MD1521G2 - Metode de inhibare a formării de trombi, metode de tratament al stărilor trombotice, compoziţii farmaceutice şi trusă pentru tratamentul stărilor trombotice - Google Patents

Metode de inhibare a formării de trombi, metode de tratament al stărilor trombotice, compoziţii farmaceutice şi trusă pentru tratamentul stărilor trombotice

Info

Publication number
MD1521G2
MD1521G2 MD96-0334A MD960334A MD1521G2 MD 1521 G2 MD1521 G2 MD 1521G2 MD 960334 A MD960334 A MD 960334A MD 1521 G2 MD1521 G2 MD 1521G2
Authority
MD
Moldova
Prior art keywords
methods
thrombotic states
kit
treatment
pharmaceutical compositions
Prior art date
Application number
MD96-0334A
Other languages
English (en)
Russian (ru)
Other versions
MD960334A (ro
MD1521F2 (ro
Inventor
Paul E. Gargan
Original Assignee
American Biogenetic Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Biogenetic Sciences, Inc. filed Critical American Biogenetic Sciences, Inc.
Publication of MD960334A publication Critical patent/MD960334A/ro
Publication of MD1521F2 publication Critical patent/MD1521F2/ro
Publication of MD1521G2 publication Critical patent/MD1521G2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Invenţia se referă la medicină, şi anume la terapie.Esenţa invenţiei constă în aceea că pentru inhibarea formării de trombi se administrează o doză eficientă de anticorp monoclonal fibrino-specific. De asemenea, se revendică compoziţii farmaceutice şi trusă ce conţin în calitate de agent activ anticorpul menţionat.Rezultatul constă în lărgirea arsenalului de remedii utilizate pentru tratamentul trombozelor şi ameliorarea efectului curativ.
MD96-0334A 1994-02-24 1995-02-21 Metode de inhibare a formării de trombi, metode de tratament al stărilor trombotice, compoziţii farmaceutice şi trusă pentru tratamentul stărilor trombotice MD1521G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/204,015 US5487892A (en) 1994-02-24 1994-02-24 Method for treating thrombotic disease using a fibrin specific monoclonal antibody
PCT/US1995/001825 WO1995022986A1 (en) 1994-02-24 1995-02-21 Fibrin-specific antibody for use as an antithrombotic agent

Publications (3)

Publication Number Publication Date
MD960334A MD960334A (ro) 1997-09-30
MD1521F2 MD1521F2 (ro) 2000-08-31
MD1521G2 true MD1521G2 (ro) 2001-03-31

Family

ID=22756260

Family Applications (1)

Application Number Title Priority Date Filing Date
MD96-0334A MD1521G2 (ro) 1994-02-24 1995-02-21 Metode de inhibare a formării de trombi, metode de tratament al stărilor trombotice, compoziţii farmaceutice şi trusă pentru tratamentul stărilor trombotice

Country Status (26)

