MX2009006397A - Derivados de imidazotiazol. - Google Patents

Derivados de imidazotiazol.

Info

Publication number
MX2009006397A
MX2009006397A MX2009006397A MX2009006397A MX2009006397A MX 2009006397 A MX2009006397 A MX 2009006397A MX 2009006397 A MX2009006397 A MX 2009006397A MX 2009006397 A MX2009006397 A MX 2009006397A MX 2009006397 A MX2009006397 A MX 2009006397A
Authority
MX
Mexico
Prior art keywords
protein
inhibit
interaction
show
mdm2
Prior art date
Application number
MX2009006397A
Other languages
English (en)
Inventor
Hiroyuki Naito
Kouichi Uoto
Haruko Kawato
Masaki Miyazaki
Yuuichi Sugimoto
Tooru Okayama
Tsunehiko Soga
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of MX2009006397A publication Critical patent/MX2009006397A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Se pretende proveer compuestos novedosos que inhiben la interacción entre la proteína Mdm2 (dobles di-minutos murinos) y la proteína p53 y muestra una actividad antitumoral; están provistos los derivados de 'midazotiazol que tienen varios sustituyentes como se representa por la siguiente fórmula general (1), la cual inhibe la interacción entre la proteína Md2 y la proteína p53 y muestra una actividad antitumoral, en donde R1, R2, R3, R4 y R5 en la fórmula general (1) cada uno son como se definen en la descripción. (ver fórmula (1)).
MX2009006397A 2006-12-14 2007-12-12 Derivados de imidazotiazol. MX2009006397A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006336662 2006-12-14
PCT/JP2007/073930 WO2008072655A1 (ja) 2006-12-14 2007-12-12 イミダゾチアゾール誘導体

Publications (1)

Publication Number Publication Date
MX2009006397A true MX2009006397A (es) 2009-08-13

Family

ID=39511672

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006397A MX2009006397A (es) 2006-12-14 2007-12-12 Derivados de imidazotiazol.

Country Status (11)

Country Link
US (1) US20090312310A1 (es)
EP (1) EP2103619A4 (es)
JP (1) JPWO2008072655A1 (es)
KR (1) KR20090090383A (es)
CN (1) CN101605798A (es)
AU (1) AU2007332493A1 (es)
BR (1) BRPI0720546A2 (es)
CA (1) CA2672565A1 (es)
MX (1) MX2009006397A (es)
TW (1) TW200831518A (es)
WO (1) WO2008072655A1 (es)

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US11192898B2 (en) 2016-04-06 2021-12-07 The Regents Of The University Of Michigan MDM2 protein degraders
CA3020281A1 (en) 2016-04-06 2017-10-12 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
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Also Published As

Publication number Publication date
CA2672565A1 (en) 2008-06-19
KR20090090383A (ko) 2009-08-25
CN101605798A (zh) 2009-12-16
TW200831518A (en) 2008-08-01
JPWO2008072655A1 (ja) 2010-04-02
BRPI0720546A2 (pt) 2015-06-23
EP2103619A1 (en) 2009-09-23
AU2007332493A1 (en) 2008-06-19
WO2008072655A1 (ja) 2008-06-19
EP2103619A4 (en) 2011-11-23
US20090312310A1 (en) 2009-12-17

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