MX2007008125A - Procedimiento para preparar aminas benciladas. - Google Patents

Procedimiento para preparar aminas benciladas.

Info

Publication number
MX2007008125A
MX2007008125A MX2007008125A MX2007008125A MX2007008125A MX 2007008125 A MX2007008125 A MX 2007008125A MX 2007008125 A MX2007008125 A MX 2007008125A MX 2007008125 A MX2007008125 A MX 2007008125A MX 2007008125 A MX2007008125 A MX 2007008125A
Authority
MX
Mexico
Prior art keywords
amine
preparing
benzylated amines
benzyl halide
benzylated
Prior art date
Application number
MX2007008125A
Other languages
English (en)
Inventor
Dennis J Kalota
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of MX2007008125A publication Critical patent/MX2007008125A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invencion se refiere a un procedimiento para preparar aminas benciladas mediante la reaccion de una amina seleccionada de metanfetamina y propilhexedrina con haluro de bencilo. Se obtienen numerosas mejoras al emplear la amina en exceso molar con respecto al haluro de bencilo, de preferencia en una relacion molar de 2 a 1. El exceso de amina se emplea para neutralizar selectivamente el subproducto acido como la sal amina. La sal amina se separa despues de la mezcla de reaccion y se basifica para reiniciar una amina de partida y reciclarla al procedimiento.
MX2007008125A 2005-01-06 2005-11-02 Procedimiento para preparar aminas benciladas. MX2007008125A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64184305P 2005-01-06 2005-01-06
PCT/US2005/039469 WO2006073547A1 (en) 2005-01-06 2005-11-02 Process for preparing benzylated amines

Publications (1)

Publication Number Publication Date
MX2007008125A true MX2007008125A (es) 2007-08-23

Family

ID=35695817

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007008125A MX2007008125A (es) 2005-01-06 2005-11-02 Procedimiento para preparar aminas benciladas.

Country Status (8)

Country Link
US (1) US7456318B2 (es)
EP (1) EP1838658A1 (es)
JP (1) JP2008526850A (es)
CN (1) CN101098848A (es)
AU (1) AU2005323338A1 (es)
CA (1) CA2593806A1 (es)
MX (1) MX2007008125A (es)
WO (1) WO2006073547A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0516270D0 (en) * 2005-08-08 2005-09-14 Glaxo Group Ltd Novel compounds
US20100113831A1 (en) * 2006-10-17 2010-05-06 Mallinckrodt Inc. Highly Pure Crystalline Benzphetamine Hydrochloride and Processes for Preparing
US8569544B2 (en) * 2009-08-19 2013-10-29 Emcure Pharmaceuticals Limited Process for preparation of benzphetamine and its pharmaceutically acceptable salts

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1854553A (en) * 1926-05-10 1932-04-19 Nat Aniline & Chem Co Inc Production of n-substituted amines
US2490813A (en) * 1944-11-29 1949-12-13 Standard Oil Co Continuous process for making aryl amines
US2789138A (en) * 1952-06-02 1957-04-16 Upjohn Co d-nu-methyl-nu-benzyl-beta-phenyliso-propylamine
US2987548A (en) * 1958-08-22 1961-06-06 California Research Corp Preparation of benzylamine
FR2068394A2 (en) 1969-08-05 1971-08-27 Amido Sa Laboratoires D-2-n-benzyl-n-methyl-amino-1-phenylpropane n-oxide salts anorectic c - stimulating
DE3163452D1 (en) * 1980-03-04 1984-06-14 Sumitomo Chemical Co Modified aluminium hydrides, their preparation and their use in reducing acetylnaphthalene derivatives
US5198587A (en) * 1980-07-29 1993-03-30 Yamanouchi Pharmaceutical Co., Ltd. Phenethylamine derivatives
US5220068A (en) * 1986-09-25 1993-06-15 Chinoin Gyogyszer - Es Vegyeszeti Termekek Gyara Rt. Psychostimulant agent
DE4410360A1 (de) 1994-03-25 1995-09-28 Basf Ag Verfahren zur Herstellung von Arylbenzylaminen
HU218927B (hu) * 1994-11-22 2000-12-28 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Eljárás propargil-ammónium-klorid-származékok előállítására
CN1266112C (zh) * 2001-04-24 2006-07-26 麻省理工学院 铜－催化的碳－杂原子键和碳－碳键的形成
US7517496B2 (en) * 2001-07-17 2009-04-14 Bio-Rad Laboratories, Inc. Latex based adsorbent chip
US6399828B1 (en) * 2001-10-29 2002-06-04 Boehringer Ingelheim Chemicals, Inc. Preparation of amphetamines from phenylpropanolamines

Also Published As

Publication number Publication date
CN101098848A (zh) 2008-01-02
EP1838658A1 (en) 2007-10-03
US7456318B2 (en) 2008-11-25
JP2008526850A (ja) 2008-07-24
AU2005323338A1 (en) 2006-07-13
CA2593806A1 (en) 2006-07-13
US20080188685A1 (en) 2008-08-07
WO2006073547A1 (en) 2006-07-13

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal