MA43529A - Modulateurs de transport nucléaire et leurs utilisations - Google Patents
Modulateurs de transport nucléaire et leurs utilisationsInfo
- Publication number
- MA43529A MA43529A MA043529A MA43529A MA43529A MA 43529 A MA43529 A MA 43529A MA 043529 A MA043529 A MA 043529A MA 43529 A MA43529 A MA 43529A MA 43529 A MA43529 A MA 43529A
- Authority
- MA
- Morocco
- Prior art keywords
- nuclear transport
- transport modulators
- modulators
- nuclear
- transport
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562273857P | 2015-12-31 | 2015-12-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA43529A true MA43529A (fr) | 2018-11-07 |
Family
ID=57799957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA043529A MA43529A (fr) | 2015-12-31 | 2016-12-30 | Modulateurs de transport nucléaire et leurs utilisations |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10526295B2 (fr) |
| EP (1) | EP3397633A1 (fr) |
| MA (1) | MA43529A (fr) |
| WO (1) | WO2017117529A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2736887B1 (fr) | 2011-07-29 | 2017-10-18 | Karyopharm Therapeutics, Inc. | Modulateurs de transport nucléaire contenant de l'hydrazide et leurs utilisations |
| US9096543B2 (en) | 2012-05-09 | 2015-08-04 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
| EP3010892B8 (fr) | 2013-06-21 | 2019-05-22 | Karyopharm Therapeutics Inc. | 1,2,4-triazoles en tant que modulateurs de transport nucléaire et leurs utilisations |
| CN111484483B (zh) | 2014-08-15 | 2023-05-26 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
| WO2017117529A1 (fr) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Modulateurs de transport nucléaire et leurs utilisations |
| US10709706B2 (en) | 2015-12-31 | 2020-07-14 | Karopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| WO2019137381A1 (fr) | 2018-01-10 | 2019-07-18 | Xw Laboratories, Inc. | Promédicaments à base de kétamine, compositions et utilisations de ceux-ci |
| WO2019232724A1 (fr) * | 2018-06-06 | 2019-12-12 | Xw Laboratories, Inc. | Composés en tant que modulateurs de transport nucléaire et leurs utilisations |
| WO2021247447A1 (fr) * | 2020-06-01 | 2021-12-09 | Luke Klele | Compositions antivirales |
| WO2022089629A1 (fr) * | 2020-11-02 | 2022-05-05 | 江苏柯菲平医药股份有限公司 | Dérivé de 1,2,4-triazole, son procédé de préparation et son utilisation |
| CN117858873A (zh) * | 2021-05-20 | 2024-04-09 | 卡尔约药物治疗公司 | ***基丙烯酰胺的杂芳基衍生物和结晶形式的合成方法 |
| CN117881394A (zh) | 2021-08-13 | 2024-04-12 | 凯瑞康宁生物工程（武汉）有限公司 | ***衍生物的药物组合物和口服剂型 |
| CN117940409A (zh) * | 2021-09-08 | 2024-04-26 | 南京明德新药研发有限公司 | 丙烯酰胺类化合物及其应用 |
| WO2023072248A1 (fr) * | 2021-10-29 | 2023-05-04 | 正大天晴药业集团股份有限公司 | Composé contenant du pyridyle |
| WO2023134629A1 (fr) * | 2022-01-12 | 2023-07-20 | 上海海雁医药科技有限公司 | Régulateur de transport nucléaire et son utilisation |
Family Cites Families (61)
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| US1017398A (en) | 1911-01-16 | 1912-02-13 | John E Folsom | Telegraph-key. |
| CS229934B2 (en) | 1981-07-07 | 1984-07-16 | Pfizer | Production method subst.indolylacryte acid derivative |
| KR840000529A (ko) | 1981-07-07 | 1984-02-25 | 콘스탄틴 루이스 클레멘트 | 인돌 유도체의 제조방법 |
| US4778796A (en) | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
| JP3111321B2 (ja) | 1990-02-23 | 2000-11-20 | 武田薬品工業株式会社 | 縮合チアゾール化合物 |
| IL97249A (en) | 1990-02-23 | 1995-01-24 | Takeda Chemical Industries Ltd | Compounds of 7,6,5,4-tetrahydrothiazole] B-5,4 [pyridine and compounds of 5,6-dihydro-H4-pyrrolo] D-3,2 [thiazole, their manufacture, and pharmaceutical compositions including or |
| US5541213A (en) | 1993-06-24 | 1996-07-30 | Eisai Co., Ltd. | Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility |
