MA39254A1 - Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh - Google Patents
Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhhInfo
- Publication number
- MA39254A1 MA39254A1 MA39254A MA39254A MA39254A1 MA 39254 A1 MA39254 A1 MA 39254A1 MA 39254 A MA39254 A MA 39254A MA 39254 A MA39254 A MA 39254A MA 39254 A1 MA39254 A1 MA 39254A1
- Authority
- MA
- Morocco
- Prior art keywords
- aggregative
- high affinity
- antibodies based
- vhh derivative
- domains
- Prior art date
Links
- 230000003612 virological effect Effects 0.000 title 1
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K39/39591—Stabilisation, fragmentation
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- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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Abstract
L'invention concerne des anticorps monoclonaux de type igg comprenant des domaines sous forme d'une combinaison d'un dérivé de vhh avec un domaine variable de chaîne légère vl. Ces anticorps peuvent comprendre des substituants d'aminoacides aux positions 44 et/ou 45 (selon la numérotation de kabat) ou leurs combinaisons. Les anticorps de l'invention possèdent une plus grande affinité et une meilleure stabilité d'agrégation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2014138740A RU2609627C2 (ru) | 2014-09-26 | 2014-09-26 | Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh |
PCT/RU2015/000163 WO2016048188A1 (fr) | 2014-09-26 | 2015-03-23 | Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh |
Publications (2)
Publication Number | Publication Date |
---|---|
MA39254A1 true MA39254A1 (fr) | 2018-05-31 |
MA39254B2 MA39254B2 (fr) | 2022-04-29 |
Family
ID=55581555
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA040763A MA40763A (fr) | 2014-09-26 | 2015-03-22 | Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh |
MA39254A MA39254B2 (fr) | 2014-09-26 | 2015-03-23 | Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA040763A MA40763A (fr) | 2014-09-26 | 2015-03-22 | Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh |
Country Status (25)
Country | Link |
---|---|
US (2) | US10442869B2 (fr) |
EP (1) | EP3199550A4 (fr) |
JP (2) | JP2017538656A (fr) |
KR (1) | KR102600823B1 (fr) |
CN (1) | CN107001458B (fr) |
AR (1) | AR101984A1 (fr) |
AU (1) | AU2015322141B2 (fr) |
BR (1) | BR112016015867A2 (fr) |
CA (1) | CA2941656C (fr) |
CL (1) | CL2016001028A1 (fr) |
EA (1) | EA037090B1 (fr) |
GE (1) | GEP20217311B (fr) |
IL (1) | IL244762B1 (fr) |
MA (2) | MA40763A (fr) |
MX (1) | MX2016012769A (fr) |
MY (1) | MY192853A (fr) |
NZ (1) | NZ724306A (fr) |
PH (1) | PH12016501391A1 (fr) |
RU (1) | RU2609627C2 (fr) |
SG (1) | SG11201607283RA (fr) |
TW (1) | TWI585104B (fr) |
UA (1) | UA125111C2 (fr) |
UY (1) | UY36319A (fr) |
WO (1) | WO2016048188A1 (fr) |
ZA (1) | ZA201605265B (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2680011C2 (ru) * | 2016-04-29 | 2019-02-14 | Закрытое Акционерное Общество "Биокад" | Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы |
JP7122672B2 (ja) * | 2018-06-08 | 2022-08-22 | パナソニックIpマネジメント株式会社 | Vhh抗体 |
EP3689907A1 (fr) | 2019-01-31 | 2020-08-05 | Numab Therapeutics AG | Anticorps dirigés contre il-17a et leurs procédés d'utilisation |
CN113631574A (zh) | 2019-01-31 | 2021-11-09 | 努玛治疗有限公司 | 对TNFα和IL-17A具有特异性的多特异性抗体、靶向IL-17A的抗体及其使用方法 |
RU2754760C2 (ru) * | 2019-04-02 | 2021-09-07 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция анти-il17a антитела и ее применение |
CN112239501B (zh) * | 2020-10-29 | 2022-01-07 | 东莞市朋志生物科技有限公司 | 抗新型冠状病毒的抗体、检测新型冠状病毒试剂和试剂盒 |
CN114380917B (zh) * | 2022-03-25 | 2022-06-14 | 南京融捷康生物科技有限公司 | 针对IL-17A和TNFα的双特异性单域抗体及其用途 |
CN114380906B (zh) * | 2022-03-25 | 2022-06-14 | 南京融捷康生物科技有限公司 | 一种抗il-17a的单域抗体及其用途 |
CN117843801A (zh) * | 2023-12-29 | 2024-04-09 | 北京贝来药业有限公司 | 以白介素家族成员为靶点的新型抗体以及下游产品 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005289809A (ja) * | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
GB0417487D0 (en) * | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
FR2879605B1 (fr) * | 2004-12-16 | 2008-10-17 | Centre Nat Rech Scient Cnrse | Production de formats d'anticorps et applications immunologiques de ces formats |
US8211648B2 (en) * | 2005-07-22 | 2012-07-03 | Kalobios Pharmaceuticals, Inc. | Secretion of antibodies without signal peptides from bacteria |
CA2651567A1 (fr) * | 2006-05-09 | 2007-11-22 | Genentech, Inc. | Polypeptides de liaison a squelettes optimises |
AU2008328781A1 (en) * | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same |
KR101710472B1 (ko) * | 2007-11-30 | 2017-02-27 | 글락소 그룹 리미티드 | 항원-결합 작제물 |
DK2217268T3 (en) * | 2007-12-07 | 2016-08-15 | Zymogenetics Inc | MONOCLONAL ANTI-HUMAN IL-21 ANTIBODIES |
GB2461546B (en) | 2008-07-02 | 2010-07-07 | Argen X Bv | Antigen binding polypeptides |
WO2010130832A2 (fr) * | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Séquences d'acides aminés dirigées contre dickkopf-1 et polypeptides comprenant ces dernières pour le traitement de maladies et de pathologies associées à la déperdition osseuse et/ou à l'ostéolyse |
AU2012245073B2 (en) * | 2011-04-21 | 2016-02-11 | Garvan Institute Of Medical Research | Modified variable domain molecules and methods for producing and using them b |
UA117218C2 (uk) * | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
US10946104B2 (en) * | 2012-01-13 | 2021-03-16 | Apo-Tb.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
GEP201706773B (en) * | 2012-02-27 | 2017-11-27 | Boehringer Ingelheim Int | Cx3cr1-binding polypeptides |
CN105190314A (zh) * | 2013-01-21 | 2015-12-23 | 阿布维公司 | 用于炎性疾病的抗-tnf和抗-il17联合疗法生物标志物 |
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2014
- 2014-09-26 RU RU2014138740A patent/RU2609627C2/ru active
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- 2015-03-22 MA MA040763A patent/MA40763A/fr unknown
- 2015-03-23 JP JP2016555526A patent/JP2017538656A/ja active Pending
- 2015-03-23 GE GEAP201514257A patent/GEP20217311B/en unknown
- 2015-03-23 SG SG11201607283RA patent/SG11201607283RA/en unknown
- 2015-03-23 UA UAA201610535A patent/UA125111C2/uk unknown
- 2015-03-23 KR KR1020167015041A patent/KR102600823B1/ko active IP Right Grant
- 2015-03-23 MA MA39254A patent/MA39254B2/fr unknown
- 2015-03-23 WO PCT/RU2015/000163 patent/WO2016048188A1/fr active Application Filing
- 2015-03-23 AU AU2015322141A patent/AU2015322141B2/en active Active
- 2015-03-23 CA CA2941656A patent/CA2941656C/fr active Active
- 2015-03-23 MX MX2016012769A patent/MX2016012769A/es unknown
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- 2015-03-23 MY MYPI2016703189A patent/MY192853A/en unknown
- 2015-03-23 EP EP15843607.1A patent/EP3199550A4/fr active Pending
- 2015-03-23 CN CN201580011619.5A patent/CN107001458B/zh active Active
- 2015-03-23 EA EA201600277A patent/EA037090B1/ru unknown
- 2015-03-23 BR BR112016015867-9A patent/BR112016015867A2/pt active Search and Examination
- 2015-09-18 AR ARP150103033A patent/AR101984A1/es unknown
- 2015-09-22 UY UY0001036319A patent/UY36319A/es active IP Right Grant
- 2015-09-24 TW TW104131631A patent/TWI585104B/zh not_active IP Right Cessation
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2016
- 2016-03-27 IL IL244762A patent/IL244762B1/en unknown
- 2016-04-29 CL CL2016001028A patent/CL2016001028A1/es unknown
- 2016-07-14 PH PH12016501391A patent/PH12016501391A1/en unknown
- 2016-07-29 ZA ZA2016/05265A patent/ZA201605265B/en unknown
- 2016-09-01 US US15/254,225 patent/US10442869B2/en active Active
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