SG11201607304WA - 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents - Google Patents

1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

Info

Publication number
SG11201607304WA
SG11201607304WA SG11201607304WA SG11201607304WA SG11201607304WA SG 11201607304W A SG11201607304W A SG 11201607304WA SG 11201607304W A SG11201607304W A SG 11201607304WA SG 11201607304W A SG11201607304W A SG 11201607304WA SG 11201607304W A SG11201607304W A SG 11201607304WA
Authority
SG
Singapore
Prior art keywords
pyrrolo
imidazol
dihydro
derivatives
antibacterial agents
Prior art date
Application number
SG11201607304WA
Inventor
Gaelle Chapoux
Jean-Christophe Gauvin
Philippe Panchaud
Jean-Luc Specklin
Jean-Philippe Surivet
Christine Schmitt
Azely Mirre
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of SG11201607304WA publication Critical patent/SG11201607304WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
SG11201607304WA 2014-03-04 2015-03-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents SG11201607304WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14157636 2014-03-04
PCT/EP2015/054358 WO2015132228A1 (en) 2014-03-04 2015-03-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

Publications (1)

Publication Number Publication Date
SG11201607304WA true SG11201607304WA (en) 2016-09-29

Family

ID=50189621

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201607304WA SG11201607304WA (en) 2014-03-04 2015-03-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

Country Status (31)