| AU4368996A (en) | 1994-11-23 | 1996-06-17 | Neurogen Corporation | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands |
| US20030018025A1 (en) | 1995-06-07 | 2003-01-23 | Neurogen Corporation, Corporation Of The State Of Delaware | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives: new classes of dopamine receptor subtype specific ligands |
| CA2229617A1 (fr) | 1995-10-20 | 1997-05-01 | Dr. Karl Thomae Gmbh | Heterocycles a 5 chainons; medicaments a base de ces composes; leur emploi et methodes pour les preparer |
| ES2273364T3 (es) | 1996-04-04 | 2007-05-01 | SHIONOGI & CO., LTD. | Compuestos dde d[cefemo y composiciones farmaceuticas que contienen estos compuestos. |
| JP4054992B2 (ja) | 1996-04-25 | 2008-03-05 | 日産化学工業株式会社 | エチレン誘導体および有害生物防除剤 |
| WO1997040009A1 (fr) | 1996-04-25 | 1997-10-30 | Nissan Chemical Industries, Ltd. | Derives ethyleniques et agents pesticides |
| DE19624659A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| US5994398A (en) | 1996-12-11 | 1999-11-30 | Elan Pharmaceuticals, Inc. | Arylsulfonamides as phospholipase A2 inhibitors |
| JP4416198B2 (ja) | 1997-12-19 | 2010-02-17 | 武田薬品工業株式会社 | アニリド誘導体、その製造法および用途 |
| AU2960599A (en) | 1998-03-30 | 1999-10-18 | Akira Karasawa | Quinazoline derivatives |
| AR029803A1 (es) | 2000-02-21 | 2003-07-16 | Smithkline Beecham Plc | Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden |
| DE60138658D1 (de) | 2000-09-29 | 2009-06-18 | Topotarget Uk Ltd | Carbaminsäurederivate enthaltend eine Amidgruppe zur Behandlung von Malaria |
| EP1429765A2 (fr) | 2001-09-14 | 2004-06-23 | Methylgene, Inc. | Inhibiteurs de l'histone-deacetylase |
| WO2004037248A2 (fr) | 2002-10-24 | 2004-05-06 | Carex Sa | Modulation de l'activite des recepteurs actives par les proliferateurs de peroxysomes |
| DE10250743A1 (de) | 2002-10-31 | 2004-05-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Amid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| TW200416029A (en) | 2002-11-01 | 2004-09-01 | Takeda Chemical Industries Ltd | Agent for preventing or treating neuropathy |
| JP4145230B2 (ja) | 2002-11-01 | 2008-09-03 | 武田薬品工業株式会社 | 神経障害の予防・治療剤 |
| WO2004043925A2 (fr) | 2002-11-08 | 2004-05-27 | Neurogen Corporation | 6-aryl pyridines substituees en 3 |
| EP1599447A1 (fr) | 2003-02-28 | 2005-11-30 | Galderma Research & Development, S.N.C. | Ligands modulant des recepteurs du type lxr |
| KR101128065B1 (ko) | 2004-05-26 | 2012-04-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물 |
| BRPI0515015A (pt) | 2004-08-11 | 2008-07-01 | Kyorin Seiyaku Kk | derivado cìclico de ácido aminobenzóico; medicamento; agonista ppar(alpha); agonista duplo ppar(alpha), y; agonista duplo ppar(alpha), (delta); modulador ppar; agente lipìdeo; agente profilático ou terapêutico compreendendo pelo menos um dos derivados cìclicos de ácido aminobenzóico ou sal do mesmo farmacêuticamente aceitável |
| WO2006019020A1 (fr) | 2004-08-16 | 2006-02-23 | Sankyo Company, Limited | Urées de substitution |
| US20100130737A1 (en) | 2005-02-18 | 2010-05-27 | Takeda Pharmaceutical Company Limited | Regulating Agent of GPR34 Receptor Function |
| PL1954684T3 (pl) | 2005-11-15 | 2014-10-31 | Otsuka Pharma Co Ltd | Związek oksazolowy i kompozycja farmaceutyczna |
| JP2007210929A (ja) | 2006-02-09 | 2007-08-23 | Sankyo Co Ltd | ウレア化合物を含有する医薬 |
| AR059955A1 (es) | 2006-03-09 | 2008-05-14 | Eisai R&D Man Co Ltd | Compuestos policiclicos no peptidicos, medicamentos que los contienen, y usos para prevenir o tratar enfermedades causadas por la produccion de beta amiloide |
| AU2007234843B2 (en) | 2006-04-07 | 2013-07-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| PL2014652T3 (pl) | 2006-04-18 | 2015-02-27 | Nippon Chemiphar Co | Czynnik aktywujący receptor aktywowany przez proliferatory peroksysomów |
