MD1521G2 - Metode de inhibare a formării de trombi, metode de tratament al stărilor trombotice, compoziţii farmaceutice şi trusă pentru tratamentul stărilor trombotice - Google Patents
Metode de inhibare a formării de trombi, metode de tratament al stărilor trombotice, compoziţii farmaceutice şi trusă pentru tratamentul stărilor tromboticeInfo
- Publication number
- MD1521G2 MD1521G2 MD96-0334A MD960334A MD1521G2 MD 1521 G2 MD1521 G2 MD 1521G2 MD 960334 A MD960334 A MD 960334A MD 1521 G2 MD1521 G2 MD 1521G2
- Authority
- MD
- Moldova
- Prior art keywords
- methods
- thrombotic states
- kit
- treatment
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Invenţia se referă la medicină, şi anume la terapie.Esenţa invenţiei constă în aceea că pentru inhibarea formării de trombi se administrează o doză eficientă de anticorp monoclonal fibrino-specific. De asemenea, se revendică compoziţii farmaceutice şi trusă ce conţin în calitate de agent activ anticorpul menţionat.Rezultatul constă în lărgirea arsenalului de remedii utilizate pentru tratamentul trombozelor şi ameliorarea efectului curativ.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/204,015 US5487892A (en) | 1994-02-24 | 1994-02-24 | Method for treating thrombotic disease using a fibrin specific monoclonal antibody |
PCT/US1995/001825 WO1995022986A1 (en) | 1994-02-24 | 1995-02-21 | Fibrin-specific antibody for use as an antithrombotic agent |
Publications (3)
Publication Number | Publication Date |
---|---|
MD960334A MD960334A (ro) | 1997-09-30 |
MD1521F2 MD1521F2 (ro) | 2000-08-31 |
MD1521G2 true MD1521G2 (ro) | 2001-03-31 |
Family
ID=22756260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD96-0334A MD1521G2 (ro) | 1994-02-24 | 1995-02-21 | Metode de inhibare a formării de trombi, metode de tratament al stărilor trombotice, compoziţii farmaceutice şi trusă pentru tratamentul stărilor trombotice |
Country Status (26)
Country | Link |
---|---|
US (1) | US5487892A (ro) |
EP (1) | EP0749320A4 (ro) |
JP (1) | JPH09509429A (ro) |
KR (1) | KR970701063A (ro) |
CN (1) | CN1146157A (ro) |
AU (1) | AU708897B2 (ro) |
BG (1) | BG62476B1 (ro) |
BR (1) | BR9506949A (ro) |
CA (1) | CA2183953A1 (ro) |
CZ (1) | CZ246496A3 (ro) |
FI (1) | FI963288A (ro) |
GE (1) | GEP20002257B (ro) |
HU (1) | HUT76536A (ro) |
LT (1) | LT4192B (ro) |
LV (1) | LV11784B (ro) |
MD (1) | MD1521G2 (ro) |
MX (1) | MX9603602A (ro) |
NO (1) | NO963497L (ro) |
NZ (1) | NZ281481A (ro) |
PL (1) | PL316005A1 (ro) |
RU (1) | RU2152801C2 (ro) |
SG (1) | SG53279A1 (ro) |
SK (1) | SK108496A3 (ro) |
TJ (1) | TJ301B (ro) |
UA (1) | UA41984C2 (ro) |
WO (1) | WO1995022986A1 (ro) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5582862A (en) * | 1988-04-04 | 1996-12-10 | General Hospital Corporation | Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin |
US5453359A (en) * | 1988-06-13 | 1995-09-26 | American Biogenetic Sciences, Inc. | Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers |
US5817768A (en) * | 1995-06-07 | 1998-10-06 | The New York Blood Center, Inc. | Monospecific antibodies against a subunit of fibrinogen |
US6727102B1 (en) * | 1997-06-20 | 2004-04-27 | Leuven Research & Development Vzw | Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins |
