (es)
NO (1) NO20092342L (es)
PE (1) PE20081844A1 (es)
PL (1) PL2125827T3 (es)
PT (1) PT2125827E (es)
RU (1) RU2009124419A (es)
TW (1) TW200835483A (es)
WO (1) WO2008080844A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE469900T1 (de) * 2006-12-07 2010-06-15 Hoffmann La Roche Spiropiperidinderivate als antagonisten des via- rezeptors
EP2535329A3 (en) * 2006-12-22 2013-03-27 F. Hoffmann-La Roche AG Spiro-piperidine derivatives
AU2010273816B2 (en) 2009-06-29 2015-07-09 Incyte Holdings Corporation Pyrimidinones as PI3K inhibitors
AR078948A1 (es) * 2009-11-30 2011-12-14 Lilly Co Eli Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes
WO2011075630A1 (en) * 2009-12-18 2011-06-23 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
WO2011130342A1 (en) 2010-04-14 2011-10-20 Incyte Corporation FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
EP2655374B1 (en) 2010-12-20 2019-10-23 Incyte Holdings Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
EP2548864B1 (en) 2011-07-22 2014-02-19 Université Joseph Fourier Novel bis-indolic derivatives, a process for preparing the same and their uses as a drug
AR087760A1 (es) 2011-09-02 2014-04-16 Incyte Corp Heterociclilaminas como inhibidores de pi3k
CN102568615B (zh) * 2011-12-13 2013-05-22 华中科技大学 一种小型精密调平装置
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
PT3262046T (pt) 2015-02-27 2020-12-24 Incyte Corp Sais de inibidor de pi3k e processos para a sua preparação
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
JP2023501949A (ja) 2019-10-29 2023-01-20 バイオジェン・エムエイ・インコーポレイテッド スピロ環ｏ－糖タンパク質－２－アセトアミド－２－デオキシ－３－ｄ－グルコピラノシダーゼ阻害剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761992B1 (fr) * 1997-04-09 1999-06-11 Hoechst Marion Roussel Inc Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
TWI279402B (en) * 1999-08-20 2007-04-21 Banyu Pharma Co Ltd Spiro compounds having NPY antagonistic activities and agents containing the same
GB0003397D0 (en) 2000-02-14 2000-04-05 Merck Sharp & Dohme Therapeutic agents
WO2005063754A1 (en) * 2003-12-22 2005-07-14 Pfizer Limited Triazole derivatives as vasopressin antagonists
GB0400700D0 (en) * 2004-01-13 2004-02-18 Pfizer Ltd Compounds useful in therapy
GB0504556D0 (en) * 2005-03-04 2005-04-13 Pfizer Ltd Novel pharmaceuticals

Also Published As

Publication number Publication date
EP2125827A1 (en) 2009-12-02
DK2125827T3 (da) 2010-12-20
EP2125827B1 (en) 2010-11-03
KR101129861B1 (ko) 2012-04-24
WO2008080844A9 (en) 2009-10-08
CA2674154A1 (en) 2008-07-10
US20080161332A1 (en) 2008-07-03
PT2125827E (pt) 2010-11-22
AU2007341379B2 (en) 2012-05-24
US8039624B2 (en) 2011-10-18
WO2008080844A1 (en) 2008-07-10
ES2351949T3 (es) 2011-02-14
NO20092342L (no) 2009-07-02
US20080161333A1 (en) 2008-07-03
CN101589046A (zh) 2009-11-25
BRPI0720827A2 (pt) 2014-03-04
KR20090094172A (ko) 2009-09-03
AR064547A1 (es) 2009-04-08
PL2125827T3 (pl) 2011-04-29
RU2009124419A (ru) 2011-02-10
CN101589046B (zh) 2011-09-21
DE602007010359D1 (de) 2010-12-16
TW200835483A (en) 2008-09-01
ATE486877T1 (de) 2010-11-15
AU2007341379A1 (en) 2008-07-10
CL2007003832A1 (es) 2008-07-25
PE20081844A1 (es) 2009-01-26
US8044202B2 (en) 2011-10-25
JP2010514727A (ja) 2010-05-06
US20080281103A1 (en) 2008-11-13
US8034937B2 (en) 2011-10-11

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