MA39707B1 - Dérivés de 1,2-dihydro-3h-pyrrolo [1,2-c]imidazol-3-one et leur utilisation comme agents antibactériens - Google Patents

Dérivés de 1,2-dihydro-3h-pyrrolo [1,2-c]imidazol-3-one et leur utilisation comme agents antibactériens

Info

Publication number
MA39707B1
MA39707B1 MA39707A MA39707A MA39707B1 MA 39707 B1 MA39707 B1 MA 39707B1 MA 39707 A MA39707 A MA 39707A MA 39707 A MA39707 A MA 39707A MA 39707 B1 MA39707 B1 MA 39707B1
Authority
MA
Morocco
Prior art keywords
pyrrolo
imidazol
dihydro
derivatives
antibacterial agents
Prior art date
Application number
MA39707A
Other languages
English (en)
Other versions
MA39707A (fr
Inventor
Jean-Philippe Surivet
Jean-Christophe Gauvin
Azely Mirre
Jean-Luc Specklin
Gaelle Chapoux
Philippe Panchaud
Christine Schmitt
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MA39707A publication Critical patent/MA39707A/fr
Publication of MA39707B1 publication Critical patent/MA39707B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des composés antibactériens de la formule (i), dans laquelle r1 est l'un des groupes représentés ci-dessous (aa), a est une liaison, ch=ch ou c=c; u est n ou ch; v est n ou ch; w représente n ou ch; r1a, r2a, r3a, r1b et r1c sont tels que définis dans les revendications; les sels de ceux-ci.
MA39707A 2014-03-04 2015-03-03 Dérivés de 1,2-dihydro-3h-pyrrolo [1,2-c]imidazol-3-one et leur utilisation comme agents antibactériens MA39707B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14157636 2014-03-04
PCT/EP2015/054358 WO2015132228A1 (fr) 2014-03-04 2015-03-03 Dérivés 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one et leur utilisation en tant qu'agents antibactériens
EP15707154.9A EP3114126B1 (fr) 2014-03-04 2015-03-03 Dérivés de 1,2-dihydro-3h-pyrrolo [1,2-c]imidazol-3-one et leur utilisation comme agents antibactériens

Publications (2)

Publication Number Publication Date
MA39707A MA39707A (fr) 2017-01-11
MA39707B1 true MA39707B1 (fr) 2019-01-31

Family

ID=50189621

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39707A MA39707B1 (fr) 2014-03-04 2015-03-03 Dérivés de 1,2-dihydro-3h-pyrrolo [1,2-c]imidazol-3-one et leur utilisation comme agents antibactériens

Country Status (31)

Country Link
US (1) US10106544B2 (fr)
EP (1) EP3114126B1 (fr)
JP (1) JP6516370B2 (fr)
KR (1) KR20160127127A (fr)
CN (1) CN106061977B (fr)
AR (1) AR099612A1 (fr)
AU (1) AU2015226250B2 (fr)
BR (1) BR112016020278A8 (fr)
CA (1) CA2938383A1 (fr)
CL (1) CL2016002207A1 (fr)
CY (1) CY1121362T1 (fr)
DK (1) DK3114126T3 (fr)
EA (1) EA030708B1 (fr)
ES (1) ES2709382T3 (fr)
HR (1) HRP20190013T1 (fr)
HU (1) HUE042371T2 (fr)
IL (1) IL247544A0 (fr)
LT (1) LT3114126T (fr)
MA (1) MA39707B1 (fr)
MX (1) MX2016011380A (fr)
PH (1) PH12016501699A1 (fr)
PL (1) PL3114126T3 (fr)
PT (1) PT3114126T (fr)
SA (1) SA516371717B1 (fr)
SG (1) SG11201607304WA (fr)
SI (1) SI3114126T1 (fr)
TR (1) TR201900393T4 (fr)
TW (1) TW201542556A (fr)
UA (1) UA118868C2 (fr)
WO (1) WO2015132228A1 (fr)
ZA (1) ZA201606794B (fr)