Country Link
US (1) US10106544B2 (en)
EP (1) EP3114126B1 (en)
JP (1) JP6516370B2 (en)
KR (1) KR20160127127A (en)
CN (1) CN106061977B (en)
AR (1) AR099612A1 (en)
AU (1) AU2015226250B2 (en)
BR (1) BR112016020278A8 (en)
CA (1) CA2938383A1 (en)
CL (1) CL2016002207A1 (en)
CY (1) CY1121362T1 (en)
DK (1) DK3114126T3 (en)
EA (1) EA030708B1 (en)
ES (1) ES2709382T3 (en)
HR (1) HRP20190013T1 (en)
HU (1) HUE042371T2 (en)
IL (1) IL247544A0 (en)
LT (1) LT3114126T (en)
MA (1) MA39707B1 (en)
MX (1) MX2016011380A (en)
PH (1) PH12016501699A1 (en)
PL (1) PL3114126T3 (en)
PT (1) PT3114126T (en)
SA (1) SA516371717B1 (en)
SG (1) SG11201607304WA (en)
SI (1) SI3114126T1 (en)
TR (1) TR201900393T4 (en)
TW (1) TW201542556A (en)
UA (1) UA118868C2 (en)
WO (1) WO2015132228A1 (en)
ZA (1) ZA201606794B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR097617A1 (en) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd ANTIBACTERIAL DERIVATIVES OF 2H-INDAZOL
JP6407288B2 (en) 2013-12-19 2018-10-17 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Antibacterial 1H-indazole and 1H-indole derivatives
EP3143007B1 (en) 2014-05-16 2018-07-11 Idorsia Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
AR105646A1 (en) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd ANTIBACTERIAL AGENTS OF 1,2-DIHIDRO-3H-PIRROLO [1,2-C] IMIDAZOL-3-ONA SUBSTITUTED
EP3341378A1 (en) * 2015-08-28 2018-07-04 Idorsia Pharmaceuticals Ltd Antibacterial annulated pyrrolidin-2-one derivatives
AR105848A1 (en) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd ANTIBACTERIAL HETEROCYCLIC DERIVATIVES
AR105889A1 (en) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd ANTIBACTERIAL COMPOUNDS 1,2-DIHIDRO-3H-PIRROLO [1,2-C] IMIDAZOL-3-ONA SUBSTITUTED
TW201840569A (en) 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 Crystalline forms of (2R)-N-hydroxy-4-(6-((1-(2-hydroxyethyl)azetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-C]imidazol-2(3H)-yl)-2-methyl-2-(methylsulfonyl)butanamide
WO2019038362A1 (en) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd Antibacterial pyrroloimidazolones
WO2019086452A1 (en) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
WO2023011574A1 (en) * 2021-08-05 2023-02-09 浙江海正药业股份有限公司 Aromatic acetylene derivative, and preparation method therefor and use thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG148857A1 (en) 2002-03-13 2009-01-29 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
US7781591B2 (en) 2006-06-13 2010-08-24 Wyeth Llc Substituted 3-cyanopyridines as protein kinase inhibitors
DE102004017930A1 (en) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg New alkyne compounds having MCH antagonist activity and medicaments containing these compounds
EP1828145A4 (en) 2004-12-10 2009-08-19 Univ Emory 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation
JP2008001635A (en) 2006-06-22 2008-01-10 Toray Ind Inc Glycine derivative and its use
DE102008044132A1 (en) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Refrigerating appliance with double-sided door
WO2010116915A1 (en) 2009-04-06 2010-10-14 第一三共株式会社 Cyclic compound having substituted phenyl group
WO2010135536A2 (en) 2009-05-20 2010-11-25 Ardea Biosciences, Inc. Methods of modulating uric acid levels
WO2011021209A1 (en) 2009-07-07 2011-02-24 Portsmouth Technologies Llc Histone deacetylase inhibitors
US8853258B2 (en) 2009-10-13 2014-10-07 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
WO2011073845A1 (en) 2009-12-16 2011-06-23 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
CN103298780A (en) 2010-11-10 2013-09-11 尔察祯有限公司 Hydroxamic acid derivatives and their use in the treatment of bacterial infections
JP2014501274A (en) 2011-01-03 2014-01-20 ハンミ ファーム． シーオー．， エルティーディー． Novel bicyclic compounds for G protein coupled receptor modulation
UA107423C2 (en) * 2011-03-07 2014-12-25 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
DK2694488T3 (en) 2011-04-08 2014-12-15 Pfizer Isoxazole derivatives useful as antibacterial SUBSTANCES
KR20130140164A (en) * 2011-04-08 2013-12-23 화이자 인코포레이티드 Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
US8859559B2 (en) 2011-12-20 2014-10-14 Boehringer Ingelheim International Gmbh Substituted pyrazines and their use in the treatment of disease
EP2847162A1 (en) 2012-05-09 2015-03-18 Achaogen, Inc. Antibacterial agents
EP2847168A1 (en) 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
AR097617A1 (en) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd ANTIBACTERIAL DERIVATIVES OF 2H-INDAZOL
JP6407288B2 (en) 2013-12-19 2018-10-17 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Antibacterial 1H-indazole and 1H-indole derivatives
EP3143007B1 (en) 2014-05-16 2018-07-11 Idorsia Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
AR105646A1 (en) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd ANTIBACTERIAL AGENTS OF 1,2-DIHIDRO-3H-PIRROLO [1,2-C] IMIDAZOL-3-ONA SUBSTITUTED
EP3341378A1 (en) 2015-08-28 2018-07-04 Idorsia Pharmaceuticals Ltd Antibacterial annulated pyrrolidin-2-one derivatives
AR105848A1 (en) 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd ANTIBACTERIAL HETEROCYCLIC DERIVATIVES
AR105889A1 (en) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd ANTIBACTERIAL COMPOUNDS 1,2-DIHIDRO-3H-PIRROLO [1,2-C] IMIDAZOL-3-ONA SUBSTITUTED
JP2019501896A (en) 2015-12-08 2019-01-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Substituted benzazinones as antibacterial compounds

