MA38948A1 - Dérivés de 2h-indazole antibactériens - Google Patents

Dérivés de 2h-indazole antibactériens

Info

Publication number
MA38948A1
MA38948A1 MA38948A MA38948A MA38948A1 MA 38948 A1 MA38948 A1 MA 38948A1 MA 38948 A MA38948 A MA 38948A MA 38948 A MA38948 A MA 38948A MA 38948 A1 MA38948 A1 MA 38948A1
Authority
MA
Morocco
Prior art keywords
antibacterial
indazole derivatives
halogen
indazole
derivatives
Prior art date
Application number
MA38948A
Other languages
English (en)
Other versions
MA38948B1 (fr
Inventor
Jean-Philippe Surivet
Jean-Christophe Gauvin
Azely Mirre
Etienne Ochala
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA38948A1 publication Critical patent/MA38948A1/fr
Publication of MA38948B1 publication Critical patent/MA38948B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems

Abstract

La présente invention concerne des composés antibactériens de formule (i) dans laquelle r1 est h ou halogène; r2 est alkynyloxy ou le groupe m; r3 est h ou halogène; m est un parmi les groupes (a, b, c, d) dans lequel a est une liaison, ch2 ch2, ch=ch ou c=c et r1a, r2a, r3a, r1b et r1c sont tels que définis dans la revendication 1; et des sels de ceux-ci.
MA38948A 2013-09-13 2014-09-12 Dérivés de 2h-indazole antibactériens MA38948B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2013058537 2013-09-13
PCT/IB2014/064458 WO2015036964A1 (fr) 2013-09-13 2014-09-12 Dérivés de 2h-indazole antibactériens

Publications (2)

Publication Number Publication Date
MA38948A1 true MA38948A1 (fr) 2017-05-31
MA38948B1 MA38948B1 (fr) 2018-04-30

Family

ID=51688371

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38948A MA38948B1 (fr) 2013-09-13 2014-09-12 Dérivés de 2h-indazole antibactériens

Country Status (29)

Country Link
US (1) US9802901B2 (fr)
EP (1) EP3044211B1 (fr)
JP (1) JP6353909B2 (fr)
KR (1) KR20160055889A (fr)
CN (1) CN105531264B (fr)
AR (1) AR097617A1 (fr)
AU (1) AU2014319966B2 (fr)
BR (1) BR112016007757A8 (fr)
CA (1) CA2923146A1 (fr)
CL (1) CL2016000568A1 (fr)
CY (1) CY1120111T1 (fr)
DK (1) DK3044211T3 (fr)
EA (1) EA031562B1 (fr)
ES (1) ES2662894T3 (fr)
HR (1) HRP20180484T1 (fr)
HU (1) HUE038519T2 (fr)
IL (1) IL244500B (fr)
LT (1) LT3044211T (fr)
MA (1) MA38948B1 (fr)
MX (1) MX361733B (fr)
MY (1) MY179283A (fr)
PH (1) PH12016500480A1 (fr)
PL (1) PL3044211T3 (fr)
PT (1) PT3044211T (fr)
SG (1) SG11201601889YA (fr)
SI (1) SI3044211T1 (fr)
TW (1) TWI646084B (fr)
UA (1) UA116484C2 (fr)
WO (1) WO2015036964A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3083567B1 (fr) 2013-12-19 2018-03-07 Idorsia Pharmaceuticals Ltd Dérivés de 1h-indazole et de 1h-indole antibactériens
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
CA2948077A1 (fr) 2014-05-16 2015-11-19 Actelion Pharmaceuticals Ltd Derives antibacteriens de quinazoline-4(3h)-one
AR102687A1 (es) 2014-11-19 2017-03-15 Actelion Pharmaceuticals Ltd Derivados de benzotiazol antibacterianos
AR105646A1 (es) * 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
EA201890600A1 (ru) * 2015-08-28 2018-09-28 Идорсиа Фармасьютиклз Лтд Антибактериальные аннелированные производные пирролидин-2-она
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) * 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
US20190315731A1 (en) * 2016-05-17 2019-10-17 Jörg Volker 6-(buta-1,3-diyn-1-yl)benzo[d]thiazole derivatives
WO2019038362A1 (fr) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd Pyrroloimidazolones antibactériennes
CN113372276B (zh) * 2021-05-25 2022-04-22 三峡大学 吲唑类衍生物及其应用