US6309888B1 (en) | 1998-09-04 | 2001-10-30 | Leuven Research & Development Vzw | Detection and determination of the stages of coronary artery disease |
IL134828A0 (en) * | 2000-03-01 | 2001-05-20 | Eship 4U Com Inc | System for delivery and receipt of dispatches especially useful for e-commerce |
US20050181451A1 (en) * | 2004-02-12 | 2005-08-18 | Bates Harold M. | Detection of asymptomatic coronary artery disease using atherogenic proteins and acute phase reactants |
WO2006070776A1 (ja) * | 2004-12-28 | 2006-07-06 | Daiichi Pure Chemicals Co., Ltd. | 抗ヒト可溶性フィブリンモノクローナル抗体及び当該抗体を用いる免疫学的測定方法 |
AU2012250924B2 (en) | 2011-05-02 | 2017-05-25 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
CN104379169A (zh) | 2012-08-14 | 2015-02-25 | Ibc药品公司 | 用于治疗疾病的t-细胞重定向双特异性抗体 |
KR102356017B1 (ko) | 2012-12-13 | 2022-01-27 | 이뮤노메딕스, 인코오포레이티드 | 개선된 효능 및 감소된 독성을 위한 항체 및 sn-38의 면역컨쥬게이트의 투약 |
CN110563258A (zh) * | 2019-09-06 | 2019-12-13 | 广东石油化工学院 | 一种猪场废水厌氧产氢与达标排放处理方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4722903A (en) * | 1983-11-14 | 1988-02-02 | New York Blood Center, Inc. | Monoclonal antibodies specific to in vivo fragments derived from human fibrinogen, human fiberin I or human fibrin II |
US4758524A (en) * | 1983-03-17 | 1988-07-19 | Fielder Gillespie David Limited | Monoclonal antibodies with specificity for crosslinked fibrin derivatives and assay for said derivatives |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2635343B2 (ja) * | 1986-04-14 | 1997-07-30 | ザ・ジェネラル・ホスピタル・コーポレーション | ヘテロ二官能性抗体および利用方法 |
US4916070A (en) * | 1986-04-14 | 1990-04-10 | The General Hospital Corporation | Fibrin-specific antibodies and method of screening for the antibodies |
IL83631A0 (en) * | 1986-08-25 | 1988-01-31 | American Biogenetic Sciences | Monoclonal antibodies to fibrin |
DE3701812A1 (de) * | 1987-01-22 | 1988-08-04 | Max Planck Gesellschaft | Fibrinspezifischer antikoerper, verfahren zur seiner herstellung und seine verwendung |
US5223410A (en) * | 1988-06-13 | 1993-06-29 | American Biogenetic Sciences, Inc. | Method for production of antibodies utilizing an antigen-free animal |
US5120834A (en) * | 1988-06-13 | 1992-06-09 | American Biogenetic Sciences, Inc. | Fibrin-specific monoclonal antibody |
SG50681A1 (en) * | 1988-06-13 | 1998-07-20 | American Biogenetic Sciences | Method for the production of monoclonal antibodies utilizing a germfree animal |
US5091512A (en) * | 1988-06-13 | 1992-02-25 | American Biogenetic Sciences, Inc. | Fibrinogen-specific monoclonal antibody |
US5206140A (en) | 1988-06-24 | 1993-04-27 | Research Corporation Technologies, Inc. | Assay for soluble crosslinked fibrin polymers |
CA2052283A1 (en) * | 1990-09-27 | 1992-03-28 | Edgar Haber | Recombinant hybrid immunoglobulin molecules and method of use |
-
1994
- 1994-02-24 US US08/204,015 patent/US5487892A/en not_active Expired - Lifetime
-
1995
- 1995-02-21 PL PL95316005A patent/PL316005A1/xx unknown
- 1995-02-21 AU AU18434/95A patent/AU708897B2/en not_active Ceased
- 1995-02-21 EP EP95910251A patent/EP0749320A4/en not_active Withdrawn
- 1995-02-21 MX MX9603602A patent/MX9603602A/es unknown
- 1995-02-21 UA UA96093639A patent/UA41984C2/uk unknown
- 1995-02-21 SK SK1084-96A patent/SK108496A3/sk unknown