Country Link
US (1) US5487892A (ro)
EP (1) EP0749320A4 (ro)
JP (1) JPH09509429A (ro)
KR (1) KR970701063A (ro)
CN (1) CN1146157A (ro)
AU (1) AU708897B2 (ro)
BG (1) BG62476B1 (ro)
BR (1) BR9506949A (ro)
CA (1) CA2183953A1 (ro)
CZ (1) CZ246496A3 (ro)
FI (1) FI963288A (ro)
GE (1) GEP20002257B (ro)
HU (1) HUT76536A (ro)
LT (1) LT4192B (ro)
LV (1) LV11784B (ro)
MD (1) MD1521G2 (ro)
MX (1) MX9603602A (ro)
NO (1) NO963497L (ro)
NZ (1) NZ281481A (ro)
PL (1) PL316005A1 (ro)
RU (1) RU2152801C2 (ro)
SG (1) SG53279A1 (ro)
SK (1) SK108496A3 (ro)
TJ (1) TJ301B (ro)
UA (1) UA41984C2 (ro)
WO (1) WO1995022986A1 (ro)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5582862A (en) * 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5453359A (en) * 1988-06-13 1995-09-26 American Biogenetic Sciences, Inc. Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers
US5817768A (en) * 1995-06-07 1998-10-06 The New York Blood Center, Inc. Monospecific antibodies against a subunit of fibrinogen
US6727102B1 (en) * 1997-06-20 2004-04-27 Leuven Research & Development Vzw Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins
US6309888B1 (en) 1998-09-04 2001-10-30 Leuven Research & Development Vzw Detection and determination of the stages of coronary artery disease
IL134828A0 (en) * 2000-03-01 2001-05-20 Eship 4U Com Inc System for delivery and receipt of dispatches especially useful for e-commerce
US20050181451A1 (en) * 2004-02-12 2005-08-18 Bates Harold M. Detection of asymptomatic coronary artery disease using atherogenic proteins and acute phase reactants
WO2006070776A1 (ja) * 2004-12-28 2006-07-06 Daiichi Pure Chemicals Co., Ltd. 抗ヒト可溶性フィブリンモノクローナル抗体及び当該抗体を用いる免疫学的測定方法
AU2012250924B2 (en) 2011-05-02 2017-05-25 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
CN104379169A (zh) 2012-08-14 2015-02-25 Ibc药品公司 用于治疗疾病的t-细胞重定向双特异性抗体
KR102356017B1 (ko) 2012-12-13 2022-01-27 이뮤노메딕스, 인코오포레이티드 개선된 효능 및 감소된 독성을 위한 항체 및 sn-38의 면역컨쥬게이트의 투약
CN110563258A (zh) * 2019-09-06 2019-12-13 广东石油化工学院 一种猪场废水厌氧产氢与达标排放处理方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4722903A (en) * 1983-11-14 1988-02-02 New York Blood Center, Inc. Monoclonal antibodies specific to in vivo fragments derived from human fibrinogen, human fiberin I or human fibrin II
US4758524A (en) * 1983-03-17 1988-07-19 Fielder Gillespie David Limited Monoclonal antibodies with specificity for crosslinked fibrin derivatives and assay for said derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2635343B2 (ja) * 1986-04-14 1997-07-30 ザ・ジェネラル・ホスピタル・コーポレーション ヘテロ二官能性抗体および利用方法
US4916070A (en) * 1986-04-14 1990-04-10 The General Hospital Corporation Fibrin-specific antibodies and method of screening for the antibodies
IL83631A0 (en) * 1986-08-25 1988-01-31 American Biogenetic Sciences Monoclonal antibodies to fibrin
DE3701812A1 (de) * 1987-01-22 1988-08-04 Max Planck Gesellschaft Fibrinspezifischer antikoerper, verfahren zur seiner herstellung und seine verwendung
US5223410A (en) * 1988-06-13 1993-06-29 American Biogenetic Sciences, Inc. Method for production of antibodies utilizing an antigen-free animal
US5120834A (en) * 1988-06-13 1992-06-09 American Biogenetic Sciences, Inc. Fibrin-specific monoclonal antibody
SG50681A1 (en) * 1988-06-13 1998-07-20 American Biogenetic Sciences Method for the production of monoclonal antibodies utilizing a germfree animal
US5091512A (en) * 1988-06-13 1992-02-25 American Biogenetic Sciences, Inc. Fibrinogen-specific monoclonal antibody
US5206140A (en) 1988-06-24 1993-04-27 Research Corporation Technologies, Inc. Assay for soluble crosslinked fibrin polymers
CA2052283A1 (en) * 1990-09-27 1992-03-28 Edgar Haber Recombinant hybrid immunoglobulin molecules and method of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4758524A (en) * 1983-03-17 1988-07-19 Fielder Gillespie David Limited Monoclonal antibodies with specificity for crosslinked fibrin derivatives and assay for said derivatives
US4722903A (en) * 1983-11-14 1988-02-02 New York Blood Center, Inc. Monoclonal antibodies specific to in vivo fragments derived from human fibrinogen, human fiberin I or human fibrin II

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Bode C. et al. Science, 1985, vol. 229, 765-67. *
Francis S.E. et al. Am. J Hem., 1985, vol. 18, p. 111-19. *
Gimple L. W. et al. Circulation, 1992, vol. 86, p. 1536-46. *
The Merck Manual of Diagnostics and Therapy, 15th Ed., Merck Sharpe & Dohme Research Labs, 1987. *
Walker K.Z. et al. Eur. J. Nucl. Med., 1990, vol. 16, p. 787-94. *

Also Published As

Publication number Publication date
BG100863A (en) 1997-08-29
BG62476B1 (bg) 1999-12-30
JPH09509429A (ja) 1997-09-22
CZ246496A3 (en) 1997-04-16
CN1146157A (zh) 1997-03-26
EP0749320A1 (en) 1996-12-27
LT96140A (en) 1997-03-25
PL316005A1 (en) 1996-12-23
LT4192B (en) 1997-07-25
LV11784A (lv) 1997-06-20
UA41984C2 (uk) 2001-10-15
NO963497L (no) 1996-10-16
SG53279A1 (en) 1998-09-28
GEP20002257B (en) 2000-10-25
FI963288A0 (fi) 1996-08-23
NZ281481A (en) 1998-07-28
CA2183953A1 (en) 1995-08-31
MD960334A (ro) 1997-09-30
KR970701063A (ko) 1997-03-17
AU1843495A (en) 1995-09-11
US5487892A (en) 1996-01-30
BR9506949A (pt) 1997-09-23
HUT76536A (en) 1997-09-29
MX9603602A (es) 1997-05-31
FI963288A (fi) 1996-08-23
RU2152801C2 (ru) 2000-07-20
EP0749320A4 (en) 1997-06-18
SK108496A3 (en) 1997-10-08
AU708897B2 (en) 1999-08-12
LV11784B (en) 1997-12-20
MD1521F2 (ro) 2000-08-31
WO1995022986A1 (en) 1995-08-31
HU9602337D0 (en) 1996-10-28
TJ301B (en) 2001-08-06
NO963497D0 (no) 1996-08-22

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Legal Events

Date Code Title Description
PD99 Pending application