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Publication number Priority date Publication date Assignee Title
BR0214748A (pt) 2001-12-05 2004-11-23 Ortho Mcneil Pharm Inc Derivados 6-oacil-cetolidas de eritromicina, úteis como antibacterianos
US6806279B2 (en) 2001-12-17 2004-10-19 Sunesis Pharmaceuticals, Inc. Small-molecule inhibitors of interleukin-2
PT2275102E (pt) 2002-03-13 2015-10-27 Array Biopharma Inc Derivados de benzimidazole alquilado n3 como inibidores de mek
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
US7495006B2 (en) 2004-12-10 2009-02-24 Emory University 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation
RU2412943C2 (ru) 2005-03-23 2011-02-27 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
CN101765585B (zh) 2007-06-12 2017-03-15 尔察祯有限公司 抗菌剂
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
WO2010100475A1 (fr) 2009-03-02 2010-09-10 Astrazeneca Ab Dérivés de l'acide hydroxamique en tant qu'agents contre des bactéries à gram négatif
US8372807B2 (en) 2009-05-20 2013-02-12 Ardea Biosciences, Inc. Methods of modulating uric acid levels
EP2451790A4 (fr) 2009-07-07 2012-12-26 Anthem Biosciences Private Ltd Inhibiteurs de l histone désacétylase
EP2488489A2 (fr) * 2009-10-13 2012-08-22 Pfizer Inc. Dérivés d'acide hydroxamique à liaison c utiles comme agents antibactériens
CA2782453C (fr) 2009-12-16 2015-11-24 Matthew Frank Brown Derives d'acide hydroxamique a liaison n, utiles comme agents antibacteriens
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
BR112013011693A2 (pt) 2010-11-10 2016-08-09 Achaogen Inc derivados de ácido hidroxâmico e seu uso no tratamento de infecções por bactérias
WO2012093809A2 (fr) 2011-01-03 2012-07-12 Hanmi Pharm Co., Ltd. Nouveau composé bicyclique pour la modulation de récepteurs couplés à la protéine g
MX341977B (es) 2011-03-07 2016-09-07 Pfizer Derivados de fluoro-piridinona utiles como agentes antibacterianos.
CA2830920C (fr) 2011-04-08 2015-07-14 Pfizer Inc. Derives d'isoxazole utiles en tant qu'agents antibacteriens
CA2830866A1 (fr) * 2011-04-08 2012-10-11 Pfizer Inc. Derives d'imidazole, de pyrazole et de triazole, utiles en tant qu'agents antibacteriens
EP2847162A1 (fr) 2012-05-09 2015-03-18 Achaogen, Inc. Agents antibactériens
EP3083567B1 (fr) 2013-12-19 2018-03-07 Idorsia Pharmaceuticals Ltd Dérivés de 1h-indazole et de 1h-indole antibactériens
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
CA2948077A1 (fr) 2014-05-16 2015-11-19 Actelion Pharmaceuticals Ltd Derives antibacteriens de quinazoline-4(3h)-one

Also Published As

Publication number Publication date
JP6353909B2 (ja) 2018-07-04
EP3044211A1 (fr) 2016-07-20
MX361733B (es) 2018-12-14
SG11201601889YA (en) 2016-04-28
IL244500B (en) 2018-05-31
EA031562B1 (ru) 2019-01-31
US20160221959A1 (en) 2016-08-04
AR097617A1 (es) 2016-04-06
AU2014319966B2 (en) 2018-11-15
PH12016500480B1 (en) 2016-05-16
WO2015036964A1 (fr) 2015-03-19
ES2662894T3 (es) 2018-04-10
US9802901B2 (en) 2017-10-31
CA2923146A1 (fr) 2015-03-19
CY1120111T1 (el) 2018-12-12
PH12016500480A1 (en) 2016-05-16
AU2014319966A1 (en) 2016-05-05
TW201542531A (zh) 2015-11-16
MY179283A (en) 2020-11-03
PT3044211T (pt) 2018-03-21
BR112016007757A8 (pt) 2018-08-14
MX2016003196A (es) 2016-06-02
EA201600248A1 (ru) 2016-08-31
PL3044211T3 (pl) 2018-06-29
KR20160055889A (ko) 2016-05-18
SI3044211T1 (en) 2018-04-30
CL2016000568A1 (es) 2016-11-11
EP3044211B1 (fr) 2018-01-03
CN105531264A (zh) 2016-04-27
TWI646084B (zh) 2019-01-01
HRP20180484T1 (hr) 2018-05-04
DK3044211T3 (en) 2018-03-12
MA38948B1 (fr) 2018-04-30
IL244500A0 (en) 2016-04-21
UA116484C2 (uk) 2018-03-26
LT3044211T (lt) 2018-04-10
BR112016007757A2 (pt) 2018-07-10
HUE038519T2 (hu) 2018-10-29
CN105531264B (zh) 2018-04-10
JP2016530327A (ja) 2016-09-29

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