ME01612B - Proces za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)amino benzonitrila - Google Patents

Proces za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)amino benzonitrila

Info

Publication number
ME01612B
ME01612B MEP-2013-136A MEP13613A ME01612B ME 01612 B ME01612 B ME 01612B ME P13613 A MEP13613 A ME P13613A ME 01612 B ME01612 B ME 01612B
Authority
ME
Montenegro
Prior art keywords
dihydro
oxo
pyrimidinyl
preparing
ester
Prior art date
Application number
MEP-2013-136A
Other languages
English (en)
Inventor
Didier Philippe Robert Schils
Alfred Elisabeth Stappers
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of ME01612B publication Critical patent/ME01612B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Ovaj pronalazak se odnosi na postupak za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)-amino]benzonitrila (I) započinjući sa esterom (II) 4-okso-1,6-dihidro-pirimidinilkarboksilne kiseline iz gvanidinskog derivata koji reaguje sa esterom alkoksimetilen malonske kiseline i daje ester (II) koji se konvertuje u (I), pri čemu pomenuta reakciona sekvenca može da se provodi u jednoj posudi.
MEP-2013-136A 2005-05-26 2006-05-24 Proces za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)amino benzonitrila ME01612B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05104531 2005-05-26
US68599305P 2005-05-31 2005-05-31
EP06755299.2A EP1888537B1 (en) 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile
PCT/EP2006/062606 WO2006125809A1 (en) 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile

Publications (1)

Publication Number Publication Date
ME01612B true ME01612B (me) 2014-09-20

Family

ID=35822492

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2013-136A ME01612B (me) 2005-05-26 2006-05-24 Proces za pripremu 4-[(1,6-dihidro-6-okso-2-pirimidinil)amino benzonitrila

Country Status (20)

Country Link
US (2) US8101752B2 (me)
EP (1) EP1888537B1 (me)
JP (2) JP5148483B2 (me)
CN (1) CN101248051B (me)
AU (1) AU2006251163C1 (me)
BR (1) BRPI0611038B8 (me)
CA (1) CA2609716C (me)
DK (1) DK1888537T3 (me)
ES (1) ES2437202T3 (me)
HK (1) HK1123551A1 (me)
HR (1) HRP20131133T1 (me)
IN (1) IN2014DN04588A (me)
ME (1) ME01612B (me)
MX (1) MX2007014881A (me)
PL (1) PL1888537T3 (me)
PT (1) PT1888537E (me)
RS (1) RS53062B (me)
RU (1) RU2458056C2 (me)
SI (1) SI1888537T1 (me)
WO (1) WO2006125809A1 (me)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5148483B2 (ja) * 2005-05-26 2013-02-20 テイボテク・フアーマシユーチカルズ ４−［（１，６−ジヒドロ−６−オキソ−２−ピリミジニル）アミノベンゾニトリルの製造方法
WO2012125993A1 (en) 2011-03-17 2012-09-20 Teva Pharmaceutical Industries Ltd. Solid state forms of rilpivirine base, and rilipivirine salts
US10112972B2 (en) 2012-03-13 2018-10-30 Octapharma Ag Process for production of fibrinogen and fibrinogen produced thereby
CN103058936B (zh) * 2013-01-23 2016-01-06 宁波九胜创新医药科技有限公司 4-[(4-氯-2-嘧啶基)氨基]苯腈的制备方法
CN103193719B (zh) * 2013-04-08 2015-07-22 宁波九胜创新医药科技有限公司 一种4-[(4-羟基-2-嘧啶基)氨基]苯腈的制备方法
CN114933567B (zh) * 2022-04-29 2023-07-11 武汉工程大学 一种2-甲硫基-4-嘧啶酮的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63502B1 (en) 1989-04-21 1995-05-03 Zeneca Ltd Aminopyrimidine derivatives useful for treating cardiovascular disorders
DE3923979A1 (de) 1989-07-20 1991-01-24 Merck Patent Gmbh Verfahren zur herstellung von aromatischen nitrilen
RU2037483C1 (ru) * 1989-07-20 1995-06-19 Мерк Патент Гмбх Способ получения замещенных ароматических нитрилов
ID26291A (id) 1998-03-27 2000-12-14 Janssen Pharmaceutica Nv Turunan-turunan pirimidina penghambat hiv
BRPI9915552B8 (pt) * 1998-11-10 2021-05-25 Janssen Pharmaceutica Nv pirimidinas inibidoras da reprodução do hiv
PL207590B1 (pl) * 1999-09-24 2011-01-31 Janssen Pharmaceutica Nv Cząstka stanowiąca dyspersję stałą oraz postać dawkowania, sposób ich otrzymywania i zastosowanie
ES2559273T3 (es) * 2000-05-08 2016-02-11 Janssen Pharmaceutica Nv Profármacos de pirimidinas que inhiben la replicación del VIH
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
CN100491371C (zh) * 2001-11-01 2009-05-27 詹森药业有限公司 用作糖原合酶激酶3β抑制剂(GSK3抑制剂)的杂芳胺化合物
CN102702111B (zh) * 2002-08-09 2014-12-17 詹森药业有限公司 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
NZ546259A (en) * 2003-09-30 2009-05-31 Janssen Pharmaceutica Nv Benzoimidazole compounds
JP5148483B2 (ja) * 2005-05-26 2013-02-20 テイボテク・フアーマシユーチカルズ ４−［（１，６−ジヒドロ−６−オキソ−２−ピリミジニル）アミノベンゾニトリルの製造方法

Also Published As

Publication number Publication date
PL1888537T3 (pl) 2014-02-28
CA2609716A1 (en) 2006-11-30
JP2008545680A (ja) 2008-12-18
DK1888537T3 (da) 2013-12-09
JP5580385B2 (ja) 2014-08-27
WO2006125809A1 (en) 2006-11-30
SI1888537T1 (sl) 2014-01-31
CN101248051B (zh) 2013-07-17
US8101752B2 (en) 2012-01-24
BRPI0611038A2 (pt) 2010-08-10
US20120083606A1 (en) 2012-04-05
RS53062B (en) 2014-04-30
HRP20131133T1 (hr) 2014-01-03
AU2006251163C1 (en) 2012-07-12
RU2458056C2 (ru) 2012-08-10
CA2609716C (en) 2014-10-14
HK1123551A1 (en) 2009-06-19
US8618291B2 (en) 2013-12-31
AU2006251163A1 (en) 2006-11-30
JP2013040194A (ja) 2013-02-28
JP5148483B2 (ja) 2013-02-20
EP1888537B1 (en) 2013-09-11
ES2437202T3 (es) 2014-01-09
CN101248051A (zh) 2008-08-20
EP1888537A1 (en) 2008-02-20
MX2007014881A (es) 2008-02-15
US20080171878A1 (en) 2008-07-17
IN2014DN04588A (me) 2015-07-10
BRPI0611038B1 (pt) 2022-02-08
AU2006251163B2 (en) 2012-03-08
BRPI0611038B8 (pt) 2022-10-25
PT1888537E (pt) 2013-11-26
RU2007148968A (ru) 2009-07-10

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