| KR101130380B1 (ko) | 2006-06-13 | 2012-04-23 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | 헤테로시클릭 비뉴클레오시드 화합물, 그의 제조방법, 약학적 조성물 및 항바이러스성 약제로서의 용도 |
| AU2007277519B2 (en) | 2006-07-27 | 2011-12-22 | Amorepacific Corporation | Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same |
| JP4388997B2 (ja) | 2006-09-05 | 2009-12-24 | 協和発酵キリン株式会社 | イミダゾール誘導体 |
| EP1942104A1 (fr) | 2006-12-20 | 2008-07-09 | sanofi-aventis | Hétéroarylcyclopropanecarboxamide et leur utilisation pharmaceutique |
| EP1939180A1 (fr) | 2006-12-20 | 2008-07-02 | sanofi-aventis | Hétéroarylacrylamides et leur utilisation en tant que médicament pour la stimulation de l'expression de la synthase NO endotheliale |
| JP2010519337A (ja) | 2007-02-26 | 2010-06-03 | コーサン バイオサイエンシーズ， インコーポレイテッド | カルバメート化合物 |
| EP2003118A1 (fr) | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Dérivés d'acides de cannelle en tant que modulateurs du récepteur EP2 |
| US20110009374A1 (en) | 2009-07-09 | 2011-01-13 | Keller Brian C | Method of wound healing and scar modulation |
| WO2011069039A1 (fr) | 2009-12-04 | 2011-06-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Composés d'hydrazone et de diacylhydrazine, et leurs procédés d'utilisation |
| CN103002742B (zh) | 2010-03-05 | 2016-07-13 | 卡尔约药物治疗公司 | 核转运调节剂及其应用 |
| EP2665362B1 (fr) | 2011-01-17 | 2016-03-30 | Karyopharm Therapeutics, Inc. | Modulateurs du transport nucléaire contenant des oléfines et leurs utilisations |
| EP2736887B1 (fr) | 2011-07-29 | 2017-10-18 | Karyopharm Therapeutics, Inc. | Modulateurs de transport nucléaire contenant de l'hydrazide et leurs utilisations |
| US9428490B2 (en) | 2011-07-29 | 2016-08-30 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| WO2013020024A2 (fr) | 2011-08-03 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Composés de maléimide et méthodes de traitement |
| US9096543B2 (en) | 2012-05-09 | 2015-08-04 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| CN102777158B (zh) | 2012-07-06 | 2014-09-10 | 西南石油大学 | 测调联动***及其操作工艺 |
| US20160016916A1 (en) | 2013-03-15 | 2016-01-21 | Karyopharm Therapeutics Inc. | Exo Olefin-Containing Nuclear Transport Modulators and Uses Thereof |
| US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
| WO2014205393A1 (fr) | 2013-06-21 | 2014-12-24 | Karyopharm Therapeutics Inc. | Modulateurs de transport nucléaire et leurs utilisations |
| EP3010892B8 (fr) | 2013-06-21 | 2019-05-22 | Karyopharm Therapeutics Inc. | 1,2,4-triazoles en tant que modulateurs de transport nucléaire et leurs utilisations |
| WO2015073908A1 (fr) | 2013-11-15 | 2015-05-21 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Procédé de sélection d'un schéma de traitement du cancer |
| JP6631616B2 (ja) | 2014-07-26 | 2020-01-15 | ノース・アンド・サウス・ブラザー・ファーマシー・インベストメント・カンパニー・リミテッド | ＣＤＫ阻害剤としての２−アミノ−ピリド［２，３−ｄ］ピリミジン−７（８Ｈ）−オン誘導体及びその使用 |
| CN111484483B (zh) | 2014-08-15 | 2023-05-26 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
| WO2017117529A1 (fr) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Modulateurs de transport nucléaire et leurs utilisations |
| US10709706B2 (en) | 2015-12-31 | 2020-07-14 | Karopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
-
2016
- 2016-12-30 WO PCT/US2016/069492 patent/WO2017117529A1/fr active Application Filing
- 2016-12-30 US US16/066,554 patent/US10526295B2/en active Active
- 2016-12-30 EP EP16826682.3A patent/EP3397633A1/fr not_active Withdrawn
- 2016-12-30 MA MA043529A patent/MA43529A/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20190016690A1 (en) | 2019-01-17 |
| WO2017117529A1 (fr) | 2017-07-06 |
| EP3397633A1 (fr) | 2018-11-07 |
| US10526295B2 (en) | 2020-01-07 |
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