MX167392B - Procedimiento para preparar ni-metil-10 metoxilumilisergol - Google Patents

Procedimiento para preparar ni-metil-10 metoxilumilisergol

Info

Publication number
MX167392B
MX167392B MX204695A MX20469585A MX167392B MX 167392 B MX167392 B MX 167392B MX 204695 A MX204695 A MX 204695A MX 20469585 A MX20469585 A MX 20469585A MX 167392 B MX167392 B MX 167392B
Authority
MX
Mexico
Prior art keywords
methyl
preparing
metoxylumilisergol
procedure
ester
Prior art date
Application number
MX204695A
Other languages
English (en)
Inventor
Ezio Bombardelli
Giuseppe Mustich
Original Assignee
Inverni Della Beffa Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inverni Della Beffa Spa filed Critical Inverni Della Beffa Spa
Publication of MX167392B publication Critical patent/MX167392B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a procedimiento para preparar N1-metil-10 metoxilumilisergol y ésteres del mismo, de fórmula I: en donde R es hidrógeno o un éster del mismo en donde R es un grupo acilo, caracterizado porque un éster de N1-metillisergol se somete a reacción fotoquímica con metanol/ácido sulfúrico y el éster resultante de N1-metilmetoxilumilisergol se somete opcionalmente a hidrólisis a transesterificación.
MX204695A 1984-03-27 1985-03-20 Procedimiento para preparar ni-metil-10 metoxilumilisergol MX167392B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20242/84A IT1173489B (it) 1984-03-27 1984-03-27 Procedimento di preparazione di 1-metil-10alfa-metossilumilisergolo e di suci esteri,e intermedi per la loro preparazione

Publications (1)

Publication Number Publication Date
MX167392B true MX167392B (es) 1993-03-19

Family

ID=11165069

Family Applications (1)

Application Number Title Priority Date Filing Date
MX204695A MX167392B (es) 1984-03-27 1985-03-20 Procedimiento para preparar ni-metil-10 metoxilumilisergol

Country Status (10)

Country Link
US (1) US4980475A (es)
EP (1) EP0156645B1 (es)
JP (1) JPH07121944B2 (es)
AT (1) ATE47714T1 (es)
DE (1) DE3574018D1 (es)
ES (1) ES541593A0 (es)
GR (1) GR850637B (es)
IT (1) IT1173489B (es)
MX (1) MX167392B (es)
PT (1) PT80174B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213206B (it) * 1984-08-07 1989-12-14 Inverni Della Beffa Spa Procedimento per la preparazione di derivati del lisergolo.
GB8515528D0 (en) * 1985-06-19 1985-07-24 Erba Farmitalia Ergoline derivatives
CH674367A5 (es) * 1987-06-16 1990-05-31 Arysearch Arylan Ag
US6060483A (en) * 1996-06-27 2000-05-09 Pharmacia & Upjohn S.P.A. Antineurodegenerative ergoline derivatives
FR2786099B1 (fr) 1998-11-24 2000-12-29 Aventis Laboratoire Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline
FR2801793B1 (fr) * 1999-12-01 2003-07-04 Aventis Pharma Sa Association d'une ergoline et de riluzole et son utilisation comme medicament
CN101781296B (zh) * 2010-02-10 2011-09-14 南昌弘益科技有限公司 尼麦角林生产方法
WO2014195849A2 (en) * 2013-06-03 2014-12-11 Mahesh Kandula Compositions and methods for the treatment of cerebrovascular diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228943A (en) * 1962-06-11 1966-01-11 Lumilysergol derivatives
FR1439953A (fr) * 1965-01-28 1966-05-27 Sandoz Sa Nouveaux dérivés de l'ergolène et leur préparation
YU92970A (en) * 1969-05-13 1978-02-28 Farmaceutici Italia Process for preparing lumilysergic acid derivatives
DE1936410A1 (de) * 1969-07-17 1971-02-11 Hoechst Ag O-Acyl-lysergole und Verfahren zu ihrer Herstellung
US3879554A (en) * 1970-03-20 1975-04-22 Farmaceutici Italia Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders
GB1513322A (en) * 1976-01-09 1978-06-07 Farmaceutici Italia Heterocyclic ergoline derivatives
IT1094965B (it) * 1978-04-05 1985-08-10 Corvi Mora E Procedimento di preparazione di derivati del lisergolo
JPS5661376A (en) * 1979-10-09 1981-05-26 Corvi Mora E Manufacture of lysergol derivative

Also Published As

Publication number Publication date
JPS60226879A (ja) 1985-11-12
DE3574018D1 (en) 1989-12-07
JPH07121944B2 (ja) 1995-12-25
ES8602781A1 (es) 1985-12-01
GR850637B (es) 1985-07-09
ATE47714T1 (de) 1989-11-15
EP0156645A2 (en) 1985-10-02
PT80174A (en) 1985-04-01
IT1173489B (it) 1987-06-24
PT80174B (pt) 1987-06-17
EP0156645B1 (en) 1989-11-02
US4980475A (en) 1990-12-25
IT8420242A0 (it) 1984-03-27
ES541593A0 (es) 1985-12-01
EP0156645A3 (en) 1986-01-29

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