MX2007015174A - Proceso para elaborar un sulfonato de 2-desoxi-2,2-difluoro-d-ribo furanosilo enriquecido con alfa-anomero y su uso para elaborar beta nucleosido. - Google Patents

Proceso para elaborar un sulfonato de 2-desoxi-2,2-difluoro-d-ribo furanosilo enriquecido con alfa-anomero y su uso para elaborar beta nucleosido.

Info

Publication number
MX2007015174A
MX2007015174A MX2007015174A MX2007015174A MX2007015174A MX 2007015174 A MX2007015174 A MX 2007015174A MX 2007015174 A MX2007015174 A MX 2007015174A MX 2007015174 A MX2007015174 A MX 2007015174A MX 2007015174 A MX2007015174 A MX 2007015174A
Authority
MX
Mexico
Prior art keywords
deoxy
alpha
making
sulfonate
anomer
Prior art date
Application number
MX2007015174A
Other languages
English (en)
Inventor
George Schloemer
Lung-Hu Wang
Allen Liu
Original Assignee
Scinopharm Taiwan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scinopharm Taiwan Ltd filed Critical Scinopharm Taiwan Ltd
Publication of MX2007015174A publication Critical patent/MX2007015174A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22—Pteridine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un proceso para preparar un sulfonato 2-deoxi-2,2-difluoro-D-ribof uranosilo rico en alfa-anomero, el cual es util como intermediario en la preparacion de un nucleosido beta, tal como gemcitabina, un agente antitumoral. Un sulfonato 2-deoxi-2,2-difluoro-D-ribofuranosilo se calienta y se convierte en un sulfonato alfa-2-deoxi-2,2-difluoro-D-ribofuranosilo en la ausencia de una cantidad eficaz de una sal de sulfonato para facilitar la conversion. Ademas, una mezcla anomerica de un alfa-anomero y un beta-anomero de sulfonato 2-deoxi-2,2-difluoro-D -ribofuranosilo pueden disolverse en una mezcla de agua y un solvente y calentarse para producir un lactol, el cual puede convertirse ademas en un sulfonato 2-deoxi-2,2-difluoro-D-ribofura nosilo rico en alfa-anomero.
MX2007015174A 2005-06-03 2006-05-24 Proceso para elaborar un sulfonato de 2-desoxi-2,2-difluoro-d-ribo furanosilo enriquecido con alfa-anomero y su uso para elaborar beta nucleosido. MX2007015174A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68759305P 2005-06-03 2005-06-03
PCT/US2006/020131 WO2006132808A1 (en) 2005-06-03 2006-05-24 Process of making an alpha-anomer enriched 2-deoxy-2,2-diflouro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside

Publications (1)

Publication Number Publication Date
MX2007015174A true MX2007015174A (es) 2008-04-22

Family

ID=37498755

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007015174A MX2007015174A (es) 2005-06-03 2006-05-24 Proceso para elaborar un sulfonato de 2-desoxi-2,2-difluoro-d-ribo furanosilo enriquecido con alfa-anomero y su uso para elaborar beta nucleosido.

Country Status (13)

Country Link
US (1) US7572898B2 (es)
EP (1) EP1891087A4 (es)
JP (2) JP5091126B2 (es)
KR (1) KR101171087B1 (es)
CN (1) CN101203525B (es)
AR (1) AR053620A1 (es)
AU (1) AU2006255706B2 (es)
BR (1) BRPI0610950A2 (es)
CA (2) CA2610283C (es)
MX (1) MX2007015174A (es)
NZ (1) NZ563995A (es)
TW (1) TWI322812B (es)
WO (1) WO2006132808A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102140124B (zh) * 2011-02-26 2013-05-15 湖南欧亚生物有限公司 一种新型的卡培他滨的合成工艺
CN109796506A (zh) * 2019-01-28 2019-05-24 江苏八巨药业有限公司 一种吉西他滨关键中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose

Also Published As

Publication number Publication date
KR20080031172A (ko) 2008-04-08
EP1891087A1 (en) 2008-02-27
KR101171087B1 (ko) 2012-08-06
WO2006132808A1 (en) 2006-12-14
JP2008542374A (ja) 2008-11-27
CA2610283C (en) 2011-08-30
AU2006255706B2 (en) 2011-06-23
TW200745150A (en) 2007-12-16
TWI322812B (en) 2010-04-01
EP1891087A4 (en) 2008-07-30
CA2689979C (en) 2013-04-23
BRPI0610950A2 (pt) 2010-08-03
CA2610283A1 (en) 2006-12-14
JP5091126B2 (ja) 2012-12-05
JP2012236851A (ja) 2012-12-06
US7572898B2 (en) 2009-08-11
AU2006255706A1 (en) 2006-12-14
CN101203525A (zh) 2008-06-18
AR053620A1 (es) 2007-05-09
CA2689979A1 (en) 2006-12-14
US20060276638A1 (en) 2006-12-07
CN101203525B (zh) 2012-06-13
NZ563995A (en) 2010-01-29

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