EA200501513A1 - Замещённые 1, 4 - диазепины и их применения - Google Patents

Замещённые 1, 4 - диазепины и их применения

Info

Publication number
EA200501513A1
EA200501513A1 EA200501513A EA200501513A EA200501513A1 EA 200501513 A1 EA200501513 A1 EA 200501513A1 EA 200501513 A EA200501513 A EA 200501513A EA 200501513 A EA200501513 A EA 200501513A EA 200501513 A1 EA200501513 A1 EA 200501513A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diazepins
substitutes
applications
given
hdm2
Prior art date
Application number
EA200501513A
Other languages
English (en)
Inventor
Тяньбао Лу
Карен Л. Милкиевич
Пьер Рабуассон
Максвелл Дэвид Каммингс
Рауль Р. Кальво
Дэниэл Дж. Паркс
Луис В. Лафранс III
Хуан Хосе Маруган Санчес
Джоан Гушу
Кристи Леонард
Original Assignee
Орто-Макнейл Фармасьютикал, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орто-Макнейл Фармасьютикал, Инк. filed Critical Орто-Макнейл Фармасьютикал, Инк.
Priority claimed from PCT/US2004/012240 external-priority patent/WO2004096134A2/en
Publication of EA200501513A1 publication Critical patent/EA200501513A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Abstract

Изобретение относится к новым 1,4-диазепинам, их фармацевтическим композициям и их применению в качестве ингибиторов взаимодействий HDM2-p53. Соединения имеют формулу I, приведенную в заявке, при этом значения от Rдо Rи Х приведены в описании изобретения, или их сольват, гидрат или фармацевтически приемлемая соль.
EA200501513A 2003-04-25 2004-04-21 Замещённые 1, 4 - диазепины и их применения EA200501513A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46526403P 2003-04-25 2003-04-25
PCT/US2004/012240 WO2004096134A2 (en) 2003-04-25 2004-04-21 Substituted 1,4-diazepines and uses thereof

Publications (1)

Publication Number Publication Date
EA200501513A1 true EA200501513A1 (ru) 2006-06-30

Family

ID=39817474

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501513A EA200501513A1 (ru) 2003-04-25 2004-04-21 Замещённые 1, 4 - диазепины и их применения

Country Status (6)

Country Link
US (2) US7115598B2 (ru)
AR (1) AR044540A1 (ru)
EA (1) EA200501513A1 (ru)
TW (1) TW200509942A (ru)
UA (1) UA82230C2 (ru)
ZA (1) ZA200509550B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186713B2 (en) 2003-01-21 2007-03-06 Ecopia Biosciences, Inc. Farnesyl dibenzodiazepinones and methods of treating cancer using same
US7358241B2 (en) * 2003-01-21 2008-04-15 Thallion Pharmaceuticals, Inc. Compositions and methods comprising farnesyl dibenzodiazepinones for treating neoplastic cells and conditions
US7655646B2 (en) * 2003-01-21 2010-02-02 Thallion Pharmaceuticals, Inc. Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals
WO2006097323A1 (en) * 2005-03-18 2006-09-21 Lutz Weber TETRAHYDRO-ISOQUINOLIN-l-ONES FOR THE TREATMENT OF CANCER
US7763604B2 (en) * 2005-05-16 2010-07-27 Thallion Pharma Ceuticals, Inc. Methods for administration of a farnesyl dibenzodiazepinone
US8470785B2 (en) 2006-07-28 2013-06-25 St. Jude Children's Research Hospital Method for treating ocular cancer
WO2008014216A1 (en) 2006-07-28 2008-01-31 St. Jude Children's Research Hospital Method for treating ocular cancer
CN101605798A (zh) 2006-12-14 2009-12-16 第一三共株式会社 咪唑并噻唑衍生物
GB0706072D0 (en) * 2007-03-28 2007-05-09 Sterix Ltd Compound
US8417305B2 (en) * 2007-05-02 2013-04-09 St. Vincents Hospital (Melbourne) Limited Non-invasive measurement of blood oxygen saturation
EP2298778A4 (en) 2008-06-12 2011-10-05 Daiichi Sankyo Co Ltd IMIDAZOTHIAZOL DERIVATIVE WITH 4,7-DIAZASPIRO [2.5] OCTAN RING STRUCTURE
WO2011098262A2 (en) * 2010-02-09 2011-08-18 Universität Bremen P19arf, hmga2 and mdm2 for use in the diagnosis and treatment of aberrant cell growth
FR2967072B1 (fr) 2010-11-05 2013-03-29 Univ Dundee Procede pour ameliorer la production de virus et semences vaccinales influenza
RU2690663C2 (ru) 2012-12-20 2019-06-05 Мерк Шарп И Доум Корп. Замещенные имидазопиридины в качестве ингибиторов hdm2
EP4277897A1 (en) * 2021-01-12 2023-11-22 Chengdu Anticancer Bioscience, Ltd. Fused azepine compounds and their use in the treatment of cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5348946A (en) * 1991-02-28 1994-09-20 Biochem Immunosystems, Inc. Heteroanthracycline antitumor analogs
US8053477B2 (en) * 2002-03-29 2011-11-08 University Of Maryland, Baltimore Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same

Also Published As

Publication number Publication date
US20040220179A1 (en) 2004-11-04
UA82230C2 (en) 2008-03-25
TW200509942A (en) 2005-03-16
US7115598B2 (en) 2006-10-03
US20060235007A1 (en) 2006-10-19
ZA200509550B (en) 2007-02-28
AR044540A1 (es) 2005-09-21

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