Also Published As

Publication number Publication date
BR112016020278A2 (en) 2017-08-15
US20170107223A1 (en) 2017-04-20
AU2015226250B2 (en) 2018-12-13
EP3114126A1 (en) 2017-01-11
CN106061977B (en) 2018-10-26
AR099612A1 (en) 2016-08-03
BR112016020278A8 (en) 2017-12-26
TR201900393T4 (en) 2019-02-21
US10106544B2 (en) 2018-10-23
EA201691775A1 (en) 2017-03-31
SA516371717B1 (en) 2018-10-25
MA39707B1 (en) 2019-01-31
CA2938383A1 (en) 2015-09-11
CL2016002207A1 (en) 2017-03-24
MA39707A (en) 2017-01-11
EP3114126B1 (en) 2018-10-31
IL247544A0 (en) 2016-11-30
KR20160127127A (en) 2016-11-02
HRP20190013T1 (en) 2019-02-22
LT3114126T (en) 2018-12-27
ZA201606794B (en) 2018-11-28
CN106061977A (en) 2016-10-26
JP2017508746A (en) 2017-03-30
PT3114126T (en) 2019-02-06
SI3114126T1 (en) 2019-01-31
PL3114126T3 (en) 2019-03-29
AU2015226250A1 (en) 2016-10-20
HUE042371T2 (en) 2019-06-28
ES2709382T3 (en) 2019-04-16
CY1121362T1 (en) 2020-05-29
MX2016011380A (en) 2016-12-07
DK3114126T3 (en) 2019-02-25
JP6516370B2 (en) 2019-05-22
TW201542556A (en) 2015-11-16
EA030708B1 (en) 2018-09-28
WO2015132228A1 (en) 2015-09-11
PH12016501699A1 (en) 2016-10-03
UA118868C2 (en) 2019-03-25

Similar Documents

Publication Publication Date Title
HRP20190013T1 (en) 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents
HK1244804A1 (en) 4h-pyrrolo[3,2-c]pyridin-4-one derivatives
IL254167A0 (en) Substituted 2,3-dihydroimidazo[1,2-c]quinazoline-containing combinations
IL253656A0 (en) Substituted mono- and polyazanaphthalene derivatives and their use
ZA201507874B (en) 2-aminopyrido[4,3-d]pyrimidin-5-one derivatives and their use as wee-1 inhibitors
HK1250645A1 (en) Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines
HK1256614A1 (en) Substituted 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one antibacterial compounds
HK1225723A1 (en) Substituted imidazo[1,2-a]pyridinecarboxamides and their use
IL263172A (en) Tricyclic heterocyclic derivatives, their preparation and use
IL261643B (en) Piperidine derivatives, their preparation and use
IL257413A (en) Substituted 1,2-dihydro-3h pyrrolo[1,2-c]imidazol-3 one antibacterials
IL256488A (en) New bicyclic lipolantipeptide, preparation and use as antimicrobial agent
IL274868A (en) Imidazopyridine derivatives and the use thereof as medicament
ZA201901945B (en) Tetrahydropyridine derivatives and their use as antibacterial agents
IL249122A0 (en) Imidazol- or 1,2,4-triazol-derivatives and their use
GB201522532D0 (en) Novel pyrrolo[3,2-c]pyridine-6-amino derivatives
PL3386988T3 (en) Novel dihydropyranopyrimidinone derivatives, and use thereof
EP3192513A4 (en) 7-fluoro-8-chloro-5 -dibenzo[b,e][1,4]diazepine derivatives and use thereof
EP3209667A4 (en) Nargenicin compounds and uses thereof as antibacterial agents
HUE038944T2 (en) Thiochromeno[2,3-c]quinolin-12-one derivatives and their use as topoisomerase inhibitors
EP3601246C0 (en) 16-methyl-oxacyclohexadecan-2-one and 16-methyl-azacyclohexadecan-2-one derivatives as antimicrobial agents
ZA201801639B (en) Substituted 1,2-dihydro-3h pyrrolo[1,2-c]imidazol-3 one antibacterials
TH1601002954A (en) New Octahydro-Cyclobuta[1,2-c;3,4-c']dipyrrole-2-yl