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AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
US9624206B2 (en) 2013-12-19 2017-04-18 Actelion Pharmaceuticals Ltd Antibacterial 1H-indazole and 1H-indole derivatives
JP2017515906A (ja) 2014-05-16 2017-06-15 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性キナゾロン−４（３ｈ）−オン誘導体
AR105646A1 (es) * 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
MA42679A (fr) * 2015-08-28 2018-07-04 Idorsia Pharmaceuticals Ltd Dérivés de pyrrolidin-2-one annelés antibactériens
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
TW201840569A (zh) 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式
WO2019038362A1 (fr) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd Pyrroloimidazolones antibactériennes
WO2019086452A1 (fr) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Composés hétéroaromatiques antibactériens
EP4382527A1 (fr) * 2021-08-05 2024-06-12 Zhejiang Hisun Pharmaceutical Co., Ltd. Dérivé d'acétylène aromatique, son procédé de préparation et son utilisation

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NZ535158A (en) 2002-03-13 2007-06-29 Array Biopharma Inc N3 alkylated benzimidazole derivatives as MEK inhibitors
US7781591B2 (en) 2006-06-13 2010-08-24 Wyeth Llc Substituted 3-cyanopyridines as protein kinase inhibitors
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
WO2006063281A2 (fr) 2004-12-10 2006-06-15 Emory University Analogues de nucleosides de cyclobutyle a substitution 2' et 3' pour le traitement des infections virales et de la proliferation cellulaire anormale
JP2008001635A (ja) 2006-06-22 2008-01-10 Toray Ind Inc グリシン誘導体及びその用途
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
JP5698658B2 (ja) 2009-04-06 2015-04-08 第一三共株式会社 置換フェニル基を有する環状化合物
WO2010135536A2 (fr) 2009-05-20 2010-11-25 Ardea Biosciences, Inc. Procédés pour moduler des taux d'acide urique
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JP5671545B2 (ja) * 2009-10-13 2015-02-18 ファイザー・インク 抗菌薬として有用なｃ結合ヒドロキサム酸誘導体
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WO2014165075A1 (fr) 2013-03-12 2014-10-09 Achaogen, Inc. Agents antibactériens
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
US9624206B2 (en) 2013-12-19 2017-04-18 Actelion Pharmaceuticals Ltd Antibacterial 1H-indazole and 1H-indole derivatives
JP2017515906A (ja) 2014-05-16 2017-06-15 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性キナゾロン−４（３ｈ）−オン誘導体
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
MA42679A (fr) 2015-08-28 2018-07-04 Idorsia Pharmaceuticals Ltd Dérivés de pyrrolidin-2-one annelés antibactériens
AR105848A1 (es) 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
US10781184B2 (en) 2015-12-08 2020-09-22 Glaxosmithkline Intellectual Property Development Limited Substituted benzazinones as antibacterial compounds

Also Published As

Publication number Publication date
KR20160127127A (ko) 2016-11-02
EP3114126A1 (fr) 2017-01-11
WO2015132228A1 (fr) 2015-09-11
HUE042371T2 (hu) 2019-06-28
AU2015226250B2 (en) 2018-12-13
CA2938383A1 (fr) 2015-09-11
CL2016002207A1 (es) 2017-03-24
US10106544B2 (en) 2018-10-23
CY1121362T1 (el) 2020-05-29
US20170107223A1 (en) 2017-04-20
PT3114126T (pt) 2019-02-06
CN106061977B (zh) 2018-10-26
AR099612A1 (es) 2016-08-03
PL3114126T3 (pl) 2019-03-29
TR201900393T4 (tr) 2019-02-21
EA201691775A1 (ru) 2017-03-31
MX2016011380A (es) 2016-12-07
SA516371717B1 (ar) 2018-10-25
ES2709382T3 (es) 2019-04-16
BR112016020278A2 (fr) 2017-08-15
SG11201607304WA (en) 2016-09-29
HRP20190013T1 (hr) 2019-02-22
SI3114126T1 (sl) 2019-01-31
UA118868C2 (uk) 2019-03-25
AU2015226250A1 (en) 2016-10-20
DK3114126T3 (en) 2019-02-25
MA39707A (fr) 2017-01-11
JP6516370B2 (ja) 2019-05-22
BR112016020278A8 (pt) 2017-12-26
EP3114126B1 (fr) 2018-10-31
JP2017508746A (ja) 2017-03-30
EA030708B1 (ru) 2018-09-28
LT3114126T (lt) 2018-12-27
ZA201606794B (en) 2018-11-28
CN106061977A (zh) 2016-10-26
IL247544A0 (en) 2016-11-30
TW201542556A (zh) 2015-11-16
PH12016501699A1 (en) 2016-10-03

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