- 1995-02-21 SG SG1996009046A patent/SG53279A1/en unknown
- 1995-02-21 RU RU96119386/14A patent/RU2152801C2/ru active
- 1995-02-21 CZ CZ962464A patent/CZ246496A3/cs unknown
- 1995-02-21 HU HU9602337A patent/HUT76536A/hu unknown
- 1995-02-21 NZ NZ281481A patent/NZ281481A/en unknown
- 1995-02-21 CN CN95192673A patent/CN1146157A/zh active Pending
- 1995-02-21 KR KR1019960704600A patent/KR970701063A/ko not_active Application Discontinuation
- 1995-02-21 CA CA002183953A patent/CA2183953A1/en not_active Abandoned
- 1995-02-21 BR BR9506949A patent/BR9506949A/pt not_active Application Discontinuation
- 1995-02-21 MD MD96-0334A patent/MD1521G2/ro unknown
- 1995-02-21 WO PCT/US1995/001825 patent/WO1995022986A1/en not_active Application Discontinuation
- 1995-02-21 TJ TJ96000411A patent/TJ301B/xx unknown
- 1995-02-21 JP JP7522375A patent/JPH09509429A/ja not_active Ceased
- 1995-02-21 GE GEAP19953380A patent/GEP20002257B/en unknown
-
1996
- 1996-08-22 NO NO963497A patent/NO963497L/no not_active Application Discontinuation
- 1996-08-23 FI FI963288A patent/FI963288A/fi unknown
- 1996-09-23 BG BG100863A patent/BG62476B1/bg unknown
- 1996-09-23 LV LVP-96-379A patent/LV11784B/en unknown
- 1996-09-24 LT LT96-140A patent/LT4192B/lt not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4758524A (en) * | 1983-03-17 | 1988-07-19 | Fielder Gillespie David Limited | Monoclonal antibodies with specificity for crosslinked fibrin derivatives and assay for said derivatives |
US4722903A (en) * | 1983-11-14 | 1988-02-02 | New York Blood Center, Inc. | Monoclonal antibodies specific to in vivo fragments derived from human fibrinogen, human fiberin I or human fibrin II |
Non-Patent Citations (5)
Title |
---|
Bode C. et al. Science, 1985, vol. 229, 765-67. * |
Francis S.E. et al. Am. J Hem., 1985, vol. 18, p. 111-19. * |
Gimple L. W. et al. Circulation, 1992, vol. 86, p. 1536-46. * |
The Merck Manual of Diagnostics and Therapy, 15th Ed., Merck Sharpe & Dohme Research Labs, 1987. * |
Walker K.Z. et al. Eur. J. Nucl. Med., 1990, vol. 16, p. 787-94. * |
Also Published As
Publication number | Publication date |
---|---|
BG100863A (en) | 1997-08-29 |
BG62476B1 (bg) | 1999-12-30 |
JPH09509429A (ja) | 1997-09-22 |
CZ246496A3 (en) | 1997-04-16 |
CN1146157A (zh) | 1997-03-26 |
EP0749320A1 (en) | 1996-12-27 |
LT96140A (en) | 1997-03-25 |
PL316005A1 (en) | 1996-12-23 |
LT4192B (en) | 1997-07-25 |
LV11784A (lv) | 1997-06-20 |
UA41984C2 (uk) | 2001-10-15 |
NO963497L (no) | 1996-10-16 |
SG53279A1 (en) | 1998-09-28 |
GEP20002257B (en) | 2000-10-25 |
FI963288A0 (fi) | 1996-08-23 |
NZ281481A (en) | 1998-07-28 |
CA2183953A1 (en) | 1995-08-31 |
MD960334A (ro) | 1997-09-30 |
KR970701063A (ko) | 1997-03-17 |
AU1843495A (en) | 1995-09-11 |
US5487892A (en) | 1996-01-30 |
BR9506949A (pt) | 1997-09-23 |
HUT76536A (en) | 1997-09-29 |
MX9603602A (es) | 1997-05-31 |
FI963288A (fi) | 1996-08-23 |
RU2152801C2 (ru) | 2000-07-20 |
EP0749320A4 (en) | 1997-06-18 |
SK108496A3 (en) | 1997-10-08 |
AU708897B2 (en) | 1999-08-12 |
LV11784B (en) | 1997-12-20 |
MD1521F2 (ro) | 2000-08-31 |
WO1995022986A1 (en) | 1995-08-31 |
HU9602337D0 (en) | 1996-10-28 |
TJ301B (en) | 2001-08-06 |
NO963497D0 (no) | 1996-08-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD99 | Pending application |